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Volumn 4, Issue MAY, 2013, Pages

Rise and dissemination of aminoglycoside resistance: The aac(6′)-Ib paradigm

Author keywords

Acetyltransferase; Aminoglycoside; Antibiotic resistance; Inhibition; Integron; Mobile elements; Transposon

Indexed keywords

ACYLTRANSFERASE; AMIKACIN; AMINOGLYCOSIDE 6' N ACETYLTRANSFERASE IB; AMINOGLYCOSIDE 6' N ACETYLTRANSFERASE IIA; AMINOGLYCOSIDE 6' N ACETYLTRANSFERASE IIB; AMINOGLYCOSIDE 6' N ACETYLTRANSFERASE IIC; AMINOGLYCOSIDE 6' N ACETYLTRANSFERASE IID; ANTISENSE OLIGONUCLEOTIDE; CIPROFLOXACIN; COENZYME A; GENTAMICIN; KANAMYCIN; MESSENGER RNA; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG;

EID: 84884236711     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2013.00121     Document Type: Review
Times cited : (118)

References (136)
  • 1
    • 79959609118 scopus 로고    scopus 로고
    • Current use of aminoglycosides: indications, pharmacokinetics and monitoring for toxicity
    • Avent, M. L., Rogers, B. A., Cheng, A. C., and Paterson, D. L. (2011). Current use of aminoglycosides: indications, pharmacokinetics and monitoring for toxicity. Intern. Med. J. 41, 441-449.
    • (2011) Intern. Med. J. , vol.41 , pp. 441-449
    • Avent, M.L.1    Rogers, B.A.2    Cheng, A.C.3    Paterson, D.L.4
  • 2
    • 0026535160 scopus 로고
    • Aminoglycoside and aminocyclitol antibiotics: hygromycin B is an atypical bactericidal compound that exerts effects on cells of Escherichia coli characteristics for bacteriostatic aminocyclitols
    • Bakker, E. P. (1992). Aminoglycoside and aminocyclitol antibiotics: hygromycin B is an atypical bactericidal compound that exerts effects on cells of Escherichia coli characteristics for bacteriostatic aminocyclitols. J. Gen. Microbiol. 138, 563-569.
    • (1992) J. Gen. Microbiol. , vol.138 , pp. 563-569
    • Bakker, E.P.1
  • 4
    • 84868199631 scopus 로고    scopus 로고
    • Sense from nonsense: therapies for premature stop codon diseases
    • Bidou, L., Allamand, V., Rousset, J. P., and Namy, O. (2012). Sense from nonsense: therapies for premature stop codon diseases. Trends Mol. Med. 18, 679-688.
    • (2012) Trends Mol. Med. , vol.18 , pp. 679-688
    • Bidou, L.1    Allamand, V.2    Rousset, J.P.3    Namy, O.4
  • 5
    • 0037330532 scopus 로고    scopus 로고
    • Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes
    • Boehr, D. D., Draker, K. A., Koteva, K., Bains, M., Hancock, R. E., and Wright, G. D. (2003). Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes. Chem. Biol. 10, 189-196.
    • (2003) Chem. Biol. , vol.10 , pp. 189-196
    • Boehr, D.D.1    Draker, K.A.2    Koteva, K.3    Bains, M.4    Hancock, R.E.5    Wright, G.D.6
  • 6
    • 84867567325 scopus 로고    scopus 로고
    • Characterization of an IncFII plasmid encoding NDM-1 from Escherichia coli ST131
    • doi: 10.1371/journal.pone.0034752
    • Bonnin, R. A., Poirel, L., Carattoli, A., and Nordmann, P. (2012). Characterization of an IncFII plasmid encoding NDM-1 from Escherichia coli ST131. PLoS ONE 7:e34752. doi: 10.1371/journal.pone.0034752
    • (2012) PLoS ONE , vol.7
    • Bonnin, R.A.1    Poirel, L.2    Carattoli, A.3    Nordmann, P.4
  • 8
    • 77951874370 scopus 로고    scopus 로고
    • Detection by Geno-type MTBDRsl test of complex resistance mechanisms to second-line drugs and ethambutol in multidrug-resistant Mycobacterium tuberculosis complex isolates
    • Brossier, F., Veziris, N., Aubry, A., Jarlier, V., and Sougakoff, W. (2010). Detection by Geno-type MTBDRsl test of complex resistance mechanisms to second-line drugs and ethambutol in multidrug-resistant Mycobacterium tuberculosis complex isolates. J. Clin. Microbiol. 48, 1683-1689.
    • (2010) J. Clin. Microbiol. , vol.48 , pp. 1683-1689
    • Brossier, F.1    Veziris, N.2    Aubry, A.3    Jarlier, V.4    Sougakoff, W.5
  • 9
    • 78650227951 scopus 로고    scopus 로고
    • Antibiotics and antibacterial agents: classifications and structure-activity relationships
    • (Washington, DC: ASM Press)
    • Bryskier, A. (2005). "Antibiotics and antibacterial agents: classifications and structure-activity relationships," in Antimicrobial Agents, ed A. Bryskier (Washington, DC: ASM Press), 13-38.
    • (2005) Antimicrobial Agents, ed A. Bryskier , pp. 13-38
    • Bryskier, A.1
  • 10
    • 0035990919 scopus 로고    scopus 로고
    • Protein kinase inhibitors and antibiotic resistance
    • Burk, D. L., and Berghuis, A. M. (2002). Protein kinase inhibitors and antibiotic resistance. Pharmacol. Ther. 93, 283-292.
    • (2002) Pharmacol. Ther. , vol.93 , pp. 283-292
    • Burk, D.L.1    Berghuis, A.M.2
  • 11
    • 0026525894 scopus 로고
    • The bactericidal action of streptomycin: membrane permeabilization caused by the insertion of mistranslated proteins into the cytoplasmic membrane of Escherichia coli and subsequent caging of the antibiotic inside the cells due to degradation of these proteins
    • Busse, H. J., Wostmann, C., and Bakker, E. P. (1992). The bactericidal action of streptomycin: membrane permeabilization caused by the insertion of mistranslated proteins into the cytoplasmic membrane of Escherichia coli and subsequent caging of the antibiotic inside the cells due to degradation of these proteins. J. Gen. Microbiol. 138, 551-561.
    • (1992) J. Gen. Microbiol. , vol.138 , pp. 551-561
    • Busse, H.J.1    Wostmann, C.2    Bakker, E.P.3
  • 13
    • 57149092385 scopus 로고    scopus 로고
    • Synonymous genes explore different evolutionary landscapes
    • doi: 10.1371/journal.pgen.1000256
    • Cambray, G., and Mazel, D. (2008). Synonymous genes explore different evolutionary landscapes. PLoS Genet. 4:e1000256. doi: 10.1371/journal.pgen.1000256
    • (2008) PLoS Genet. , vol.4
    • Cambray, G.1    Mazel, D.2
  • 14
    • 0031938055 scopus 로고    scopus 로고
    • Aminoglycoside 6β-N-acetyltransferase variants of the Ib type with altered substrate profile in clinical isolates of Enterobacter cloacae and Citrobacter freundii
    • Casin, I., Bordon, F., Bertin, P., Coutrot, A., Podglajen, I., Brasseur, R., et al. (1998). Aminoglycoside 6β-N-acetyltransferase variants of the Ib type with altered substrate profile in clinical isolates of Enterobacter cloacae and Citrobacter freundii. Antimicrob. Agents Chemother. 42, 209-215.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 209-215
    • Casin, I.1    Bordon, F.2    Bertin, P.3    Coutrot, A.4    Podglajen, I.5    Brasseur, R.6
  • 15
    • 0037310049 scopus 로고    scopus 로고
    • Salmonella enterica serovar Typhimurium bla(PER-1)-carrying plasmid pSTI1 encodes an extended-spectrum aminoglycoside 6β-N-acetyltransferase of type Ib
    • Casin, I., Hanau-Bercot, B., Podglajen, I., Vahaboglu, H., and Collatz, E. (2003). Salmonella enterica serovar Typhimurium bla(PER-1)-carrying plasmid pSTI1 encodes an extended-spectrum aminoglycoside 6β-N-acetyltransferase of type Ib. Antimicrob. Agents Chemother. 47, 697-703.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 697-703
    • Casin, I.1    Hanau-Bercot, B.2    Podglajen, I.3    Vahaboglu, H.4    Collatz, E.5
  • 16
    • 65649086093 scopus 로고    scopus 로고
    • Plasmid-mediated quinolone resistance in gram-negative bacterial species: an update
    • Cattoir, V., and Nordmann, P. (2009). Plasmid-mediated quinolone resistance in gram-negative bacterial species: an update. Curr. Med. Chem. 16, 1028-1046.
    • (2009) Curr. Med. Chem. , vol.16 , pp. 1028-1046
    • Cattoir, V.1    Nordmann, P.2
  • 17
    • 0032705999 scopus 로고    scopus 로고
    • Effects of F171 mutations in the 6β-N-acetyltransferase type Ib [AAC(6β)-Ib] enzyme on susceptibility to aminoglycosides
    • Chavideh, R., Sholly, S., Panaite, D., and Tolmasky, M. E. (1999). Effects of F171 mutations in the 6β-N-acetyltransferase type Ib [AAC(6β)-Ib] enzyme on susceptibility to aminoglycosides. Antimicrob. Agents Chemother. 43, 2811-2812.
    • (1999) Antimicrob. Agents Chemother. , vol.43 , pp. 2811-2812
    • Chavideh, R.1    Sholly, S.2    Panaite, D.3    Tolmasky, M.E.4
  • 18
    • 84861146913 scopus 로고    scopus 로고
    • Multiplex real-time PCR for detection of an epidemic KPC-producing Klebsiella pneumoniae ST258 clone
    • Chen, L., Chavda, K. D., Mediavilla, J. R., Zhao, Y., Fraimow, H. S., Jenkins, S. G., et al. (2012). Multiplex real-time PCR for detection of an epidemic KPC-producing Klebsiella pneumoniae ST258 clone. Antimicrob. Agents Chemother. 56, 3444-3447.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 3444-3447
    • Chen, L.1    Chavda, K.D.2    Mediavilla, J.R.3    Zhao, Y.4    Fraimow, H.S.5    Jenkins, S.G.6
  • 21
    • 0030848695 scopus 로고    scopus 로고
    • Inhibition of aminoglycoside antibiotic resistance enzymes by protein kinase inhibitors
    • Daigle, D. M., McKay, G. A., and Wright, G. D. (1997). Inhibition of aminoglycoside antibiotic resistance enzymes by protein kinase inhibitors. J. Biol. Chem. 272, 24755-24758.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24755-24758
    • Daigle, D.M.1    McKay, G.A.2    Wright, G.D.3
  • 22
    • 77954368284 scopus 로고    scopus 로고
    • Antibiotic resistance by enzyme inactivation: from mechanisms to solutions
    • De Pascale, G., and Wright, G. D. (2010). Antibiotic resistance by enzyme inactivation: from mechanisms to solutions. Chembiochem 11, 1325-1334.
    • (2010) Chembiochem , vol.11 , pp. 1325-1334
    • De Pascale, G.1    Wright, G.D.2
  • 23
    • 0030874840 scopus 로고    scopus 로고
    • Characterization of the replication and mobilization regions of the multiresistance Klebsiella pneumoniae plasmid pJHCMW1
    • Dery, K. J., Chavideh, R., Waters, V., Chamorro, R., Tolmasky, L. S., and Tolmasky, M. E. (1997). Characterization of the replication and mobilization regions of the multiresistance Klebsiella pneumoniae plasmid pJHCMW1. Plasmid 38, 97-105.
    • (1997) Plasmid , vol.38 , pp. 97-105
    • Dery, K.J.1    Chavideh, R.2    Waters, V.3    Chamorro, R.4    Tolmasky, L.S.5    Tolmasky, M.E.6
  • 24
    • 0041922659 scopus 로고    scopus 로고
    • The aminoglycoside 6β-N-acetyltransferase type Ib encoded by Tn1331 is evenly distributed within the cell's cytoplasm
    • Dery, K. J., Soballe, B., Witherspoon, M. S., Bui, D., Koch, R., Sherratt, D. J., et al. (2003). The aminoglycoside 6β-N-acetyltransferase type Ib encoded by Tn1331 is evenly distributed within the cell's cytoplasm. Antimicrob. Agents Chemother. 47, 2897-2902.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 2897-2902
    • Dery, K.J.1    Soballe, B.2    Witherspoon, M.S.3    Bui, D.4    Koch, R.5    Sherratt, D.J.6
  • 25
    • 84884263676 scopus 로고    scopus 로고
    • pMdT1, a small ColE1-like plasmid mobilizing a new variant of the aac (6β)-Ib-cr gene in Salmonella enterica serovar Typhimurium
    • doi: 10.1093/jac/dkt001. [Epub ahead of print]
    • De Toro, M., Rodriguez, I., Rojo-Bezares, B., Helmuth, R., Torres, C., Guerra, B., et al. (2013). pMdT1, a small ColE1-like plasmid mobilizing a new variant of the aac (6β)-Ib-cr gene in Salmonella enterica serovar Typhimurium. J. Antimicrob. Chemother. doi: 10.1093/jac/dkt001. [Epub ahead of print].
    • (2013) J. Antimicrob. Chemother.
    • De Toro, M.1    Rodriguez, I.2    Rojo-Bezares, B.3    Helmuth, R.4    Torres, C.5    Guerra, B.6
  • 26
    • 0038728733 scopus 로고    scopus 로고
    • Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6β)-Ii from Enterococcus faecium: evidence of dimer subunit cooperativity
    • Draker, K. A., Northrop, D. B., and Wright, G. D. (2003). Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6β)-Ii from Enterococcus faecium: evidence of dimer subunit cooperativity. Biochemistry 42, 6565-6574.
    • (2003) Biochemistry , vol.42 , pp. 6565-6574
    • Draker, K.A.1    Northrop, D.B.2    Wright, G.D.3
  • 27
    • 74249108028 scopus 로고    scopus 로고
    • Three decades of beta-lactamase inhibitors
    • Drawz, S. M., and Bonomo, R. A. (2010). Three decades of beta-lactamase inhibitors. Clin. Microbiol. Rev. 23, 160-201.
    • (2010) Clin. Microbiol. Rev. , vol.23 , pp. 160-201
    • Drawz, S.M.1    Bonomo, R.A.2
  • 28
    • 0036167876 scopus 로고    scopus 로고
    • Molecular characterization of a novel class 1 integron containing bla(GES-1) and a fused product of aac3-Ib/aac6β-Ibβ gene cassettes in Pseudomonas aeruginosa
    • Dubois, V., Poirel, L., Marie, C., Arpin, C., Nordmann, P., and Quentin, C. (2002). Molecular characterization of a novel class 1 integron containing bla(GES-1) and a fused product of aac3-Ib/aac6β-Ibβ gene cassettes in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 46, 638-645.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 638-645
    • Dubois, V.1    Poirel, L.2    Marie, C.3    Arpin, C.4    Nordmann, P.5    Quentin, C.6
  • 30
    • 70349315442 scopus 로고    scopus 로고
    • ACHN-490, a neoglycoside with potent in vitro activity against multidrug-resistant Klebsiella pneumoniae isolates
    • Endimiani, A., Hujer, K. M., Hujer, A. M., Armstrong, E. S., Choudhary, Y., Aggen, J. B., et al. (2009). ACHN-490, a neoglycoside with potent in vitro activity against multidrug-resistant Klebsiella pneumoniae isolates. Antimicrob. Agents Chemother. 53, 4504-4507.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 4504-4507
    • Endimiani, A.1    Hujer, K.M.2    Hujer, A.M.3    Armstrong, E.S.4    Choudhary, Y.5    Aggen, J.B.6
  • 31
    • 0036751668 scopus 로고    scopus 로고
    • Transferable plasmid mediating resistance to multiple antimicrobial agents in Klebsiella pneumoniae isolates in Greece
    • Galani, I., Xirouchaki, E., Kanellakopoulou, K., Petrikkos, G., and Giamarellou, H. (2002). Transferable plasmid mediating resistance to multiple antimicrobial agents in Klebsiella pneumoniae isolates in Greece. Clin. Microbiol. Infect. 8, 579-588.
    • (2002) Clin. Microbiol. Infect. , vol.8 , pp. 579-588
    • Galani, I.1    Xirouchaki, E.2    Kanellakopoulou, K.3    Petrikkos, G.4    Giamarellou, H.5
  • 32
    • 27544453423 scopus 로고    scopus 로고
    • Regio-and chemoselective 6β-N-derivatization of aminoglycosides: bisubstrate inhibitors as probes to study aminoglycoside 6β-N-acetyltransferases
    • Gao, F., Yan, X., Baettig, O. M., Berghuis, A. M., and Auclair, K. (2005). Regio-and chemoselective 6β-N-derivatization of aminoglycosides: bisubstrate inhibitors as probes to study aminoglycoside 6β-N-acetyltransferases. Angew. Chem. Int. Ed. Engl. 44, 6859-6862.
    • (2005) Angew. Chem. Int. Ed. Engl. , vol.44 , pp. 6859-6862
    • Gao, F.1    Yan, X.2    Baettig, O.M.3    Berghuis, A.M.4    Auclair, K.5
  • 33
    • 33747494199 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6β-N-acetyltransferases
    • Gao, F., Yan, X., Shakya, T., Baettig, O. M., Ait-Mohand-Brunet, S., Berghuis, A. M., et al. (2006). Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6β-N-acetyltransferases. J. Med. Chem. 49, 5273-5281.
    • (2006) J. Med. Chem. , vol.49 , pp. 5273-5281
    • Gao, F.1    Yan, X.2    Shakya, T.3    Baettig, O.M.4    Ait-Mohand-Brunet, S.5    Berghuis, A.M.6
  • 34
    • 84858682206 scopus 로고    scopus 로고
    • Klebsiella pneumoniae ST258 producing KPC-3 identified in italy carries novel plasmids and OmpK36/OmpK35 porin variants
    • Garcia-Fernandez, A., Villa, L., Carta, C., Venditti, C., Giordano, A., Venditti, M., et al. (2012). Klebsiella pneumoniae ST258 producing KPC-3 identified in italy carries novel plasmids and OmpK36/OmpK35 porin variants. Antimicrob. Agents Chemother. 56, 2143-2145.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 2143-2145
    • Garcia-Fernandez, A.1    Villa, L.2    Carta, C.3    Venditti, C.4    Giordano, A.5    Venditti, M.6
  • 35
    • 79959277696 scopus 로고    scopus 로고
    • Effects of altering aminoglycoside structures on bacterial resistance enzyme activities
    • Green, K. D., Chen, W., and Garneau-Tsodikova, S. (2011). Effects of altering aminoglycoside structures on bacterial resistance enzyme activities. Antimicrob. Agents Chemother. 55, 3207-3213.
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 3207-3213
    • Green, K.D.1    Chen, W.2    Garneau-Tsodikova, S.3
  • 36
    • 84555188476 scopus 로고    scopus 로고
    • Identification and characterization of inhibitors of the aminoglycoside resistance acetyltransferase Eis from Mycobacterium tuberculosis
    • Green, K. D., Chen, W., and Garneau-Tsodikova, S. (2012). Identification and characterization of inhibitors of the aminoglycoside resistance acetyltransferase Eis from Mycobacterium tuberculosis. ChemMedChem 7, 73-77.
    • (2012) ChemMedChem , vol.7 , pp. 73-77
    • Green, K.D.1    Chen, W.2    Garneau-Tsodikova, S.3
  • 37
    • 75649101296 scopus 로고    scopus 로고
    • Exploring the substrate promiscuity of drug-modifying enzymes for the chemoenzymatic generation of N-acylated aminoglycosides
    • Green, K. D., Chen, W., Houghton, J. L., Fridman, M., and Garneau-Tsodikova, S. (2010). Exploring the substrate promiscuity of drug-modifying enzymes for the chemoenzymatic generation of N-acylated aminoglycosides. Chembiochem 11, 119-126.
    • (2010) Chembiochem , vol.11 , pp. 119-126
    • Green, K.D.1    Chen, W.2    Houghton, J.L.3    Fridman, M.4    Garneau-Tsodikova, S.5
  • 38
    • 0030844329 scopus 로고    scopus 로고
    • Phenotypic conversion of drug-resistant bacteria to drug sensitivity
    • Guerrier-Takada, C., Salavati, R., and Altman, S. (1997). Phenotypic conversion of drug-resistant bacteria to drug sensitivity. Proc. Natl. Acad. Sci. U.S.A. 94, 8468-8472.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 8468-8472
    • Guerrier-Takada, C.1    Salavati, R.2    Altman, S.3
  • 39
    • 0033596314 scopus 로고    scopus 로고
    • An antibiotic cloaked by its own resistance enzyme
    • Haddad, J., Vakulenko, S. B., and Mobashery, S. (1999). An antibiotic cloaked by its own resistance enzyme. J. Am. Chem. Soc. 121, 11922-11923.
    • (1999) J. Am. Chem. Soc. , vol.121 , pp. 11922-11923
    • Haddad, J.1    Vakulenko, S.B.2    Mobashery, S.3
  • 40
    • 84865998603 scopus 로고    scopus 로고
    • Integrons and gene cassettes: hotspots of diversity in bacterial genomes
    • Hall, R. M. (2012). Integrons and gene cassettes: hotspots of diversity in bacterial genomes. Ann. N.Y. Acad. Sci. 1267, 71-78.
    • (2012) Ann. N.Y. Acad. Sci. , vol.1267 , pp. 71-78
    • Hall, R.M.1
  • 41
    • 0019779495 scopus 로고
    • Aminoglycoside uptake and mode of action-with special reference to streptomycin and gentamicin
    • Hancock, R. E. (1981). Aminoglycoside uptake and mode of action-with special reference to streptomycin and gentamicin. I. Antagonists and mutants. J. Antimicrob. Chemother. 8, 249-276.
    • (1981) I. Antagonists and mutants. J. Antimicrob. Chemother. , vol.8 , pp. 249-276
    • Hancock, R.E.1
  • 42
    • 34547093657 scopus 로고    scopus 로고
    • Aminoglycoside antibiotics: old drugs and new therapeutic approaches
    • Hermann, T. (2007). Aminoglycoside antibiotics: old drugs and new therapeutic approaches. Cell. Mol. Life Sci. 64, 1841-1852.
    • (2007) Cell. Mol. Life Sci. , vol.64 , pp. 1841-1852
    • Hermann, T.1
  • 44
    • 0037378945 scopus 로고    scopus 로고
    • MexXY-OprM efflux pump is necessary for a adaptive resistance of Pseudomonas aeruginosa to aminoglycosides
    • Hocquet, D., Vogne, C., El Garch, F., Vejux, A., Gotoh, N., Lee, A., et al. (2003). MexXY-OprM efflux pump is necessary for a adaptive resistance of Pseudomonas aeruginosa to aminoglycosides. Antimicrob. Agents Chemother. 47, 1371-1375.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 1371-1375
    • Hocquet, D.1    Vogne, C.2    El Garch, F.3    Vejux, A.4    Gotoh, N.5    Lee, A.6
  • 46
    • 84862854161 scopus 로고    scopus 로고
    • Outcomes of intratympanic gentamicin injection to treat Meniere's disease
    • Huon, L. K., Fang, T. Y., and Wang, P. C. (2012). Outcomes of intratympanic gentamicin injection to treat Meniere's disease. Otol. Neurotol. 33, 706-714.
    • (2012) Otol. Neurotol. , vol.33 , pp. 706-714
    • Huon, L.K.1    Fang, T.Y.2    Wang, P.C.3
  • 47
    • 33644547013 scopus 로고    scopus 로고
    • Molecular understanding of aminoglycoside action and resistance
    • Jana, S., and Deb, J. K. (2006). Molecular understanding of aminoglycoside action and resistance. Appl. Microbiol. Biotechnol. 70, 140-150.
    • (2006) Appl. Microbiol. Biotechnol. , vol.70 , pp. 140-150
    • Jana, S.1    Deb, J.K.2
  • 48
    • 84870990953 scopus 로고    scopus 로고
    • Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations
    • Kandasamy, J., Atia-Glikin, D., Shulman, E., Shapira, K., Shavit, M., Belakhov, V., et al. (2012). Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations. J. Med. Chem. 55, 10630-10643.
    • (2012) J. Med. Chem. , vol.55 , pp. 10630-10643
    • Kandasamy, J.1    Atia-Glikin, D.2    Shulman, E.3    Shapira, K.4    Shavit, M.5    Belakhov, V.6
  • 49
    • 84875619226 scopus 로고    scopus 로고
    • MAFFT multiple sequence alignment software version 7: improvements in performance and usability
    • Katoh, K., and Standley, D. (2013). MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Mol. Biol. Evol. 30, 772-780.
    • (2013) Mol. Biol. Evol. , vol.30 , pp. 772-780
    • Katoh, K.1    Standley, D.2
  • 50
    • 33845935532 scopus 로고    scopus 로고
    • Translational readthrough induction of pathogenic nonsense mutations
    • Kellermayer, R. (2006). Translational readthrough induction of pathogenic nonsense mutations. Eur. J. Med. Genet. 49, 445-450.
    • (2006) Eur. J. Med. Genet. , vol.49 , pp. 445-450
    • Kellermayer, R.1
  • 51
    • 34247577481 scopus 로고    scopus 로고
    • Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib/AAC(6β)-Ib' from Pseudomonas aeruginosa
    • Kim, C., Villegas-Estrada, A., Hesek, D., and Mobashery, S. (2007). Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib/AAC(6β)-Ib' from Pseudomonas aeruginosa. Biochemistry 46, 5270-5282.
    • (2007) Biochemistry , vol.46 , pp. 5270-5282
    • Kim, C.1    Villegas-Estrada, A.2    Hesek, D.3    Mobashery, S.4
  • 52
    • 79955995216 scopus 로고    scopus 로고
    • Identification of strain harboring both aac(6β)-Ib and aac(6β)-Ib-cr variant simultaneously in Escherichia coli and Klebsiella pneumoniae
    • Kim, Y. T., Jang, J. H., Kim, H. C., Kim, H., Lee, K. R., Park, K. S., et al. (2011). Identification of strain harboring both aac(6β)-Ib and aac(6β)-Ib-cr variant simultaneously in Escherichia coli and Klebsiella pneumoniae. BMB Rep. 44, 262-266.
    • (2011) BMB Rep. , vol.44 , pp. 262-266
    • Kim, Y.T.1    Jang, J.H.2    Kim, H.C.3    Kim, H.4    Lee, K.R.5    Park, K.S.6
  • 53
    • 34548213103 scopus 로고    scopus 로고
    • A common mechanism of cellular death induced by bactericidal antibiotics
    • Kohanski, M. A., Dwyer, D. J., Hayete, B., Lawrence, C. A., and Collins, J. J. (2007). A common mechanism of cellular death induced by bactericidal antibiotics. Cell 130, 797-810.
    • (2007) Cell , vol.130 , pp. 797-810
    • Kohanski, M.A.1    Dwyer, D.J.2    Hayete, B.3    Lawrence, C.A.4    Collins, J.J.5
  • 54
    • 34948883252 scopus 로고    scopus 로고
    • Differential selectivity of natural and synthetic aminoglycosides towards the eukaryotic and prokaryotic decoding A sites
    • Kondo, J., Hainrichson, M., Nudelman, I., Shallom-Shezifi, D., Barbieri, C. M., Pilch, D. S., et al. (2007). Differential selectivity of natural and synthetic aminoglycosides towards the eukaryotic and prokaryotic decoding A sites. Chembiochem 8, 1700-1709.
    • (2007) Chembiochem , vol.8 , pp. 1700-1709
    • Kondo, J.1    Hainrichson, M.2    Nudelman, I.3    Shallom-Shezifi, D.4    Barbieri, C.M.5    Pilch, D.S.6
  • 55
    • 0034891626 scopus 로고    scopus 로고
    • Once-a-day individualized amikacin dosing for suspected infection at birth based on population pharmacokinetic models
    • Labaune, J. M., Bleyzac, N., Maire, P., Jelliffe, R. W., Boutroy, M. J., Aulagner, G., et al. (2001). Once-a-day individualized amikacin dosing for suspected infection at birth based on population pharmacokinetic models. Biol. Neonate 80, 142-147.
    • (2001) Biol. Neonate , vol.80 , pp. 142-147
    • Labaune, J.M.1    Bleyzac, N.2    Maire, P.3    Jelliffe, R.W.4    Boutroy, M.J.5    Aulagner, G.6
  • 56
    • 0028055090 scopus 로고
    • A spontaneous point mutation in the aac(6β)-Ib' gene results in altered substrate specificity of aminoglycoside 6β-N-acetyltransferase of a Pseudomonas fluorescens strain
    • Lambert, T., Ploy, M. C., and Courvalin, P. (1994). A spontaneous point mutation in the aac(6β)-Ib' gene results in altered substrate specificity of aminoglycoside 6β-N-acetyltransferase of a Pseudomonas fluorescens strain. FEMS Microbiol. Lett. 115, 297-304.
    • (1994) FEMS Microbiol. Lett. , vol.115 , pp. 297-304
    • Lambert, T.1    Ploy, M.C.2    Courvalin, P.3
  • 57
    • 78651462031 scopus 로고    scopus 로고
    • Antimicrobial activity of a novel aminoglycoside, ACHN-490, against Acinetobacter baumannii and Pseudomonas aeruginosa from New York City
    • Landman, D., Kelly, P., Backer, M., Babu, E., Shah, N., Bratu, S., et al. (2011). Antimicrobial activity of a novel aminoglycoside, ACHN-490, against Acinetobacter baumannii and Pseudomonas aeruginosa from New York City. J. Antimicrob. Chemother. 66, 332-334.
    • (2011) J. Antimicrob. Chemother. , vol.66 , pp. 332-334
    • Landman, D.1    Kelly, P.2    Backer, M.3    Babu, E.4    Shah, N.5    Bratu, S.6
  • 58
    • 0034602208 scopus 로고    scopus 로고
    • Tethered bisubstrate derivatives as probes for mechanism and as inhibitors of aminoglycoside 3β-phosphotransferases
    • Liu, M., Haddad, J., Azucena, E., Kotra, L. P., Kirzhner, M., and Mobashery, S. (2000). Tethered bisubstrate derivatives as probes for mechanism and as inhibitors of aminoglycoside 3β-phosphotransferases. J. Org. Chem. 65, 7422-7431.
    • (2000) J. Org. Chem. , vol.65 , pp. 7422-7431
    • Liu, M.1    Haddad, J.2    Azucena, E.3    Kotra, L.P.4    Kirzhner, M.5    Mobashery, S.6
  • 59
    • 49249098322 scopus 로고    scopus 로고
    • NMR-guided fragment-based approach for the design of AAC(6β)-Ib ligands
    • Lombes, T., Begis, G., Maurice, F., Turcaud, S., Lecourt, T., Dardel, F., et al. (2008). NMR-guided fragment-based approach for the design of AAC(6β)-Ib ligands. Chembiochem 9, 1368-1371.
    • (2008) Chembiochem , vol.9 , pp. 1368-1371
    • Lombes, T.1    Begis, G.2    Maurice, F.3    Turcaud, S.4    Lecourt, T.5    Dardel, F.6
  • 60
    • 77952881006 scopus 로고    scopus 로고
    • Inhibition of gene expression by RNase P
    • Lundblad, E. W., and Altman, S. (2010). Inhibition of gene expression by RNase P. N. Biotechnol. 27, 212-221.
    • (2010) N. Biotechnol. , vol.27 , pp. 212-221
    • Lundblad, E.W.1    Altman, S.2
  • 61
    • 0034031728 scopus 로고    scopus 로고
    • Aminoglycoside-resistance mechanisms for cystic fibrosis Pseudomonas aeruginosa isolates are unchanged by long-term, intermittent, inhaled tobramycin treatment
    • Macleod, D. L., Nelson, L. E., Shawar, R. M., Lin, B. B., Lockwood, L. G., Dirk, J. E., et al. (2000). Aminoglycoside-resistance mechanisms for cystic fibrosis Pseudomonas aeruginosa isolates are unchanged by long-term, intermittent, inhaled tobramycin treatment. J. Infect. Dis. 181, 1180-1184.
    • (2000) J. Infect. Dis. , vol.181 , pp. 1180-1184
    • Macleod, D.L.1    Nelson, L.E.2    Shawar, R.M.3    Lin, B.B.4    Lockwood, L.G.5    Dirk, J.E.6
  • 62
    • 38849185275 scopus 로고    scopus 로고
    • Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6β-N-acetyltransferase
    • Magalhaes, M. L., Vetting, M. W., Gao, F., Freiburger, L., Auclair, K., and Blanchard, J. S. (2008). Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6β-N-acetyltransferase. Biochemistry 47, 579-584.
    • (2008) Biochemistry , vol.47 , pp. 579-584
    • Magalhaes, M.L.1    Vetting, M.W.2    Gao, F.3    Freiburger, L.4    Auclair, K.5    Blanchard, J.S.6
  • 63
    • 14844348264 scopus 로고    scopus 로고
    • Molecular insights into aminoglycoside action and resistance
    • Magnet, S., and Blanchard, J. S. (2005). Molecular insights into aminoglycoside action and resistance. Chem. Rev. 105, 477-498.
    • (2005) Chem. Rev. , vol.105 , pp. 477-498
    • Magnet, S.1    Blanchard, J.S.2
  • 64
    • 0037997163 scopus 로고    scopus 로고
    • Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase
    • Magnet, S., Smith, T. A., Zheng, R., Nordmann, P., and Blanchard, J. S. (2003). Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase. Antimicrob. Agents Chemother. 47, 1577-1583.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 1577-1583
    • Magnet, S.1    Smith, T.A.2    Zheng, R.3    Nordmann, P.4    Blanchard, J.S.5
  • 66
    • 48749103032 scopus 로고    scopus 로고
    • Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance
    • Maurice, F., Broutin, I., Podglajen, I., Benas, P., Collatz, E., and Dardel, F. (2008). Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance. EMBO Rep. 9, 344-349.
    • (2008) EMBO Rep. , vol.9 , pp. 344-349
    • Maurice, F.1    Broutin, I.2    Podglajen, I.3    Benas, P.4    Collatz, E.5    Dardel, F.6
  • 67
    • 0043026695 scopus 로고    scopus 로고
    • Neomycin and paromomycin inhibit 30S ribosomal subunit assembly in Staphylococcus aureus
    • Mehta, R., and Champney, W. S. (2003). Neomycin and paromomycin inhibit 30S ribosomal subunit assembly in Staphylococcus aureus. Curr. Microbiol. 47, 237-243.
    • (2003) Curr. Microbiol. , vol.47 , pp. 237-243
    • Mehta, R.1    Champney, W.S.2
  • 68
    • 9644302496 scopus 로고    scopus 로고
    • Integron carrying a novel metallo-b-lactamase gene, blaIMP-16, and a fused form of aminoglycoside-resistance gene aac(6β)-30/aac(6β)-Ib: report from the SENTRY antimicrobial surveillance program
    • Mendes, R., Toleman, M., Ribeiro, J., Sader, H., Jones, R., and Walsh, T. (2004). Integron carrying a novel metallo-b-lactamase gene, blaIMP-16, and a fused form of aminoglycoside-resistance gene aac(6β)-30/aac(6β)-Ib: report from the SENTRY antimicrobial surveillance program. Antimicrob. Agents Chemother. 48, 4693-4702.
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 4693-4702
    • Mendes, R.1    Toleman, M.2    Ribeiro, J.3    Sader, H.4    Jones, R.5    Walsh, T.6
  • 69
    • 70349634546 scopus 로고    scopus 로고
    • Effect of duration and intermittency of rifampin on tuberculosis treatment outcomes: a systematic review and meta-analysis
    • doi: 10.1371/journal.pmed.1000146
    • Menzies, D., Benedetti, A., Paydar, A., Martin, I., Royce, S., Pai, M., et al. (2009). Effect of duration and intermittency of rifampin on tuberculosis treatment outcomes: a systematic review and meta-analysis. PLoS Med. 6:e1000146. doi: 10.1371/journal.pmed.1000146
    • (2009) PLoS Med. , vol.6
    • Menzies, D.1    Benedetti, A.2    Paydar, A.3    Martin, I.4    Royce, S.5    Pai, M.6
  • 71
    • 0031021201 scopus 로고    scopus 로고
    • The most frequent aminoglycoside resistance mechanisms-changes with time and geographic area: a reflection of aminoglycoside usage patterns? Aminoglycoside Resistance Study Groups
    • Miller, G. H., Sabatelli, F. J., Hare, R. S., Glupczynski, Y., Mackey, P., Shlaes, D., et al. (1997). The most frequent aminoglycoside resistance mechanisms-changes with time and geographic area: a reflection of aminoglycoside usage patterns? Aminoglycoside Resistance Study Groups. Clin. Infect. Dis. 24(Suppl. 1), S46-S62.
    • (1997) Clin. Infect. Dis. , vol.24 , Issue.SUPPL. 1
    • Miller, G.H.1    Sabatelli, F.J.2    Hare, R.S.3    Glupczynski, Y.4    Mackey, P.5    Shlaes, D.6
  • 72
    • 84875898775 scopus 로고    scopus 로고
    • MexXY multidrug efflux system of Pseudomonas aeruginosa
    • doi: 10.3389/fmicb.2012.00408
    • Morita, Y., Tomida, J., and Kawamura, Y. (2012). MexXY multidrug efflux system of Pseudomonas aeruginosa. Front. Microbiol. 3:408. doi: 10.3389/fmicb.2012.00408
    • (2012) Front. Microbiol. , vol.3 , pp. 408
    • Morita, Y.1    Tomida, J.2    Kawamura, Y.3
  • 73
    • 0021189724 scopus 로고
    • Effect of growth rate on streptomycin accumulation by Escherichia coli and Bacillus megaterium
    • Muir, M. E., Van Heeswyck, R. S., and Wallace, B. J. (1984). Effect of growth rate on streptomycin accumulation by Escherichia coli and Bacillus megaterium. J. Gen. Microbiol. 130, 2015-2022.
    • (1984) J. Gen. Microbiol. , vol.130 , pp. 2015-2022
    • Muir, M.E.1    Van Heeswyck, R.S.2    Wallace, B.J.3
  • 74
    • 0030954208 scopus 로고    scopus 로고
    • GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein
    • Neuwald, A. F., and Landsman, D. (1997). GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein. Trends Biochem. Sci. 22, 154-155.
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 154-155
    • Neuwald, A.F.1    Landsman, D.2
  • 75
    • 0026322432 scopus 로고
    • Interaction between 16S ribosomal RNA and ribosomal protein S12: differential effects of paromomycin and streptomycin
    • O'Connor, M., De Stasio, E. A., and Dahlberg, A. E. (1991). Interaction between 16S ribosomal RNA and ribosomal protein S12: differential effects of paromomycin and streptomycin. Biochimie 73, 1493-1500.
    • (1991) Biochimie , vol.73 , pp. 1493-1500
    • O'Connor, M.1    De Stasio, E.A.2    Dahlberg, A.E.3
  • 76
    • 0035468327 scopus 로고    scopus 로고
    • The changing nature of aminoglycoside resistance mechanisms and prevalence of newly recognized resistance mechanisms in Turkey
    • Aminoglycoside Resistance Study Group
    • Over, U., Gur, D., Unal, S., Miller, G. H., and Aminoglycoside Resistance Study Group. (2001). The changing nature of aminoglycoside resistance mechanisms and prevalence of newly recognized resistance mechanisms in Turkey. Clin. Microbiol. Infect. 7, 470-478.
    • (2001) Clin. Microbiol. Infect. , vol.7 , pp. 470-478
    • Over, U.1    Gur, D.2    Unal, S.3    Miller, G.H.4
  • 78
    • 0031896382 scopus 로고    scopus 로고
    • Characterization of mutants of the 6β-N-acetyltransferase encoded by the multiresistance transposon Tn1331: effect of Phen171-to-Leu171 and Tyr80-to-Cys80 substitutions
    • Panaite, D. M., and Tolmasky, M. E. (1998). Characterization of mutants of the 6β-N-acetyltransferase encoded by the multiresistance transposon Tn1331: effect of Phen171-to-Leu171 and Tyr80-to-Cys80 substitutions. Plasmid 39, 123-133.
    • (1998) Plasmid , vol.39 , pp. 123-133
    • Panaite, D.M.1    Tolmasky, M.E.2
  • 79
    • 33746863343 scopus 로고    scopus 로고
    • Class II transposon-borne structure harboring metallo-beta-lactamase gene blaVIM-2 in Pseudomonas putida
    • Poirel, L., Cabanne, L., Collet, L., and Nordmann, P. (2006). Class II transposon-borne structure harboring metallo-beta-lactamase gene blaVIM-2 in Pseudomonas putida. Antimicrob. Agents Chemother. 50, 2889-2891.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 2889-2891
    • Poirel, L.1    Cabanne, L.2    Collet, L.3    Nordmann, P.4
  • 80
    • 21444453271 scopus 로고    scopus 로고
    • Mutagenesis analysis of a conserved region involved in acetyl coenzyme A binding in the aminoglycoside 6β-N-acetyltransferase type Ib encoded by plasmid pJHCMW1
    • Pourreza, A., Witherspoon, M., Fox, J., Newmark, J., Bui, D., and Tolmasky, M. E. (2005). Mutagenesis analysis of a conserved region involved in acetyl coenzyme A binding in the aminoglycoside 6β-N-acetyltransferase type Ib encoded by plasmid pJHCMW1. Antimicrob. Agents Chemother. 49, 2979-2982.
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 2979-2982
    • Pourreza, A.1    Witherspoon, M.2    Fox, J.3    Newmark, J.4    Bui, D.5    Tolmasky, M.E.6
  • 81
    • 36749021567 scopus 로고    scopus 로고
    • Complex class 1 integrons with diverse variable regions, including aac(6β)-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina
    • Quiroga, M. P., Andres, P., Petroni, A., Soler Bistue, A. J., Guerriero, L., Vargas, L. J., et al. (2007). Complex class 1 integrons with diverse variable regions, including aac(6β)-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. Antimicrob. Agents Chemother. 51, 4466-4470.
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 4466-4470
    • Quiroga, M.P.1    Andres, P.2    Petroni, A.3    Soler Bistue, A.J.4    Guerriero, L.5    Vargas, L.J.6
  • 83
  • 84
    • 0026751304 scopus 로고
    • Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6β-N-acetyltransferase Ib and IIa proteins
    • Rather, P. N., Munayyer, H., Mann, P. A., Hare, R. S., Miller, G. H., and Shaw, K. J. (1992). Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6β-N-acetyltransferase Ib and IIa proteins. J. Bacteriol. 174, 3196-3203.
    • (1992) J. Bacteriol. , vol.174 , pp. 3196-3203
    • Rather, P.N.1    Munayyer, H.2    Mann, P.A.3    Hare, R.S.4    Miller, G.H.5    Shaw, K.J.6
  • 85
    • 42549171131 scopus 로고    scopus 로고
    • Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE
    • Rice, L. B. (2008). Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. J. Infect. Dis. 197, 1079-1081.
    • (2008) J. Infect. Dis. , vol.197 , pp. 1079-1081
    • Rice, L.B.1
  • 86
    • 50949095507 scopus 로고    scopus 로고
    • The KQ element, a complex genetic region conferring transferable resistance to carbapenems, aminoglycosides, and fluoroquinolones in Klebsiella pneumoniae
    • Rice, L. B., Carias, L. L., Hutton, R. A., Rudin, S. D., Endimiani, A., and Bonomo, R. A. (2008). The KQ element, a complex genetic region conferring transferable resistance to carbapenems, aminoglycosides, and fluoroquinolones in Klebsiella pneumoniae. Anti-microb. Agents Chemother. 52, 3427-3429.
    • (2008) Anti-microb. Agents Chemother. , vol.52 , pp. 3427-3429
    • Rice, L.B.1    Carias, L.L.2    Hutton, R.A.3    Rudin, S.D.4    Endimiani, A.5    Bonomo, R.A.6
  • 87
    • 0025155528 scopus 로고
    • Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells
    • Rich, D. P., Anderson, M. P., Gregory, R. J., Cheng, S. H., Paul, S., Jefferson, D. M., et al. (1990). Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells. Nature 347, 358-363.
    • (1990) Nature , vol.347 , pp. 358-363
    • Rich, D.P.1    Anderson, M.P.2    Gregory, R.J.3    Cheng, S.H.4    Paul, S.5    Jefferson, D.M.6
  • 88
    • 30044445411 scopus 로고    scopus 로고
    • Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase
    • Robicsek, A., Strahilevitz, J., Jacoby, G. A., Macielag, M., Abbanat, D., Park, C. H., et al. (2006). Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nat. Med. 12, 83-88.
    • (2006) Nat. Med. , vol.12 , pp. 83-88
    • Robicsek, A.1    Strahilevitz, J.2    Jacoby, G.A.3    Macielag, M.4    Abbanat, D.5    Park, C.H.6
  • 90
    • 84871062858 scopus 로고    scopus 로고
    • Comparing aminoglycoside binding sites in bacterial ribosomal RNA and aminoglycoside modifying enzymes
    • Romanowska, J., Reuter, N., and Trylska, J. (2013). Comparing aminoglycoside binding sites in bacterial ribosomal RNA and aminoglycoside modifying enzymes. Proteins 81, 63-80.
    • (2013) Proteins , vol.81 , pp. 63-80
    • Romanowska, J.1    Reuter, N.2    Trylska, J.3
  • 91
    • 84864586160 scopus 로고    scopus 로고
    • Transferable mechanisms of quinolone resistance
    • Ruiz, J., Pons, M. J., and Gomes, C. (2012). Transferable mechanisms of quinolone resistance. Int. J. Antimicrob. Agents 40, 196-203.
    • (2012) Int. J. Antimicrob. Agents , vol.40 , pp. 196-203
    • Ruiz, J.1    Pons, M.J.2    Gomes, C.3
  • 92
    • 0037387470 scopus 로고    scopus 로고
    • Determining the limits of the evolutionary potential of an antibiotic resistance gene
    • Salipante, S. J., and Hall, B. G. (2003). Determining the limits of the evolutionary potential of an antibiotic resistance gene. Mol. Biol. Evol. 20, 653-659.
    • (2003) Mol. Biol. Evol. , vol.20 , pp. 653-659
    • Salipante, S.J.1    Hall, B.G.2
  • 93
    • 0141924827 scopus 로고    scopus 로고
    • Inhibition of aminoglycoside 6β-N-acetyltransferase type Ib-mediated amikacin resistance by antisense oligodeoxynucleotides
    • Sarno, R., Ha, H., Weinsetel, N., and Tolmasky, M. E. (2003). Inhibition of aminoglycoside 6β-N-acetyltransferase type Ib-mediated amikacin resistance by antisense oligodeoxynucleotides. Antimicrob. Agents Chemother. 47, 3296-3304.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 3296-3304
    • Sarno, R.1    Ha, H.2    Weinsetel, N.3    Tolmasky, M.E.4
  • 95
    • 64649099870 scopus 로고    scopus 로고
    • Structural bases for 16 s rRNA methylation catalyzed by ArmA and RmtB methyltransferases
    • Schmitt, E., Galimand, M., Panvert, M., Courvalin, P., and Mechulam, Y. (2009). Structural bases for 16 s rRNA methylation catalyzed by ArmA and RmtB methyltransferases. J. Mol. Biol. 388, 570-582.
    • (2009) J. Mol. Biol. , vol.388 , pp. 570-582
    • Schmitt, E.1    Galimand, M.2    Panvert, M.3    Courvalin, P.4    Mechulam, Y.5
  • 96
    • 79956281536 scopus 로고    scopus 로고
    • Assessment of 6β-and 6β"-N-acylation of aminoglycosides as a strategy to overcome bacterial resistance
    • Shaul, P., Green, K. D., Rutenberg, R., Kramer, M., Berkov-Zrihen, Y., Breiner-Goldstein, E., et al. (2011). Assessment of 6β-and 6β"-N-acylation of aminoglycosides as a strategy to overcome bacterial resistance. Org. Biomol. Chem. 9, 4057-4063.
    • (2011) Org. Biomol. Chem. , vol.9 , pp. 4057-4063
    • Shaul, P.1    Green, K.D.2    Rutenberg, R.3    Kramer, M.4    Berkov-Zrihen, Y.5    Breiner-Goldstein, E.6
  • 97
    • 0027478123 scopus 로고
    • Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes
    • Shaw, K. J., Rather, P. N., Hare, R. S., and Miller, G. H. (1993). Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. Microbiol. Rev. 57, 138-163.
    • (1993) Microbiol. Rev. , vol.57 , pp. 138-163
    • Shaw, K.J.1    Rather, P.N.2    Hare, R.S.3    Miller, G.H.4
  • 98
    • 0035191930 scopus 로고    scopus 로고
    • Systematic analysis of a conserved region of the aminoglycoside 6β-Nacetyltransferase type Ib
    • Shmara, A., Weinsetel, N., Dery, K. J., Chavideh, R., and Tolmasky, M. E. (2001). Systematic analysis of a conserved region of the aminoglycoside 6β-Nacetyltransferase type Ib. Antimicrob. Agents Chemother. 45, 3287-3292.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 3287-3292
    • Shmara, A.1    Weinsetel, N.2    Dery, K.J.3    Chavideh, R.4    Tolmasky, M.E.5
  • 100
    • 48849103513 scopus 로고    scopus 로고
    • Klebsiella pneumoniae multiresistance plasmid pMET1: similarity with the Yersinia pestis plasmid pCRY and integrative conjugative elements
    • doi: 10.1371/journal.pone.0001800
    • Soler Bistue, A. J., Birshan, D., Tomaras, A. P., Dandekar, M., Tran, T., Newmark, J., et al. (2008). Klebsiella pneumoniae multiresistance plasmid pMET1: similarity with the Yersinia pestis plasmid pCRY and integrative conjugative elements. PLoS ONE 3:e1800. doi: 10.1371/journal.pone.0001800
    • (2008) PLoS ONE , vol.3
    • Soler Bistue, A.J.1    Birshan, D.2    Tomaras, A.P.3    Dandekar, M.4    Tran, T.5    Newmark, J.6
  • 102
    • 33646443933 scopus 로고    scopus 로고
    • Vibrio cholerae InV117, a class 1 integron harboring aac(6β)-Ib and blaCTX-M-2, is linked to transposition genes
    • Soler Bistue, A. J., Martin, F. A., Petroni, A., Faccone, D., Galas, M., Tolmasky, M. E., et al. (2006). Vibrio cholerae InV117, a class 1 integron harboring aac(6β)-Ib and blaCTX-M-2, is linked to transposition genes. Antimicrob. Agents Chemother. 50, 1903-1907.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 1903-1907
    • Soler Bistue, A.J.1    Martin, F.A.2    Petroni, A.3    Faccone, D.4    Galas, M.5    Tolmasky, M.E.6
  • 103
    • 69449104409 scopus 로고    scopus 로고
    • Inhibition of aac(6β)-Ib-mediated amikacin resistance by nucleaseresistant external guide sequences in bacteria
    • Soler Bistue, A. J., Martin, F. A., Vozza, N., Ha, H., Joaquin, J. C., Zorreguieta, A., et al. (2009). Inhibition of aac(6β)-Ib-mediated amikacin resistance by nucleaseresistant external guide sequences in bacteria. Proc. Natl. Acad. Sci. U.S.A. 106, 13230-13235.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 13230-13235
    • Soler Bistue, A.J.1    Martin, F.A.2    Vozza, N.3    Ha, H.4    Joaquin, J.C.5    Zorreguieta, A.6
  • 108
    • 0025601944 scopus 로고
    • Sequencing and expression of aadA, bla, and tnpR from the multiresistance transposon Tn1331
    • Tolmasky, M. E. (1990). Sequencing and expression of aadA, bla, and tnpR from the multiresistance transposon Tn1331. Plasmid 24, 218-226.
    • (1990) Plasmid , vol.24 , pp. 218-226
    • Tolmasky, M.E.1
  • 110
    • 0023499778 scopus 로고
    • Tn1331, a novel multiresistance transposon encoding resistance to amikacin and ampicillin in Klebsiella pneumoniae
    • Tolmasky, M. E., and Crosa, J. H. (1987). Tn1331, a novel multiresistance transposon encoding resistance to amikacin and ampicillin in Klebsiella pneumoniae. Antimicrob. Agents Chemother. 31, 1955-1960.
    • (1987) Antimicrob. Agents Chemother. , vol.31 , pp. 1955-1960
    • Tolmasky, M.E.1    Crosa, J.H.2
  • 111
    • 0026045614 scopus 로고
    • Regulation of plasmid-mediated iron transport and virulence in Vibrio anguillarum
    • Tolmasky, M. E., and Crosa, J. H. (1991). Regulation of plasmid-mediated iron transport and virulence in Vibrio anguillarum. Biol. Met. 4, 33-35.
    • (1991) Biol. Met. , vol.4 , pp. 33-35
    • Tolmasky, M.E.1    Crosa, J.H.2
  • 112
    • 0027402956 scopus 로고
    • Genetic organization of antibiotic resistance genes (aac(6β)-Ib, aadA, and oxa9) in the multiresistance transposon Tn1331
    • Tolmasky, M. E., and Crosa, J. H. (1993). Genetic organization of antibiotic resistance genes (aac(6β)-Ib, aadA, and oxa9) in the multiresistance transposon Tn1331. Plasmid 29, 31-40.
    • (1993) Plasmid , vol.29 , pp. 31-40
    • Tolmasky, M.E.1    Crosa, J.H.2
  • 114
    • 0037770202 scopus 로고    scopus 로고
    • Versatility of aminoglycosides and prospects for their future
    • Vakulenko, S. B., and Mobashery, S. (2003). Versatility of aminoglycosides and prospects for their future. Clin. Microbiol. Rev. 16, 430-450.
    • (2003) Clin. Microbiol. Rev. , vol.16 , pp. 430-450
    • Vakulenko, S.B.1    Mobashery, S.2
  • 115
    • 26944433798 scopus 로고    scopus 로고
    • Outbreak of infection with a multiresistant Klebsiella pneumoniae strain associated with contaminated roll boards in operating rooms
    • Van 't Veen, A., Van Der Zee, A., Nelson, J., Speelberg, B., Kluytmans, J. A., and Buiting, A. G. (2005). Outbreak of infection with a multiresistant Klebsiella pneumoniae strain associated with contaminated roll boards in operating rooms. J. Clin. Microbiol. 43, 4961-4967.
    • (2005) J. Clin. Microbiol. , vol.43 , pp. 4961-4967
    • Van't Veen, A.1    Van Der Zee, A.2    Nelson, J.3    Speelberg, B.4    Kluytmans, J.A.5    Buiting, A.G.6
  • 117
    • 1942490112 scopus 로고    scopus 로고
    • A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones
    • Vetting, M. W., Magnet, S., Nieves, E., Roderick, S. L., and Blanchard, J. S. (2004). A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones. Chem. Biol. 11, 565-573.
    • (2004) Chem. Biol. , vol.11 , pp. 565-573
    • Vetting, M.W.1    Magnet, S.2    Nieves, E.3    Roderick, S.L.4    Blanchard, J.S.5
  • 118
    • 51849143320 scopus 로고    scopus 로고
    • Mechanistic and structural analysis of aminoglycoside Nacetyltransferase AAC(6β)-Ib and its bifunctional, fluoroquinolone-active AAC(6β)-Ib-cr variant
    • Vetting, M. W., Park, C. H., Hegde, S. S., Jacoby, G. A., Hooper, D. C., and Blanchard, J. S. (2008). Mechanistic and structural analysis of aminoglycoside Nacetyltransferase AAC(6β)-Ib and its bifunctional, fluoroquinolone-active AAC(6β)-Ib-cr variant. Biochemistry 47, 9825-9835.
    • (2008) Biochemistry , vol.47 , pp. 9825-9835
    • Vetting, M.W.1    Park, C.H.2    Hegde, S.S.3    Jacoby, G.A.4    Hooper, D.C.5    Blanchard, J.S.6
  • 119
    • 0042337397 scopus 로고    scopus 로고
    • Molecular recognition of aminoglycoside antibiotics by ribosomal RNA and resistance enzymes: an analysis of x-ray crystal structures
    • Vicens, Q., and Westhof, E. (2003). Molecular recognition of aminoglycoside antibiotics by ribosomal RNA and resistance enzymes: an analysis of x-ray crystal structures. Biopolymers 70, 42-57.
    • (2003) Biopolymers , vol.70 , pp. 42-57
    • Vicens, Q.1    Westhof, E.2
  • 120
    • 84862699980 scopus 로고    scopus 로고
    • Complete sequencing of an IncH plasmid carrying the blaNDM-1, blaCTX-M-15 and qnrB1 genes
    • Villa, L., Poirel, L., Nordmann, P., Carta, C., and Carattoli, A. (2012). Complete sequencing of an IncH plasmid carrying the blaNDM-1, blaCTX-M-15 and qnrB1 genes. J. Antimicrob. Chemother. 67, 1645-1650.
    • (2012) J. Antimicrob. Chemother. , vol.67 , pp. 1645-1650
    • Villa, L.1    Poirel, L.2    Nordmann, P.3    Carta, C.4    Carattoli, A.5
  • 121
    • 84858643163 scopus 로고    scopus 로고
    • Inhibitors of aminoglycoside resistance activated in cells
    • Vong, K., Tam, I. S., Yan, X., and Auclair, K. (2012). Inhibitors of aminoglycoside resistance activated in cells. ACS Chem. Biol. 7, 470-475.
    • (2012) ACS Chem. Biol. , vol.7 , pp. 470-475
    • Vong, K.1    Tam, I.S.2    Yan, X.3    Auclair, K.4
  • 122
    • 84862638890 scopus 로고    scopus 로고
    • Exogenously acquired 16S rRNA methyltransferases found in aminoglycoside-resistant pathogenic Gram-negative bacteria: an update
    • Wachino, J., and Arakawa, Y. (2012). Exogenously acquired 16S rRNA methyltransferases found in aminoglycoside-resistant pathogenic Gram-negative bacteria: an update. Drug Resist. Updat. 15, 133-148.
    • (2012) Drug Resist. Updat. , vol.15 , pp. 133-148
    • Wachino, J.1    Arakawa, Y.2
  • 123
    • 84858672399 scopus 로고    scopus 로고
    • A carbapenem-resistant Klebsiella pneumoniae epidemic clone in Jerusalem: sequence type 512 carrying a plasmid encoding aac(6β)-I
    • Warburg, G., Hidalgo-Grass, C., Partridge, S. R., Tolmasky, M. E., Temper, V., Moses, A. E., et al. (2012). A carbapenem-resistant Klebsiella pneumoniae epidemic clone in Jerusalem: sequence type 512 carrying a plasmid encoding aac(6β)-Ib. J. Antimicrob. Chemother. 67, 898-901.
    • (2012) J. Antimicrob. Chemother. , vol.67 , pp. 898-901
    • Warburg, G.1    Hidalgo-Grass, C.2    Partridge, S.R.3    Tolmasky, M.E.4    Temper, V.5    Moses, A.E.6
  • 124
  • 125
    • 0018608501 scopus 로고
    • Synthesis of a tight-binding, multisubstrate analog inhibitor of gentamicin acetyltransferase I
    • Williams, J. W., and Northrop, D. B. (1979). Synthesis of a tight-binding, multisubstrate analog inhibitor of gentamicin acetyltransferase I. J. Antibiot. 32, 1147-1154.
    • (1979) J. Antibiot. , vol.32 , pp. 1147-1154
    • Williams, J.W.1    Northrop, D.B.2
  • 126
    • 0022612661 scopus 로고
    • Plasmid-encoded amikacin resistance in multiresistant strains of Klebsiella pneumoniae isolated from neonates with meningitis
    • Woloj, M., Tolmasky, M. E., Roberts, M. C., and Crosa, J. H. (1986). Plasmid-encoded amikacin resistance in multiresistant strains of Klebsiella pneumoniae isolated from neonates with meningitis. Antimicrob. Agents Chemother. 29, 315-319.
    • (1986) Antimicrob. Agents Chemother. , vol.29 , pp. 315-319
    • Woloj, M.1    Tolmasky, M.E.2    Roberts, M.C.3    Crosa, J.H.4
  • 127
    • 70349315444 scopus 로고    scopus 로고
    • Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone
    • Woodford, N., Carattoli, A., Karisik, E., Underwood, A., Ellington, M. J., and Livermore, D. M. (2009). Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone. Antimicrob. Agents Chemother. 53, 4472-4482.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 4472-4482
    • Woodford, N.1    Carattoli, A.2    Karisik, E.3    Underwood, A.4    Ellington, M.J.5    Livermore, D.M.6
  • 128
    • 0032828903 scopus 로고    scopus 로고
    • Aminoglycoside-modifying enzymes
    • Wright, G. D. (1999). Aminoglycoside-modifying enzymes. Curr. Opin. Microbiol. 2, 499-503.
    • (1999) Curr. Opin. Microbiol. , vol.2 , pp. 499-503
    • Wright, G.D.1
  • 130
    • 0030956595 scopus 로고    scopus 로고
    • Overexpression and characterization of the chromosomal aminoglycoside 6β-N-acetyltransferase from Enterococcus faecium
    • Wright, G. D., and Ladak, P. (1997). Overexpression and characterization of the chromosomal aminoglycoside 6β-N-acetyltransferase from Enterococcus faecium. Antimicrob. Agents Chemother. 41, 956-960.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 956-960
    • Wright, G.D.1    Ladak, P.2
  • 131
    • 0033135707 scopus 로고    scopus 로고
    • Crystal structure of an aminoglycoside 6β-N-acetyltransferase: defining the GCN5-related N-acetyltransferase superfamily fold
    • Wybenga-Groot, L. E., Draker, K., Wright, G. D., and Berghuis, A. M. (1999). Crystal structure of an aminoglycoside 6β-N-acetyltransferase: defining the GCN5-related N-acetyltransferase superfamily fold. Structure 7, 497-507.
    • (1999) Structure , vol.7 , pp. 497-507
    • Wybenga-Groot, L.E.1    Draker, K.2    Wright, G.D.3    Berghuis, A.M.4
  • 133
    • 71249134038 scopus 로고    scopus 로고
    • Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from Indi
    • Yong, D., Toleman, M. A., Giske, C. G., Cho, H. S., Sundman, K., Lee, K., et al. (2009). Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob. Agents Chemother. 53, 5046-5054.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 5046-5054
    • Yong, D.1    Toleman, M.A.2    Giske, C.G.3    Cho, H.S.4    Sundman, K.5    Lee, K.6
  • 134
    • 60149099539 scopus 로고    scopus 로고
    • Fidelity at the molecular level: lessons from protein synthesis
    • Zaher, H. S., and Green, R. (2009). Fidelity at the molecular level: lessons from protein synthesis. Cell 136, 746-762.
    • (2009) Cell , vol.136 , pp. 746-762
    • Zaher, H.S.1    Green, R.2
  • 135
    • 33845996905 scopus 로고    scopus 로고
    • Aminoglycoside-induced translational read-through in disease: overcoming nonsense mutations by pharmacogenetic therapy
    • Zingman, L. V., Park, S., Olson, T. M., Alekseev, A. E., and Terzic, A. (2007). Aminoglycoside-induced translational read-through in disease: overcoming nonsense mutations by pharmacogenetic therapy. Clin. Pharmacol. Ther. 81, 99-103.
    • (2007) Clin. Pharmacol. Ther. , vol.81 , pp. 99-103
    • Zingman, L.V.1    Park, S.2    Olson, T.M.3    Alekseev, A.E.4    Terzic, A.5
  • 136
    • 65649152411 scopus 로고    scopus 로고
    • A blaVEB-1 variant, blaVEB-6, associated with repeated elements in a complex genetic structure
    • Zong, Z., Partridge, S. R., and Iredell, J. R. (2009). A blaVEB-1 variant, blaVEB-6, associated with repeated elements in a complex genetic structure. Antimicrob. Agents Chemother. 53, 1693-1697.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 1693-1697
    • Zong, Z.1    Partridge, S.R.2    Iredell, J.R.3


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