Electronegative LDL: A circulating modified LDL with a role in inflammation

Mediators of Inflammation

Volumn 2013, Issue , 2013, Pages

  Estruch, Montserrat ^a,b   Sánchez Quesada, José Luis ^a,c   Ordóñez Llanos, Jordi ^b,c   Benítez, Sònia ^a,c  

^a BIOMEDICAL RESEARCH INSTITUTE SANT PAU IIB SANT PAU   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; ALPHA TOCOPHEROL; APOLIPOPROTEIN B; ELECTRONEGATIVE LOW DENSITY LIPOPROTEIN; FATTY ACID; FIBROBLAST GROWTH FACTOR 2; INTERLEUKIN 8; LIPID PEROXIDE; LOW DENSITY LIPOPROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHOLIPASE A2; PHOSPHOLIPASE C; PROTEOGLYCAN; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; LIGAND; LIPOPOLYSACCHARIDE; OXIDIZED LOW DENSITY LIPOPROTEIN; OXYGEN;

ANGIOGENESIS; ANTIGEN ANTIBODY COMPLEX; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL REGENERATION; CONFORMATION; CYTOTOXICITY; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; ENZYME ACTIVITY; GLYCOSYLATION; HYDROLYSIS; IMMUNE RESPONSE; INFLAMMATION; MONOCYTE; MONONUCLEAR CELL; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; T LYMPHOCYTE; UMBILICAL VEIN ENDOTHELIAL CELL; ANIMAL; ATHEROSCLEROSIS; CHEMISTRY; CYTOLOGY; HUMAN; LEUKOCYTE; PATHOLOGY; PATHOPHYSIOLOGY; REVIEW;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; ATHEROSCLEROSIS; ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; LEUKOCYTES; LIGANDS; LIPOPOLYSACCHARIDES; LIPOPROTEINS, LDL; MONOCYTES; OXYGEN;

EID: 84884246172     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2013/181324     Document Type: Article

References (101)

1. Kovanen P. T., Pentikäinen M. O., Circulating lipoproteins as proinflammatory and anti-inflammatory particles in atherogenesis. Current Opinion in Lipidology 2003 14 5 411 419 2-s2.0-0142124861 10.1097/00041433- 200310000-00001
2. Navab M., Berliner J. A., Watson A. D., Hama S. Y., Territo M. C., Lusis A. J., Shih D. M., Van Lenten B. J., Frank J. S., Demer L. L., Edwards P. A., Fogelman A. M., The Yin and Yang of oxidation in the development of the fatty streak: a review based on the 1994 George Lyman Duff memorial lecture. Arteriosclerosis, Thrombosis, and Vascular Biology 1996 16 7 831 842 2-s2.0-8944258922
3. Ishigaki Y., Oka Y., Katagiri H., Circulating oxidized LDL: a biomarker and a pathogenic factor. Current Opinion in Lipidology 2009 20 5 363 369 2-s2.0-73349101401 10.1097/MOL.0b013e32832fa58d
4. Avogaro P., Bon G. B., Gazzolato G., Presence of a modified low density lipoprotein in humans. Arteriosclerosis 1988 8 1 79 87 2-s2.0-0023833209
5. Sanchez-Quesada J. L., Benitez S., Ordonez-Llanos J., Electronegative low-density lipoprotein. Current Opinion in Lipidology 2004 15 329 335
6. Sanchez-Quesada J. L., Villegas S., Ordonez-Llanos J., Electronegative low-density lipoprotein. A link between apolipoprotein B misfolding, lipoprotein aggregation and proteoglycan binding. Current Opinion in Lipidology 2012 23 479 486
7. De Castellarnau C., Sánchez-Quesada J. L., Benítez S., Rosa R., Caveda L., Vila L., Ordóñez-Llanos J., Electronegative LDL from normolipemic subjects induces IL-8 and monocyte chemotactic protein secretion by human endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology 2000 20 10 2281 2287 2-s2.0-0033786167
8. Benítez S., Camacho M., Arcelus R., Vila L., Bancells C., Ordóñez-Llanos J., Sánchez-Quesada J. L., Increased lysophosphatidylcholine and non-esterified fatty acid content in LDL induces chemokine release in endothelial cells: relationship with electronegative LDL. Atherosclerosis 2004 177 2 299 305 2-s2.0-8644239488 10.1016/j.atherosclerosis. 2004.07.027
9. Estruch M., Sanchez-Quesada J. L., Beloki L., Ordonez-Llanos J., Benitez S., The induction of cytokine release in monocytes by electronegative low-density lipoprotein (LDL) is related to its higher ceramide content than native LDL. International Journal of Molecular Sciences 2013 14 2601 2616
10. Benítez S., Sánchez-Quesada J. L., Ribas V., Jorba O., Blanco-Vaca F., González-Sastre F., Ordóñez-Llanos J., Platelet-activating factor acetylhydrolase is mainly associated with electronegative low-density lipoprotein subfraction. Circulation 2003 108 1 92 96 2-s2.0-17344394888 10.1161/01.CIR.0000072791.40232.8F
11. Bancells C., Benítez S., Villegas S., Jorba O., Ordóñez-Llanos J., Sánchez-Quesada J. L., Novel phospholipolytic activities associated with electronegative low-density lipoprotein are involved in increased self-aggregation. Biochemistry 2008 47 31 8186 8194 2-s2.0-48649097203 10.1021/bi800537h
12. Bancells C., Benítez S., Ordóñez-Llanos J., Öörni K., Kovanen P. T., Milne R. W., Sánchez-Quesada J. L., Immunochemical analysis of the electronegative LDL subfraction shows that abnormal N-terminal apolipoprotein B conformation is involved in increased binding to proteoglycans. Journal of Biological Chemistry 2011 286 2 1125 1133 2-s2.0-78651392002 10.1074/jbc.M110.175315
13. Demuth K., Myara I., Chappey B., Vedie B., Pech-Amsellem M. A., Haberland M. E., Moatti N., A cytotoxic electronegative LDL subfraction is present in human plasma. Arteriosclerosis, Thrombosis, and Vascular Biology 1996 16 6 773 783 2-s2.0-0029940303
14. Hodis H. N., Kramsch D. M., Avogaro P., Bittolo-Bon G., Cazzolato G., Hwang J., Peterson H., Sevanian A., Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-). Journal of Lipid Research 1994 35 4 669 677 2-s2.0-0028218536
15. Benítez S., Bancells C., Ordóñez-Llanos J., Sánchez-Quesada J. L., Pro-inflammatory action of LDL(-) on mononuclear cells is counteracted by increased IL10 production. Biochimica et Biophysica Acta 2007 1771 5 613 622 2-s2.0-34247640096 10.1016/j.bbalip.2007.03.001
16. Estruch M., Sanchez-Quesada J. L., Beloki L., Ordonez-Llanos J., Benitez S., CD14 and TLR4 mediate cytokine release promoted by electronegative LDL in monocytes. Atherosclerosis 2013 229 356 362
17. Sevanian A., Bittolo-Bon G., Cazzolato G., Hodis H., Hwang J., Zamburlini A., Maiorino M., Ursini F., LDL- is a lipid hydroperoxide-enriched circulating lipoprotein. Journal of Lipid Research 1997 38 3 419 428 2-s2.0-0031089461
18. Sevanian A., Hwang J., Hodis H., Cazzolato G., Avogaro P., Bittolo-Bon G., Contribution of an in vivo oxidized LDL to LDL oxidation and its association with dense LDL subpopulations. Arteriosclerosis, Thrombosis, and Vascular Biology 1996 16 6 784 793 2-s2.0-0030006777
19. Shimano H., Yamada N., Ishibashi S., Mokuno H., Mori N., Gotoda T., Harada K., Akanuma Y., Murase T., Yazaki Y., Takaku F., Oxidation-labile subfraction of human plasma low density lipoprotein isolated by ion-exchange chromatography. Journal of Lipid Research 1991 32 5 763 773 2-s2.0-0025820853
20. Sánchez-Quesada J. L., Camacho M., Antón R., Benítez S., Vila L., Ordóñez-Llanos J., Electronegative LDL of FH subjects: chemical characterization and induction of chemokine release from human endothelial cells. Atherosclerosis 2003 166 2 261 270 2-s2.0-12244279990 10.1016/S0021-9150(02)00374-X
21. Yang C.-Y., Raya J. L., Chen H.-H., Chen C.-H., Abe Y., Pownall H. J., Taylor A. A., Smith C. V., Isolation, characterization, and functional assessment of oxidatively modified subfractions of circulating low-density lipoproteins. Arteriosclerosis, Thrombosis, and Vascular Biology 2003 23 6 1083 1090 2-s2.0-0038797786 10.1161/01.ATV.0000071350.78872.C4
22. Nevalainen T. J., Serum phospholipases A2 in inflammatory diseases. Clinical Chemistry 1993 39 12 2453 2459 2-s2.0-0027787847
23. Schissel S. L., Tweedie-Hardman J., Rapp J. H., Graham G., Williams K. J., Tabas I., Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein: proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins. Journal of Clinical Investigation 1996 98 6 1455 1464 2-s2.0-0029762320
24. Sánchez-Quesada J. L., Benítez S., Otal C., Franco M., Blanco-Vaca F., Ordóñez-Llanos J., Density distribution of electronegative LDL in normolipemic and hyperlipemic subjects. Journal of Lipid Research 2002 43 5 699 705 2-s2.0-0036254352
25. Bancells C., Canals F., Benítez S., Colomé N., Julve J., Ordóñez-Llanos J., Sánchez-Quesada J. L., Proteomic analysis of electronegative low-density lipoprotein. Journal of Lipid Research 2010 51 12 3508 3515 2-s2.0-78650038243 10.1194/jlr.M009258
26. Bancells C., Sánchez-Quesada J. L., Birkelund R., Ordóñez-Llanos J., Benítez S., HDL and electronegative LDL exchange anti- and pro-inflammatory properties. Journal of Lipid Research 2010 51 10 2947 2956 2-s2.0-77956813107 10.1194/jlr.M005777
27. Bancells C., Villegas S., Blanco F. J., Benítez S., Gállego I., Beloki L., Pérez-Cuellar M., Ordóñez-Llanos J., Sánchez-Quesada J. L., Aggregated electronegative low density lipoprotein in human plasma shows a high tendency toward phospholipolysis and particle fusion. Journal of Biological Chemistry 2010 285 42 32425 32435 2-s2.0-77957803559 10.1074/jbc.M110.139691
28. Sanchez-Quesada J. L., Estruch M., Benitez S., Ordonez-Llanos J., Electronegative low-density lipoprotein: a useful biomarker of cardiovascular risk? Journal of Clinical Lipidology 2012 7 1 15
29. Mello A. P. Q., da Silva I. T., Abdalla D. S. P., Damasceno N. R. T., Electronegative low-density lipoprotein: origin and impact on health and disease. Atherosclerosis 2011 215 2 257 265 2-s2.0-79953062925 10.1016/j.atherosclerosis.2010.12.028
30. Benítez S., Ordóñez-Llanos J., Franco M., Marín C., Paz E., López-Miranda J., Otal C., Pérez- Jiménez F., Sánchez-Quesada J. L., Effect of simvastatin in familial hypercholesterolemia on the affinity of electronegative low-density lipoprotein subfractions to the low-density lipoprotein receptor. American Journal of Cardiology 2004 93 4 414 420 2-s2.0-1242292993 10.1016/j.amjcard. 2003.10.034
31. Sánchez-Quesada J. L., Pérez A., Caixàs A., Ordónmez-Llanos J., Carreras G., Payés A., González-Sastre F., De Leiva A., Electronegative low density lipoprotein subform is increased in patients with short-duration IDDM and is closely related to glycaemic control. Diabetologia 1996 39 12 1469 1476 2-s2.0-0029961240 10.1007/s001250050600
32. Sánchez-Quesada J. L., Pérez A., Caixàs A., Rigla M., Payés A., Benítez S., Ordóñez-Llanos J., Effect of glycemic optimization on electronegative low-density lipoprotein in diabetes: relation to nonenzymatic glycosylation and oxidative modification. Journal of Clinical Endocrinology and Metabolism 2001 86 7 3243 3249 2-s2.0-0034917786 10.1210/jc.86.7.3243
33. Lobo J. C., Mafra D., Farage N. E., Faulin T. D. E. S., Abdalla D. S. P., de Nóbrega A. C. L., Torres J. P. M., Increased electronegative LDL and decreased antibodies against electronegative LDL levels correlate with inflammatory markers and adhesion molecules in hemodialysed patients. Clinica Chimica Acta 2011 412 19-20 1788 1792 2-s2.0-79960645980 10.1016/j.cca.2011.05. 034
34. Hirowatari Y., Homma Y., Yoshizawa J., Homma K., Increase of electronegative-LDL-fraction ratio and IDL-cholesterol in chronic kidney disease patients with hemodialysis treatment. Lipids in Health and Disease 2012 11, article 111 10.1186/1476-511X-11-111
35. Dai L., Zhang Z., Winyard P. G., Gaffney K., Jones H., Blake D. R., Morris C. J., A modified form of low-density lipoprotein with increased electronegative charge is present in rheumatoid arthritis synovial fluid. Free Radical Biology and Medicine 1997 22 4 705 710 2-s2.0-0031019339 10.1016/S0891-5849(96)00389-9
36. Chang P. Y., Chen Y. J., Chang F. H., Aspirin protects human coronary artery endothelial cells against atherogenic electronegative LDL via an epigenetic mechanism: a novel cytoprotective role of aspirin in acute myocardial infarction. Cardiovascular Research 2013 99 1 137 145 10.1093/cvr/cvt062
37. Niccoli G., Baca M., De Spirito M., Impact of electronegative low-density lipoprotein on angiographic coronary atherosclerotic burden. Atherosclerosis 2012 223 166 170
38. de Queiroz Mello A. P., Da Silva I. T., Oliveira A. S., Nunes V. S., Abdalla D. S. P., Gidlund M., Damasceno N. R. T., Electronegative low-density lipoprotein is associated with dense low-density lipoprotein in subjects with different levels of cardiovascular risk. Lipids 2010 45 7 619 625 2-s2.0-77955664817 10.1007/s11745-010-3439-7
39. Faulin T. D. E. S., Sena-Evangelista K. C. M. D., Pacheco D. B., Augusto E. M., Abdalla D. S. P., Development of immunoassays for anti-electronegative LDL autoantibodies and immune complexes. Clinica Chimica Acta 2012 413 1-2 291 297 2-s2.0-82955227448 10.1016/j.cca.2011.10.004
40. Apolinario E., Ferderbar S., Pereira E., Minimally modified (electronegative) LDL(-) and anti-LDL(-) autoantibodies in diabetes mellitus and impaired glucose tolerance. International Journal of Atherosclerosis 2006 1 42 47
41. Oliveira J. A., Sevanian A., Rodrigues R. J., Apolinário E., Abdalla D. S. P., Minimally modified electronegative LDL and its autoantibodies in acute and chronic coronary syndromes. Clinical Biochemistry 2006 39 7 708 714 2-s2.0-33746021209 10.1016/j.clinbiochem.2006.05.002
42. Grosso D. M., Ferderbar S., Wanschel A. C. B. A., Krieger M. H., Higushi M. L., Abdalla D. S. P., Antibodies against electronegative LDL inhibit atherosclerosis in LDLr-/- mice. Brazilian Journal of Medical and Biological Research 2008 41 12 1086 1092 2-s2.0-62749092047
43. Sevanian A., Hodis H. N., Hwang J., McLeod L. L., Peterson H., Characterization of endothelial cell injury by cholesterol oxidation products found in oxidized LDL. Journal of Lipid Research 1995 36 9 1971 1986 2-s2.0-0029164664
44. Chen C.-H., Jiang T., Yang J.-H., Jiang W., Lu J., Marathe G. K., Pownall H. J., Ballantyne C. M., McIntyre T. M., Henry P. D., Yang C.-Y., Low-density lipoprotein in hypercholesterolemic human plasma induces vascular endothelial cell apoptosis by inhibiting fibroblast growth factor 2 transcription. Circulation 2003 107 16 2102 2108 2-s2.0-0038416942 10.1161/01.CIR.0000065220. 70220.F7
45. Tai M.-H., Kuo S.-M., Liang H.-T., Chiou K.-R., Lam H.-C., Hsu C.-M., Pownall H. J., Chen H.-H., Huang M. T., Yang C.-Y., Modulation of angiogenic processes in cultured endothelial cells by low density lipoproteins subfractions from patients with familial hypercholesterolemia. Atherosclerosis 2006 186 2 448 457 2-s2.0-33646410140 10.1016/j.atherosclerosis.2005.08.022
46. Lu J., Jiang W., Yang J.-H., Chang P.-Y., Walterscheid J. P., Chen H.-H., Marcelli M., Tang D., Lee Y.-T., Liao W. S. L., Yang C.-Y., Chen C.-H., Electronegative LDL impairs vascular endothelial cell integrity in diabetes by disrupting fibroblast growth factor 2 (FGF2) autoregulation. Diabetes 2008 57 1 158 166 2-s2.0-38449095405 10.2337/db07-1287
47. Yang C.-Y., Chen H.-H., Huang M. T., Raya J. L., Yang J.-H., Chen C.-H., Gaubatz J. W., Pownall H. J., Taylor A. A., Ballantyne C. M., Jenniskens F. A., Smith C. V., Pro-apoptotic low-density lipoprotein subfractions in type II diabetes. Atherosclerosis 2007 193 2 283 291 2-s2.0-34447498859 10.1016/j.atherosclerosis.2006.08.059
48. Tang D., Lu J., Walterscheid J. P., Chen H.-H., Engler D. A., Sawamura T., Chang P.-Y., Safi H. J., Yang C.-Y., Chen C.-H., Electronegative LDL circulating in smokers impairs endothelial progenitor cell differentiation by inhibiting Akt phosphorylation via LOX-1. Journal of Lipid Research 2008 49 1 33 47 2-s2.0-38049134443 10.1194/jlr.M700305-JLR200
49. Mathias S., Peña L. A., Kolesnick R. N., Signal transduction of stress via ceramide. Biochemical Journal 1998 335 3 465 480 2-s2.0-0032211769
50. Pedrosa A. M. C., Faine L. A., Grosso D. M., de Las Heras B., Boscá L., Abdalla D. S. P., Electronegative LDL induction of apoptosis in macrophages: involvement of Nrf2. Biochimica et Biophysica Acta 2010 1801 4 430 437 2-s2.0-76549120707 10.1016/j.bbalip.2009.12.001
51. Lee A.-S., Wang G.-J., Chan H.-C., Chen F.-Y., Chang C.-M., Yang C.-Y., Lee Y.-T., Chang K.-C., Chen C.-H., Electronegative low-density lipoprotein induces cardiomyocyte apoptosis indirectly through endothelial cell-released chemokines. Apoptosis 2012 17 9 1009 1018 2-s2.0-84860575436 10.1007/s10495-012-0726-1
52. Bancells C., Sánchez-Quesada J. L., Birkelund R., Ordóñez-Llanos J., Benítez S., Electronegative LDL induces Fas and modifies gene expression in mononuclear cells. Frontiers in Bioscience 2010 2 78 86
53. Itoh N., Yonehara S., Ishii A., Yonehara M., Mizushima S.-I., Sameshima M., Hase A., Seto Y., Nagata S., The polypeptide encoded by the cDNA for human cell surface antigen fas can mediate apoptosis. Cell 1991 66 2 233 243 2-s2.0-0025916387
54. Lu J., Yang J.-H., Burns A. R., Chen H.-H., Tang D., Walterscheid J. P., Suzuki S., Yang C.-Y., Sawamura T., Chen C.-H., Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis. Circulation Research 2009 104 5 619 627 2-s2.0-63649125916 10.1161/CIRCRESAHA.108.190116
55. Chen C. Y., Hsu H. C., Lee A. S., The most negatively charged low-density lipoprotein L5 induces stress pathways in vascular endothelial cells. Journal of Vascular Research 2012 49 329 341
56. Abe Y., Fornage M., Yang C.-Y., Bui-Thanh N.-A., Wise V., Chen H.-H., Rangaraj G., Ballantyne C. M., L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion. Atherosclerosis 2007 192 1 56 66 2-s2.0-34247340176 10.1016/j.atherosclerosis.2006.06.012
57. Ziouzenkova O., Asatryan L., Sahady D., Orasanu G., Perrey S., Cutak B., Hassell T., Akiyama T. E., Berger J. P., Sevanian A., Plutzky J., Dual roles for lipolysis and oxidation in peroxisome proliferation-activator receptor responses to electronegative low density lipoprotein. Journal of Biological Chemistry 2003 278 41 39874 39881 2-s2.0-0141960099 10.1074/jbc.M306786200
58. Benítez S., Pérez A., Sánchez-Quesada J. L., Wagner A. M., Rigla M., Arcelus R., Jorba Ó., Ordóñez-Llanos J., Electronegative low-density lipoprotein subfraction from type 2 diabetic subjects is proatherogenic and unrelated to glycemic control. Diabetes/Metabolism Research and Reviews 2007 23 1 26 34 2-s2.0-33846509268 10.1002/dmrr.643
59. Benítez S., Camacho M., Bancells C., Vila L., Sánchez- Quesada J. L., Ordóñez-Llanos J., Wide proinflammatory effect of electronegative low-density lipoprotein on human endothelial cells assayed by a protein array. Biochimica et Biophysica Acta 2006 1761 9 1014 1021 2-s2.0-33748444617 10.1016/j.bbalip.2006.03.020
60. de Castellarnau C., Bancells C., Benítez S., Reina M., Ordóñez-Llanos J., Sánchez-Quesada J. L., Atherogenic and inflammatory profile of human arterial endothelial cells (HUAEC) in response to LDL subfractions. Clinica Chimica Acta 2007 376 1-2 233 236 2-s2.0-33845321954 10.1016/j.cca.2006.07.024
61. Park D. R., Thomsen A. R., Frevert C. W., Pham U., Skerrett S. J., Kiener P. A., Liles W. C., Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages. Journal of Immunology 2003 170 12 6209 6216 2-s2.0-0038618996
62. Mallat Z., Heymes C., Ohan J., Faggin E., Lesèche G., Tedgui A., Expression of interleukin-10 in advanced human atherosclerotic plaques: relation to inducible nitric oxide synthase expression and cell death. Arteriosclerosis, Thrombosis, and Vascular Biology 1999 19 3 611 616 2-s2.0-0033015659
63. Pinderski Oslund L. J., Hedrick C. C., Olvera T., Hagenbaugh A., Territo M., Berliner J. A., Fyfe A. I., Interleukin-10 blocks atherosclerotic events in vitro and in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology 1999 19 12 2847 2853 2-s2.0-0000614773
64. Terkeltaub R. A., IL-10: an "immunologic scalpel" for atherosclerosis? Arteriosclerosis, Thrombosis, and Vascular Biology 1999 19 12 2823 2825 2-s2.0-0033382702
65. Asatryan L., Ziouzenkova O., Duncan R., Sevanian A., Heme and lipid peroxides in hemoglobin-modified low-density lipoprotein mediate cell survival and adaptation to oxidative stress. Blood 2003 102 5 1732 1739 2-s2.0-0042442081 10.1182/blood-2003-01-0293
66. Halvorsen B., Wæhre T., Scholz H., Clausen O. P., Von Der Thüsen J. H., Müller F., Heimli H., Tonstad S., Hall C., Frøland S. S., Biessen E. A., Damås J. K., Aukrust P., Interleukin-10 enhances the oxidized LDL-induced foam cell formation of macrophages by antiapoptotic mechanisms. Journal of Lipid Research 2005 46 2 211 219 2-s2.0-13944251986 10.1194/jlr.M400324-JLR200
67. Fuhrman B., Partoush A., Volkova N., Aviram M., Ox-LDL induces monocyte-to-macrophage differentiation in vivo: possible role for the macrophage colony stimulating factor receptor (M-CSF-R). Atherosclerosis 2008 196 2 598 607 2-s2.0-38349099867 10.1016/j.atherosclerosis.2007.06.026
68. Nagy L., Tontonoz P., Alvarez J. G. A., Chen H., Evans R. M., Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR γ Cell 1998 93 2 229 240 2-s2.0-0032540325 10.1016/S0092-8674(00)81574-3
69. Ricote M., Huang J. T., Welch J. S., Glass C. K., The peroxisome proliferator-activated receptor γ (PPAR γ) as a regulator of monocyte/macrophage function. Journal of Leukocyte Biology 1999 66 5 733 739 2-s2.0-0032737858
70. Sester D. P., Trieu A., Brion K., Schroder K., Ravasi T., Robinson J. A., McDonald R. C., Ripoll V., Wells C. A., Suzuki H., Hayashizaki Y., Stacey K. J., Hume D. A., Sweet M. J., LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action. Immunobiology 2005 210 2-4 97 107 2-s2.0-22644447586 10.1016/j.imbio.2005.05.004
71. Hamilton T. A., Ma G., Chisolm G. M., Oxidized low density lipoprotein suppresses the expression of tumor necrosis factor- α mRNA in stimulated murine peritoneal macrophages. Journal of Immunology 1990 144 6 2343 2350 2-s2.0-0025214424
72. Kannan Y., Sundaram K., Aluganti Narasimhulu C., Parthasarathy S., Wewers M. D., Oxidatively modified low density lipoprotein (LDL) inhibits TLR2 and TLR4 cytokine responses in human monocytes but not in macrophages. The Journal of Biological Chemistry 2012 287 23479 23488
73. Netea M. G., Kullberg B. J., Demacker P. N. M., Jacobs L. E. H., Verver-Jansen T. J. G., Hijmans A., Van Tits L. H. J., Hoenderop J. G. J., Willems P. H. G. M., Van Der Meer J. W. M., Stalenhoef A. F. H., Native LDL potentiate TNF α and IL-8 production by human mononuclear cells. Journal of Lipid Research 2002 43 7 1065 1071 2-s2.0-0036317951 10.1194/jlr.M100254- JLR200
74. Wiesner P., Choi S.-H., Almazan F., Benner C., Huang W., Diehl C. J., Gonen A., Butler S., Witztum J. L., Glass C. K., Miller Y. I., Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor b and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circulation Research 2010 107 1 56 65 2-s2.0-77954762141 10.1161/CIRCRESAHA.110. 218420
75. Bochkov V. N., Inflammatory profile of oxidized phospholipids. Thrombosis and Haemostasis 2007 97 3 348 354 2-s2.0-33947321122 10.1160/TH06-08-0474
76. Walton K. A., Cole A. L., Yeh M., Subbanagounder G., Krutzik S. R., Modlin R. L., Lucas R. M., Nakai J., Smart E. J., Vora D. K., Berliner J. A., Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2. Arteriosclerosis, Thrombosis, and Vascular Biology 2003 23 7 1197 1203 2-s2.0-10744226347 10.1161/01.ATV.0000079340.80744.B8
77. Erridge C., Kennedy S., Spickett C. M., Webb D. J., Oxidized phospholipid inhibition of Toll-Like Receptor (TLR) signaling is restricted to TLR2 and TLR4: roles for CD14, LPS-binding protein, and MD2 as targets for specificity of inhibition. Journal of Biological Chemistry 2008 283 36 24748 24759 2-s2.0-54049122271 10.1074/jbc.M800352200
78. von Schlieffen E., Oskolkova O. V., Schabbauer G., Gruber F., Blüml S., Genest M., Kadi A., Marsik C., Knapp S., Chow J., Leitinger N., Binder B. R., Bochkov V. N., Multi-hit inhibition of circulating and cell-associated components of the toll-like receptor 4 pathway by oxidized phospholipids. Arteriosclerosis, Thrombosis, and Vascular Biology 2009 29 3 356 362 2-s2.0-61549140074 10.1161/ATVBAHA.108.173799
79. Pfeiffer A., Bottcher A., Orso E., Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts. European Journal of Immunology 2001 31 3153 3164
80. Benítez S., Villegas V., Bancells C., Jorba O., González-Sastre F., Ordóñez-Llanos J., Sánchez- Quesada J. L., Impaired binding affinity of electronegative low-density lipoprotein (LDL) to the LDL receptor is related to nonesterified fatty acids and lysophosphatidylcholine content. Biochemistry 2004 43 50 15863 15872 2-s2.0-10844238941 10.1021/bi048825z
81. Chappey B., Myara I., Benoit M.-O., Maziere C., Maziere J.-C., Moatti N., Characteristics of ten charge-differing subfractions isolated from human native low-density lipoproteins (LDL). No evidence of peroxidative modifications. Biochimica et Biophysica Acta 1995 1259 3 261 270 2-s2.0-0029562876 10.1016/0005-2760(95)00172-7
82. Kodama T., Reddy P., Kishimoto C., Krieger M., Purification and characterization of a bovine acetyl low density lipoprotein receptor. Proceedings of the National Academy of Sciences of the United States of America 1988 85 23 9238 9242 2-s2.0-0009720857
83. Cazzolato G., Avogaro P., Bittolo-Bon G., Characterization of a more electronegatively charged LDL subfraction by ion exchange HPLC. Free Radical Biology and Medicine 1991 11 3 247 253 2-s2.0-0025838106 10.1016/0891-5849(91) 90120-R
84. Holvoet P., Perez G., Zhao Z., Brouwers E., Bernar H., Collen D., Malondialdehyde-modified low density lipoproteins in patients with atherosclerotic disease. Journal of Clinical Investigation 1995 95 6 2611 2619 2-s2.0-0029017015
85. Tertov V. V., Naturally occurring modified low density lipoproteins are similar if not identical: more electronegative and desialylated lipoprotein subfractions. Experimental and Molecular Pathology 1995 62 3 166 172 2-s2.0-0029555988 10.1006/exmp.1995.1018
86. Dunn S., Vohra R. S., Murphy J. E., Homer-Vanniasinkam S., Walker J. H., Ponnambalam S., The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease. Biochemical Journal 2008 409 2 349 355 2-s2.0-38749118269 10.1042/BJ20071196
87. Faulin T. D. E. S., Cavalcante M. F., Abdalla D. S. P., Role of electronegative LDL and its associated antibodies in the pathogenesis of atherosclerosis. Clinical Lipidology 2010 5 5 719 729 2-s2.0-78149459415 10.2217/clp.10.52
88. Schoneveld A. H., Hoefer I., Sluijter J. P. G., Laman J. D., de Kleijn D. P. V., Pasterkamp G., Atherosclerotic lesion development and Toll like receptor 2 and 4 responsiveness. Atherosclerosis 2008 197 1 95 104 2-s2.0-39449089764 10.1016/j.atherosclerosis.2007.08.004
89. Monaco C., Cole J. E., Georgiou E., The expression and functions of toll-like receptors in atherosclerosis. Mediators of Inflammation 2010 2010 18 2-s2.0-77955412192 10.1155/2010/393946 393946
90. Miller Y. I., Viriyakosol S., Binder C. J., Feramisco J. R., Kirkland T. N., Witztum J. L., Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. Journal of Biological Chemistry 2003 278 3 1561 1568 2-s2.0-0037449723 10.1074/jbc.M209634200
91. Choi S.-H., Harkewicz R., Lee J. H., Boullier A., Almazan F., Li A. C., Witztum J. L., Bae Y. S., Miller Y. I., Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake. Circulation Research 2009 104 12 1355 1363 2-s2.0-67650266902 10.1161/CIRCRESAHA.108.192880
92. Miller Y. I., Viriyakosol S., Worrall D. S., Boullier A., Butler S., Witztum J. L., Toll-like receptor 4-dependent and -independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25 6 1213 1219 2-s2.0-20144385204 10.1161/01.ATV.0000159891.73193.31
93. Chávez-Sánchez L., Chávez-Rueda K., Legorreta-Haquet M. V., Zenteno E., Ledesma-Soto Y., Montoya-Díaz E., Tesoro-Cruz E., Madrid-Miller A., Blanco-Favela F., The activation of CD14, TLR4, and TLR2 by mmLDL induces IL-1 β IL-6, and IL-10 secretion in human monocytes and macrophages. Lipids in Health and Disease 2010 9, article 117 2-s2.0-77957796096 10.1186/1476-511X-9-117
94. Chávez-Sánchez L., Madrid-Miller A., Chávez-Rueda K., Legorreta-Haquet M. V., Tesoro-Cruz E., Blanco-Favela F., Activation of TLR2 and TLR4 by minimally modified low-density lipoprotein in human macrophages and monocytes triggers the inflammatory response. Human Immunology 2010 71 8 737 744 2-s2.0-77954760594 10.1016/j.humimm.2010.05.005
95. Geng H., Wang A., Rong G., Zhu B., Deng Y., Chen J., Zhong R., The effects of ox-LDL in human atherosclerosis may be mediated in part via the toll-like receptor 4 pathway. Molecular and Cellular Biochemistry 2010 342 1-2 201 206 2-s2.0-77955851805 10.1007/s11010-010-0484-8
96. Mogilenko D. A., Kudriavtsev I. V., Trulioff A. S., Shavva V. S., Dizhe E. B., Missyul B. V., Zhakhov A. V., Ischenko A. M., Perevozchikov A. P., Orlov S. V., Modified low density lipoprotein stimulates complement C3 expression and secretion via liver X receptor and toll-like receptor 4 activation in human macrophages. Journal of Biological Chemistry 2012 287 8 5954 5968 2-s2.0-84857327497 10.1074/jbc.M111.289322
97. Bae Y. S., Lee J. H., Choi S. H., Kim S., Almazan F., Witztum J. L., Miller Y. I., Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2. Circulation Research 2009 104 2 210 218 2-s2.0-59849086158 10.1161/CIRCRESAHA.108.181040
98. Choi S.-H., Wiesner P., Almazan F., Kim J., Miller Y. I., Spleen tyrosine kinase regulates AP-1 dependent transcriptional response to minimally oxidized LDL. PLoS ONE 2012 7 2 2-s2.0-84857471414 10.1371/journal.pone.0032378 e32378
99. Su X., Ao L., Shi Y., Johnson T. R., Fullerton D. A., Meng X., Oxidized low density lipoprotein induces bone morphogenetic protein-2 in coronary artery endothelial cells via toll-like receptors 2 and 4. Journal of Biological Chemistry 2011 286 14 12213 12220 2-s2.0-79953295363 10.1074/jbc.M110.214619
100. Sánchez-Quesada J. L., Benítez S., Pérez A., Wagner A. M., Rigla M., Carreras G., Vila L., Camacho M., Arcelus R., Ordóñez-Llanos J., The inflammatory properties of electronegative low-density lipoprotein from type 1 diabetic patients are related to increased platelet-activating factor acetylhydrolase activity. Diabetologia 2005 48 10 2162 2169 2-s2.0-26244452534 10.1007/s00125-005-1899-8
101. Tabas I., Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency. Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25 11 2255 2264 2-s2.0-27644537437 10.1161/01.ATV.0000184783.04864.9f