The role of IL-22 and Th22 cells in human skin diseases

Journal of Dermatological Science

Volumn 72, Issue 1, 2013, Pages 3-8

  Fujita, Hideki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Atopic dermatitis; Contact dermatitis; IL 22; Psoriasis; Scleroderma; Squamous cell carcinoma

Indexed keywords

ALPHA INTERFERON; CALGRANULIN A; CALGRANULIN B; CHEMOKINE RECEPTOR CCR10; CHEMOKINE RECEPTOR CCR4; COLLAGEN TYPE 1; CUTANEOUS T CELL ATTRACTING CHEMOKINE; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 22; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; PSORIASIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE;

ATOPIC DERMATITIS; CELL DIFFERENTIATION; CONTACT DERMATITIS; CUTANEOUS T CELL LYMPHOMA; CYTOKINE PRODUCTION; DISEASE COURSE; DISEASE SEVERITY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; IMMUNOPATHOGENESIS; IMMUNOREGULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PSORIASIS; REVIEW; SCLERODERMA; SQUAMOUS CELL CARCINOMA; T LYMPHOCYTE; TH17 CELL; TH22 CELL;

ATOPIC DERMATITIS; CONTACT DERMATITIS; IL-22; PSORIASIS; SCLERODERMA; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; DERMATITIS, ATOPIC; DERMATITIS, CONTACT; HUMANS; INTERLEUKINS; LYMPHOMA, T-CELL, CUTANEOUS; PSORIASIS; SCLERODERMA, LOCALIZED; SKIN DISEASES; SKIN NEOPLASMS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84883798482     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2013.04.028     Document Type: Review

References (61)

1. Sonnenberg G.F., Fouser L.A., Artis D. Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nat Immunol 2011, 12:383-390.
2. Sonnenberg G.F., Fouser L.A., Artis D. Functional biology of the IL-22-IL-22R pathway in regulating immunity and inflammation at barrier surfaces. Adv Immunol 2010, 107:1-29.
3. Zenewicz L.A., Flavell R.A. Recent advances in IL-22 biology. Int Immunol 2011, 23:159-163.
4. Souwer Y., Szegedi K., Kapsenberg M.L., de Jong E.C. IL-17 and IL-22 in atopic allergic disease. Curr Opin Immunol 2010, 22:821-826.
5. Rutz S., Ouyang W. Regulation of interleukin-10 and interleukin-22 expression in T helper cells. Curr Opin Immunol 2011, 23:605-612.
6. Boniface K., Bernard F.X., Garcia M., Gurney A.L., Lecron J.C., Morel F. IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes. J Immunol 2005, 174:3695-3702.
7. Nograles K.E., Zaba L.C., Guttman-Yassky E., Fuentes-Duculan J., Suarez-Farinas M., Cardinale I., et al. Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways. Br J Dermatol 2008, 159:1092-1102.
8. Duhen T., Geiger R., Jarrossay D., Lanzavecchia A., Sallusto F. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat Immunol 2009, 10:857-863.
9. Trifari S., Kaplan C.D., Tran E.H., Crellin N.K., Spits H. Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells. Nat Immunol 2009, 10:864-871.
10. Ramirez J.M., Brembilla N.C., Sorg O., Chicheportiche R., Matthes T., Dayer J.M., et al. Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells. Eur J Immunol 2010, 40:2450-2459.
11. Eyerich S., Eyerich K., Pennino D., Carbone T., Nasorri F., Pallotta S., et al. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest 2009, 119:3573-3585.
12. Res P.C., Piskin G., de Boer O.J., van der Loos C.M., Teeling P., Bos J.D., et al. Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis. PloS ONE 2010, 5:e14108.
13. + T cells lacking IL-17 production. Proc Natl Acad Sci U S A 2009, 106:21795-21800.
14. de Jong A., Pena-Cruz V., Cheng T.Y., Clark R.A., Van Rhijn I., Moody D.B. CD1a-autoreactive T cells are a normal component of the human alphabeta T cell repertoire. Nat Immunol 2010, 11:1102-1109.
15. Boniface K., Guignouard E., Pedretti N., Garcia M., Delwail A., Bernard F.X., et al. A role for T cell-derived interleukin 22 in psoriatic skin inflammation. Clin Exp Immunol 2007, 150:407-415.
16. Wolk K., Kunz S., Witte E., Friedrich M., Asadullah K., Sabat R. IL-22 increases the innate immunity of tissues. Immunity 2004, 21:241-254.
17. Wolk K., Witte E., Wallace E., Docke W.D., Kunz S., Asadullah K., et al. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol 2006, 36:1309-1323.
18. Caproni M., Antiga E., Melani L., Volpi W., Del Bianco E., Fabbri P. Serum levels of IL-17 and IL-22 are reduced by etanercept, but not by acitretin, in patients with psoriasis: a randomized-controlled trial. J Clin Immunol 2009, 29:210-214.
19. Kagami S., Rizzo H.L., Lee J.J., Koguchi Y., Blauvelt A. Circulating Th17, Th22, and Th1 cells are increased in psoriasis. J Invest Dermatol 2010, 130:1373-1383.
20. Nograles K.E., Zaba L.C., Shemer A., Fuentes-Duculan J., Cardinale I., Kikuchi T., et al. IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells. J Allergy Clin Immunol 2009, 123:1244-1252.
21. Ferran M., Galvan A.B., Rincon C., Romeu E.R., Sacrista M., Barboza E., et al. Streptococcus induces circulating CLA(+) memory T-cell-dependent epidermal cell activation in psoriasis. J Invest Dermatol 2013, 133:999-1007.
22. Sa S.M., Valdez P.A., Wu J., Jung K., Zhong F., Hall L., et al. The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J Immunol 2007, 178:2229-2240.
23. Wolk K., Haugen H.S., Xu W., Witte E., Waggie K., Anderson M., et al. IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not. J Mol Med (Berl) 2009, 87:523-536.
24. Broome A.M., Ryan D., Eckert R.L. S100 protein subcellular localization during epidermal differentiation and psoriasis. J Histochem Cytochem 2003, 51:675-685.
25. Guilloteau K., Paris I., Pedretti N., Boniface K., Juchaux F., Huguier V., et al. Skin inflammation induced by the synergistic action of IL-17A, IL-22, oncostatin M, IL-1 apha and TNF-alpha recapitulates some features of psoriasis. J Immunol 2010, 184:5263-5270.
26. Guttman-Yassky E., Nograles K.E., Krueger J.G. Contrasting pathogenesis of atopic dermatitis and psoriasis - Part II. Immune cell subsets and therapeutic concepts. J Allergy Clin Immunol 2011, 127:1420-1432.
27. Harper E.G., Guo C., Rizzo H., Lillis J.V., Kurtz S.E., Skorcheva I., et al. Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis. J Invest Dermatol 2009, 129:2175-2183.
28. Tohyama M., Hanakawa Y., Shirakata Y., Dai X., Yang L., Hirakawa S., et al. IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression. Eur J Immunol 2009, 39:2779-2788.
29. Tohyama M., Yang L., Hanakawa Y., Dai X., Shirakata Y., Sayama K. IFN-alpha enhances IL-22 receptor expression in keratinocytes: a possible role in the development of psoriasis. J Invest Dermatol 2012, 132:1933-1935.
30. Guttman-Yassky E., Lowes M.A., Fuentes-Duculan J., Zaba L.C., Cardinale I., Nograles K.E., et al. Low expression of the IL-23/Th17 pathway in atopic dermatitis compared to psoriasis. J Immunol 2008, 181:7420-7427.
31. Koga C., Kabashima K., Shiraishi N., Kobayashi M., Tokura Y. Possible pathogenic role of Th17 cells for atopic dermatitis. J Invest Dermatol 2008, 128:2625-2630.
32. Szegedi K., Kremer A.E., Kezic S., Teunissen M.B., Bos J.D., Luiten R.M., et al. Increased frequencies of IL-31-producing T cells are found in chronic atopic dermatitis skin. Exp Dermatol 2012, 21:431-436.
33. Gittler J.K., Shemer A., Suarez-Farinas M., Fuentes-Duculan J., Gulewicz K.J., Wang C.Q., et al. Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis. J Allergy Clin Immunol 2012, 130:1344-1354.
34. Hayashida S., Uchi H., Takeuchi S., Esaki H., Moroi Y., Furue M. Significant correlation of serum IL-22 levels with CCL17 levels in atopic dermatitis. J Dermatol Sci 2011, 61:78-79.
35. Kanda N., Watanabe S. Increased serum human beta-defensin-2 levels in atopic dermatitis: relationship to IL-22 and oncostatin M. Immunobiology 2012, 217:436-445.
36. Kakinuma T., Nakamura K., Wakugawa M., Mitsui H., Tada Y., Saeki H., et al. Thymus and activation-regulated chemokine in atopic dermatitis: serum thymus and activation-regulated chemokine level is closely related with disease activity. J Allergy Clin Immunol 2001, 107:535-541.
37. Homey B., Alenius H., Muller A., Soto H., Bowman E.P., Yuan W., et al. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat Med 2002, 8:157-165.
38. Kakinuma T., Saeki H., Tsunemi Y., Fujita H., Asano N., Mitsui H., et al. Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris. J Allergy Clin Immunol 2003, 111:592-597.
39. Dubrac S., Schmuth M., Ebner S. Atopic dermatitis: the role of Langerhans cells in disease pathogenesis. Immunol Cell Biol 2010, 88:400-409.
40. Klechevsky E., Morita R., Liu M., Cao Y., Coquery S., Thompson-Snipes L., et al. Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells. Immunity 2008, 29:497-510.
41. Chorro L., Sarde A., Li M., Woollard K.J., Chambon P., Malissen B., et al. Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network. J Exp Med 2009, 206:3089-3100.
42. Fujita H., Shemer A., Suarez-Farinas M., Johnson-Huang L.M., Tintle S., Cardinale I., et al. Lesional dendritic cells in patients with chronic atopic dermatitis and psoriasis exhibit parallel ability to activate T-cell subsets. J Allergy Clin Immunol 2011, 128:574-582.
43. Gutowska-Owsiak D., Schaupp A.L., Salimi M., Taylor S., Ogg G.S. Interleukin-22 downregulates filaggrin expression and affects expression of profilaggrin processing enzymes. Br J Dermatol 2011, 165:492-498.
44. Tintle S., Shemer A., Suarez-Farinas M., Fujita H., Gilleaudeau P., Sullivan-Whalen M., et al. Reversal of atopic dermatitis with narrow-band UVB phototherapy and biomarkers for therapeutic response. J Allergy Clin Immunol 2011, 128:583-593.
45. Niebuhr M., Scharonow H., Gathmann M., Mamerow D., Werfel T. Staphylococcal exotoxins are strong inducers of IL-22: a potential role in atopic dermatitis. J Allergy Clin Immunol 2010, 126:1176-1183.
46. Harder J., Dressel S., Wittersheim M., Cordes J., Meyer-Hoffert U., Mrowietz U., et al. Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury. J Invest Dermatol 2010, 130:1355-1364.
47. Kanda N., Kamata M., Tada Y., Ishikawa T., Sato S., Watanabe S. Human beta-defensin-2 enhances IFN-gamma and IL-10 production and suppresses IL-17 production in T cells. J Leukoc Biol 2011, 89:935-944.
48. Albanesi C., Fairchild H.R., Madonna S., Scarponi C., De Pita O., Leung D.Y., et al. IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3. J Immunol 2007, 179:984-992.
49. Larsen J.M., Bonefeld C.M., Poulsen S.S., Geisler C., Skov L. IL-23 and T(H)17-mediated inflammation in human allergic contact dermatitis. J Allergy Clin Immunol 2009, 123:486-492.
50. Ricciardi L., Minciullo P.L., Saitta S., Trombetta D., Saija A., Gangemi S. Increased serum levels of IL-22 in patients with nickel contact dermatitis. Contact Dermatitis 2009, 60:57-58.
51. Truchetet M.E., Brembilla N.C., Montanari E., Allanore Y., Chizzolini C. Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease. Arthritis Res Ther 2011, 13. R166.
52. Mathian A., Parizot C., Dorgham K., Trad S., Arnaud L., Larsen M., et al. Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions. Ann Rheum Dis 2012, 71:1227-1234.
53. Aden N., Nuttall A., Shiwen X., de Winter P., Leask A., Black C.M., et al. Epithelial cells promote fibroblast activation via IL-1alpha in systemic sclerosis. J Invest Dermatol 2010, 130:2191-2200.
54. Kim H.J., Cho D.H., Lee K.J., Cho C.S., Bang S.I., Cho B.K., et al. LL-37 suppresses sodium nitroprusside-induced apoptosis of systemic sclerosis dermal fibroblasts. Exp Dermatol 2011, 20:843-845.
55. McGee H.M., Schmidt B.A., Booth C.J., Yancopoulos G.D., Valenzuela D.M., Murphy A.J., et al. IL-22 promotes fibroblast-mediated wound repair in the skin. J Invest Dermatol 2013, 133:1321-1329.
56. Braun R.K., Martin A., Shah S., Iwashima M., Medina M., Byrne K., et al. Inhibition of bleomycin-induced pulmonary fibrosis through pre-treatment with collagen type V. J Heart Lung Transplant 2010, 29:873-880.
57. Kurzinski K., Torok K.S. Cytokine profiles in localized scleroderma and relationship to clinical features. Cytokine 2011, 55:157-164.
58. Furuzawa-Carballeda J., Ortiz-Avalos M., Lima G., Jurado-Santa Cruz F., Llorente L. Subcutaneous administration of polymerized type I collagen downregulates interleukin (IL)-17A, IL-22 and transforming growth factor-beta1 expression, and increases Foxp3-expressing cells in localized scleroderma. Clin Exp Dermatol 2012, 37:599-609.
59. Miyagaki T., Sugaya M., Suga H., Kamata M., Ohmatsu H., Fujita H., et al. IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma. Clin Cancer Res 2011, 17:7529-7538.
60. Shimauchi T., Sasada K., Kito Y., Mori T., Hata M., Fujiyama T., et al. CD8(+) Sezary syndrome with IL-22 production modulated by bacterial sepsis. Br J Dermatol 2013, 168:881-883.
61. Zhang S., Fujita H., Mitsui H., Fuentes-Duculan J., Yanofsky V.R., Pettersen J.S., et al. Increased Tc22 and Treg/CD8 ratio contribute to aggressive growth of transplant associated squamous cell carcinoma. PloS ONE 2013, 8:e62154.