Hepcidin is correlated to soluble hemojuvelin but not to increased GDF15 during pregnancy

Blood Cells, Molecules, and Diseases

Volumn 48, Issue 4, 2012, Pages 233-237

  Finkenstedt, A ^a   Widschwendter, A ^a   Brasse Lagnel, C G ^b   Theurl, I ^a   Hubalek, M ^a   Dieplinger, H ^a   Tselepis, C ^c   Ward, D G ^c   Vogel, W ^a   Zoller, H ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b HÔpital Universitaire de Rouen Rouen   (France)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Eclampsia; Erythroid regulator; Erythropoietin; Gestation; Iron homeostasis

Indexed keywords

ERYTHROPOIETIN; FERRITIN; GROWTH DIFFERENTIATION FACTOR 15; HEMOGLOBIN; HEMOJUVELIN; HEPCIDIN; IRON; TRANSFERRIN;

ADOLESCENT; ADULT; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HEMOGLOBIN BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; IRON BLOOD LEVEL; IRON METABOLISM; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; NORMAL HUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; ANTIMICROBIAL CATIONIC PEPTIDES; FEMALE; FERRITINS; GPI-LINKED PROTEINS; GROWTH DIFFERENTIATION FACTOR 15; HUMANS; IRON; PREGNANCY; TIME FACTORS; YOUNG ADULT;

ANIMALIA;

EID: 84858796078     PISSN: 10799796     EISSN: 10960961     Source Type: Journal    
DOI: 10.1016/j.bcmd.2012.02.001     Document Type: Article

References (21)

1. Barrett J.F., Whittaker P.G., Williams J.G., Lind T. Absorption of non-haem iron from food during normal pregnancy. BMJ 1994, 309:79-82.
2. Millard K.N., Frazer D.M., Wilkins S.J., Anderson G.J. Changes in the expression of intestinal iron transport and hepatic regulatory molecules explain the enhanced iron absorption associated with pregnancy in the rat. Gut 2004, 53:655-660.
3. Brasse-Lagnel C., Karim Z., Letteron P. Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation. Gastroenterology 2011, 140:1261-1271. e1.
4. Nemeth E., Tuttle M.S., Powelson J., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004, 306:2090-2093.
5. Camaschella C., Silvestri L. New and old players in the hepcidin pathway. Haematologica 2008, 93:1441-1444.
6. Silvestri L., Pagani A., Camaschella C. Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis. Blood 2008, 111:924-931.
7. Silvestri L., Pagani A., Nai A., et al. The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab. 2008, 8:502-511.
8. Nili M., Shinde U., Rotwein P. Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression. J. Biol. Chem. 2010, 285:24783-24792.
9. Moore A.G., Brown D.A., Fairlie W.D., et al. The transforming growth factor-ss superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women. J. Clin. Endocrinol. Metab. 2000, 85:4781-4788.
10. Tong S., Marjono B., Brown D.A., et al. Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage. Lancet 2004, 363:129-130.
11. Tamary H., Shalev H., Perez-Avraham G., et al. Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I. Blood 2008, 112:5241-5244.
12. Tanno T., Bhanu N.V., Oneal P.A., et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat. Med. 2007, 13:1096-1101.
13. Ward D.G., Roberts K., Stonelake P., et al. SELDI-TOF-MS determination of hepcidin in clinical samples using stable isotope labelled hepcidin as an internal standard. Proteome Sci. 2008, 6:28.
14. Brasse-Lagnel C., Poli M., Lesueur C. Immunoassay for human serum hemojuvelin. Haematologica 2010, 95:2031-2037.
15. Finkenstedt A., Bianchi P., Theurl I., et al. Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency. Br. J. Haematol. 2009, 144:789-793.
16. McMullin M.F., White R., Lappin T., Reeves J., MacKenzie G. Haemoglobin during pregnancy: relationship to erythropoietin and haematinic status. Eur. J. Haematol. 2003, 71:44-50.
17. Milman N., Graudal N., Nielsen O.J., Agger A.O. Serum erythropoietin during normal pregnancy: relationship to hemoglobin and iron status markers and impact of iron supplementation in a longitudinal, placebo-controlled study on 118 women. Int. J. Hematol. 1997, 66:159-168.
18. Finch C. Regulators of iron balance in humans. Blood 1994, 84:1697-1702.
19. Sugulle M., Dechend R., Herse F., et al. Circulating and placental growth-differentiation factor 15 in preeclampsia and in pregnancy complicated by diabetes mellitus. Hypertension 2009, 54:106-112.
20. Lakhal S., Schodel J., Townsend A.R., et al. Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis. J. Biol. Chem. 2011, 286:4090-4097.
21. Rodesch F., Simon P., Donner C., Jauniaux E. Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy. Obstet. Gynecol. 1992, 80:283-285.