Modified low density lipoprotein stimulates complement C3 expression and secretion via liver X receptor and toll-like receptor 4 activation in human macrophages

Journal of Biological Chemistry

Volumn 287, Issue 8, 2012, Pages 5954-5968

  Mogilenko, Denis A ^a,b   Kudriavtsev, Igor V ^a,b   Trulioff, Andrey S ^a   Shavva, Vladimir S ^a,b   Dizhe, Ella B ^a   Missyul, Boris V ^a   Zhakhov, Alexander V ^c   Ischenko, Alexander M ^c   Perevozchikov, Andrej P ^a,b   Orlov, Sergey V ^a,b  

^a INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

^b ST PETERSBURG STATE UNIVERSITY   (Russian Federation)

^c Institute for Highly Pure Biopreparations   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHYLATOXIN; ATHEROGENESIS; ATHEROSCLEROTIC LESIONS; HEPG2 CELLS; HUMAN HEPATOMAS; HUMAN MACROPHAGES; LIVER X RECEPTORS; LOW DENSITY LIPOPROTEINS; OXIDIZED LOW-DENSITY LIPOPROTEINS (OXLDL); PROMOTER REGION; PROTEIN SECRETION; TOLL-LIKE RECEPTOR 4; UP-REGULATION;

ACTIVATION ANALYSIS; CYTOLOGY; GENES; PHYSIOLOGY; TRANSCRIPTION; WELL STIMULATION;

MACROPHAGES;

ACETYL LOW DENSITY LIPOPROTEIN; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3A; GAMMA INTERFERON; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; LIVER X RECEPTOR BETA; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; OXIDIZED LOW DENSITY LIPOPROTEIN; TOLL LIKE RECEPTOR 4;

ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; C3 GENE; CELL SPECIFICITY; COMPLEMENT ACTIVATION; CONTROLLED STUDY; DNA STRUCTURE; GENE ACTIVATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE GENE; LIPID METABOLISM; MACROPHAGE ACTIVATION; MONOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SECRETION; RECEPTOR BINDING; TRANSCRIPTION REGULATION;

BASE SEQUENCE; BIOLOGICAL TRANSPORT; COMPLEMENT C3; GENE EXPRESSION REGULATION; HEP G2 CELLS; HUMANS; LIPOPROTEINS, LDL; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; NF-KAPPA B; ORPHAN NUCLEAR RECEPTORS; PROMOTER REGIONS, GENETIC; TOLL-LIKE RECEPTOR 4; TRANSCRIPTION, GENETIC;

EID: 84857327497     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.289322     Document Type: Article

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