Recent advances in small-molecule modulation of epigenetic targets: Discovery and development of histone methyltransferase and bromodomain inhibitors

Annual Reports in Medicinal Chemistry

Volumn 48, Issue , 2013, Pages 185-203

  Sweis, Ramzi F ^a   Michaelides, Michael R ^a  

^a ABBVIE INC   (United States)

Author keywords

BET; BRD4; Bromodomain; DOT1L; Epigenetics; EZH2; G9a; Histone methyltransferase

Indexed keywords

2 CYCLOHEXYL N (1 ISOPROPYL 4 PIPERIDINYL) 6 METHOXY 7 [3 (1 PYRROLIDINYL)PROPOXY] 4 QUINAZOLINAMINE; 4,6 DISUBSTITUTED 3 AMIDOMETHYL PYRIDONE; 7 [3 (DIMETHYLAMINO)PROPOXY] 2 (HEXAHYDRO 4 METHYL 1H 1,4 DIAZEPIN 1 YL) 6 METHOXY N (1 METHYL 4 PIPERIDINYL) 4 QUINAZOLINAMINE; BENZODIAZEPINE; BROMODOMAIN INHIBITOR; ENHANCER OF ZESTE HOMOLOG 2 INHIBITOR; EPZ 004777; EPZ 005687; EPZ 5676; EPZ 6438; G9A INHIBITOR; GSK 126; GSK 343; GSK 525762; GSK 525762A; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE INHIBITOR; HISTONE LYSINE METHYLTRANSFERASE; HISTONE METHYLTRANSFERASE; I BET 151; INDOLE AMIDE; N (1 BENZYL 4 PIPERIDINYL) 2 (HEXAHYDRO 4 METHYL 1H 1,4 DIAZEPIN 1 YL) 6,7 DIMETHOXY 4 QUINAZOLINAMINE; PROTEIN INHIBITOR; PYRAZOLOPYRIDINE AMIDE; QUINAZOLINE; RVX 208; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; TETRAMETHYLPIPERIDINE 4 BENZAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CELL PROLIFERATION; CYTOTOXICITY; EPIGENETICS; GENE SILENCING; HIGH THROUGHPUT SCREENING; HISTONE MODIFICATION; HUMAN; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; SUMOYLATION; UBIQUITINATION;

EID: 84884135909     PISSN: 00657743     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-417150-3.00013-2     Document Type: Chapter

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