Unbinding pathways from the glucocorticoid receptor shed light on the reduced sensitivity of glucocorticoid ligands to a naturally occurring, clinically relevant mutant receptor

Journal of Medicinal Chemistry

Volumn 56, Issue 17, 2013, Pages 7003-7014

  Capelli, Anna Maria ^a,b   Bruno, Agostino ^b,d   Entrena Guadix, Antonio ^c   Costantino, Gabriele ^b  

^a CHIESI FARMACEUTICI S P A   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

^c Facultad de Farmacia   (Spain)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID RECEPTOR;

ARTICLE; DISSOCIATION; ENERGY; FORCE; HUMAN; LIGAND BINDING; MOLECULAR DYNAMICS; MUTANT; SENSITIVITY ANALYSIS; SYNTHESIS;

GLUCOCORTICOIDS; LIGANDS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTATION; RECEPTORS, GLUCOCORTICOID;

EID: 84884235713     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400802b     Document Type: Article

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