Effect of glycemic optimization on electronegative low-density lipoprotein in diabetes: Relation to nonenzymatic glycosylation and oxidative modification

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 7, 2001, Pages 3243-3249

  Sánchez Quesada, José L ^a   Pérez, Antonio ^a   Caixàs, Assumpta ^a   Rigla, Mercedes ^a   Payés, Amalia ^a   Benítez, Sonia ^a   Ordóñez Llanos, Jordi ^a,b  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PHOSPHOLIPID; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DIABETES CONTROL; FEMALE; GLYCOSYLATION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LIPID BLOOD LEVEL; LIPOPROTEIN METABOLISM; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATION; PRIORITY JOURNAL;

ADULT; AGED; BLOOD GLUCOSE; CHOLESTEROL, HDL; CHOLESTEROL, VLDL; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; ELECTROCHEMISTRY; FEMALE; GLYCOSYLATION; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INSULIN; LIPID PEROXIDATION; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; OXIDATION-REDUCTION; TRIGLYCERIDES;

EID: 0034917786     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.86.7.3243     Document Type: Article

References (55)

1. Diabetes and atherosclerosis: An epidemiologic view
2. The prospective cardiovascular Munster (PROCAM) study. Prevalence of hyperlipidemia in persons with hypertension and/or diabetes mellitus and the relationship to coronary heart disease
3. Improvement of glycemic control in diabetes decreases the atherogenic small dense LDL particles
4. Electronegative low density lipoprotein subform is increased in patients with short-duration IDDM and is closely related to glycaemic control
5. Lipoprotein compositional abnormalities in type I diabetes: Effect of improved glycaemic control
6. Beyond cholesterol. Modifications of low density lipoprotein that increase its atherogenicity
7. Modified forms of low density lipoprotein and atherosclerosis
8. Lipoprotein glycation and its metabolic consequences
9. Glucosylation of low density lipoproteins to an extent comparable to that seen in diabetes slows their catabolism
10. Nonenzymatic glucosylation of low density lipoprotein alters its biologic activity
11. Stimulation of cholesteryl ester synthesis in human monocyte-derived macrophages by low density lipoproteins from type I (insulin dependent) diabetic patients: The influence of non-enzymatic glycosylation of low density lipoprotein
12. Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose
13. Oxidized low density lipoproteins: A role in the pathogenesis of atherosclerosis in diabetes?
14. Glycation and oxidation of human low density lipoproteins reduces heparin binding and modifies charge
15. Presence of a modified low density lipoprotein in humans
16. Oxidation-labile subfraction of human plasma low density lipoprotein isolated by ion-exchange chromatography
17. Characteristics of ten charge-differing subfractions isolated from human native low density lipoprotein (LDL). No evidence of peroxidative modifications
18. Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-)
19. A cytotoxic electronegative LDL subfraction is present in human plasma
20. Electronegative LDL (LDL(-)) from normolipemic subjects induces interleukin-8 and monocyte chemoattractant protein secretion by human endothelial cells
21. Glycosylated low density lipoprotein is more sensitive to oxidation: Implications for the diabetic patient?
22. Increased susceptibility of LDL to in vitro oxidation in patients with insulin-dependent and non-insulin-dependent diabetes mellitus
23. Oxidation of low density lipoprotein in NIDDM: Its relationship to fatty acid composition
24. Effects of vitamin E on susceptibility of low-denstity lipoprotein and low-density lipoprotein subfractions to oxidation and on protein glycation in NIDDM
25. Increased oxidizability of plasma lipoproteins in diabetic patients can be decreased by probucol therapy and is not due to glycation
26. Increased susceptibility to lipid oxidation of low density lipoproteins and erythrocyte membranes from diabetic patients
27. Electronegative low density lipoprotein subform (LDL-) is increased in type 2 (non-insulin-dependent) microalbuminuric diabetic patients and is closely associated with LDL susceptibility to oxidation
28. Is glycation of low density lipoproteins in patients with type 2 diabetes mellitus a LDL pre-oxidative condition?
29. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance
30. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
31. Continuous monitoring of in vitro oxidation of human low density lipoprotein
32. Fractionation of charge-modified low density lipoprotein by fast protein liquid chromatography
33. Preparation and use of boronic acid affinity support for separation and quantitation of glycosylated hemoglobins
34. Characterization and determinants of an electronegatively charged low density lipoprotein in human plasma
35. Effect of simvastatin treatment on the electronegative low density lipoprotein present in patients with heterozygous familial hypercholesterolemia
36. Characterization of a more electronegatively charged LDL subfraction by ion exchange HPLC
37. LDL(-) is a lipid hydroperoxide-enriched circulating lipoprotein
38. Some questions concerning a small, more electronegative LDL circulating in human plasma
39. Contribution of an in vivo oxidized LDL to LDL oxidation and its association with dense LDL subpopulations
40. Increase of LDL susceptibility to oxidation occurring after intense, long duration aerobic exercise
41. Ascorbic acid inhibits the increase of LDL susceptibility to oxidation and electronegative LDL proportion induced by intense aerobic exercise
42. Susceptibility to low density oxidation and coronary atherosclerosis in man
43. Enhanced in vitro oxidation of plasma lipoprotein derived from hypercholesterolemic patients
44. Predisposition to LDL oxidation in patients with and without angiographically established coronary artery disease
45. Susceptibility of small, dense low density lipoproteins to oxidative modification in individuals with the atherogenic lipoprotein phenotype, pattern B
46. Dense low density lipoprotein subspecies with diminished oxidative resistance predominate in combined hyperlipidemia
47. Oxidisability of low density lipoproteins in patients with carotid or femoral artery atherosclerosis
48. Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects
49. Lipid peroxide level in plasma of diabetic patients
50. Lipid peroxides and atherosclerosis
51. Lower susceptibility of low density lipoprotein to in vitro oxidation in diabetic patients
52. Susceptibility to copper-enhanced autoxidation of VLDL+LDL fractions from diabetic patients
53. LDL from patients with well-controlled IDDM is not more susceptible to in vitro oxidation
54. Susceptibility to oxidation and physicochemical properties of LDL in insulin-dependent diabetes