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Volumn 4, Issue JUN, 2013, Pages

Lessons to be learned from natural control of HIV - future directions, therapeutic, and preventive implications

Author keywords

CD8+ T cells; Elite controllers; HIV; HIV vaccine; Immune activation

Indexed keywords

ALPHA INTERFERON; ANTIINFLAMMATORY AGENT; ANTIRETROVIRUS AGENT; C REACTIVE PROTEIN; CD16 ANTIGEN; CD163 ANTIGEN; CD38 ANTIGEN; CHEMOKINE RECEPTOR CCR5; COLLAGEN; D DIMER; GAMMA INTERFERON; HLA ANTIGEN CLASS 1; HLA B27 ANTIGEN; HLA B35 ANTIGEN; HLA B57 ANTIGEN; HLA DR ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; SIMIAN IMMUNODEFICIENCY VIRUS VACCINE; TUMOR NECROSIS FACTOR ALPHA; ZINC FINGER NUCLEASE;

EID: 84883828717     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00162     Document Type: Review
Times cited : (21)

References (91)
  • 1
    • 84865522930 scopus 로고    scopus 로고
    • Reclassification of risk of death with the knowledge of D-dimer in a cohort of treated HIV-infected individuals
    • doi:10.1097/QAD.0b013e328355d659
    • Achhra, A. C., Amin, J., Sabin, C., Chu, H., Dunn, D., Kuller, L. H., et al. (2012). Reclassification of risk of death with the knowledge of D-dimer in a cohort of treated HIV-infected individuals. AIDS 26, 1707-1717. doi:10.1097/QAD.0b013e328355d659
    • (2012) AIDS , vol.26 , pp. 1707-1717
    • Achhra, A.C.1    Amin, J.2    Sabin, C.3    Chu, H.4    Dunn, D.5    Kuller, L.H.6
  • 2
    • 0037302428 scopus 로고    scopus 로고
    • Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load
    • doi:10.1128/JVI.77.3.2081-2092.2003
    • Addo, M. M., Yu, X. G., Rathod, A., Cohen, D., Eldridge, R. L., Strick, D., et al. (2003). Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol. 77, 2081-2092. doi:10.1128/JVI.77.3.2081-2092.2003
    • (2003) J. Virol. , vol.77 , pp. 2081-2092
    • Addo, M.M.1    Yu, X.G.2    Rathod, A.3    Cohen, D.4    Eldridge, R.L.5    Strick, D.6
  • 3
    • 79953117041 scopus 로고    scopus 로고
    • Evidence for the cure of HIV infection by CCR5δ32/δ32 stem cell transplantation
    • doi:10.1182/blood-2010-09-309591
    • Allers, K., Hutter, G., Hofmann, J., Loddenkemper, C., Rieger, K., Thiel, E., et al. (2011). Evidence for the cure of HIV infection by CCR5δ32/δ32 stem cell transplantation. Blood 117, 2791-2799. doi:10.1182/blood-2010-09-309591
    • (2011) Blood , vol.117 , pp. 2791-2799
    • Allers, K.1    Hutter, G.2    Hofmann, J.3    Loddenkemper, C.4    Rieger, K.5    Thiel, E.6
  • 4
    • 49849090609 scopus 로고    scopus 로고
    • Greater viral rebound and reduced time to resume antiretroviral therapy after therapeutic immunization with the ALVAC-HIV vaccine (vCP1452)
    • doi:10.1097/QAD.0b013e3282fdce94
    • Autran, B., Murphy, R. L., Costagliola, D., Tubiana, R., Clotet, B., Gatell, J., et al. (2008). Greater viral rebound and reduced time to resume antiretroviral therapy after therapeutic immunization with the ALVAC-HIV vaccine (vCP1452). AIDS 22, 1313-1322. doi:10.1097/QAD.0b013e3282fdce94
    • (2008) AIDS , vol.22 , pp. 1313-1322
    • Autran, B.1    Murphy, R.L.2    Costagliola, D.3    Tubiana, R.4    Clotet, B.5    Gatell, J.6
  • 6
    • 84864936397 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells (pDCs) from HIV controllers produce interferon-alpha and differentiate into functional killer pDCs under HIV activation
    • doi:10.1093/infdis/jis384
    • Barblu, L., Machmach, K., Gras, C., Delfraissy, J. F., Boufassa, F., Leal, M., et al. (2012). Plasmacytoid dendritic cells (pDCs) from HIV controllers produce interferon-alpha and differentiate into functional killer pDCs under HIV activation. J. Infect. Dis. 206, 790-801. doi:10.1093/infdis/jis384
    • (2012) J. Infect. Dis. , vol.206 , pp. 790-801
    • Barblu, L.1    Machmach, K.2    Gras, C.3    Delfraissy, J.F.4    Boufassa, F.5    Leal, M.6
  • 7
    • 84856482137 scopus 로고    scopus 로고
    • Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys
    • doi:10.1038/nature10766
    • Barouch, D. H., Liu, J., Li, H., Maxfield, L. F., Abbink, P., Lynch, D. M., et al. (2012). Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys. Nature 482, 89-93. doi:10.1038/nature10766
    • (2012) Nature , vol.482 , pp. 89-93
    • Barouch, D.H.1    Liu, J.2    Li, H.3    Maxfield, L.F.4    Abbink, P.5    Lynch, D.M.6
  • 8
    • 80051961211 scopus 로고    scopus 로고
    • Transduction of SIV-specific TCR genes into rhesus macaque CD8+ T cells conveys the ability to suppress SIV replication
    • doi:10.1371/journal.pone.0023703
    • Barsov, E. V., Trivett, M. T., Minang, J. T., Sun, H., Ohlen, C., and Ott, D. E. (2011). Transduction of SIV-specific TCR genes into rhesus macaque CD8+ T cells conveys the ability to suppress SIV replication. PLoS ONE 6, e23703. doi:10.1371/journal.pone.0023703
    • (2011) PLoS ONE , vol.6
    • Barsov, E.V.1    Trivett, M.T.2    Minang, J.T.3    Sun, H.4    Ohlen, C.5    Ott, D.E.6
  • 9
    • 0035198096 scopus 로고    scopus 로고
    • Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection
    • doi:10.1128/JVI.75.24.11983-11991.2001
    • Betts, M. R., Ambrozak, D. R., Douek, D. C., Bonhoeffer, S., Brenchley, J. M., Casazza, J. P., et al. (2001). Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection. J. Virol. 75, 11983-11991. doi:10.1128/JVI.75.24.11983-11991.2001
    • (2001) J. Virol. , vol.75 , pp. 11983-11991
    • Betts, M.R.1    Ambrozak, D.R.2    Douek, D.C.3    Bonhoeffer, S.4    Brenchley, J.M.5    Casazza, J.P.6
  • 10
    • 33646686040 scopus 로고    scopus 로고
    • HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
    • doi:10.1182/blood-2005-12-4818
    • Betts, M. R., Nason, M. C., West, S. M., De Rosa, S. C., Migueles, S. A., Abraham, J., et al. (2006). HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood 107, 4781-4789. doi:10.1182/blood-2005-12-4818
    • (2006) Blood , vol.107 , pp. 4781-4789
    • Betts, M.R.1    Nason, M.C.2    West, S.M.3    De Rosa, S.C.4    Migueles, S.A.5    Abraham, J.6
  • 11
    • 33847176917 scopus 로고    scopus 로고
    • Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors
    • doi:10.1128/JVI.02165-06
    • Blankson, J. N., Bailey, J. R., Thayil, S., Yang, H. C., Lassen, K., Lai, J., et al. (2007). Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors. J. Virol. 81, 2508-2518. doi:10.1128/JVI.02165-06
    • (2007) J. Virol. , vol.81 , pp. 2508-2518
    • Blankson, J.N.1    Bailey, J.R.2    Thayil, S.3    Yang, H.C.4    Lassen, K.5    Lai, J.6
  • 12
    • 73949102416 scopus 로고    scopus 로고
    • Trafficking, persistence, and activation state of adoptively transferred allogeneic and autologous simian immunodeficiency virus-specific CD8(+) T cell clones during acute and chronic infection of rhesus macaques
    • doi:10.4049/jimmunol.0902413
    • Bolton, D. L., Minang, J. T., Trivett, M. T., Song, K., Tuscher, J. J., Li, Y., et al. (2010). Trafficking, persistence, and activation state of adoptively transferred allogeneic and autologous simian immunodeficiency virus-specific CD8(+) T cell clones during acute and chronic infection of rhesus macaques. J. Immunol. 184, 303-314. doi:10.4049/jimmunol.0902413
    • (2010) J. Immunol. , vol.184 , pp. 303-314
    • Bolton, D.L.1    Minang, J.T.2    Trivett, M.T.3    Song, K.4    Tuscher, J.J.5    Li, Y.6
  • 13
    • 84874147989 scopus 로고    scopus 로고
    • Increases in adult life expectancy in rural South Africa: valuing the scale-up of HIV treatment
    • doi:10.1126/science.1230413
    • Bor, J., Herbst, A. J., Newell, M. L., and Barnighausen, T. (2013). Increases in adult life expectancy in rural South Africa: valuing the scale-up of HIV treatment. Science 339, 961-965. doi:10.1126/science.1230413
    • (2013) Science , vol.339 , pp. 961-965
    • Bor, J.1    Herbst, A.J.2    Newell, M.L.3    Barnighausen, T.4
  • 14
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • doi:10.1038/nm1511
    • Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., et al. (2006). Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat. Med. 12, 1365-1371. doi:10.1038/nm1511
    • (2006) Nat. Med. , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1    Price, D.A.2    Schacker, T.W.3    Asher, T.E.4    Silvestri, G.5    Rao, S.6
  • 15
    • 56649105122 scopus 로고    scopus 로고
    • Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the step study): a double-blind, randomised, placebo-controlled, test-of-concept trial
    • doi:10.1016/S0140-6736(08)61591-3
    • Buchbinder, S. P., Mehrotra, D. V., Duerr, A., Fitzgerald, D. W., Mogg, R., Li, D., et al. (2008). Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the step study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet 372, 1881-1893. doi:10.1016/S0140-6736(08)61591-3
    • (2008) Lancet , vol.372 , pp. 1881-1893
    • Buchbinder, S.P.1    Mehrotra, D.V.2    Duerr, A.3    Fitzgerald, D.W.4    Mogg, R.5    Li, D.6
  • 16
    • 84870686389 scopus 로고    scopus 로고
    • Inhibitory potential of subpopulations of CD8+ T cells in HIV-1-infected elite suppressors
    • doi:10.1128/JVI.02439-12
    • Buckheit, R. W. 3rd, Salgado, M., Silciano, R. F., and Blankson, J. N. (2012). Inhibitory potential of subpopulations of CD8+ T cells in HIV-1-infected elite suppressors. J. Virol. 86, 13679-13688. doi:10.1128/JVI.02439-12
    • (2012) J. Virol. , vol.86 , pp. 13679-13688
    • Buckheit, R.W.1    Salgado, M.2    Silciano, R.F.3    Blankson, J.N.4
  • 18
    • 77950537810 scopus 로고    scopus 로고
    • HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects
    • doi:10.1038/nm.2111
    • Buzón, M. J., Massanella, M., Llibre, J. M., Esteve, A., Dahl, V., Puertas, M. C., et al. (2010). HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects. Nat. Med. 16, 460-465. doi:10.1038/nm.2111
    • (2010) Nat. Med. , vol.16 , pp. 460-465
    • Buzón, M.J.1    Massanella, M.2    Llibre, J.M.3    Esteve, A.4    Dahl, V.5    Puertas, M.C.6
  • 19
    • 0033548497 scopus 로고    scopus 로고
    • HLA and HIV-1: heterozygote advantage and B'35-Cw'04 disadvantage
    • doi:10.1126/science.283.5408.1748
    • Carrington, M., Nelson, G. W., Martin, M. P., Kissner, T., Vlahov, D., Goedert, J. J., et al. (1999). HLA and HIV-1: heterozygote advantage and B'35-Cw'04 disadvantage. Science 283, 1748-1752. doi:10.1126/science.283.5408.1748
    • (1999) Science , vol.283 , pp. 1748-1752
    • Carrington, M.1    Nelson, G.W.2    Martin, M.P.3    Kissner, T.4    Vlahov, D.5    Goedert, J.J.6
  • 20
    • 79953305839 scopus 로고    scopus 로고
    • CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21
    • doi:10.1172/JCI44539
    • Chen, H., Li, C., Huang, J., Cung, T., Seiss, K., Beamon, J., et al. (2011). CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21. J. Clin. Invest. 121, 1549-1560. doi:10.1172/JCI44539
    • (2011) J. Clin. Invest. , vol.121 , pp. 1549-1560
    • Chen, H.1    Li, C.2    Huang, J.3    Cung, T.4    Seiss, K.5    Beamon, J.6
  • 21
    • 84862621390 scopus 로고    scopus 로고
    • TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection
    • doi:10.1038/ni.2342
    • Chen, H., Ndhlovu, Z. M., Liu, D., Porter, L. C., Fang, J. W., Darko, S., et al. (2012). TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection. Nat. Immunol. 13, 691-700. doi:10.1038/ni.2342
    • (2012) Nat. Immunol. , vol.13 , pp. 691-700
    • Chen, H.1    Ndhlovu, Z.M.2    Liu, D.3    Porter, L.C.4    Fang, J.W.5    Darko, S.6
  • 22
    • 85027941566 scopus 로고    scopus 로고
    • Resumption of HIV replication is associated with monocyte/macrophage derived cytokine and chemokine changes: results from a large international clinical trial
    • doi:10.1097/QAD.0b013e3283471f10
    • Cozzi-Lepri, A., French, M. A., Baxter, J., Okhuysen, P., Plana, M., Neuhaus, J., et al. (2011). Resumption of HIV replication is associated with monocyte/macrophage derived cytokine and chemokine changes: results from a large international clinical trial. AIDS 25, 1207-1217. doi:10.1097/QAD.0b013e3283471f10
    • (2011) AIDS , vol.25 , pp. 1207-1217
    • Cozzi-Lepri, A.1    French, M.A.2    Baxter, J.3    Okhuysen, P.4    Plana, M.5    Neuhaus, J.6
  • 23
    • 34548689151 scopus 로고    scopus 로고
    • Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy
    • doi:10.1016/j.immuni.2007.08.010
    • Deeks, S. G., and Walker, B. D. (2007). Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy. Immunity 27, 406-416. doi:10.1016/j.immuni.2007.08.010
    • (2007) Immunity , vol.27 , pp. 406-416
    • Deeks, S.G.1    Walker, B.D.2
  • 24
    • 59849114234 scopus 로고    scopus 로고
    • Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection
    • doi:10.1186/1742-4690-5-112
    • Dyer, W. B., Zaunders, J. J., Yuan, F. F., Wang, B., Learmont, J. C., Geczy, A. F., et al. (2008). Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection. Retrovirology 5, 112. doi:10.1186/1742-4690-5-112
    • (2008) Retrovirology , vol.5 , pp. 112
    • Dyer, W.B.1    Zaunders, J.J.2    Yuan, F.F.3    Wang, B.4    Learmont, J.C.5    Geczy, A.F.6
  • 25
    • 34548134145 scopus 로고    scopus 로고
    • A whole-genome association study of major determinants for host control of HIV-1
    • doi:10.1126/science.1143767
    • Fellay, J., Shianna, K. V., Ge, D., Colombo, S., Ledergerber, B., Weale, M., et al. (2007). A whole-genome association study of major determinants for host control of HIV-1. Science 317, 944-947. doi:10.1126/science.1143767
    • (2007) Science , vol.317 , pp. 944-947
    • Fellay, J.1    Shianna, K.V.2    Ge, D.3    Colombo, S.4    Ledergerber, B.5    Weale, M.6
  • 26
    • 77957944425 scopus 로고    scopus 로고
    • HIV controllers with HLA-DRB113 and HLA-DQB106 alleles have strong, polyfunctional mucosal CD4+ T-cell responses
    • doi:10.1128/JVI.00980-10
    • Ferre, A. L., Hunt, P. W., McConnell, D. H., Morris, M. M., Garcia, J. C., Pollard, R. B., et al. (2010). HIV controllers with HLA-DRB113 and HLA-DQB106 alleles have strong, polyfunctional mucosal CD4+ T-cell responses. J. Virol. 84, 11020-11029. doi:10.1128/JVI.00980-10
    • (2010) J. Virol. , vol.84 , pp. 11020-11029
    • Ferre, A.L.1    Hunt, P.W.2    McConnell, D.H.3    Morris, M.M.4    Garcia, J.C.5    Pollard, R.B.6
  • 27
    • 79954672355 scopus 로고    scopus 로고
    • Impact of CD4 T cell count on the outcome of planned treatment interruptions in early-treated human immunodeficiency virus-infected children
    • doi:10.1097/INF.0b013e3181ff8661
    • Fortuny, C., Noguera-Julian, A., Alsina, L., Bellido, R., Sánchez, E., Muñoz-Almagro, C., et al. (2011). Impact of CD4 T cell count on the outcome of planned treatment interruptions in early-treated human immunodeficiency virus-infected children. Pediatr. Infect. Dis. J. 30, 435-438. doi:10.1097/INF.0b013e3181ff8661
    • (2011) Pediatr. Infect. Dis. J. , vol.30 , pp. 435-438
    • Fortuny, C.1    Noguera-Julian, A.2    Alsina, L.3    Bellido, R.4    Sánchez, E.5    Muñoz-Almagro, C.6
  • 28
    • 84872037286 scopus 로고    scopus 로고
    • A dendritic cell-based vaccine elicits T cell responses associated with control of HIV-1 replication
    • doi:10.1126/scitranslmed.3004682
    • García, F., Climent, N., Guardo, A. C., Gil, C., León, A., Autran, B., et al. (2013). A dendritic cell-based vaccine elicits T cell responses associated with control of HIV-1 replication. Sci. Transl. Med. 5, 166ra2. doi:10.1126/scitranslmed.3004682
    • (2013) Sci. Transl. Med. , vol.5
    • García, F.1    Climent, N.2    Guardo, A.C.3    Gil, C.4    León, A.5    Autran, B.6
  • 29
    • 79952072932 scopus 로고    scopus 로고
    • Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and offHAART
    • doi:10.1371/journal.ppat.1001300
    • Graf, E. H., Mexas, A. M., Yu, J. J., Shaheen, F., Liszewski, M. K., Di Mascio, M., et al. (2011). Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and offHAART. PLoS Pathog. 7, e1001300. doi:10.1371/journal.ppat.1001300
    • (2011) PLoS Pathog. , vol.7
    • Graf, E.H.1    Mexas, A.M.2    Yu, J.J.3    Shaheen, F.4    Liszewski, M.K.5    Di Mascio, M.6
  • 30
    • 80755123417 scopus 로고    scopus 로고
    • Premature age-related comorbidities among HIV-infected persons compared with the general population
    • doi:10.1093/cid/cir627
    • Guaraldi, G., Orlando, G., Zona, S., Menozzi, M., Carli, F., Garlassi, E., et al. (2011). Premature age-related comorbidities among HIV-infected persons compared with the general population. Clin. Infect. Dis. 53, 1120-1126. doi:10.1093/cid/cir627
    • (2011) Clin. Infect. Dis. , vol.53 , pp. 1120-1126
    • Guaraldi, G.1    Orlando, G.2    Zona, S.3    Menozzi, M.4    Carli, F.5    Garlassi, E.6
  • 31
    • 54849146700 scopus 로고    scopus 로고
    • Maraviroc for previously treated patients with R5 HIV-1 infection
    • doi:10.1056/NEJMoa0803152
    • Gulick, R. M., Lalezari, J., Goodrich, J., Clumeck, N., DeJesus, E., Horban, A., et al. (2008). Maraviroc for previously treated patients with R5 HIV-1 infection. N. Engl. J. Med. 359, 1429-1441. doi:10.1056/NEJMoa0803152
    • (2008) N. Engl. J. Med. , vol.359 , pp. 1429-1441
    • Gulick, R.M.1    Lalezari, J.2    Goodrich, J.3    Clumeck, N.4    DeJesus, E.5    Horban, A.6
  • 32
    • 79957618772 scopus 로고    scopus 로고
    • Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
    • doi:10.1038/nature10003
    • Hansen, S. G., Ford, J. C., Lewis, M. S., Ventura, A. B., Hughes, C. M., Coyne-Johnson, L., et al. (2011). Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature 473, 523-527. doi:10.1038/nature10003
    • (2011) Nature , vol.473 , pp. 523-527
    • Hansen, S.G.1    Ford, J.C.2    Lewis, M.S.3    Ventura, A.B.4    Hughes, C.M.5    Coyne-Johnson, L.6
  • 33
    • 61949216736 scopus 로고    scopus 로고
    • Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge
    • doi:10.1038/nm.1935
    • Hansen, S. G., Vieville, C., Whizin, N., Coyne-Johnson, L., Siess, D. C., Drummond, D. D., et al. (2009). Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge. Nat. Med. 15, 293-299. doi:10.1038/nm.1935
    • (2009) Nat. Med. , vol.15 , pp. 293-299
    • Hansen, S.G.1    Vieville, C.2    Whizin, N.3    Coyne-Johnson, L.4    Siess, D.C.5    Drummond, D.D.6
  • 34
    • 58149382617 scopus 로고    scopus 로고
    • Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy
    • doi:10.1128/JVI.01763-08
    • Hatano, H., Delwart, E. L., Norris, P. J., Lee, T. H., Dunn-Williams, J., Hunt, P. W., et al. (2009). Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy. J. Virol. 83, 329-335. doi:10.1128/JVI.01763-08
    • (2009) J. Virol. , vol.83 , pp. 329-335
    • Hatano, H.1    Delwart, E.L.2    Norris, P.J.3    Lee, T.H.4    Dunn-Williams, J.5    Hunt, P.W.6
  • 36
    • 77953916829 scopus 로고    scopus 로고
    • Long-term immunovirologic control following antiretroviral therapy interruption in patients treated at the time of primary HIV-1 infection
    • doi:10.1097/QAD.0b013e32833b61ba
    • Hocqueloux, L., Prazuck, T., Avettand-Fenoel, V., Lafeuillade, A., Cardon, B., Viard, J. P., et al. (2010). Long-term immunovirologic control following antiretroviral therapy interruption in patients treated at the time of primary HIV-1 infection. AIDS 24, 1598-1601. doi:10.1097/QAD.0b013e32833b61ba
    • (2010) AIDS , vol.24 , pp. 1598-1601
    • Hocqueloux, L.1    Prazuck, T.2    Avettand-Fenoel, V.3    Lafeuillade, A.4    Cardon, B.5    Viard, J.P.6
  • 37
    • 81055149608 scopus 로고    scopus 로고
    • Human T cells expressing two additional receptors (TETARs) specific for HIV-1 recognize both epitopes
    • doi:10.1182/blood-2011-04-347005
    • Hofmann, C., oḦfflin, S., Hückelhoven, A., Bergmann, S., Harrer, E., Schuler, G., et al. (2011). Human T cells expressing two additional receptors (TETARs) specific for HIV-1 recognize both epitopes. Blood 118, 5174-5177. doi:10.1182/blood-2011-04-347005
    • (2011) Blood , vol.118 , pp. 5174-5177
    • Hofmann, C.1    Höfflin, S.2    Hückelhoven, A.3    Bergmann, S.4    Harrer, E.5    Schuler, G.6
  • 38
    • 78650735673 scopus 로고    scopus 로고
    • Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
    • doi:10.1038/nbt.1663
    • Holt, N., Wang, J., Kim, K., Friedman, G., Wang, X., Taupin, V., et al. (2010). Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat. Biotechnol. 28, 839-847. doi:10.1038/nbt.1663
    • (2010) Nat. Biotechnol. , vol.28 , pp. 839-847
    • Holt, N.1    Wang, J.2    Kim, K.3    Friedman, G.4    Wang, X.5    Taupin, V.6
  • 39
    • 67651125105 scopus 로고    scopus 로고
    • Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis
    • doi:10.1097/QAD.0b013e32832b514b
    • Hsue, P. Y., Hunt, P. W., Schnell, A., Kalapus, S. C., Hoh, R., Ganz, P., et al. (2009). Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis. AIDS 23, 1059-1067. doi:10.1097/QAD.0b013e32832b514b
    • (2009) AIDS , vol.23 , pp. 1059-1067
    • Hsue, P.Y.1    Hunt, P.W.2    Schnell, A.3    Kalapus, S.C.4    Hoh, R.5    Ganz, P.6
  • 40
    • 84881480492 scopus 로고    scopus 로고
    • Carotid intima-media thickness progression in HIV-infected adults occurs preferentially at the carotid bifurcation and is predicted by inflammation
    • doi:10.1161/JAHA.111.000422
    • Hsue, P. Y., Scherzer, R., Hunt, P. W., Schnell, A., Bolger, A. F., Kalapus, S. C., et al. (2012). Carotid intima-media thickness progression in HIV-infected adults occurs preferentially at the carotid bifurcation and is predicted by inflammation. J. Am. Heart Assoc. 1, 1-12. doi:10.1161/JAHA.111.000422
    • (2012) J. Am. Heart Assoc. , vol.1 , pp. 1-12
    • Hsue, P.Y.1    Scherzer, R.2    Hunt, P.W.3    Schnell, A.4    Bolger, A.F.5    Kalapus, S.C.6
  • 41
    • 77956033397 scopus 로고    scopus 로고
    • Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers
    • doi:10.1128/JVI.01009-10
    • Huang, J., Burke, P. S., Cung, T. D., Pereyra, F., Toth, I., Walker, B. D., et al. (2010). Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers. J. Virol. 84, 9463-9471. doi:10.1128/JVI.01009-10
    • (2010) J. Virol. , vol.84 , pp. 9463-9471
    • Huang, J.1    Burke, P.S.2    Cung, T.D.3    Pereyra, F.4    Toth, I.5    Walker, B.D.6
  • 42
    • 39349088126 scopus 로고    scopus 로고
    • Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy
    • doi:10.1086/524143
    • Hunt, P. W., Brenchley, J., Sinclair, E., McCune, J. M., Roland, M., Page-Shafer, K., et al. (2008). Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J. Infect. Dis. 197, 126-133. doi:10.1086/524143
    • (2008) J. Infect. Dis. , vol.197 , pp. 126-133
    • Hunt, P.W.1    Brenchley, J.2    Sinclair, E.3    McCune, J.M.4    Roland, M.5    Page-Shafer, K.6
  • 43
    • 79551649723 scopus 로고    scopus 로고
    • A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers
    • doi:10.1371/journal.pone.0015924
    • Hunt, P. W., Landay, A. L., Sinclair, E., Martinson, J. A., Hatano, H., Emu, B., et al. (2011). A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers. PLoS ONE 6:e15924. doi:10.1371/journal.pone.0015924
    • (2011) PLoS ONE , vol.6
    • Hunt, P.W.1    Landay, A.L.2    Sinclair, E.3    Martinson, J.A.4    Hatano, H.5    Emu, B.6
  • 44
    • 60549090253 scopus 로고    scopus 로고
    • Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation
    • doi:10.1056/NEJMoa0802905
    • Hütter, G., Nowak, D., Mossner, M., Ganepola, S., Müssig, A., Allers, K., et al. (2009). Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N. Engl. J. Med. 360, 692-698. doi:10.1056/NEJMoa0802905
    • (2009) N. Engl. J. Med. , vol.360 , pp. 692-698
    • Hütter, G.1    Nowak, D.2    Mossner, M.3    Ganepola, S.4    Müssig, A.5    Allers, K.6
  • 45
    • 84864345953 scopus 로고    scopus 로고
    • Towards an HIV cure: a global scientific strategy
    • International AIDS Society Scientific Working Group on HIV Cure doi:10.1038/nri3262
    • International AIDS Society Scientific Working Group on HIV Cure, Deeks, S. G., Autran, B., Berkhout, B., Benkirane, M., Cairns, S., et al. (2012). Towards an HIV cure: a global scientific strategy. Nat. Rev. Immunol. 12, 607-614. doi:10.1038/nri3262
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 607-614
    • Deeks, S.G.1    Autran, B.2    Berkhout, B.3    Benkirane, M.4    Cairns, S.5
  • 46
    • 78650084232 scopus 로고    scopus 로고
    • The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
    • International HIV Controllers Study doi:10.1126/science.1195271
    • International HIV Controllers Study, Pereyra, F., Jia, X., McLaren, P. J., Telenti, A., de Bakker, P. I., et al. (2010). The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science 330, 1551-1557. doi:10.1126/science.1195271
    • (2010) Science , vol.330 , pp. 1551-1557
    • Pereyra, F.1    Jia, X.2    McLaren, P.J.3    Telenti, A.4    de Bakker, P.I.5
  • 47
    • 0033559648 scopus 로고    scopus 로고
    • Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques
    • doi:10.1084/jem.189.6.991
    • Jin, X., Bauer, D. E., Tuttleton, S. E., Lewin, S., Gettie, A., Blanchard, J., et al. (1999). Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques. J. Exp. Med. 189, 991-998. doi:10.1084/jem.189.6.991
    • (1999) J. Exp. Med. , vol.189 , pp. 991-998
    • Jin, X.1    Bauer, D.E.2    Tuttleton, S.E.3    Lewin, S.4    Gettie, A.5    Blanchard, J.6
  • 48
    • 40149106131 scopus 로고    scopus 로고
    • Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity
    • doi:10.1128/JVI.01812-07
    • Joseph, A., Zheng, J. H., Follenzi, A., Dilorenzo, T., Sango, K., Hyman, J., et al. (2008). Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity. J. Virol. 82, 3078-3089. doi:10.1128/JVI.01812-07
    • (2008) J. Virol. , vol.82 , pp. 3078-3089
    • Joseph, A.1    Zheng, J.H.2    Follenzi, A.3    Dilorenzo, T.4    Sango, K.5    Hyman, J.6
  • 49
    • 77954752400 scopus 로고    scopus 로고
    • Infrequent recovery of HIV from but robust exogenous infection of activated CD4(+) T cells in HIV elite controllers
    • doi:10.1086/653677
    • Julg, B., Pereyra, F., Buzón, M. J., Piechocka-Trocha, A., Clark, M. J., Baker, B. M., et al. (2010). Infrequent recovery of HIV from but robust exogenous infection of activated CD4(+) T cells in HIV elite controllers. Clin. Infect. Dis. 51, 233-238. doi:10.1086/653677
    • (2010) Clin. Infect. Dis. , vol.51 , pp. 233-238
    • Julg, B.1    Pereyra, F.2    Buzón, M.J.3    Piechocka-Trocha, A.4    Clark, M.J.5    Baker, B.M.6
  • 50
    • 15744361847 scopus 로고    scopus 로고
    • Limited durability of viral control following treated acute HIV infection
    • doi:10.1371/journal.pmed.0010036
    • Kaufmann, D. E., Lichterfeld, M., Altfeld, M., Addo, M. M., Johnston, M. N., Lee, P. K., et al. (2004). Limited durability of viral control following treated acute HIV infection. PLoS Med. 1:e36. doi:10.1371/journal.pmed.0010036
    • (2004) PLoS Med. , vol.1
    • Kaufmann, D.E.1    Lichterfeld, M.2    Altfeld, M.3    Addo, M.M.4    Johnston, M.N.5    Lee, P.K.6
  • 51
    • 84873369889 scopus 로고    scopus 로고
    • Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques
    • doi:10.1172/JCI66227
    • Klatt, N. R., Canary, L. A., Sun, X., Vinton, C. L., Funderburg, N. T., Morcock, D. R., et al. (2013). Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques. J. Clin. Invest. 123, 903-907. doi:10.1172/JCI66227
    • (2013) J. Clin. Invest. , vol.123 , pp. 903-907
    • Klatt, N.R.1    Canary, L.A.2    Sun, X.3    Vinton, C.L.4    Funderburg, N.T.5    Morcock, D.R.6
  • 52
    • 77952742298 scopus 로고    scopus 로고
    • Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection
    • doi:10.1038/nature08997
    • Kosmrlj, A., Read, E. L., Qi, Y., Allen, T. M., Altfeld, M., Deeks, S. G., et al. (2010). Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection. Nature 465, 350-354. doi:10.1038/nature08997
    • (2010) Nature , vol.465 , pp. 350-354
    • Kosmrlj, A.1    Read, E.L.2    Qi, Y.3    Allen, T.M.4    Altfeld, M.5    Deeks, S.G.6
  • 53
    • 84875520974 scopus 로고    scopus 로고
    • A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells
    • doi:10.1016/j.immuni.2012.11.021
    • Ladell, K., Hashimoto, M., Iglesias, M. C., Wilmann, P. G., McLaren, J. E., Gras, S., et al. (2013). A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells. Immunity 38, 425-436. doi:10.1016/j.immuni.2012.11.021
    • (2013) Immunity , vol.38 , pp. 425-436
    • Ladell, K.1    Hashimoto, M.2    Iglesias, M.C.3    Wilmann, P.G.4    McLaren, J.E.5    Gras, S.6
  • 54
    • 67149120819 scopus 로고    scopus 로고
    • Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers
    • doi:10.1097/QAD.0b013e328329f97d
    • Lambotte, O., Ferrari, G., Moog, C., Yates, N. L., Liao, H. X., Parks, R. J., et al. (2009). Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers. AIDS 23, 897-906. doi:10.1097/QAD.0b013e328329f97d
    • (2009) AIDS , vol.23 , pp. 897-906
    • Lambotte, O.1    Ferrari, G.2    Moog, C.3    Yates, N.L.4    Liao, H.X.5    Parks, R.J.6
  • 55
    • 0030854210 scopus 로고    scopus 로고
    • Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients
    • Lieberman, J., Skolnik, P. R., Parkerson, G. R. 3rd, Fabry, J. A., Landry, B., Bethel, J., et al. (1997). Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients. Blood 90, 2196-2206.
    • (1997) Blood , vol.90 , pp. 2196-2206
    • Lieberman, J.1    Skolnik, P.R.2    Parkerson, G.R.3    Fabry, J.A.4    Landry, B.5    Bethel, J.6
  • 56
    • 33846904554 scopus 로고    scopus 로고
    • Survival of persons with and without HIV infection in Denmark, 1995-2005
    • doi:10.7326/0003-4819-146-2-200701160-00003
    • Lohse, N., Hansen, A. B., Pedersen, G., Kronborg, G., Gerstoft, J., Sørensen, H. T., et al. (2007). Survival of persons with and without HIV infection in Denmark, 1995-2005. Ann. Intern. Med. 146, 87-95. doi:10.7326/0003-4819-146-2-200701160-00003
    • (2007) Ann. Intern. Med. , vol.146 , pp. 87-95
    • Lohse, N.1    Hansen, A.B.2    Pedersen, G.3    Kronborg, G.4    Gerstoft, J.5    Sørensen, H.T.6
  • 57
    • 0032950189 scopus 로고    scopus 로고
    • Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in human immunodeficiency virus-1-infected individuals
    • Magierowska, M., Theodorou, I., Debré, P., Sanson, F., Autran, B., Rivière, Y., et al. (1999). Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in human immunodeficiency virus-1-infected individuals. Blood 93, 936-941.
    • (1999) Blood , vol.93 , pp. 936-941
    • Magierowska, M.1    Theodorou, I.2    Debré, P.3    Sanson, F.4    Autran, B.5    Rivière, Y.6
  • 58
    • 84875420616 scopus 로고    scopus 로고
    • Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5
    • doi:10.1089/hum.2012.172
    • Maier, D. A., Brennan, A. L., Jiang, S., Binder-Scholl, G. K., Lee, G., Plesa, G., et al. (2013). Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5. Hum. Gene Ther. 24, 245-258. doi:10.1089/hum.2012.172
    • (2013) Hum. Gene Ther. , vol.24 , pp. 245-258
    • Maier, D.A.1    Brennan, A.L.2    Jiang, S.3    Binder-Scholl, G.K.4    Lee, G.5    Plesa, G.6
  • 59
    • 84872345652 scopus 로고    scopus 로고
    • Markers of microbial translocation and risk of AIDS-related lymphoma
    • doi:10.1097/QAD.0b013e32835c1333
    • Marks, M. A., Rabkin, C. S., Engels, E. A., Busch, E., Kopp, W., Rager, H., et al. (2013). Markers of microbial translocation and risk of AIDS-related lymphoma. AIDS 27, 469-474. doi:10.1097/QAD.0b013e32835c1333
    • (2013) AIDS , vol.27 , pp. 469-474
    • Marks, M.A.1    Rabkin, C.S.2    Engels, E.A.3    Busch, E.4    Kopp, W.5    Rager, H.6
  • 60
    • 84879774999 scopus 로고    scopus 로고
    • Dynamics of CD8 T-cell activation after discontinuation of HIV treatment intensification
    • doi:10.1097/QAI.0b013e318289439a
    • Massanella, M., Esteve, A., Buzón, M. J., Llibre, J. M., Puertas, M. C., Gatell, J. M., et al. (2013). Dynamics of CD8 T-cell activation after discontinuation of HIV treatment intensification. J. Acquir. Immune Defic. Syndr. 63, 152-160. doi:10.1097/QAI.0b013e318289439a
    • (2013) J. Acquir. Immune Defic. Syndr. , vol.63 , pp. 152-160
    • Massanella, M.1    Esteve, A.2    Buzón, M.J.3    Llibre, J.M.4    Puertas, M.C.5    Gatell, J.M.6
  • 61
    • 56649114351 scopus 로고    scopus 로고
    • HIV-1 vaccine-induced immunity in the test-of-concept step study: a case-cohort analysis
    • doi:10.1016/S0140-6736(08)61592-5
    • McElrath, M. J., De Rosa, S. C., Moodie, Z., Dubey, S., Kierstead, L., Janes, H., et al. (2008). HIV-1 vaccine-induced immunity in the test-of-concept step study: a case-cohort analysis. Lancet 372, 1894-1905. doi:10.1016/S0140-6736(08)61592-5
    • (2008) Lancet , vol.372 , pp. 1894-1905
    • McElrath, M.J.1    De Rosa, S.C.2    Moodie, Z.3    Dubey, S.4    Kierstead, L.5    Janes, H.6
  • 62
    • 0036852179 scopus 로고    scopus 로고
    • HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors
    • doi:10.1038/ni845
    • Migueles, S. A., Laborico, A. C., Shupert, W. L., Sabbaghian, M. S., Rabin, R., Hallahan, C. W., et al. (2002). HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat. Immunol. 3, 1061-1068. doi:10.1038/ni845
    • (2002) Nat. Immunol. , vol.3 , pp. 1061-1068
    • Migueles, S.A.1    Laborico, A.C.2    Shupert, W.L.3    Sabbaghian, M.S.4    Rabin, R.5    Hallahan, C.W.6
  • 63
    • 57449109484 scopus 로고    scopus 로고
    • Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control
    • doi:10.1016/j.immuni.2008.10.010
    • Migueles, S. A., Osborne, C. M., Royce, C., Compton, A. A., Joshi, R. P., Weeks, K. A., et al. (2008). Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control. Immunity 29, 1009-1021. doi:10.1016/j.immuni.2008.10.010
    • (2008) Immunity , vol.29 , pp. 1009-1021
    • Migueles, S.A.1    Osborne, C.M.2    Royce, C.3    Compton, A.A.4    Joshi, R.P.5    Weeks, K.A.6
  • 64
    • 0034646143 scopus 로고    scopus 로고
    • HLA B5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors
    • doi:10.1073/pnas.050567397
    • Migueles, S. A., Sabbaghian, M. S., Shupert, W. L., Bettinotti, M. P., Marincola, F. M., Martino, L., et al. (2000). HLA B5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors. Proc. Natl. Acad. Sci. U.S.A. 97, 2709-2714. doi:10.1073/pnas.050567397
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 2709-2714
    • Migueles, S.A.1    Sabbaghian, M.S.2    Shupert, W.L.3    Bettinotti, M.P.4    Marincola, F.M.5    Martino, L.6
  • 65
    • 62749177486 scopus 로고    scopus 로고
    • HLA-B57/B5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition
    • doi:10.1128/JVI.00579-09
    • Miura, T., Brockman, M. A., Schneidewind, A., Lobritz, M., Pereyra, F., Rathod, A., et al. (2009). HLA-B57/B5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition. J. Virol. 83, 2743-2755. doi:10.1128/JVI.00579-09
    • (2009) J. Virol. , vol.83 , pp. 2743-2755
    • Miura, T.1    Brockman, M.A.2    Schneidewind, A.3    Lobritz, M.4    Pereyra, F.5    Rathod, A.6
  • 66
    • 77954512323 scopus 로고    scopus 로고
    • Impaired replication capacity of acute/early viruses in persons who become HIV controllers
    • doi:10.1128/JVI.00286-10
    • Miura, T., Brumme, Z. L., Brockman, M. A., Rosato, P., Sela, J., Brumme, C. J., et al. (2010). Impaired replication capacity of acute/early viruses in persons who become HIV controllers. J. Virol. 84, 7581-7591. doi:10.1128/JVI.00286-10
    • (2010) J. Virol. , vol.84 , pp. 7581-7591
    • Miura, T.1    Brumme, Z.L.2    Brockman, M.A.3    Rosato, P.4    Sela, J.5    Brumme, C.J.6
  • 67
    • 84873412156 scopus 로고    scopus 로고
    • Elevations in D-dimer and C-reactive protein are associated with the development of osteonecrosis of the hip in HIV-infected adults
    • doi:10.1097/QAD.0b013e32835c206a
    • Morse, C. G., Dodd, L. E., Nghiem, K., Costello, R., Csako, G., Lane, H. C., et al. (2013). Elevations in D-dimer and C-reactive protein are associated with the development of osteonecrosis of the hip in HIV-infected adults. AIDS 27, 591-595. doi:10.1097/QAD.0b013e32835c206a
    • (2013) AIDS , vol.27 , pp. 591-595
    • Morse, C.G.1    Dodd, L.E.2    Nghiem, K.3    Costello, R.4    Csako, G.5    Lane, H.C.6
  • 68
    • 84855343477 scopus 로고    scopus 로고
    • Projected life expectancy of people with HIV according to timing of diagnosis
    • doi:10.1097/QAD.0b013e32834dcec9
    • Nakagawa, F., Lodwick, R. K., Smith, C. J., Smith, R., Cambiano, V., Lundgren, J. D., et al. (2012). Projected life expectancy of people with HIV according to timing of diagnosis. AIDS 26, 335-343. doi:10.1097/QAD.0b013e32834dcec9
    • (2012) AIDS , vol.26 , pp. 335-343
    • Nakagawa, F.1    Lodwick, R.K.2    Smith, C.J.3    Smith, R.4    Cambiano, V.5    Lundgren, J.D.6
  • 69
    • 84873542088 scopus 로고    scopus 로고
    • High-dimensional immune monitoring models of HIV-1-specific CD8 T cell responses accurately identify subjects achieving spontaneous viral control
    • doi:10.1182/blood-2012-06-436295
    • Ndhlovu, Z. M., Chibnik, L. B., Proudfoot, J., Vine, S., McMullen, A., Cesa, K., et al. (2012a). High-dimensional immune monitoring models of HIV-1-specific CD8 T cell responses accurately identify subjects achieving spontaneous viral control. Blood 121, 801-811. doi:10.1182/blood-2012-06-436295
    • (2012) Blood , vol.121 , pp. 801-811
    • Ndhlovu, Z.M.1    Chibnik, L.B.2    Proudfoot, J.3    Vine, S.4    McMullen, A.5    Cesa, K.6
  • 70
    • 84864020166 scopus 로고    scopus 로고
    • Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses
    • doi:10.1128/JVI.00531-12
    • Ndhlovu, Z. M., Proudfoot, J., Cesa, K., Alvino, D. M., McMullen, A., Vine, S., et al. (2012b). Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses. J. Virol. 86, 6959-6969. doi:10.1128/JVI.00531-12
    • (2012) J. Virol. , vol.86 , pp. 6959-6969
    • Ndhlovu, Z.M.1    Proudfoot, J.2    Cesa, K.3    Alvino, D.M.4    McMullen, A.5    Vine, S.6
  • 71
    • 77953791222 scopus 로고    scopus 로고
    • Control of HIV-1 in elite suppressors despite ongoing replication and evolution in plasma virus
    • doi:10.1128/JVI.00548-10
    • O'Connell, K. A., Brennan, T. P., Bailey, J. R., Ray, S. C., Siliciano, R. F., and Blankson, J. N. (2010). Control of HIV-1 in elite suppressors despite ongoing replication and evolution in plasma virus. J. Virol. 84, 7018-7028. doi:10.1128/JVI.00548-10
    • (2010) J. Virol. , vol.84 , pp. 7018-7028
    • O'Connell, K.A.1    Brennan, T.P.2    Bailey, J.R.3    Ray, S.C.4    Siliciano, R.F.5    Blankson, J.N.6
  • 72
    • 77950278694 scopus 로고    scopus 로고
    • CD4 T cell count reconstitution in HIV controllers after highly active antiretroviral therapy
    • doi:10.1086/651421
    • Okulicz, J. F., Grandits, G. A., Weintrob, A. C., Landrum, M. L., Ganesan, A., Crum-Cianflone, N. F., et al. (2010). CD4 T cell count reconstitution in HIV controllers after highly active antiretroviral therapy. Clin. Infect. Dis. 50, 1187-1191. doi:10.1086/651421
    • (2010) Clin. Infect. Dis. , vol.50 , pp. 1187-1191
    • Okulicz, J.F.1    Grandits, G.A.2    Weintrob, A.C.3    Landrum, M.L.4    Ganesan, A.5    Crum-Cianflone, N.F.6
  • 73
    • 84870251319 scopus 로고    scopus 로고
    • Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers
    • doi:10.1097/QAD.0b013e32835a9950
    • Pereyra, F., Lo, J., Triant, V. A., Wei, J., Buzon, M. J., Fitch, K. V., et al. (2012). Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers. AIDS 26, 2409-2412. doi:10.1097/QAD.0b013e32835a9950
    • (2012) AIDS , vol.26 , pp. 2409-2412
    • Pereyra, F.1    Lo, J.2    Triant, V.A.3    Wei, J.4    Buzon, M.J.5    Fitch, K.V.6
  • 74
    • 70349434887 scopus 로고    scopus 로고
    • Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters
    • doi:10.1086/605446
    • Pereyra, F., Palmer, S., Miura, T., Block, B. L., Wiegand, A., Rothchild, A. C., et al. (2009). Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters. J. Infect. Dis. 200, 984-990. doi:10.1086/605446
    • (2009) J. Infect. Dis. , vol.200 , pp. 984-990
    • Pereyra, F.1    Palmer, S.2    Miura, T.3    Block, B.L.4    Wiegand, A.5    Rothchild, A.C.6
  • 76
    • 43949099690 scopus 로고    scopus 로고
    • Safety and immunogenicity of a replication-incompetent adenovirus type 5 HIV-1 clade B gag/pol/nef vaccine in healthy adults
    • doi:10.1086/587993
    • Priddy, F. H., Brown, D., Kublin, J., Monahan, K., Wright, D. P., Lalezari, J., et al. (2008). Safety and immunogenicity of a replication-incompetent adenovirus type 5 HIV-1 clade B gag/pol/nef vaccine in healthy adults. Clin. Infect. Dis. 46, 1769-1781. doi:10.1086/587993
    • (2008) Clin. Infect. Dis. , vol.46 , pp. 1769-1781
    • Priddy, F.H.1    Brown, D.2    Kublin, J.3    Monahan, K.4    Wright, D.P.5    Lalezari, J.6
  • 77
    • 84879096060 scopus 로고    scopus 로고
    • Persistent immune activation in chronic HIV infection: do any interventions work?
    • doi:10.1097/QAD.0b013e32835ecb8b
    • Rajasuriar, R., Khoury, G., Kamarulzaman, A., French, M. A., Cameron, P. U., and Lewin, S. R. (2013). Persistent immune activation in chronic HIV infection: do any interventions work?. AIDS 27, 1199-1208. doi:10.1097/QAD.0b013e32835ecb8b
    • (2013) AIDS , vol.27 , pp. 1199-1208
    • Rajasuriar, R.1    Khoury, G.2    Kamarulzaman, A.3    French, M.A.4    Cameron, P.U.5    Lewin, S.R.6
  • 78
    • 79961008229 scopus 로고    scopus 로고
    • Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers
    • doi:10.1182/blood-2010-12-327106
    • Sáez-Cirión, A., Hamimi, C., Bergamaschi, A., David, A., Versmisse, P., Mélard, A., et al. (2011). Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers. Blood 118, 955-964. doi:10.1182/blood-2010-12-327106
    • (2011) Blood , vol.118 , pp. 955-964
    • Sáez-Cirión, A.1    Hamimi, C.2    Bergamaschi, A.3    David, A.4    Versmisse, P.5    Mélard, A.6
  • 79
    • 34249852256 scopus 로고    scopus 로고
    • HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
    • doi:10.1073/pnas.0611244104
    • Sáez-Cirión, A., Lacabaratz, C., Lambotte, O., Versmisse, P., Urrutia, A., Boufassa, F., et al. (2007). HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype. Proc. Natl. Acad. Sci. U.S.A. 104, 6776-6781. doi:10.1073/pnas.0611244104
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 6776-6781
    • Sáez-Cirión, A.1    Lacabaratz, C.2    Lambotte, O.3    Versmisse, P.4    Urrutia, A.5    Boufassa, F.6
  • 81
    • 0033524838 scopus 로고    scopus 로고
    • Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
    • doi:10.1126/science.283.5403.857
    • Schmitz, J. E., Kuroda, M. J., Santra, S., Sasseville, V. G., Simon, M. A., Lifton, M. A., et al. (1999). Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science 283, 857-860. doi:10.1126/science.283.5403.857
    • (1999) Science , vol.283 , pp. 857-860
    • Schmitz, J.E.1    Kuroda, M.J.2    Santra, S.3    Sasseville, V.G.4    Simon, M.A.5    Lifton, M.A.6
  • 82
    • 0037122719 scopus 로고    scopus 로고
    • Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity
    • doi:10.1038/415331a
    • Shiver, J. W., Fu, T. M., Chen, L., Casimiro, D. R., Davies, M. E., Evans, R. K., et al. (2002). Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature 415, 331-335. doi:10.1038/415331a
    • (2002) Nature , vol.415 , pp. 331-335
    • Shiver, J.W.1    Fu, T.M.2    Chen, L.3    Casimiro, D.R.4    Davies, M.E.5    Evans, R.K.6
  • 83
    • 0033105536 scopus 로고    scopus 로고
    • Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome
    • Tan, R., Xu, X., Ogg, G. S., Hansasuta, P., Dong, T., Rostron, T., et al. (1999). Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome. Blood 93, 1506-1510.
    • (1999) Blood , vol.93 , pp. 1506-1510
    • Tan, R.1    Xu, X.2    Ogg, G.S.3    Hansasuta, P.4    Dong, T.5    Rostron, T.6
  • 85
    • 40449085117 scopus 로고    scopus 로고
    • Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection
    • doi:10.1038/nm1728
    • van Grevenynghe, J, Procopio, F. A., He, Z., Chomont, N., Riou, C., Zhang, Y., et al. (2008). Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection. Nat. Med. 14, 266-274. doi:10.1038/nm1728
    • (2008) Nat. Med. , vol.14 , pp. 266-274
    • van Grevenynghe, J.1    Procopio, F.A.2    He, Z.3    Chomont, N.4    Riou, C.5    Zhang, Y.6
  • 86
    • 57349118383 scopus 로고    scopus 로고
    • Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor
    • doi:10.1038/nm.1779
    • Varela-Rohena, A., Molloy, P. E., Dunn, S. M., Li, Y., Suhoski, M. M., Carroll, R. G., et al. (2008). Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor. Nat. Med. 14, 1390-1395. doi:10.1038/nm.1779
    • (2008) Nat. Med. , vol.14 , pp. 1390-1395
    • Varela-Rohena, A.1    Molloy, P.E.2    Dunn, S.M.3    Li, Y.4    Suhoski, M.M.5    Carroll, R.G.6
  • 87
    • 77950210095 scopus 로고    scopus 로고
    • Specific phenotypic and functional features of natural killer cells from HIV-infected long-term nonprogressors and HIV controllers
    • doi:10.1097/QAI.0b013e3181d0c5b4
    • Vieillard, V., Fausther-Bovendo, H., Samri, A., and Debre, P. (2010). Specific phenotypic and functional features of natural killer cells from HIV-infected long-term nonprogressors and HIV controllers. J. Acquir. Immune Defic. Syndr. 53, 564-573. doi:10.1097/QAI.0b013e3181d0c5b4
    • (2010) J. Acquir. Immune Defic. Syndr. , vol.53 , pp. 564-573
    • Vieillard, V.1    Fausther-Bovendo, H.2    Samri, A.3    Debre, P.4
  • 88
    • 77649245149 scopus 로고    scopus 로고
    • HIV controller CD4+ T cells respond to minimal amounts of gag antigen due to high TCR avidity
    • doi:10.1371/journal.ppat.1000780
    • Vingert, B., Perez-Patrigeon, S., Jeannin, P., Lambotte, O., Boufassa, F., Lemaître, F., et al. (2010). HIV controller CD4+ T cells respond to minimal amounts of gag antigen due to high TCR avidity. PLoS Pathog. 6:e1000780. doi:10.1371/journal.ppat.1000780
    • (2010) PLoS Pathog , vol.6
    • Vingert, B.1    Perez-Patrigeon, S.2    Jeannin, P.3    Lambotte, O.4    Boufassa, F.5    Lemaître, F.6
  • 89
    • 80053987071 scopus 로고    scopus 로고
    • Moving ahead an HIV vaccine: use both arms to beat HIV
    • doi:10.1038/nm.2529
    • Walker, B. D., Ahmed, R., and Plotkin, S. (2011). Moving ahead an HIV vaccine: use both arms to beat HIV. Nat. Med. 17, 1194-1195. doi:10.1038/nm.2529
    • (2011) Nat. Med. , vol.17 , pp. 1194-1195
    • Walker, B.D.1    Ahmed, R.2    Plotkin, S.3
  • 90
    • 77952916199 scopus 로고    scopus 로고
    • Microbial translocation induces persistent macrophage activation unrelated to HIV-1 levels or T-cell activation following therapy
    • doi:10.1097/QAD.0b013e328339e228
    • Wallet, M. A., Rodriguez, C. A., Yin, L., Saporta, S., Chinratanapisit, S., Hou, W., et al. (2010). Microbial translocation induces persistent macrophage activation unrelated to HIV-1 levels or T-cell activation following therapy. AIDS 24, 1281-1290. doi:10.1097/QAD.0b013e328339e228
    • (2010) AIDS , vol.24 , pp. 1281-1290
    • Wallet, M.A.1    Rodriguez, C.A.2    Yin, L.3    Saporta, S.4    Chinratanapisit, S.5    Hou, W.6
  • 91
    • 80051882327 scopus 로고    scopus 로고
    • Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load
    • doi:10.1016/j.immuni.2011.05.017
    • West, E. E., Youngblood, B., Tan, W. G., Jin, H. T., Araki, K., Alexe, G., et al. (2011). Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load. Immunity 35, 285-298. doi:10.1016/j.immuni.2011.05.017
    • (2011) Immunity , vol.35 , pp. 285-298
    • West, E.E.1    Youngblood, B.2    Tan, W.G.3    Jin, H.T.4    Araki, K.5    Alexe, G.6


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