T lymphocyte subset abnormalities in the blood and lung in pulmonary arterial hypertension

Respiratory Medicine

Volumn 104, Issue 3, 2010, Pages 454-462

  Austin, E D ^a   Rock, M T ^b   Mosse, C A ^b   Vnencak Jones, C L ^b   Yoder, S M ^b   Robbins, I M ^b   Loyd, J E ^b   Meyrick, B O ^b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR7;

ADULT; ARTICLE; CD3+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IDIOPATHIC DISEASE; IMMUNE DYSREGULATION; IMMUNOCOMPETENT CELL; IMMUNOCYTOCHEMISTRY; IMMUNOPATHOGENESIS; IMMUNOPHENOTYPING; LUNG; LUNG PARENCHYMA; MALE; MEMORY CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; REGULATORY T LYMPHOCYTE; SYSTEMIC CIRCULATION; T LYMPHOCYTE SUBPOPULATION;

ADULT; FEMALE; FLOW CYTOMETRY; HUMANS; HYPERTENSION, PULMONARY; IMMUNOLOGIC MEMORY; LUNG; MALE; MIDDLE AGED; T-LYMPHOCYTE SUBSETS;

EID: 76649142387     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2009.10.004     Document Type: Article

References (44)

1. Simonneau G., Galie N., Rubin L.J., Langleben D., Seeger W., Domenighetti G., et al. Clinical classification of pulmonary hypertension. J Am Coll Cardiol 43 12 Suppl S (2004) 5S-12S
2. Tuder R.M., Groves B., Badesch D.B., and Voelkel N.F. Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am J Pathol 144 2 (1994) 275-285
3. Steen V.D., Lucas M., Fertig N., and Medsger Jr. T.A. Pulmonary arterial hypertension and severe pulmonary fibrosis in systemic sclerosis patients with a nucleolar antibody. J Rheumatol 34 11 (2007) 2230-2235
4. Humbert M., Monti G., Brenot F., Sitbon O., Portier A., Grangeot-Keros L., et al. Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension. Am J Respir Crit Care Med 151 5 (1995) 1628-1631
5. Otterdal K., Andreassen A.K., Yndestad A., Oie E., Sandberg W.J., Dahl C.P., et al. Raised LIGHT levels in pulmonary arterial hypertension: potential role in thrombus formation. Am J Respir Crit Care Med 177 2 (2008) 202-207
6. Tamby M.C., Chanseaud Y., Humbert M., Fermanian J., Guilpain P., Garcia-de-la-Pena-Lefebvre P., et al. Anti-endothelial cell antibodies in idiopathic and systemic sclerosis associated pulmonary arterial hypertension. Thorax 60 9 (2005) 765-772
7. Tamby M.C., Humbert M., Guilpain P., Servettaz A., Dupin N., Christner J.J., et al. Antibodies to fibroblasts in idiopathic and scleroderma-associated pulmonary hypertension. Eur Respir J 28 4 (2006) 799-807
8. Barst R.J., and Loyd J.E. Genetics and immunogenetic aspects of primary pulmonary hypertension. Chest 114 3 Suppl (1998) 231S-236S
9. Nicolls M.R., Taraseviciene-Stewart L., Rai P.R., Badesch D.B., and Voelkel N.F. Autoimmunity and pulmonary hypertension: a perspective. Eur Respir J 26 6 (2005) 1110-1118
10. Mouthon L., Guillevin L., and Humbert M. Pulmonary arterial hypertension: an autoimmune disease?. Eur Respir J 26 6 (2005) 986-988
11. Taraseviciene-Stewart L., Nicolls M.R., Kraskauskas D., Scerbavicius R., Burns N., Cool C., et al. Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling. Am J Respir Crit Care Med 175 12 (2007) 1280-1289
12. Ulrich S., Nicolls M.R., Taraseviciene L., Speich R., and Voelkel N. Increased regulatory and decreased CD8+ cytotoxic T cells in the blood of patients with idiopathic pulmonary arterial hypertension. Respiration 75 3 (2008) 272-280
13. Cogan J.D., Pauciulo M.W., Batchman A.P., Prince M.A., Robbins I.M., Hedges L.K., et al. High Frequency of BMPR2 exonic deletions/duplications in familial pulmonary arterial hypertension. Am J Respir Crit Care Med 174 5 (2006) 590-598
14. Sztrymf B., Yaici A., Girerd B., and Humbert M. Genes and pulmonary arterial hypertension. Respiration 74 2 (2007) 123-132
15. Valeri C.R., and Pivacek L.E. Effects of the temperature, the duration of frozen storage, and the freezing container on in vitro measurements in human peripheral blood mononuclear cells. Transfusion 36 4 (1996) 303-308
16. Axelsson S., Faresjo M., Hedman M., Ludvigsson J., and Casas R. Cryopreserved peripheral blood mononuclear cells are suitable for the assessment of immunological markers in type 1 diabetic children. Cryobiology 57 3 (2008 Dec) 201-208
17. Perfetto S.P., Chattopadhyay P.K., Lamoreaux L., Nguyen R., Ambrozak D., Koup R.A., et al. Amine reactive dyes: an effective tool to discriminate live and dead cells in polychromatic flow cytometry. J Immunol Methods 313 1-2 (2006) 199-208
18. Rock M.T., Yoder S.M., Wright P.F., Talbot T.R., Edwards K.M., and Crowe Jr. J.E. Differential regulation of granzyme and perforin in effector and memory T cells following smallpox immunization. J Immunol 174 6 (2005) 3757-3764
19. Ebert L.M., Schaerli P., and Moser B. Chemokine-mediated control of T cell traffic in lymphoid and peripheral tissues. Mol Immunol 42 7 (2005) 799-809
20. Romero P., Zippelius A., Kurth I., Pittet M.J., Touvrey C., Iancu E.M., et al. Four functionally distinct populations of human effector-memory CD8+ T lymphocytes. J Immunol 178 7 (2007) 4112-4119
21. Lewis M., Tarlton J.F., and Cose S. Memory versus naive T-cell migration. Immunol Cell Biol 86 3 (2008) 226-231
22. Sakaguchi S., Ono M., Setoguchi R., Yagi H., Hori S., Fehervari Z., et al. Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 212 (2006) 8-27
23. Brusko T.M., Putnam A.L., and Bluestone J.A. Human regulatory T cells: role in autoimmune disease and therapeutic opportunities. Immunol Rev 223 (2008) 371-390
24. Lesprit P., Godeau B., Authier F.J., Soubrier M., Zuber M., Larroche C., et al. Pulmonary hypertension in POEMS syndrome: a new feature mediated by cytokines. Am J Respir Crit Care Med 157 3 Pt 1 (1998) 907-911
25. Jouve P., Humbert M., Chauveheid M.P., Jais X., and Papo T. POEMS syndrome-related pulmonary hypertension is steroid-responsive. Respir Med 101 2 (2007) 353-355
26. Dorfmuller P., Perros F., Balabanian K., and Humbert M. Inflammation in pulmonary arterial hypertension. Eur Respir J 22 2 (2003) 358-363
27. Fearon D.T., Manders P., and Wagner S.D. Arrested differentiation, the self-renewing memory lymphocyte, and vaccination. Science 293 5528 (2001) 248-250
28. Perros F., Cohen-Kaminsky S., and Humbert M. Understanding the role of CD4+ CD25(high) (so-called regulatory) T cells in idiopathic pulmonary arterial hypertension. Respiration 75 3 (2008) 253-256
29. Guyot-Revol V., Innes J.A., Hackforth S., Hinks T., and Lalvani A. Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis. Am J Respir Crit Care Med 173 7 (2006) 803-810
30. Miyara M., Amoura Z., Parizot C., Badoual C., Dorgham K., Trad S., et al. The immune paradox of sarcoidosis and regulatory T cells. J Exp Med 203 2 (2006) 359-370
31. Luttmann W., Herzog V., Matthys H., Thierauch K.H., Virchow J.C., and Kroegel C. Modulation of cytokine release from mononuclear cells by prostacyclin, IL-4 and IL-13. Cytokine 11 2 (1999 Feb) 127-133
32. Luttmann W., Herzog V., Virchow Jr. J.C., Matthys H., Thierauch K.H., and Kroegel C. Prostacyclin modulates granulocyte/macrophage colony-stimulating factor release by human blood mononuclear cells. Pulm Pharmacol 9 1 (1996) 43-48
33. Zhou W., Blackwell T.S., Goleniewska K., O'Neal J.F., Fitzgerald G.A., Lucitt M., et al. Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells. J Leukoc Biol 81 3 (2007) 809-817
34. Zhou W., Hashimoto K., Goleniewska K., O'Neal J.F., Ji S., Blackwell T.S., et al. Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. J Immunol 178 2 (2007) 702-710
35. Bonnet S., Rochefort G., Sutendra G., Archer S.L., Haromy A., Webster L., et al. The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. Proc Natl Acad Sci U S A 104 27 (2007) 11418-11423
36. Perros F., Dorfmuller P., Souza R., Durand-Gasselin I., Mussot S., Mazmanian M., et al. Dendritic cell recruitment in lesions of human and experimental pulmonary hypertension. Eur Respir J 29 3 (2007) 462-468
37. Galkina E., Thatte J., Dabak V., Williams M.B., Ley K., and Braciale T.J. Preferential migration of effector CD8+ T cells into the interstitium of the normal lung. J Clin Invest 115 12 (2005) 3473-3483
38. Dorfmuller P., Zarka V., Durand-Gasselin I., Monti G., Balabanian K., Garcia G., et al. Chemokine RANTES in severe pulmonary arterial hypertension. Am J Respir Crit Care Med 165 4 (2002) 534-539
39. Daley E., Emson C., Guignabert C., de Waal Malefyt R., Louten J., Kurup V.P., et al. Pulmonary arterial remodeling induced by a Th2 immune response. J Exp Med 205 2 (2008) 361-372
40. Tavora F., Drachenberg C., Iacono A., and Burke A.P. Quantitation of T lymphocytes in posttransplant transbronchial biopsies. Hum Pathol 40 4 (2009) 505-515
41. Blanco P., Pitard V., Viallard J.F., Taupin J.L., Pellegrin J.L., and Moreau J.F. Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus. Arthritis Rheum 52 1 (2005) 201-211
42. Blanco P., Viallard J.F., Pellegrin J.L., and Moreau J.F. Cytotoxic T lymphocytes and autoimmunity. Curr Opin Rheumatol 17 6 (2005) 731-734
43. Campbell P.D., Estella E., Dudek N.L., Jhala G., Thomas H.E., Kay T.W., et al. Cytotoxic T-lymphocyte-mediated killing of human pancreatic islet cells in vitro. Hum Immunol 69 9 (2008) 543-551
44. Ely K.H., Cauley L.S., Roberts A.D., Brennan J.W., Cookenham T., and Woodland D.L. Nonspecific recruitment of memory CD8+ T cells to the lung airways during respiratory virus infections. J Immunol 170 3 (2003) 1423-1429