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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 3, 2013, Pages 733-736

Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: Reducing cytotoxicity by structural simplification

(9) Fujishiro, Shinya a Dodo, Kosuke a,b Iwasa, Eriko a,b Teng, Yuou a,b Sohtome, Yoshihiro a Hamashima, Yoshitaka a,c Ito, Akihiro a Yoshida, Minoru a Sodeoka, Mikiko a,b

a RIKEN (Japan)

b JAPAN SCIENCE AND TECHNOLOGY AGENCY (Japan)

c UNIVERSITY OF SHIZUOKA (Japan)

Author keywords

Chaetocin; Epidithiodiketopiperazines; Epigenetics; Methyltransferase inhibitor; Protein methylation

Indexed keywords

ALKALOID; CHETOCIN; EPIDITHIODIKETOPIPERAZINE; METHYLTRANSFERASE; METHYLTRANSFERASE INHIBITOR; PROTEIN LYSINE METHYLTRANSFERASE G9A INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHAETOMIUM; CHAETOMIUM MINUTUM; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

CELL SURVIVAL; CHAETOMIUM; DIKETOPIPERAZINES; ENZYME INHIBITORS; HISTONE-LYSINE N-METHYLTRANSFERASE; HL-60 CELLS; HUMANS; MOLECULAR STRUCTURE; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOREDOXIN-DISULFIDE REDUCTASE;

CHAETOMIUM;

EID: 84872358341 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.11.087 Document Type: Article

Times cited : (41)

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