메뉴 건너뛰기




Volumn 23, Issue 5, 2012, Pages 479-486

Electronegative low-density lipoprotein. A link between apolipoprotein B misfolding, lipoprotein aggregation and proteoglycan binding

Author keywords

apoB structure; LDL aggregation; phospholipase C; proteoglycans; sphingomyelinase

Indexed keywords

APOLIPOPROTEIN B; LOW DENSITY LIPOPROTEIN; PHOSPHOLIPASE C; PROTEOGLYCAN;

EID: 84866320576     PISSN: 09579672     EISSN: 14736535     Source Type: Journal    
DOI: 10.1097/MOL.0b013e328357c933     Document Type: Review
Times cited : (43)

References (49)
  • 1
    • 0031761005 scopus 로고    scopus 로고
    • The response-to-retention hypothesis of atherogenesis reinforced
    • DOI 10.1097/00041433-199810000-00012
    • Williams KJ, Tabas I. The response-to-retention hypothesis of atherogenesis reinforced. Curr Opin Lipidol 1998; 9:471-474. (Pubitemid 28495557)
    • (1998) Current Opinion in Lipidology , vol.9 , Issue.5 , pp. 471-474
    • Williams, K.J.1    Tabas, I.2
  • 2
    • 0034036648 scopus 로고    scopus 로고
    • Modified LDL - Trigger of atherosclerosis and inflammation in the arterial intima
    • DOI 10.1046/j.1365-2796.2000.00655.x
    • Pentikainen MO, Oorni K, Ala-Korpela M, Kovanen PT. Modified LDL-trigger of atherosclerosis and inflammation in the arterial intima. J Intern Med 2000; 247:359-370. (Pubitemid 30180038)
    • (2000) Journal of Internal Medicine , vol.247 , Issue.3 , pp. 359-370
    • Pentikainen, M.O.1    Oorni, K.2    Ala-Korpela, M.3    Kovanen, P.T.4
  • 5
    • 79953062925 scopus 로고    scopus 로고
    • Electronegative low-density lipoprotein: Origin and impact on health and disease
    • Mello AP, da Silva IT, Abdalla DS, Damasceno NR. Electronegative low-density lipoprotein: origin and impact on health and disease. Atherosclerosis 2011; 215:257-265.
    • (2011) Atherosclerosis , vol.215 , pp. 257-265
    • Mello, A.P.1    Da Silva, I.T.2    Abdalla, D.S.3    Damasceno, N.R.4
  • 6
    • 0035571550 scopus 로고    scopus 로고
    • Myeloperoxidase and hypochlorite, but not copper ions, oxidize heparin-bound LDL particles and release them from heparin
    • Pentikainen MO, Oörni K, Kovanen PT. Myeloperoxidase and hypochlorite, but not copper ions, oxidize heparin-bound LDL particles and release them from heparin. Arterioscler Thromb Vasc Biol 2001; 21:1902-1908. (Pubitemid 34219739)
    • (2001) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.21 , Issue.12 , pp. 1902-1908
    • Pentikainen, M.O.1    Oorni, K.2    Kovanen, P.T.3
  • 7
    • 34247340176 scopus 로고    scopus 로고
    • L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion
    • DOI 10.1016/j.atherosclerosis.2006.06.012, PII S0021915006003509
    • Abe Y, Fornage M, Yang CY, et al. L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion. Atherosclerosis 2007; 192:56-66. (Pubitemid 46628805)
    • (2007) Atherosclerosis , vol.192 , Issue.1 , pp. 56-66
    • Abe, Y.1    Fornage, M.2    Yang, C.-y.3    Bui-Thanh, N.-A.4    Wise, V.5    Chen, H.-H.6    Rangaraj, G.7    Ballantyne, C.M.8
  • 10
    • 33845321954 scopus 로고    scopus 로고
    • Atherogenic and inflammatory profile of human arterial endothelial cells (HUAEC) in response to LDL subfractions
    • DOI 10.1016/j.cca.2006.07.024, PII S0009898106004827
    • DeCastellarnau C, Bancells C, Benitez S, et al. Atherogenicand inflammatory profile of human arterial endothelial cells (HUAEC) in response to LDL subfractions. Clin Chim Acta 2007; 376:233-236. (Pubitemid 44880988)
    • (2007) Clinica Chimica Acta , vol.376 , Issue.1-2 , pp. 233-236
    • De Castellarnau, C.1    Bancells, C.2    Benitez, S.3    Reina, M.4    Ordonez-Llanos, J.5    Sanchez-Quesada, J.L.6
  • 11
    • 38449095405 scopus 로고    scopus 로고
    • Electronegative LDL impairs vascular endothelial cell integrity in diabetes by disrupting fibroblast growth factor 2 (FGF2) autoregulation
    • Lu J, Jiang W, Yang JH, et al. Electronegative LDL impairs vascular endothelial cell integrity in diabetes by disrupting fibroblast growth factor 2 (FGF2) autoregulation. Diabetes 2008; 57:158-166.
    • (2008) Diabetes , vol.57 , pp. 158-166
    • Lu, J.1    Jiang, W.2    Yang, J.H.3
  • 12
    • 63649125916 scopus 로고    scopus 로고
    • Mediation of electronegative low-density lipoprotein signaling by LOX-1: A possible mechanism of endothelial apop-tosis
    • Lu J, Yang JH, Burns AR, et al. Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apop-tosis. Circ Res 2009; 104:619-627.
    • (2009) Circ Res , vol.104 , pp. 619-627
    • Lu, J.1    Yang, J.H.2    Burns, A.R.3
  • 13
    • 38049134443 scopus 로고    scopus 로고
    • Electronegative LDL circulating in smokers impairs endothelial progenitor cell differentiation by inhibiting Akt phosphorylation via LOX-1
    • Tang D, Lu J, Walterscheid JP, et al. Electronegative LDL circulating in smokers impairs endothelial progenitor cell differentiation by inhibiting Akt phosphorylation via LOX-1. J Lipid Res 2008; 49:33-47.
    • (2008) J Lipid Res , vol.49 , pp. 33-47
    • Tang, D.1    Lu, J.2    Walterscheid, J.P.3
  • 16
    • 76549120707 scopus 로고    scopus 로고
    • Electronegative LDL induction of apoptosis in macrophages: Involvement of Nrf2
    • Pedrosa AM, Faine LA, Grosso DM, et al. Electronegative LDL induction of apoptosis in macrophages: involvement of Nrf2. Biochim Biophys Acta 2010; 1801:430-437.
    • (2010) Biochim Biophys Acta , pp. 430-437
    • Pedrosa, A.M.1    Faine, L.A.2    Grosso, D.M.3
  • 19
    • 68849102153 scopus 로고    scopus 로고
    • Generation in human plasma of misfolded, aggregation-prone electronegative low density lipoprotein
    • Greco G, Balogh G, Brunelli R, et al. Generation in human plasma of misfolded, aggregation-prone electronegative low density lipoprotein. Biophys J 2009; 97:628-635.
    • (2009) Biophys J , vol.97 , pp. 628-635
    • Greco, G.1    Balogh, G.2    Brunelli, R.3
  • 20
    • 77956039939 scopus 로고    scopus 로고
    • Estradiol binding prevents ApoB-100 misfolding in electronegative LDL(\)
    • Brunelli R, Balogh G, Costa G, et al. Estradiol binding prevents ApoB-100 misfolding in electronegative LDL(\). Biochemistry 2010; 49:7297-7302.
    • (2010) Biochemistry , vol.49 , pp. 7297-7302
    • Brunelli, R.1    Balogh, G.2    Costa, G.3
  • 21
    • 11244321987 scopus 로고    scopus 로고
    • LDL phospholipid hydrolysis produces modified electronegative particles with an unfolded apoB-100 protein
    • DOI 10.1194/jlr.M400306-JLR200
    • Asatryan L, Hamilton RT, Isas JM, et al. LDLphospholipid hydrolysis produces modified electronegative particles with an unfolded apoB-100 protein. J Lipid Res 2005; 46:115-122. (Pubitemid 40066677)
    • (2005) Journal of Lipid Research , vol.46 , Issue.1 , pp. 115-122
    • Asatryan, L.1    Hamilton, R.T.2    Isas, J.M.3    Hwang, J.4    Kayed, R.5    Sevanian, A.6
  • 22
    • 48649097203 scopus 로고    scopus 로고
    • Novel phospholipolytic activities associated with electronegative low-density lipoprotein are involved in increased self-aggregation
    • Bancells C, Benitez S, Villegas S, et al. Novel phospholipolytic activities associated with electronegative low-density lipoprotein are involved in increased self-aggregation. Biochemistry 2008; 47:8186-8194.
    • (2008) Biochemistry , vol.47 , pp. 8186-8194
    • Bancells, C.1    Benitez, S.2    Villegas, S.3
  • 23
    • 64349100818 scopus 로고    scopus 로고
    • High binding affinity of electronegative LDL to human aortic proteoglycans depends on its aggregation level
    • Bancells C, Benitez S, Jauhiainen M, et al. High binding affinity of electronegative LDL to human aortic proteoglycans depends on its aggregation level. J Lipid Res 2009; 50:446-455.
    • (2009) J Lipid Res , vol.50 , pp. 446-455
    • Bancells, C.1    Benitez, S.2    Jauhiainen, M.3
  • 24
    • 77952710230 scopus 로고    scopus 로고
    • 2D-NMR reveals different populations of exposed lysine residues in the apoB-100 protein of electronegative and electropositive fractions of LDL particles
    • Blanco FJ, Villegas S, Benitez S, et al. 2D-NMR reveals different populations of exposed lysine residues in the apoB-100 protein of electronegative and electropositive fractions of LDL particles. J Lipid Res 2010; 51:1560-1565.
    • (2010) J Lipid Res , vol.51 , pp. 1560-1565
    • Blanco, F.J.1    Villegas, S.2    Benitez, S.3
  • 25
    • 78651392002 scopus 로고    scopus 로고
    • Immunochemical analysis of the electronegative LDL subfraction shows that abnormal N-terminal apoli-poprotein B conformation is involved in increased binding to proteoglycans
    • Bancells C, Benitez S, Ordonez-Llanos J, et al. Immunochemical analysis of the electronegative LDL subfraction shows that abnormal N-terminal apoli-poprotein B conformation is involved in increased binding to proteoglycans. J Biol Chem 2011; 286:1125-1133.
    • (2011) J Biol Chem , vol.286 , pp. 1125-1133
    • Bancells, C.1    Benitez, S.2    Ordonez-Llanos, J.3
  • 27
    • 10844238941 scopus 로고    scopus 로고
    • Impaired binding affinity of electronegative low-density lipoprotein (LDL) to the LDL receptor is related to nonesterified fatty acids and lysophosphatidylcholine content
    • DOI 10.1021/bi048825z
    • Benitez S, Villegas V, Bancells C, et al. Impaired binding affinity of electronegative low-density lipoprotein (LDL) to the LDL receptor is related to nonesterified fatty acids and lysophosphatidylcholine content. Biochemistry 2004; 43:15863-15872. (Pubitemid 39665085)
    • (2004) Biochemistry , vol.43 , Issue.50 , pp. 15863-15872
    • Benitez, S.1    Villegas, V.2    Bancells, C.3    Jorba, O.4    Gonzalez-Sastre, F.5    Ordonez-Llanos, J.6    Sanchez-Quesada, J.L.7
  • 28
    • 0023833209 scopus 로고
    • Presence of a modified low density lipoprotein in humans
    • Avogaro P, Bon GB, Cazzolato G. Presence of a modified low density lipoprotein in humans. Arteriosclerosis 1988; 8:79-87. (Pubitemid 18049179)
    • (1988) Arteriosclerosis , vol.8 , Issue.1 , pp. 79-87
    • Avogaro, P.1    Bon, G.B.2    Gazzolato, G.3
  • 30
    • 0032582694 scopus 로고    scopus 로고
    • 2 only aggregation, of low density lipoprotein (LDL) particles: Two distinct mechanisms leading to increased binding strength of LDL to human aortic proteoglycans
    • DOI 10.1074/jbc.273.44.29127
    • Oorni K, Hakala JK, Annila A, et al. Sphingomyelinase induces aggregation and fusion, but phospholipase A2 only aggregation, of low density lipoprotein (LDL) particles. Two distinct mechanisms leading to increased binding strength of LDL to human aortic proteoglycans. J Biol Chem 1998; 273: 29127-29134. (Pubitemid 28507611)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.44 , pp. 29127-29134
    • Oorni, K.1    Hakala, J.K.2    Annila, A.3    Ala-Korpela, M.4    Kovanen, P.T.5
  • 31
    • 79956031847 scopus 로고    scopus 로고
    • Immuno-electron cryo-microscopy imaging reveals a looped topology of apoB at the surface of human LDL
    • Liu Y, Atkinson D. Immuno-electron cryo-microscopy imaging reveals a looped topology of apoB at the surface of human LDL. J Lipid Res 2011; 52:1111-1116.
    • (2011) J Lipid Res , vol.52 , pp. 1111-1116
    • Liu, Y.1    Atkinson, D.2
  • 34
    • 79953171886 scopus 로고    scopus 로고
    • Effects of phospholipase A(2) and its products on structural stability of human LDL: Relevance to formation of LDL-derived lipid droplets
    • Jayaraman S, Gantz DL, Gursky O. Effects of phospholipase A(2) and its products on structural stability of human LDL: relevance to formation of LDL-derived lipid droplets. J Lipid Res 2011; 52:549-557.
    • (2011) J Lipid Res , vol.52 , pp. 549-557
    • Jayaraman, S.1    Gantz, D.L.2    Gursky, O.3
  • 36
    • 77957803559 scopus 로고    scopus 로고
    • Aggregated electronegative low density lipoprotein in human plasma shows a high tendency toward phos-pholipolysis and particle fusion
    • Bancells C, Villegas S, Blanco FJ, et al. Aggregated electronegative low density lipoprotein in human plasma shows a high tendency toward phos-pholipolysis and particle fusion. J Biol Chem 2010; 285:32425-32435.
    • (2010) J Biol Chem , vol.285 , pp. 32425-32435
    • Bancells, C.1    Villegas, S.2    Blanco, F.J.3
  • 38
    • 78650038243 scopus 로고    scopus 로고
    • Proteomic analysis of electronegative low-density lipoprotein
    • Bancells C, Canals F, Benitez S, et al. Proteomic analysis of electronegative low-density lipoprotein. J Lipid Res 2010; 51:3508-3515.
    • (2010) J Lipid Res , vol.51 , pp. 3508-3515
    • Bancells, C.1    Canals, F.2    Benitez, S.3
  • 39
    • 0034161616 scopus 로고    scopus 로고
    • Clusterin is a secreted mammalian chaperone
    • DOI 10.1016/S0968-0004(99)01534-0, PII S0968000499015340
    • Wilson MR, Easterbrook-Smith SB. Clusterin is a secreted mammalian chaperone. Trends Biochem Sci 2000; 25:95-98. (Pubitemid 30122416)
    • (2000) Trends in Biochemical Sciences , vol.25 , Issue.3 , pp. 95-98
    • Wilson, M.R.1    Easterbrook-Smith, S.B.2
  • 40
    • 77949292454 scopus 로고    scopus 로고
    • Identification of human plasma proteins as major clients for the extracellular chaperone clusterin
    • Wyatt AR, Wilson MR. Identification of human plasma proteins as major clients for the extracellular chaperone clusterin. J Biol Chem 2010; 285:3532-3539.
    • (2010) J Biol Chem , vol.285 , pp. 3532-3539
    • Wyatt, A.R.1    Wilson, M.R.2
  • 41
    • 79951685847 scopus 로고    scopus 로고
    • LDL-associated apolipoprotein J and lysozyme are associated with atherogenic properties of LDL found in type 2 diabetes and the metabolic syndrome
    • Pettersson C, Karlsson H, Stahlman M, et al. LDL-associated apolipoprotein J and lysozyme are associated with atherogenic properties of LDL found in type 2 diabetes and the metabolic syndrome. J Intern Med 2011; 269:306-321.
    • (2011) J Intern Med , vol.269 , pp. 306-321
    • Pettersson, C.1    Karlsson, H.2    Stahlman, M.3
  • 42
    • 84862299070 scopus 로고    scopus 로고
    • Effect of improving glycemic control in patients with type 2 diabetes mellitus on low-density lipoprotein size, electronegative low-density lipoprotein and lipoprotein-associated phospholipase A2 distribution
    • Sanchez-Quesada JL, Vinagre I, Juan-Franco ED, et al. Effect of improving glycemic control in patients with type 2 diabetes mellitus on low-density lipoprotein size, electronegative low-density lipoprotein and lipoprotein-associated phospholipase A2 distribution. Am J Cardiol 2012; 110: 67-71.
    • (2012) Am J Cardiol , vol.110 , pp. 67-71
    • Sanchez-Quesada, J.L.1    Vinagre, I.2    Juan-Franco, E.D.3
  • 43
    • 28544437885 scopus 로고    scopus 로고
    • Quality control of protein folding in extracellular space
    • DOI 10.1038/sj.embor.7400586, PII 7400586
    • Yerbury JJ, Stewart EM, Wyatt AR, Wilson MR. Quality control of protein folding in extracellular space. EMBO Rep 2005; 6:1131-1136. (Pubitemid 41741695)
    • (2005) EMBO Reports , vol.6 , Issue.12 , pp. 1131-1136
    • Yerbury, J.J.1    Stewart, E.M.2    Wyatt, A.R.3    Wilson, M.R.4
  • 44
    • 0034595643 scopus 로고    scopus 로고
    • Sphingomyelinase activity associated with human plasma low density lipoprotein possible functional implications
    • DOI 10.1074/jbc.275.22.16484
    • Holopainen JM, Medina OP, Metso AJ, Kinnunen PK. Sphingomyelinase activity associated with human plasma low density lipoprotein. J Biol Chem 2000; 275:16484-16489. (Pubitemid 30398870)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.22 , pp. 16484-16489
    • Holopainen, J.M.1    Medina, O.P.2    Metso, A.J.3    Kinnunen, P.K.J.4
  • 45
    • 0036006942 scopus 로고    scopus 로고
    • Sphingomyelinase activity of LDLA link between atherosclerosis, ceramide, and apoptosis?
    • DOI 10.1016/S1050-1738(01)00143-8, PII S1050173801001438
    • Kinnunen PK, Holopainen JM. Sphingomyelinase activity of LDL: a link between atherosclerosis, ceramide, and apoptosis? Trends Cardiovasc Med 2002; 12:37-42. (Pubitemid 34048709)
    • (2002) Trends in Cardiovascular Medicine , vol.12 , Issue.1 , pp. 37-42
    • Kinnunen, P.K.J.1    Holopainen, J.M.2
  • 46
    • 0033729477 scopus 로고    scopus 로고
    • Aggregation, fusion, and vesicle formation of modified low density lipoprotein particles: Molecular mechanisms and effects on matrix interactions
    • Oorni K, Pentikainen MO, Ala-Korpela M, Kovanen PT. Aggregation, fusion, and vesicle formation of modified low density lipoprotein particles: molecular mechanisms and effects on matrix interactions. J Lipid Res 2000; 41:1 703-1714.
    • (2000) J Lipid Res , vol.41 , Issue.1 , pp. 703-1714
    • Oorni, K.1    Pentikainen, M.O.2    Ala-Korpela, M.3    Kovanen, P.T.4
  • 47
    • 0032526201 scopus 로고    scopus 로고
    • Identification of the principal proteoglycan-binding site in LDL: A single-point mutation in apo-B100 severely affects proteoglycan interaction without affecting LDL receptor binding
    • Boren J, Olin K, Lee I, et al. Identification of the principal proteoglycan-binding site in LDL. A single-point mutation in apo-B100 severely affects proteoglycan interaction without affecting LDL receptor binding. J Clin Invest 1998; 101:2658-2664. (Pubitemid 28294574)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.12 , pp. 2658-2664
    • Boren, J.1    Olin, K.2    Lee, I.3    Chait, A.4    Wight, T.N.5    Innerarity, T.L.6
  • 49
    • 80052096203 scopus 로고    scopus 로고
    • Glycation of LDL by methylglyoxal increases arterial atherogenicity: A possible contributor to increased risk of cardiovascular disease in diabetes
    • Rabbani N, Godfrey L, Xue M, et al. Glycation of LDL by methylglyoxal increases arterial atherogenicity: a possible contributor to increased risk of cardiovascular disease in diabetes. Diabetes 2011; 60:1-8.
    • (2011) Diabetes , vol.60 , pp. 1-8
    • Rabbani, N.1    Godfrey, L.2    Xue, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.