Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: Potential for new antibacterial agents

Journal of Medicinal Chemistry

Volumn 56, Issue 17, 2013, Pages 6967-6984

  Keough, Dianne T ^a   Hocková, Dana ^b   Rejman, Dominik ^b   Špaček, Petr ^b   Vrbková, Silvie ^b   Krečmerová, Marcela ^b   Eng, Wai Soon ^a   Jans, Harmen ^c   West, Nicholas P ^a   Naesens, Lieve M J ^c   De Jersey, John ^a   Guddat, Luke W ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3 (HYPOXANTHIN 9 YL)PYRROLIDIN 1 N YLACETYLPHOSPHONIC ACID; 4 (GUANIN 9 YL) 3 (2 PHOSPHONOACETYL)PYRROLIDIN 1 N YLACETYLPHOSPHONIC ACID; 4 (GUANIN 9 YL) 3 HYDROXYPYRROLIDIN 1 N YLACETYLPHOSPHONIC ACID; 4(GUANIN 9 YL) 3 HYDROXYPYRROLIDIN 1 N YLACETYLPHOSPHONIC ACID; 6 OXOPURINE PHOSPHORIBOSYLTRANSFERASE; ALANINE; AMINO ACID; ANTIINFECTIVE AGENT; GUANINE; HYPOXANTHINE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; NUCLEOSIDE PHOSPHONATE; PHOSPHONIC ACID DERIVATIVE; PHOSPHORIBOSYLTRANSFERASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL; BINDING AFFINITY; CATALYSIS; CELL ASSAY; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG BINDING; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ESCHERICHIA COLI; IC 50; MASS SPECTROMETRY; MYCOBACTERIUM TUBERCULOSIS; PROTON NUCLEAR MAGNETIC RESONANCE; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; CATALYSIS; CATALYTIC DOMAIN; ESCHERICHIA COLI; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84884252460     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400779n     Document Type: Article

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