A novel p38 mitogen-activated protein kinase/Elk-1 transcription factor-dependent molecular mechanism underlying abnormal endothelial cell proliferation in plexogenic pulmonary arterial hypertension

Journal of Biological Chemistry

Volumn 288, Issue 36, 2013, Pages 25701-25716

  Patel, Monal ^a   Predescu, Dan ^a   Tandon, Rajive ^a   Bardita, Cristina ^a   Pogoriler, Jennifer ^b   Bhorade, Sangeeta ^b   Wang, Minhua ^a   Comhair, Suzy ^c   Ryan Hemnes, Anna ^d   Chen, Jiwang ^e   Machado, Roberto ^e   Husain, Aliya ^b   Erzurum, Serpil ^c   Predescu, Sanda ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d VANDERBILT UNIVERSITY   (United States)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANZYME B; MOLECULAR MECHANISM; P38 MITOGEN-ACTIVATED PROTEIN KINASE; P38MAPK; PULMONARY ARTERIAL HYPERTENSION;

CELL PROLIFERATION; TRANSCRIPTION FACTORS;

ENDOTHELIAL CELLS;

GRANZYME B; INTERSECTIN; INTERSECTIN 1S; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; RAS PROTEIN; TRANSCRIPTION FACTOR ELK 1; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREACTIVITY; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PULMONARY HYPERTENSION;

ENDOTHELIUM; P38 MAPK; PROLIFERATION; PULMONARY HYPERTENSION; VASCULAR BIOLOGY;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CELL LINE; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; ETS-DOMAIN PROTEIN ELK-1; GRANZYMES; HUMANS; HYPERTENSION, PULMONARY; LUNG; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS;

EID: 84883671146     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.502674     Document Type: Article

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