Identification of strain harboring both aac(6')-Ib and aac(6')-Ib-cr variant simultaneously in Escherichia coli and Klebsiella pneumoniae

BMB Reports

Volumn 44, Issue 4, 2011, Pages 262-266

  Kim, Yun Tae ^a   Jang, Ji Hyun ^a   Kim, Hyun Chul ^a   Kim, Hyogyeong ^a   Lee, Kyoung Ryul ^a   Park, Kyung Sun ^b   Lee, Hee Joo ^b   Kim, Young Jin ^a  

^a Seoul Medical Science Institute   (South Korea)

^b Kyung Hee University College of Medicine   (South Korea)

Author keywords

Aac(6') Ib; Aac(6') Ib cr; DHPLC; Restriction enzyme; Sequence analysis

Indexed keywords

ACYLTRANSFERASE; AMINOGLYCOSIDE N(6') ACETYLTRANSFERASE; AMINOGLYCOSIDE N(6')-ACETYLTRANSFERASE; BACTERIAL PROTEIN; ESCHERICHIA COLI PROTEIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; KLEBSIELLA PNEUMONIAE; MUTATION; NUCLEOTIDE SEQUENCE;

ACETYLTRANSFERASES; BACTERIAL PROTEINS; BASE SEQUENCE; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENES, BACTERIAL; KLEBSIELLA PNEUMONIAE; MUTATION;

ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE;

EID: 79955995216     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2011.44.4.262     Document Type: Article

References (21)

1. Hooper, D. C. (2000) Mechanisms of action and resistance of older and newer fluoroquinolones. Clin. Infect. Dis. 31, S24-S28.
2. Robicsek, A., Jacoby, G. A. and Hooper, D. C. (2006) The worldwide emergence of plasmid-mediated quinolone resistance. Lancet Infect. Dis. 6, 629-640.
3. Vakulenko, S. B. and Mobashery, S. (2003) Versatility of aminoglycosides and prospects for their future. Clin. Microbiol. Rev. 16, 430-450.
4. Tolmasky, M. E., Roberts, M., Woloj, M. and Crosa, J. H. (1986) Molecular cloning of amikacin resistance determinants from a Klebsiella pneumoniae plasmid. Antimicrob. Agents Chemother. 30, 315-320.
5. Robicsek, A., Strahilevitz, J., Jacoby, G. A., Macielag, M., Abbanat, D., Park, C. H., Bush, K. and Hooper, D. C. (2006) Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nat. Med. 12, 83-88.
6. Hidalgo-Grass, C. and Strahilevitz, J. (2010) High-resolution melt curve analysis for identification of single nucleotide mutations in the quinolone resistance gene aac(6')-Ib-cr. Antimicrob. Agents Chemother. 54, 3509-3511.
7. Martínez-M., L., Eliecer, C. M., Manuel, R.-M. J., Calvo, J. and Pascual, Á. (2008) Plasmid-mediated quinolone resistance. Expert. Rev. Anti-Infect. Ther. 6, 685-711.
8. Strahilevitz, J., Jacoby, G. A., Hooper, D. C. and Robicsek, A. (2009) Plasmid-Mediated quinolone resistance: a multifaceted threat. Clin. Microbiol. Rev. 22, 664-689.
9. Flórez, A. B., Ladero, V., Álvarez-Martín, P., Ammor, M. S., Álvarez, M. Á. and Mayo, B. (2007) Acquired macrolide resistance in the human intestinal strain Lactobacillus rhamnosus E41 associated with a transition mutation in 23S rRNA genes. Int. J. Antimicrob. Agents 30, 341-344.
10. Turnpenny, P. D. and Ellard, S. (2007) Emery's Elements of Medical Genetics. 13th ed. Elsevier Limited, Amsterdam, Netherlands.
11. Guillard, T., Duval, V., Moret, H., Brasme, L., Vernet-Garnier, V. and de Champs, C. (2009) Rapid detection of quinolone resistance gene aac(6')-Ib-cr by pyrosequencing. J. Clin. Microbiol. 48, 286-289.
12. Bell, J. M., Turnidge, J. D. and Andersson, P. (2010) aac(6')-Ib-cr genotyping by simultaneous high resolution melting analysis of an unlabelled probe and full length amplicon. Antimicrob. Agents Chemother. 54, 1378-1380.
13. Park, C. H., Robicsek, A., Jacoby, G. A., Sahm, D. and Hooper, D. C. (2006) Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin modifying enzyme. Antimicrob. Agents Chemother. 50, 3953-3955.
14. Robicsek, A., Strahilevitz, J., Sahm, D. F., Jacoby, G. A. and Hooper, D. C. (2006) qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States. Antimicrob. Agents Chemother. 50, 2872-2874.
15. Robicsek, A., Strahilevitz, J., Jacoby, G. A., Macielag, M., Abbanat, D., Bush, K. and Hooper, D. C. (2006) Fluoroquinolone modifying enzyme: a novel adaptation of a common aminoglycoside acetyltransferase. Nat. Med. 12, 83-88.
16. Katsumi, S., Toshiro, S., Hiroshi, O., Kazushi, T., Tohru, U., Sadao, K., Soichi, A. and Akinobu, G. (2004) Rapid detection of gyrA and parC mutations in fluoroquinoloneresistant Neisseria gonorrhoeae by denaturing high-performance liquid chromatography. J. Microbiol. Met. 59, 415-421.
17. Deborah, J. E., Ernesto, L., Martin, J. W. and Laura, J. V. P. (2002) Detection of gyrA mutations in quinolone-resistant Salmonella enterica by denaturing high-performance liquid chromatography. J. Clin. Microbiol. 40, 4121-4125.
18. Heisig, P., Schedletzky, H. and Falkenstein-Paul, H. (1993) Mutations in the gyrA gene of a highly fluoroquinolone-resistant clinical isolate of Escherichia coli. Antimicrob. Agents Chemother. 37, 696-701.
19. Vila, J., Ruiz, J., Marco, F., Barcelo, A., Gon.i, P., Giralt, E. and Jimenez, de A. T. (1994) Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs. Antimicrob. Agents Chemother. 38, 2477-2479.
20. Kim, H. B., Wang, M., Park, C. H., Kim, E. C., Jacoby, G. A. and Hooper, D. C. (2009) oqxAB encoding a multidrug efflux pump in human clinical isolates of Enterobacteriaceae. Antimicrob. Agents Chemother. 53, 3582-3584.
21. Clinical and Laboratory Standards Institute (2008) Performance Standards for Antimicrobial Susceptibility Testing; Eighteenth Informational Supplement, M2-A9 and M7-A7, Wayne, PA, USA