NMR-guided fragment-based approach for the design of AAC(6′)-lb ligands

ChemBioChem

Volumn 9, Issue 9, 2008, Pages 1368-1371

  Lombès, Thomas ^a   Bégis, Guillaume ^a   Maurice, Frédérique ^b   Turcaud, Serge ^a   Lecourt, Thomas ^a   Dardel, Frédéric ^b   Micouin, Laurent ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Aminoglycosides; Antibiotics; Coenzyme A; Fragment based synthesis; NMR spectroscopy

Indexed keywords

ACYLTRANSFERASE; AMIKACIN; AMINOGLYCOSIDE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AROMATIC COMPOUND; COENZYME A; ENZYME INHIBITOR; GENTAMICIN; KANAMYCIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TRYPTOPHAN; AMINOGLYCOSIDE N(6') ACETYLTRANSFERASE; AMINOGLYCOSIDE N(6')-ACETYLTRANSFERASE; LIGAND;

ACETYLATION; ANTIBIOTIC RESISTANCE; ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG MECHANISM; DRUG POTENTIATION; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; LIGAND BINDING; MOLECULAR INTERACTION; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; BINDING SITE; DRUG ANTAGONISM; DRUG DESIGN; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; SYNTHESIS;

ACETYLTRANSFERASES; AMINOGLYCOSIDES; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING;

EID: 49249098322     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200700677     Document Type: Article

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