Deciphering modern glucocorticoid cross-pharmacology using ancestral corticosteroid receptors

Journal of Biological Chemistry

Volumn 287, Issue 20, 2012, Pages 16267-16275

  Kohn, Jeffrey A ^a   Deshpande, Kirti ^a   Ortlund, Eric A ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CROSS-REACTIVITY; EVOLUTIONARY RELATIONSHIPS; FUNCTIONAL DATAS; HIGH QUALITY; HORMONE RECEPTORS; LIGAND BINDING; MINERALOCORTICOID RECEPTORS; MOLECULAR SWITCHES; MOMETASONE FUROATE; MUTATIONAL ANALYSIS; RECEPTOR-LIGAND COMPLEX; SINGLE RESIDUE; STEROID RECEPTORS; STRUCTURAL FEATURE; STRUCTURAL MECHANISMS;

COMPLEXATION; GENES; TRANSCRIPTION FACTORS;

LIGANDS;

CORTICOSTEROID RECEPTOR; MOMETASONE FUROATE; NUCLEAR RECEPTOR COACTIVATOR 2;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG CROSS REACTIVITY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; GENE MUTATION; HUMAN; LIGAND BINDING; MOLECULAR EVOLUTION; MOLECULAR STABILITY; MUTAGENESIS; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR UPREGULATION;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MUTAGENESIS; PREGNADIENEDIOLS; RECEPTORS, MINERALOCORTICOID;

METAZOA;

EID: 84860877711     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.346411     Document Type: Article

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