Tiron, a ROS scavenger, protects human lung cancer Calu-6 cells against antimycin A-induced cell death

Oncology Reports

Volumn 21, Issue 1, 2009, Pages 253-261

  Han, Yong Hwan ^a   Park, Woo Hyun ^a  

^a Chonbuk National University   (South Korea)

Author keywords

Antimycin A; Apoptosis; Calu 6; Cell cycle; Mitochondria; Reactive oxygen species

Indexed keywords

ANTIMYCIN A1; CATALASE; GLUTATHIONE; REACTIVE OXYGEN METABOLITE; SCAVENGER; SUPEROXIDE DISMUTASE; TIRON; CITRININ; DRUG DERIVATIVE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; UPREGULATION; DRUG EFFECT; LUNG TUMOR; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

1,2-DIHYDROXYBENZENE-3,5-DISULFONIC ACID DISODIUM SALT; ANTIMYCIN A; APOPTOSIS; CATALASE; CELL LINE, TUMOR; FREE RADICAL SCAVENGERS; GLUTATHIONE; HUMANS; LUNG NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

EID: 61449282229     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000216     Document Type: Article

References (42)

1. Zorov DB, Juhaszova M and Sollott SJ: Mitochondrial ROS-induced ROS release: An update and review. Biochim Biophys Acta 1757: 509-517, 2006.
2. Simon HU, Haj-Yehia A and Levi-Schaffer F: Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5: 415-418, 2000.
3. Gonzalez C, Sanz-Alfayate G, Agapito MT, Gomez-Nino A, Rocher A and Obeso A: Significance of ROS in oxygen sensing in cell systems with sensitivity to physiological hypoxia. Respir Physiol Neurobiol 132: 17-41, 2002.
4. Wilcox CS: Reactive oxygen species: roles in blood pressure and kidney function. Curr Hypertens Rep 4: 160-166, 2002.
5. Poot M, Teubert H, Rabinovitch PS and Kavanagh TJ: De novo synthesis of glutathione is required for both entry into and progression through the cell cycle. J Cell Physiol 163: 555-560, 1995.
6. Schnelldorfer T, Gansauge S, Gansauge F, Schlosser S, Beger HG and Nussler AK: Glutathione depletion causes cell growth inhibition and enhanced apoptosis in pancreatic cancer cells. Cancer 89: 1440-1447, 2000.
7. Lauterburg BH: Analgesics and glutathione. Am J Ther 9: 225-233, 2002.
8. Chen TJ, Jeng JY, Lin CW, Wu CY and Chen YC: Quercetin inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cells. Toxicology 223: 113-126, 2006.
9. Dasmahapatra G, Rahmani M, Dent P and Grant S: The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism. Blood 107: 232-240, 2006.
10. Wallach-Dayan SB, Izbicki G, Cohen PY, Gerstl-Golan R, Fine A and Breuer R: Bleomycin initiates apoptosis of lung epithelial cells by ROS but not by Fas/FasL pathway. Am J Physiol Lung Cell Mol Physiol 290: L790-L796, 2006.
11. Shim HY, Park JH, Paik HD, Nah SY, Kim DS and Han YS: Acacetin-induced apoptosis of human breast cancer MCF-7 cells involves caspase cascade, mitochondria-mediated death signaling and SAPK/JNK1/2-c-Jun activation. Mol Cells 24: 95-104, 2007.
12. Nakayama K, Okamoto F and Harada Y: Antimycin A: isolation from a new Streptomyces and activity against rice plant blast fungi. J Antibiot 9: 63-66, 1956.
13. Campo ML, Kinnally KW and Tedeschi H: The effect of antimycin A on mouse liver inner mitochondrial membrane channel activity. J Biol Chem 267: 8123-8127, 1992.
14. Maguire JJ, Kagan VE and Packer L: Electron transport between cytochrome c and alpha tocopherol. Biochem Biophys Res Commun 188: 190-197, 1992.
15. Pham NA, Robinson BH and Hedley DW: Simultaneous detection of mitochondrial respiratory chain activity and reactive oxygen in digitonin-permeabilized cells using flow cytometry. Cytometry 41: 245-251, 2000.
16. Alexandre A and Lehninger AL: Bypasses of the antimycin a block of mitochondrial electron transport in relation to ubisemiquinone function. Biochim Biophys Acta 767: 120-129, 1984.
17. Balaban RS, Nemoto S and Finkel T: Mitochondria, oxidants, and aging. Cell 120: 483-495, 2005.
18. Panduri V, Weitzman SA, Chandel NS and Kamp DW: Mitochondrial-derived free radicals mediate asbestos-induced alveolar epithelial cell apoptosis. Am J Physiol Lung Cell Mol Physiol 286: L1220-L1227, 2004.
19. Petronilli V, Penzo D, Scorrano L, Bernardi P and Di Lisa F: The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ. J Biol Chem 276: 12030-12034, 2001.
20. Costantini P, Chernyak BV, Petronilli V and Bernardi P: Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites. J Biol Chem 271: 6746-6751, 1996.
21. Pastorino JG, Tafani M, Rothman RJ, Marcinkeviciute A, Hoek JB and Farber JL: Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore. J Biol Chem 274: 31734-31739, 1999.
22. 2 are an important factor maintaining mitochondria membrane potential of antimycin A-treated As4. 1 juxtaglomerular cells. Biochem Pharmacol 73: 863-872, 2007.
23. King MA: Antimycin A-induced killing of HL-60 cells: apoptosis initiated from within mitochondria does not necessarily proceed via caspase 9. Cytometry A 63: 69-76, 2005.
24. Wolvetang EJ, Johnson KL, Krauer K, Ralph SJ and Linnane AW: Mitochondrial respiratory chain inhibitors induce apoptosis. FEBS Lett 339: 40-44, 1994.
25. Kaushal GP, Ueda N and Shah SV: Role of caspases (ICE/CED 3 proteases) in DNA damage and cell death in response to a mitochondrial inhibitor, antimycin A. Kidney Int 52: 438-445, 1997.
26. de Graaf AO, Meijerink JP, van den Heuvel LP, et al: Bcl-2 protects against apoptosis induced by antimycin A and bongkrekic acid without restoring cellular ATP levels. Biochim Biophys Acta 1554: 57-65, 2002.
27. Park WH, Han YW, Kim SW, Kim SH, Cho KW and Kim SZ: Antimycin A induces apoptosis in As4. 1 juxtaglomerular cells. Cancer Lett 251: 68-77, 2007.
28. Petty RD, Nicolson MC, Kerr KM, Collie-Duguid E and Murray GI: Gene expression profiling in non-small cell lung cancer: from molecular mechanisms to clinical application. Clin Cancer Res 10: 3237-3248, 2004.
29. Park WH, Seol JG, Kim ES, et al: Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis. Cancer Res 60: 3065-3071, 2000.
30. Macho A, Hirsch T, Marzo I, et al: Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis. J Immunol 158: 4612-4619, 1997.
31. Hedley DW and Chow S: Evaluation of methods for measuring cellular glutathione content using flow cytometry. Cytometry 15: 349-358, 1994.
32. Park WH, Jung CW, Park JO, et al: Trichostatin inhibits the growth of ACHN renal cell carcinoma cells via cell cycle arrest in association with p27, or apoptosis. Int J Oncol 22: 1129-1134, 2003.
33. Yamada J, Yoshimura S, Yamakawa H, et al: Cell permeable ROS scavengers, tiron and tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenation. Neurosci Res 45: 1-8, 2003.
34. Mitchell JB, Samuni A, Krishna MC, et al: Biologically active metal-independent superoxide dismutase mimics. Biochemistry 29: 2802-2807, 1990.
35. Ledenev AN, Konstantinov AA, Popova E and Ruuge EK: A simple assay of the superoxide generation rate with Tiron as an EPR-visible radical scavenger. Biochem Int 13: 391-396, 1986.
36. Tikhaze AK, Lankin VZ, Zharova EA and Kolycheva SV: Trimetazidine as indirect antioxidant. Bull Exp Biol Med 130: 951-953, 2000.
37. Stanley WC and Marzilli M: Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine. Fundam Clin Pharmacol 17: 133-145, 2003.
38. Chen HM, Ma HH and Yan XJ: Inhibitory effect of agarohexaose on antimycin A induced generation of reactive oxygen species. Yao Xue Xue Bao 40: 903-907, 2005.
39. Chen HM and Yan XJ: Antioxidant activities of agaro-oligosaccharides with different degrees of polymerization in cell-based system. Biochim Biophys Acta 1722: 103-111, 2005.
40. Li C, Wright MM and Jackson RM: Reactive species mediated injury of human lung epithelial cells after hypoxia-reoxygenation. Exp Lung Res 28: 373-389, 2002.
41. Estrela JM, Ortega A and Obrador E: Glutathione in cancer biology and therapy. Crit Rev Clin Lab Sci 43: 143-181, 2006.
42. Higuchi Y: Glutathione depletion-induced chromosomal DNA fragmentation associated with apoptosis and necrosis. J Cell Mol Med 8: 455-464, 2004.