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Volumn 231, Issue 2, 2013, Pages 147-157

Epigenetics and chromatin remodeling in adult cardiomyopathy

Author keywords

adult cardiomyopathy; cardiac hypertrophy; chromatin remodeling; epigenetics; gene regulation; Histone modification

Indexed keywords

ADENOSINE TRIPHOSPHATE; BAF60C PROTEIN; BARRIER TO AUTOINTEGRATION FACTOR; BRG1 PROTEIN; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE H3; HISTONE H3 S10; HISTONE H3 S28; HISTONE H3K27; HISTONE H3K36; HISTONE H3K4; HISTONE H3K79; HISTONE H3K9; PROTAMINE KINASE; PROTEIN SWI; TRANSCRIPTION FACTOR SNF; UNCLASSIFIED DRUG;

EID: 84883857540     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4234     Document Type: Review
Times cited : (34)

References (108)
  • 1
    • 0033529565 scopus 로고    scopus 로고
    • Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome
    • Kornberg RD, Lorch Y,. Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell 1999; 98: 285-294.
    • (1999) Cell , vol.98 , pp. 285-294
    • Kornberg, R.D.1    Lorch, Y.2
  • 2
    • 78650304236 scopus 로고    scopus 로고
    • Charting histone modifications and the functional organization of mammalian genomes
    • Zhou VW, Goren A, Bernstein BE,. Charting histone modifications and the functional organization of mammalian genomes. Nat Rev Genet 2011; 12: 7-18.
    • (2011) Nat Rev Genet , vol.12 , pp. 7-18
    • Zhou, V.W.1    Goren, A.2    Bernstein, B.E.3
  • 3
    • 34249299791 scopus 로고    scopus 로고
    • The complex language of chromatin regulation during transcription
    • Berger SL,. The complex language of chromatin regulation during transcription. Nature 2007; 447: 407-412.
    • (2007) Nature , vol.447 , pp. 407-412
    • Berger, S.L.1
  • 4
    • 0033994292 scopus 로고    scopus 로고
    • ATP-dependent chromatin-remodeling complexes
    • Vignali M, Hassan AH, Neely KE, et al., ATP-dependent chromatin-remodeling complexes. Mol Cell Biol 2000; 20: 1899-1910.
    • (2000) Mol Cell Biol , vol.20 , pp. 1899-1910
    • Vignali, M.1    Hassan, A.H.2    Neely, K.E.3
  • 5
    • 27744561591 scopus 로고    scopus 로고
    • Chromatin remodeling complexes: ATP-dependent machines in action
    • Johnson CN, Adkins NL, Georgel P,. Chromatin remodeling complexes: ATP-dependent machines in action. Biochem Cell Biol 2005; 83: 405-417.
    • (2005) Biochem Cell Biol , vol.83 , pp. 405-417
    • Johnson, C.N.1    Adkins, N.L.2    Georgel, P.3
  • 6
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T, Allis CD,. Translating the histone code. Science 2001; 293: 1074-1080.
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 8
    • 84863149111 scopus 로고    scopus 로고
    • Epigenetics and cardiovascular development
    • Chang CP, Bruneau BG,. Epigenetics and cardiovascular development. Annu Rev Physiol 2012; 74: 41-68.
    • (2012) Annu Rev Physiol , vol.74 , pp. 41-68
    • Chang, C.P.1    Bruneau, B.G.2
  • 9
    • 81355160424 scopus 로고    scopus 로고
    • Epigenetic regulation of endothelial lineage committed genes in pro-angiogenic hematopoietic and endothelial progenitor cells
    • Ohtani K, Vlachojannis GJ, Koyanagi M, et al., Epigenetic regulation of endothelial lineage committed genes in pro-angiogenic hematopoietic and endothelial progenitor cells. Circ Res 2011; 109: 1219-1229.
    • (2011) Circ Res , vol.109 , pp. 1219-1229
    • Ohtani, K.1    Vlachojannis, G.J.2    Koyanagi, M.3
  • 10
    • 79955055958 scopus 로고    scopus 로고
    • Epigenetics in cardiovascular disease
    • Shirodkar AV, Marsden PA,. Epigenetics in cardiovascular disease. Curr Opin Cardiol 2011; 26: 209-215.
    • (2011) Curr Opin Cardiol , vol.26 , pp. 209-215
    • Shirodkar, A.V.1    Marsden, P.A.2
  • 11
    • 84862127099 scopus 로고    scopus 로고
    • Environmental exposures, epigenetics and cardiovascular disease
    • Baccarelli A, Ghosh S,. Environmental exposures, epigenetics and cardiovascular disease. Curr Opin Clin Nutr Metab Care 2012; 15: 323-329.
    • (2012) Curr Opin Clin Nutr Metab Care , vol.15 , pp. 323-329
    • Baccarelli, A.1    Ghosh, S.2
  • 12
    • 84867849133 scopus 로고    scopus 로고
    • The function of miRNA in cardiac hypertrophy
    • Wang J, Yang X,. The function of miRNA in cardiac hypertrophy. Cell Mol Life Sci 2012; 69: 3561-3570.
    • (2012) Cell Mol Life Sci , vol.69 , pp. 3561-3570
    • Wang, J.1    Yang, X.2
  • 13
  • 14
    • 84860145591 scopus 로고    scopus 로고
    • Role of microRNAs in the reperfused myocardium towards post-infarct remodelling
    • Zhu H, Fan GC,. Role of microRNAs in the reperfused myocardium towards post-infarct remodelling. Cardiovasc Res 2012; 94: 284-292.
    • (2012) Cardiovasc Res , vol.94 , pp. 284-292
    • Zhu, H.1    Fan, G.C.2
  • 15
    • 79952811715 scopus 로고    scopus 로고
    • MicroRNAs in cardiac disease
    • Dorn GW, 2nd,. MicroRNAs in cardiac disease. Transl Res 2011; 157: 226-235.
    • (2011) Transl Res , vol.157 , pp. 226-235
    • Dorn II, G.W.1
  • 16
    • 77649253288 scopus 로고    scopus 로고
    • MicroRNAs add a new dimension to cardiovascular disease
    • Small EM, Frost RJ, Olson EN,. MicroRNAs add a new dimension to cardiovascular disease. Circulation 2010; 121: 1022-1032.
    • (2010) Circulation , vol.121 , pp. 1022-1032
    • Small, E.M.1    Frost, R.J.2    Olson, E.N.3
  • 18
    • 0026739478 scopus 로고
    • Protein kinase C and calmodulin kinase are required for endothelin- stimulated atrial natriuretic factor secretion from primary atrial myocytes
    • Irons CE, Sei CA, Hidaka H, et al., Protein kinase C and calmodulin kinase are required for endothelin- stimulated atrial natriuretic factor secretion from primary atrial myocytes. J Biol Chem 1992; 267: 5211-5216.
    • (1992) J Biol Chem , vol.267 , pp. 5211-5216
    • Irons, C.E.1    Sei, C.A.2    Hidaka, H.3
  • 19
    • 0034685545 scopus 로고    scopus 로고
    • Ca2+/calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy
    • Zhu W, Zou Y, Shiojima I, et al., Ca2+/calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy. J Biol Chem 2000; 275: 15239-15245.
    • (2000) J Biol Chem , vol.275 , pp. 15239-15245
    • Zhu, W.1    Zou, Y.2    Shiojima, I.3
  • 20
    • 33744971423 scopus 로고    scopus 로고
    • Management of hypertrophic cardiomyopathy
    • Spirito P, Autore C,. Management of hypertrophic cardiomyopathy. BMJ 2006; 332: 1251-1255.
    • (2006) BMJ , vol.332 , pp. 1251-1255
    • Spirito, P.1    Autore, C.2
  • 21
    • 33748323383 scopus 로고    scopus 로고
    • Regulation of cardiac hypertrophy by intracellular signalling pathways
    • Heineke J, Molkentin JD,. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol 2006; 7: 589-600.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 589-600
    • Heineke, J.1    Molkentin, J.D.2
  • 22
    • 34347403248 scopus 로고    scopus 로고
    • Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses
    • Clerk A, Cullingford TE, Fuller SJ, et al., Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses. J Cell Physiol 2007; 212: 311-322.
    • (2007) J Cell Physiol , vol.212 , pp. 311-322
    • Clerk, A.1    Cullingford, T.E.2    Fuller, S.J.3
  • 23
    • 0036532026 scopus 로고    scopus 로고
    • Histone modifications in transcriptional regulation
    • Berger SL,. Histone modifications in transcriptional regulation. Curr Opin Genet Dev 2002; 12: 142-148.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 142-148
    • Berger, S.L.1
  • 24
    • 0030798245 scopus 로고    scopus 로고
    • Histone acetylation in chromatin structure and transcription
    • Grunstein M., Histone acetylation in chromatin structure and transcription. Nature 1997; 389: 349-352.
    • (1997) Nature , vol.389 , pp. 349-352
    • Grunstein, M.1
  • 25
    • 0034707037 scopus 로고    scopus 로고
    • Global histone acetylation and deacetylation in yeast
    • Vogelauer M, Wu J, Suka N, et al., Global histone acetylation and deacetylation in yeast. Nature 2000; 408: 495-498.
    • (2000) Nature , vol.408 , pp. 495-498
    • Vogelauer, M.1    Wu, J.2    Suka, N.3
  • 26
    • 0033848849 scopus 로고    scopus 로고
    • Histone acetylation and an epigenetic code
    • Turner BM,. Histone acetylation and an epigenetic code. Bioessays 2000; 22: 836-845.
    • (2000) Bioessays , vol.22 , pp. 836-845
    • Turner, B.M.1
  • 27
    • 0036211013 scopus 로고    scopus 로고
    • Histone acetylation: A switch between repressive and permissive chromatin. Second in review series on chromatin dynamics
    • Eberharter A, Becker PB,. Histone acetylation: a switch between repressive and permissive chromatin. Second in review series on chromatin dynamics. EMBO Rep 2002; 3: 224-229.
    • (2002) EMBO Rep , vol.3 , pp. 224-229
    • Eberharter, A.1    Becker, P.B.2
  • 28
    • 33644837326 scopus 로고    scopus 로고
    • Control of Cardiac Growth by Histone Acetylation/Deacetylation
    • Backs J, Olson EN,. Control of Cardiac Growth by Histone Acetylation/Deacetylation. Circulation Research 2006; 98: 15-24.
    • (2006) Circulation Research , vol.98 , pp. 15-24
    • Backs, J.1    Olson, E.N.2
  • 29
    • 17644445419 scopus 로고    scopus 로고
    • Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300
    • Yao TP, Oh SP, Fuchs M, et al., Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell 1998; 93: 361-372.
    • (1998) Cell , vol.93 , pp. 361-372
    • Yao, T.P.1    Oh, S.P.2    Fuchs, M.3
  • 30
    • 0141753974 scopus 로고    scopus 로고
    • Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation
    • Shikama N, Lutz W, Kretzschmar R, et al., Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation. The EMBO Journal 2003; 22: 5175-5185.
    • (2003) The EMBO Journal , vol.22 , pp. 5175-5185
    • Shikama, N.1    Lutz, W.2    Kretzschmar, R.3
  • 31
    • 0038302887 scopus 로고    scopus 로고
    • Cardiac p300 is involved in myocyte growth with decompensated heart failure
    • Yanazume T, Hasegawa K, Morimoto T, et al., Cardiac p300 is involved in myocyte growth with decompensated heart failure. Mol Cell Biol 2003; 23: 3593-3606.
    • (2003) Mol Cell Biol , vol.23 , pp. 3593-3606
    • Yanazume, T.1    Hasegawa, K.2    Morimoto, T.3
  • 32
    • 0037470133 scopus 로고    scopus 로고
    • The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity
    • Gusterson RJ, Jazrawi E, Adcock IM, et al., The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. J Biol Chem 2003; 278: 6838-6847.
    • (2003) J Biol Chem , vol.278 , pp. 6838-6847
    • Gusterson, R.J.1    Jazrawi, E.2    Adcock, I.M.3
  • 33
    • 33644849325 scopus 로고    scopus 로고
    • Histone acetyltransferase activity of p300 is required for the promotion of left ventricular remodeling after myocardial infarction in adult mice in vivo
    • Miyamoto S, Kawamura T, Morimoto T, et al., Histone acetyltransferase activity of p300 is required for the promotion of left ventricular remodeling after myocardial infarction in adult mice in vivo. Circulation 2006; 113: 679-690.
    • (2006) Circulation , vol.113 , pp. 679-690
    • Miyamoto, S.1    Kawamura, T.2    Morimoto, T.3
  • 34
    • 77951920924 scopus 로고    scopus 로고
    • Cardiac ventricular chambers are epigenetically distinguishable
    • Mathiyalagan P, Chang L, Du XJ, et al., Cardiac ventricular chambers are epigenetically distinguishable. Cell Cycle 2010; 9: 612-617.
    • (2010) Cell Cycle , vol.9 , pp. 612-617
    • Mathiyalagan, P.1    Chang, L.2    Du, X.J.3
  • 35
    • 41549112501 scopus 로고    scopus 로고
    • FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16
    • Heo K, Kim H, Choi SH, et al., FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol Cell 2008; 30: 86-97.
    • (2008) Mol Cell , vol.30 , pp. 86-97
    • Heo, K.1    Kim, H.2    Choi, S.H.3
  • 36
    • 57749170458 scopus 로고    scopus 로고
    • The many roles of histone deacetylases in development and physiology: Implications for disease and therapy
    • Haberland M, Montgomery RL, Olson EN,. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 2009; 10: 32-42.
    • (2009) Nat Rev Genet , vol.10 , pp. 32-42
    • Haberland, M.1    Montgomery, R.L.2    Olson, E.N.3
  • 37
    • 33947482638 scopus 로고
    • The Occurrence of Epsilon-N-Methyl Lysine in Histones
    • Murray K,. The Occurrence Of Epsilon-N-Methyl Lysine In Histones. Biochemistry 1964; 3: 10-15.
    • (1964) Biochemistry , vol.3 , pp. 10-15
    • Murray, K.1
  • 38
    • 0033603396 scopus 로고    scopus 로고
    • Regulation of transcription by a protein methyltransferase
    • Chen D, Ma H, Hong H, et al., Regulation of transcription by a protein methyltransferase. Science 1999; 284: 2174-2177.
    • (1999) Science , vol.284 , pp. 2174-2177
    • Chen, D.1    Ma, H.2    Hong, H.3
  • 39
    • 0033592999 scopus 로고    scopus 로고
    • Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena
    • Strahl BD, Ohba R, Cook RG, et al., Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena. Proc Natl Acad Sci U S A 1999; 96: 14967-14972.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 14967-14972
    • Strahl, B.D.1    Ohba, R.2    Cook, R.G.3
  • 42
    • 79959980701 scopus 로고    scopus 로고
    • Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes
    • Stein AB, Jones TA, Herron TJ, et al., Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes. J Clin Invest 2011; 121: 2641-2650.
    • (2011) J Clin Invest , vol.121 , pp. 2641-2650
    • Stein, A.B.1    Jones, T.A.2    Herron, T.J.3
  • 43
    • 84863083797 scopus 로고    scopus 로고
    • Distribution of histone3 lysine 4 trimethylation at T3-responsive loci in the heart during reversible changes in gene expression
    • Pandya K, Kohro T, Mimura I, et al., Distribution of histone3 lysine 4 trimethylation at T3-responsive loci in the heart during reversible changes in gene expression. Gene Expr 2012; 15: 183-198.
    • (2012) Gene Expr , vol.15 , pp. 183-198
    • Pandya, K.1    Kohro, T.2    Mimura, I.3
  • 44
    • 33745120788 scopus 로고    scopus 로고
    • Laminin activates CaMK-II to stabilize nascent embryonic axons
    • Easley CA, Faison MO, Kirsch TL, et al., Laminin activates CaMK-II to stabilize nascent embryonic axons. Brain Res 2006; 1092: 59-68.
    • (2006) Brain Res , vol.1092 , pp. 59-68
    • Easley, C.A.1    Faison, M.O.2    Kirsch, T.L.3
  • 45
    • 84859731822 scopus 로고    scopus 로고
    • Epigenetic modifications in cardiovascular disease
    • Lorenzen JM, Martino F, Thum T,. Epigenetic modifications in cardiovascular disease. Basic Res Cardiol 2012; 107: 245-245.
    • (2012) Basic Res Cardiol , vol.107 , pp. 245-245
    • Lorenzen, J.M.1    Martino, F.2    Thum, T.3
  • 46
    • 79551607266 scopus 로고    scopus 로고
    • DOT1L regulates dystrophin expression and is critical for cardiac function
    • Nguyen AT, Xiao B, Neppl RL, et al., DOT1L regulates dystrophin expression and is critical for cardiac function. Genes Dev 2011; 25: 263-274.
    • (2011) Genes Dev , vol.25 , pp. 263-274
    • Nguyen, A.T.1    Xiao, B.2    Neppl, R.L.3
  • 47
    • 33646882068 scopus 로고    scopus 로고
    • Polycomb complexes repress developmental regulators in murine embryonic stem cells
    • Boyer LA, Plath K, Zeitlinger J, et al., Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 2006; 441: 349-353.
    • (2006) Nature , vol.441 , pp. 349-353
    • Boyer, L.A.1    Plath, K.2    Zeitlinger, J.3
  • 48
    • 33750488431 scopus 로고    scopus 로고
    • The genomic landscape of histone modifications in human T cells
    • Roh TY, Cuddapah S, Cui K, et al., The genomic landscape of histone modifications in human T cells. Proc Natl Acad Sci U S A 2006; 103: 15782-15787.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 15782-15787
    • Roh, T.Y.1    Cuddapah, S.2    Cui, K.3
  • 49
    • 35148867907 scopus 로고    scopus 로고
    • UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
    • Agger K, Cloos PA, Christensen J, et al., UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 2007; 449: 731-734.
    • (2007) Nature , vol.449 , pp. 731-734
    • Agger, K.1    Cloos, P.A.2    Christensen, J.3
  • 50
    • 84855957128 scopus 로고    scopus 로고
    • UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program
    • Lee S, Lee JW, Lee SK,. UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program. Dev Cell 2012; 22: 25-37.
    • (2012) Dev Cell , vol.22 , pp. 25-37
    • Lee, S.1    Lee, J.W.2    Lee, S.K.3
  • 51
    • 79957892087 scopus 로고    scopus 로고
    • The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice
    • Zhang QJ, Chen HZ, Wang L, et al., The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice. J Clin Invest 2011; 121: 2447-2456.
    • (2011) J Clin Invest , vol.121 , pp. 2447-2456
    • Zhang, Q.J.1    Chen, H.Z.2    Wang, L.3
  • 52
    • 19944430797 scopus 로고    scopus 로고
    • Genomic maps and comparative analysis of histone modifications in human and mouse
    • Bernstein BE, Kamal M, Lindblad-Toh K, et al., Genomic maps and comparative analysis of histone modifications in human and mouse. Cell 2005; 120: 169-181.
    • (2005) Cell , vol.120 , pp. 169-181
    • Bernstein, B.E.1    Kamal, M.2    Lindblad-Toh, K.3
  • 53
    • 23844519339 scopus 로고    scopus 로고
    • A high-resolution map of active promoters in the human genome
    • Kim TH, Barrera LO, Zheng M, et al., A high-resolution map of active promoters in the human genome. Nature 2005; 436: 876-880.
    • (2005) Nature , vol.436 , pp. 876-880
    • Kim, T.H.1    Barrera, L.O.2    Zheng, M.3
  • 54
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein BE, Mikkelsen TS, Xie X, et al., A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006; 125: 315-326.
    • (2006) Cell , vol.125 , pp. 315-326
    • Bernstein, B.E.1    Mikkelsen, T.S.2    Xie, X.3
  • 55
    • 33646872978 scopus 로고    scopus 로고
    • Chromatin signatures of pluripotent cell lines
    • Azuara V, Perry P, Sauer S, et al., Chromatin signatures of pluripotent cell lines. Nature cell biology 2006; 8: 532-538.
    • (2006) Nature Cell Biology , vol.8 , pp. 532-538
    • Azuara, V.1    Perry, P.2    Sauer, S.3
  • 56
    • 58049145427 scopus 로고    scopus 로고
    • Genome-wide histone methylation profile for heart failure
    • Kaneda R, Takada S, Yamashita Y, et al., Genome-wide histone methylation profile for heart failure. Genes Cells 2009; 14: 69-77.
    • (2009) Genes Cells , vol.14 , pp. 69-77
    • Kaneda, R.1    Takada, S.2    Yamashita, Y.3
  • 57
    • 82355180985 scopus 로고    scopus 로고
    • Distinct epigenomic features in end-stage failing human hearts
    • Movassagh M, Choy MK, Knowles DA, et al., Distinct epigenomic features in end-stage failing human hearts. Circulation 2011; 124: 2411-2422.
    • (2011) Circulation , vol.124 , pp. 2411-2422
    • Movassagh, M.1    Choy, M.K.2    Knowles, D.A.3
  • 58
    • 0034644473 scopus 로고    scopus 로고
    • Signaling to chromatin through histone modifications
    • Cheung P, Allis CD, Sassone-Corsi P,. Signaling to chromatin through histone modifications. Cell 2000; 103: 263-271.
    • (2000) Cell , vol.103 , pp. 263-271
    • Cheung, P.1    Allis, C.D.2    Sassone-Corsi, P.3
  • 59
    • 0032538809 scopus 로고    scopus 로고
    • In vivo prevention of adriamycin cardiotoxicity by cyclosporin A or FK506
    • Al-Nasser IA,. In vivo prevention of adriamycin cardiotoxicity by cyclosporin A or FK506. Toxicology 1998; 131: 175-181.
    • (1998) Toxicology , vol.131 , pp. 175-181
    • Al-Nasser, I.A.1
  • 60
    • 23844518230 scopus 로고    scopus 로고
    • Inducible covalent posttranslational modification of histone H3
    • Bode AM, Dong Z,. Inducible covalent posttranslational modification of histone H3. Sci STKE 2005; 2005: re4.
    • (2005) Sci STKE , vol.2005
    • Bode, A.M.1    Dong, Z.2
  • 61
    • 0033520367 scopus 로고    scopus 로고
    • Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation
    • Goto H, Tomono Y, Ajiro K, et al., Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation. J Biol Chem 1999; 274: 25543-25549.
    • (1999) J Biol Chem , vol.274 , pp. 25543-25549
    • Goto, H.1    Tomono, Y.2    Ajiro, K.3
  • 62
    • 0033200205 scopus 로고    scopus 로고
    • The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase
    • Thomson S, Clayton AL, Hazzalin CA, et al., The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase. EMBO J 1999; 18: 4779-4793.
    • (1999) EMBO J , vol.18 , pp. 4779-4793
    • Thomson, S.1    Clayton, A.L.2    Hazzalin, C.A.3
  • 63
    • 0038511129 scopus 로고    scopus 로고
    • Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression
    • Yamamoto Y, Verma UN, Prajapati S, et al., Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression. Nature 2003; 423: 655-659.
    • (2003) Nature , vol.423 , pp. 655-659
    • Yamamoto, Y.1    Verma, U.N.2    Prajapati, S.3
  • 64
    • 26944477381 scopus 로고    scopus 로고
    • Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3
    • Macdonald N, Welburn JP, Noble ME, et al., Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. Mol Cell 2005; 20: 199-211.
    • (2005) Mol Cell , vol.20 , pp. 199-211
    • Macdonald, N.1    Welburn, J.P.2    Noble, M.E.3
  • 65
    • 0032514228 scopus 로고    scopus 로고
    • Ventricular myocytes are not terminally differentiated in the adult mammalian heart
    • Anversa P, Kajstura J,. Ventricular myocytes are not terminally differentiated in the adult mammalian heart. Circ Res 1998; 83: 1-14.
    • (1998) Circ Res , vol.83 , pp. 1-14
    • Anversa, P.1    Kajstura, J.2
  • 66
    • 77955172516 scopus 로고    scopus 로고
    • Cardiomyogenesis in the adult human heart
    • Kajstura J, Urbanek K, Perl S, et al., Cardiomyogenesis in the adult human heart. Circ Res 2010; 107: 305-315.
    • (2010) Circ Res , vol.107 , pp. 305-315
    • Kajstura, J.1    Urbanek, K.2    Perl, S.3
  • 67
    • 77950877955 scopus 로고    scopus 로고
    • Cardiac progenitor cell cycling stimulated by pim-1 kinase
    • Cottage CT, Bailey B, Fischer KM, et al., Cardiac progenitor cell cycling stimulated by pim-1 kinase. Circ Res 2010; 106: 891-901.
    • (2010) Circ Res , vol.106 , pp. 891-901
    • Cottage, C.T.1    Bailey, B.2    Fischer, K.M.3
  • 68
    • 79952065525 scopus 로고    scopus 로고
    • Transient regenerative potential of the neonatal mouse heart
    • Porrello ER, Mahmoud AI, Simpson E, et al., Transient regenerative potential of the neonatal mouse heart. Science 2011; 331: 1078-1080.
    • (2011) Science , vol.331 , pp. 1078-1080
    • Porrello, E.R.1    Mahmoud, A.I.2    Simpson, E.3
  • 69
    • 0018092777 scopus 로고
    • Studies of nuclear proteins in the heart of the cardiomyopathic Syrian hamster - Phosphorylation of histones
    • Liew CC, Sole MJ,. Studies of nuclear proteins in the heart of the cardiomyopathic Syrian hamster - phosphorylation of histones. J Mol Cell Cardiol 1978; 10: 847-855.
    • (1978) J Mol Cell Cardiol , vol.10 , pp. 847-855
    • Liew, C.C.1    Sole, M.J.2
  • 70
    • 0034604354 scopus 로고    scopus 로고
    • Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes
    • Hsu JY, Sun ZW, Li X, et al., Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell 2000; 102: 279-291.
    • (2000) Cell , vol.102 , pp. 279-291
    • Hsu, J.Y.1    Sun, Z.W.2    Li, X.3
  • 71
    • 0034604329 scopus 로고    scopus 로고
    • Mitotic histone H3 phosphorylation by the NIMA kinase in Aspergillus nidulans
    • De Souza CP, Osmani AH, Wu LP, et al., Mitotic histone H3 phosphorylation by the NIMA kinase in Aspergillus nidulans. Cell 2000; 102: 293-302.
    • (2000) Cell , vol.102 , pp. 293-302
    • De Souza, C.P.1    Osmani, A.H.2    Wu, L.P.3
  • 72
    • 0033529706 scopus 로고    scopus 로고
    • Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3
    • Sassone-Corsi P, Mizzen CA, Cheung P, et al., Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. Science 1999; 285: 886-891.
    • (1999) Science , vol.285 , pp. 886-891
    • Sassone-Corsi, P.1    Mizzen, C.A.2    Cheung, P.3
  • 73
    • 0037497184 scopus 로고    scopus 로고
    • A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression
    • Anest V, Hanson JL, Cogswell PC, et al., A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression. Nature 2003; 423: 659-663.
    • (2003) Nature , vol.423 , pp. 659-663
    • Anest, V.1    Hanson, J.L.2    Cogswell, P.C.3
  • 74
    • 34547599505 scopus 로고    scopus 로고
    • PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation
    • Zippo A, De Robertis A, Serafini R, et al., PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation. Nature cell biology 2007; 9: 932-944.
    • (2007) Nature Cell Biology , vol.9 , pp. 932-944
    • Zippo, A.1    De Robertis, A.2    Serafini, R.3
  • 75
    • 79955505888 scopus 로고    scopus 로고
    • When signaling kinases meet histones and histone modifiers in the nucleus
    • Baek SH,. When signaling kinases meet histones and histone modifiers in the nucleus. Mol Cell 2011; 42: 274-284.
    • (2011) Mol Cell , vol.42 , pp. 274-284
    • Baek, S.H.1
  • 76
    • 70349975711 scopus 로고    scopus 로고
    • JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin
    • Dawson MA, Bannister AJ, Gottgens B, et al., JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 2009; 461: 819-822.
    • (2009) Nature , vol.461 , pp. 819-822
    • Dawson, M.A.1    Bannister, A.J.2    Gottgens, B.3
  • 77
    • 77956294919 scopus 로고    scopus 로고
    • Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation
    • Bungard D, Fuerth BJ, Zeng PY, et al., Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science 2010; 329: 1201-1205.
    • (2010) Science , vol.329 , pp. 1201-1205
    • Bungard, D.1    Fuerth, B.J.2    Zeng, P.Y.3
  • 78
    • 0036852779 scopus 로고    scopus 로고
    • Interplay between the cardiac renin angiotensin system and JAK-STAT signaling: Role in cardiac hypertrophy, ischemia/reperfusion dysfunction, and heart failure
    • Booz GW, Day JN, Baker KM,. Interplay between the cardiac renin angiotensin system and JAK-STAT signaling: role in cardiac hypertrophy, ischemia/reperfusion dysfunction, and heart failure. J Mol Cell Cardiol 2002; 34: 1443-1453.
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 1443-1453
    • Booz, G.W.1    Day, J.N.2    Baker, K.M.3
  • 79
    • 34447643051 scopus 로고    scopus 로고
    • Leptin as a cardiac hypertrophic factor: A potential target for therapeutics
    • Karmazyn M, Purdham DM, Rajapurohitam V, et al., Leptin as a cardiac hypertrophic factor: a potential target for therapeutics. Trends Cardiovasc Med 2007; 17: 206-211.
    • (2007) Trends Cardiovasc Med , vol.17 , pp. 206-211
    • Karmazyn, M.1    Purdham, D.M.2    Rajapurohitam, V.3
  • 80
    • 84886854631 scopus 로고    scopus 로고
    • Nuclear CaMKII Enhances Histone H3 Phosphorylation and Remodels Chromatin during Cardiac Hypertrophy
    • In Press
    • Mahmoud SA KM, Little G.H, Bai Y,., An W,., Bers D,., Kedes L,. and, Poizat C,. Nuclear CaMKII Enhances Histone H3 Phosphorylation and Remodels Chromatin During Cardiac Hypertrophy. Nucleic Acids Res 2013; In Press.
    • (2013) Nucleic Acids Res
    • Mahmoud Sa, K.M.1    Little, G.H.2    Bai, Y.3    An, W.4    Bers, D.5    Kedes, L.6    Poizat, C.7
  • 81
    • 4544315655 scopus 로고    scopus 로고
    • Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5
    • Vega RB, Harrison BC, Meadows E, et al., Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5. Mol Cell Biol 2004; 24: 8374-8385.
    • (2004) Mol Cell Biol , vol.24 , pp. 8374-8385
    • Vega, R.B.1    Harrison, B.C.2    Meadows, E.3
  • 82
    • 33745812011 scopus 로고    scopus 로고
    • CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy
    • Backs J, Song K, Bezprozvannaya S, et al., CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy. The Journal of Clinical Investigation 2006: 1-12.
    • (2006) The Journal of Clinical Investigation , pp. 1-12
    • Backs, J.1    Song, K.2    Bezprozvannaya, S.3
  • 83
    • 34147093584 scopus 로고    scopus 로고
    • Nuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells
    • Little GH, Bai Y, Williams T, et al., Nuclear calcium/calmodulin- dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells. J Biol Chem 2007; 282: 7219-7231.
    • (2007) J Biol Chem , vol.282 , pp. 7219-7231
    • Little, G.H.1    Bai, Y.2    Williams, T.3
  • 84
    • 60549085044 scopus 로고    scopus 로고
    • The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload
    • Backs J, Backs T, Neef S, et al., The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload. Proc Natl Acad Sci U S A 2009; 106: 2342-2347.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 2342-2347
    • Backs, J.1    Backs, T.2    Neef, S.3
  • 85
    • 79958168664 scopus 로고    scopus 로고
    • Casein kinase-2alpha1 induces hypertrophic response by phosphorylation of histone deacetylase 2 S394 and its activation in the heart
    • Eom GH, Cho YK, Ko JH, et al., Casein kinase-2alpha1 induces hypertrophic response by phosphorylation of histone deacetylase 2 S394 and its activation in the heart. Circulation 2011; 123: 2392-2403.
    • (2011) Circulation , vol.123 , pp. 2392-2403
    • Eom, G.H.1    Cho, Y.K.2    Ko, J.H.3
  • 86
    • 0019332846 scopus 로고
    • ADP-ribosylation of histone H2B. Identification of glutamic acid residue 2 as the modification site
    • Ogata N, Ueda K, Hayaishi O,. ADP-ribosylation of histone H2B. Identification of glutamic acid residue 2 as the modification site. J Biol Chem 1980; 255: 7610-7615.
    • (1980) J Biol Chem , vol.255 , pp. 7610-7615
    • Ogata, N.1    Ueda, K.2    Hayaishi, O.3
  • 87
    • 33749339049 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy
    • Pillai JB, Gupta M, Rajamohan SB, et al., Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy. Am J Physiol Heart Circ Physiol 2006; 291: H1545-1553.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • Pillai, J.B.1    Gupta, M.2    Rajamohan, S.B.3
  • 88
    • 67651097788 scopus 로고    scopus 로고
    • PARP inhibition delays transition of hypertensive cardiopathy to heart failure in spontaneously hypertensive rats
    • Bartha E, Solti I, Kereskai L, et al., PARP inhibition delays transition of hypertensive cardiopathy to heart failure in spontaneously hypertensive rats. Cardiovasc Res 2009; 83: 501-510.
    • (2009) Cardiovasc Res , vol.83 , pp. 501-510
    • Bartha, E.1    Solti, I.2    Kereskai, L.3
  • 89
    • 77954222814 scopus 로고    scopus 로고
    • Chromatin regulation by Brg1 underlies heart muscle development and disease
    • Hang CT, Yang J, Han P, et al., Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature 2010; 466: 62-67.
    • (2010) Nature , vol.466 , pp. 62-67
    • Hang, C.T.1    Yang, J.2    Han, P.3
  • 90
    • 25644445311 scopus 로고    scopus 로고
    • The role of Akt and mitogen-activated protein kinase systems in the protective effect of poly(ADP-ribose) polymerase inhibition in Langendorff perfused and in isoproterenol-damaged rat hearts
    • Palfi A, Toth A, Kulcsar G, et al., The role of Akt and mitogen-activated protein kinase systems in the protective effect of poly(ADP-ribose) polymerase inhibition in Langendorff perfused and in isoproterenol-damaged rat hearts. J Pharmacol Exp Ther 2005; 315: 273-282.
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 273-282
    • Palfi, A.1    Toth, A.2    Kulcsar, G.3
  • 91
    • 33745391346 scopus 로고    scopus 로고
    • PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway
    • Palfi A, Toth A, Hanto K, et al., PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway. J Mol Cell Cardiol 2006; 41: 149-159.
    • (2006) J Mol Cell Cardiol , vol.41 , pp. 149-159
    • Palfi, A.1    Toth, A.2    Hanto, K.3
  • 92
    • 22844457491 scopus 로고    scopus 로고
    • DNA methylation and human disease
    • Robertson KD,. DNA methylation and human disease. Nat Rev Genet 2005; 6: 597-610.
    • (2005) Nat Rev Genet , vol.6 , pp. 597-610
    • Robertson, K.D.1
  • 93
    • 40449104358 scopus 로고    scopus 로고
    • Transient cyclical methylation of promoter DNA
    • Kangaspeska S, Stride B, Metivier R, et al., Transient cyclical methylation of promoter DNA. Nature 2008; 452: 112-115.
    • (2008) Nature , vol.452 , pp. 112-115
    • Kangaspeska, S.1    Stride, B.2    Metivier, R.3
  • 94
    • 79957463780 scopus 로고    scopus 로고
    • Epigenetic modifications: Basic mechanisms and role in cardiovascular disease
    • Handy DE, Castro R, Loscalzo J,. Epigenetic modifications: basic mechanisms and role in cardiovascular disease. Circulation 2011; 123: 2145-2156.
    • (2011) Circulation , vol.123 , pp. 2145-2156
    • Handy, D.E.1    Castro, R.2    Loscalzo, J.3
  • 95
    • 77649197044 scopus 로고    scopus 로고
    • Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure
    • Movassagh M, Choy MK, Goddard M, et al., Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure. PLoS One 2010; 5: e8564.
    • (2010) PLoS One , vol.5
    • Movassagh, M.1    Choy, M.K.2    Goddard, M.3
  • 96
    • 0034594876 scopus 로고    scopus 로고
    • Early expression of angiogenesis factors in acute myocardial ischemia and infarction
    • Lee SH, Wolf PL, Escudero R, et al., Early expression of angiogenesis factors in acute myocardial ischemia and infarction. N Engl J Med 2000; 342: 626-633.
    • (2000) N Engl J Med , vol.342 , pp. 626-633
    • Lee, S.H.1    Wolf, P.L.2    Escudero, R.3
  • 97
    • 0029157378 scopus 로고
    • Evolution of the SNF2 family of proteins: Subfamilies with distinct sequences and functions
    • Eisen JA, Sweder KS, Hanawalt PC,. Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions. Nucleic Acids Res 1995; 23: 2715-2723.
    • (1995) Nucleic Acids Res , vol.23 , pp. 2715-2723
    • Eisen, J.A.1    Sweder, K.S.2    Hanawalt, P.C.3
  • 98
    • 0026641776 scopus 로고
    • Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection
    • Winston F, Carlson M,. Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection. Trends Genet 1992; 8: 387-391.
    • (1992) Trends Genet , vol.8 , pp. 387-391
    • Winston, F.1    Carlson, M.2
  • 99
    • 0028467446 scopus 로고
    • Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex
    • Cote J, Quinn J, Workman JL, et al., Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex. Science 1994; 265: 53-60.
    • (1994) Science , vol.265 , pp. 53-60
    • Cote, J.1    Quinn, J.2    Workman, J.L.3
  • 100
    • 33745122231 scopus 로고    scopus 로고
    • Identification of multiple distinct Snf2 subfamilies with conserved structural motifs
    • Flaus A, Martin DMA, Barton GJ, et al., Identification of multiple distinct Snf2 subfamilies with conserved structural motifs. Nucleic Acids Res 2006; 34: 2887-2905.
    • (2006) Nucleic Acids Res , vol.34 , pp. 2887-2905
    • Flaus, A.1    Martin, D.M.A.2    Barton, G.J.3
  • 101
    • 34447249019 scopus 로고    scopus 로고
    • An essential switch in subunit composition of a chromatin remodeling complex during neural development
    • Lessard J, Wu JI, Ranish JA, et al., An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron 2007; 55: 201-215.
    • (2007) Neuron , vol.55 , pp. 201-215
    • Lessard, J.1    Wu, J.I.2    Ranish, J.A.3
  • 102
    • 8544270889 scopus 로고    scopus 로고
    • Baf60c is essential for function of BAF chromatin remodelling complexes in heart development
    • Lickert H, Takeuchi JK, Von Both I, et al., Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature 2004; 432: 107-112.
    • (2004) Nature , vol.432 , pp. 107-112
    • Lickert, H.1    Takeuchi, J.K.2    Von Both, I.3
  • 103
    • 38849156394 scopus 로고    scopus 로고
    • Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis
    • Stankunas K, Hang CT, Tsun ZY, et al., Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev Cell 2008; 14: 298-311.
    • (2008) Dev Cell , vol.14 , pp. 298-311
    • Stankunas, K.1    Hang, C.T.2    Tsun, Z.Y.3
  • 104
    • 0033602549 scopus 로고    scopus 로고
    • Isolated noncompaction of the myocardium
    • Jenni R, Rojas J, Oechslin E,. Isolated noncompaction of the myocardium. N Engl J Med 1999; 340: 966-967.
    • (1999) N Engl J Med , vol.340 , pp. 966-967
    • Jenni, R.1    Rojas, J.2    Oechslin, E.3
  • 105
    • 23044514669 scopus 로고    scopus 로고
    • Epigenetic differences arise during the lifetime of monozygotic twins
    • Fraga MF, Ballestar E, Paz MF, et al., Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A 2005; 102: 10604-10609.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 10604-10609
    • Fraga, M.F.1    Ballestar, E.2    Paz, M.F.3
  • 106
    • 33746103352 scopus 로고    scopus 로고
    • Biomagnetic characterization of spatiotemporal parameters of the gastric slow wave
    • Bradshaw LA, Irimia A, Sims JA, et al., Biomagnetic characterization of spatiotemporal parameters of the gastric slow wave. Neurogastroenterol Motil 2006; 18: 619-631.
    • (2006) Neurogastroenterol Motil , vol.18 , pp. 619-631
    • Bradshaw, L.A.1    Irimia, A.2    Sims, J.A.3
  • 107
    • 75649151209 scopus 로고    scopus 로고
    • Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
    • Javierre BM, Fernandez AF, Richter J, et al., Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome research 2010; 20: 170-179.
    • (2010) Genome Research , vol.20 , pp. 170-179
    • Javierre, B.M.1    Fernandez, A.F.2    Richter, J.3
  • 108
    • 77449137288 scopus 로고    scopus 로고
    • Explaining inter-individual variability in phenotype: Is epigenetics up to the challenge?
    • Turan N, Katari S, Coutifaris C, et al., Explaining inter-individual variability in phenotype: is epigenetics up to the challenge? Epigenetics 2010; 5: 16-19.
    • (2010) Epigenetics , vol.5 , pp. 16-19
    • Turan, N.1    Katari, S.2    Coutifaris, C.3


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