N -phosphonocarbonylpyrrolidine derivatives of guanine: A new class of Bi-substrate inhibitors of human purine nucleoside phosphorylase

Journal of Medicinal Chemistry

Volumn 55, Issue 4, 2012, Pages 1612-1621

  Rejman, Dominik ^a   Panova, Natalya ^a   Klener, Pavel ^b   Maswabi, Bokang ^b   Pohl, Radek ^a   Rosenberg, Ivan ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

3 (GUANIN 9 YL)PYRROLIDIN 1 N YLCARBONYLPHOSPHONIC ACID; 3 (GUANIN 9 YL)PYRROLIDIN N YLCARBONYLPHOSPHONIC ACID; 4 (GUANIN 9 YL) 3 HYDROXYPYRROLIDIN 1 N YLCARBONYLPHOSPHONIC ACID; 4 (GUANIN 9 YL) 3 HYDROXYPYRROLIDINE; 4 AMINO 1 N BOC 3 HYDROXYPYRROLIDINE; 4 AMINO 1 N TERT BUTYLOXYCARBONYL 3 HYDROXYPYRROLIDINE; GUANINE; N PHOSPHONOCARBONYLPYRROLIDINE DERIVATIVE; PURINE NUCLEOSIDE PHOSPHORYLASE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BONE MARROW CELL; CELL LINE; DRUG PURIFICATION; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME ISOLATION; HUMAN; HUMAN EXPERIMENT; LYMPHOID CELL; PERIPHERAL BLOOD MONONUCLEAR CELL;

CELL LINE, TUMOR; GUANINE; GUANINE NUCLEOTIDES; HUMANS; LEUKOCYTES, MONONUCLEAR; ORGANOPHOSPHONATES; PHOSPHOROUS ACIDS; PURINE-NUCLEOSIDE PHOSPHORYLASE; PYRROLIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84857406209     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201409u     Document Type: Article

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