Klebsiella pneumoniae ST258 producing KPC-3 identified in Italy carries novel plasmids and OmpK36/OmpK35 porin variants

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 4, 2012, Pages 2143-2145

  García Fernández, Aurora ^a   Villa, Laura ^a   Carta, Claudio ^a   Venditti, Carolina ^a   Giordano, Alessandra ^b   Venditti, Mario ^b   Mancini, Carlo ^b   Carattoli, Alessandra ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; OMPK35 PROTEIN; OMPK36 PROTEIN; OUTER MEMBRANE PROTEIN; PORIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; DNA SEQUENCE; GENE SEQUENCE; ITALY; KLEBSIELLA PNEUMONIAE; NONSENSE MUTATION; NUCLEOTIDE SEQUENCE; OMPK36 GENE; PLASMID; PRIORITY JOURNAL; STOP CODON;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; DRUG RESISTANCE, BACTERIAL; GENES, BACTERIAL; GENETIC VARIATION; HUMANS; IRON; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; METALS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PLASMIDS; PORINS;

EID: 84858682206     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.05308-11     Document Type: Article

References (22)

1. Arlet G, Rouveau M, Philippon A. 1997. Substitution of alanine for aspartate at position 179 in the SHV-6 extended-spectrum beta-lactamase. FEMS Microbiol. Lett. 152:163-167. (Pubitemid 27293282)
2. Baraniak A, et al. 2009. The emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland. Antimicrob. Agents Chemother. 53:4565-4567.
3. KPC-2 gene. Emerg. Infect. Dis. 16:1349-1356.
4. Diancourt L, Passet V, Verhoef J, Grimont PA, Brisse S. 2005. Multi-locus sequence typing of Klebsiella pneumoniae nosocomial isolates. J. Clin. Microbiol. 43:4178-4182. (Pubitemid 41129719)
5. García-Fernández A, et al. 2010. An ertapenem-resistant ESBL-producing Klebsiella pneumoniae clone carries a novel OmpK36 porin variant. Antimicrob. Agents Chemother. 54:4178-4184.
6. Giamarellou H, Poulakou G. 2009. Multidrug-resistant Gram-negative infections: what are the treatment options? Drugs 69:1879-1901.
7. Giani T, et al. 2009. Emergence in Italy of Klebsiella pneumoniae sequence type 258 producing KPC-3 carbapenemase. J. Clin. Microbiol. 47:3793-3794.
8. KPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. Antimicrob. Agents Chemother. 53:1998-2004.
9. ACT-1 β-lactamase production, porin OmpK35/36 insertional inactivation, and down-regulation of the phosphate transport porin PhoE. Antimicrob. Agents Chemother. 50:3396-3406.
10. Kitchel B, et al. 2009. Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258. Antimicrob. Agents Chemother. 53:3365-3370.
11. Leavitt A, Chmelnitsky I, Carmeli Y, Navon-Venezia S. 2010. Complete nucleotide sequence of KPC-3-encoding plasmid pKpQIL in the epidemic Klebsiella pneumoniae sequence type 258. Antimicrob. Agents Chemother. 54:4493-4496.
12. Mabilat C, Goussard S, Sougakoff W, Spencer RC, Courvalin P. 1990. Direct sequencing of the amplified structural gene and promoter for the extended-broad-spectrum beta-lactamase TEM-9 (RHH-1) of Klebsiella pneumoniae. Plasmid 23:27-34. (Pubitemid 20163384)
13. Mezzatesta ML, et al. 7 May 2011. Outbreak of KPC-3-producing, and colistin-resistant, Klebsiella pneumoniae infections in two Sicilian hospitals. Clin. Microbiol. Infect. doi:10.1111/j.1469-0691.2011.03572.
14. Orsi GB, et al. 2011. Risk factors and clinical significance of ertapenem-resistant Klebsiella pneumoniae in hospitalised patients. J. Hosp. Infect. 78:54-58.
15. Pérez-Pérez FJ, Hanson ND. 2002. Detection of plasmid-mediated AmpC beta-lactamase genes in clinical isolates by using multiplex PCR. J. Clin. Microbiol. 40:2153-2162. (Pubitemid 34596400)
16. Poirel L, Heritier C, Tolun V, Nordmann P. 2004. Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae. Antimicrob. Agents Chemother. 48:15-22. (Pubitemid 38040171)
17. Rasheed JK, et al. 2008. Detection of the Klebsiella pneumoniae carbapenemase type 2 carbapenem-hydrolyzing enzyme in clinical isolates of Citrobacter freundii and K. oxytoca carrying a common plasmid. J. Clin. Microbiol. 46:2066-2069. (Pubitemid 351831844)
18. Samuelsen O, et al. 2009. Emergence of clonally related Klebsiella pneumoniae isolates of sequence type 258 producing plasmid-mediated KPC carbapenemase in Norway and Sweden. J. Antimicrob. Chemother. 63: 654-658.
19. Tsakris A, et al. 2010. A simple phenotypic method for the differentiation of metallo-beta-lactamases and class A KPC carbapenemases in Enterobacteriaceae clinical isolates. J. Antimicrob. Chemother. 65:1664-1671.
20. Villa L, García-Fernández A, Fortini D, Carattoli A. 2010. Replicon sequence typing of IncF plasmids carrying virulence and resistance determinants. J. Antimicrob. Chemother. 65:2518-2529.
21. Weldhagen GF, Prinsloo A. 2004. Molecular detection of GES-2 extended spectrum beta-lactamase producing Pseudomonas aeruginosa in Pretoria, South Africa. Int. J. Antimicrob. Agents 24:35-38. (Pubitemid 38844559)
22. Woodford N, et al. 2008. Arrival of Klebsiella pneumoniae producing KPC carbapenemase in the United Kingdom. J. Antimicrob. Chemother. 62: 1261-1264.