Elevations in D-dimer and C-reactive protein are associated with the development of osteonecrosis of the hip in HIV-infected adults

AIDS

Volumn 27, Issue 4, 2013, Pages 591-595

  Morse, Caryn G ^a   Dodd, Lori E ^b   Nghiem, Khanh ^a   Costello, Rene ^a   Csako, Gyorgy ^a   Lane, H Clifford ^b   Lozier, Jay N ^a   Kovacs, Joseph A ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

C reactive protein; D dimer; HIV; osteonecrosis

Indexed keywords

C REACTIVE PROTEIN; D DIMER;

ADULT; ARTICLE; BLOOD SAMPLING; BONE NECROSIS; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HIP OSTEONECROSIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ADULT; AGED; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CD4 LYMPHOCYTE COUNT; FEMALE; FEMUR HEAD NECROSIS; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HIV SEROPOSITIVITY; HUMANS; INCIDENCE; INFLAMMATION; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; RISK FACTORS; TREATMENT OUTCOME; VIRAL LOAD;

EID: 84873412156     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32835c206a     Document Type: Article

References (23)

1. Morse CG, Mican JM, Jones EC, Joe GO, Rick ME, Formentini E, et al. The incidence and natural history of osteonecrosis in HIV-infected adults. Clin Infect Dis 2007; 44:739-748.
2. Allison GT, Bostrom MP, Glesby MJ. Osteonecrosis in HIV disease: epidemiology, etiologies, and clinical management. AIDS 2003; 17:1-9.
3. Glesby MJ, Hoover DR, Vaamonde CM. Osteonecrosis in patients infected with human immunodeficiency virus: a case-control study. J Infect Dis 2001; 184:519-523.
4. Hasse B, Ledergerber B, Egger M, Flepp M, Bachmann S, Bernasconi E, et al. Antiretroviral treatment and osteonecrosis in patients of the Swiss HIV Cohort Study: a nested case-control study. AIDS Res Hum Retrovir 2004; 20:909- 915.
5. Martin K, Lawson-Ayayi S, Miremont-Salame G, Blaizeau MJ, Balestre E, Lacoste D, et al. Symptomatic bone disorders in HIV-infected patients: incidence in the Aquitaine cohort (1999-2002). HIV Med 2004; 5:421-426.
6. Miller KD, Masur H, Jones EC, Joe GO, Rick ME, Kelly GG, et al. High prevalence of osteonecrosis of the femoral head in HIV-infected adults. Ann Intern Med 2002; 137:17-25.
7. Glueck CJ, Freiberg RA, Fontaine RN, Tracy T, Wang P. Hypofibrinolysis, thrombophilia, osteonecrosis. Clin Orthop Relat Res 2001; 386:19-33.
8. Jones LC, Mont MA, Le TB, Petri M, Hungerford DS, Wang P, et al. Procoagulants and osteonecrosis. J Rheumatol 2003; 30:783-791.
9. Kuller LH, Tracy R, Belloso W, De Wit S, Drummond F, Lane HC, et al. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med 2008; 5:1496-1508.
10. Rodger AJ, Fox Z, Lundgren JD, Kuller LH, Boesecke C, Gey D, et al. Activation and coagulation biomarkers are independent predictors of the development of opportunistic disease in patients with HIV infection. J Infect Dis 2009; 200:973-983.
11. Reingold J, Wanke C, Kotler D, Lewis C, Tracy R, Heymsfield S, et al. Association of HIV infection and HIV/HCV coinfection with C-reactive protein levels: the fat redistribution and metabolic change in HIV infection (FRAM) study. J Acquir Immune Defic Syndr 2008; 48:142-148.
12. Boger MS, Shintani A, Redhage LA, Mitchell V, Haas DW, Morrow JD, et al. Highly sensitive C-reactive protein, body mass index, and serum lipids in HIV-infected persons receiving antiretroviral therapy: a longitudinal study. J Acquir Immune Defic Syndr 2009; 52:480-487.
13. Feldman JG, Goldwasser P, Holman S, DeHovitz J, Minkoff H. C-reactive protein is an independent predictor of mortality in women with HIV-1 infection. J Acquir Immune Defic Syndr 2003; 32:210-214.
14. Lau B, Sharrett AR, Kingsley LA, Post W, Palella FJ, Visscher B, et al. C-reactive protein is a marker for human immunodeficiency virus disease progression. Arch Intern Med 2006; 166:64-70.
15. Masia M, Bernal E, Padilla S, Graells ML, Jarrin I, Almenar MV, et al. The role of C-reactive protein as a marker for cardiovascular risk associated with antiretroviral therapy in HIVinfected patients. Atherosclerosis 2007; 195:167-171.
16. Samaras K, Gan SK, Peake PW, Carr A, Campbell LV. Proinflammatory markers, insulin sensitivity, and cardiometabolic risk factors in treated HIV infection. Obesity 2009; 17:53-59.
17. Nilsson IM, Krook H, Sternby NH, Soderberg E, Soderstrom N. Severe thrombotic disease in a young man with bone marrow and skeletal changes and with a high content of an inhibitor in the fibrinolytic system. Acta Med Scand 1961; 169:323-337.
18. Glueck CJ, Glueck HI, Mieczkowski L, Tracy T, Speirs J, Stroop D. Familial high plasminogen activator inhibitor with hypofibrinolysis, a new pathophysiologic cause of osteonecrosis? Thromb Haemost 1993; 69:460-465.
19. Cenni E, Fotia C, Rustemi E, Yuasa K, Caltavuturo G, Giunti A, et al. Idiopathic and secondary osteonecrosis of the femoral head show different thrombophilic changes and normal or higher levels of platelet growth factors. Acta Orthop 2011; 82:42-49.
20. Shitrit D, Rudensky B, Zimran A, Elstein D. D-dimer assay in Gaucher disease: correlation with severity of bone and lung involvement. Am J Hematol 2003; 73:236-239.
21. Shuai B, Shen L, Yang YP, Xie J, Shou ZX, Wei B. Low plasma adiponectin as a potential biomarker for osteonecrosis of the femoral head. J Rheumatol 2010; 37:2151-2155.
22. Sun W, Li ZR, Shi ZC, Zhang NF, Zhang YC. Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population. Int Orthop 2006; 30:143-146.
23. Porter BO, Shen J, Kovacs JA, Davey RT, Rehm C, Lozier J, et al. Interleukin-2 cycling causes transient increases in highsensitivity C-reactive protein and D-dimer that are not associated with plasma HIV-RNA levels. AIDS 2009; 23:2015-2019.