Suppression of survival kinases and activation of JNK mediate ethanol-induced cell death in the developing rat brain

Neuroscience Letters

Volumn 398, Issue 1-2, 2006, Pages 113-117

  Han, Jae Yoon ^a   Jeong, Joo Yeon ^a   Lee, Yeon Kung ^a   Roh, Gu Seob ^a   Kim, Hyun Joon ^a   Kang, Sang Soo ^a   Cho, Gyeong Jae ^a   Choi, Wan Sung ^a  

^a Gyeongsang National University School of Medicine   (South Korea)

Author keywords

14 3 3; Bad; Cell death; Ethanol; JNK; Survival kinase

Indexed keywords

ALCOHOL; CYCLIC AMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOTRANSFERASE; PROTEIN BAD; PROTEIN BCL 2; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; BAD PROTEIN, RAT; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PROTEIN 14 3 3; PROTEIN KINASE;

ANIMAL CELL; ARTICLE; BRAIN DEVELOPMENT; CELL DEATH; ENZYME ACTIVATION; ENZYME REPRESSION; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN INTERACTION; RAT; ANIMAL; APOPTOSIS; BRAIN; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; METABOLISM; NEWBORN; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

14-3-3 PROTEINS; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BRAIN; CELL SURVIVAL; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; ETHANOL; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33646369705     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2005.12.065     Document Type: Article

References (25)

1. Bonni A., Brunet A., West A.E., Datta S.R., Takasu M.A., and Greenberg M.G. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286 (1999) 1358-1362
2. Chetkovich D.M., and Sweatt J.D. NMDA receptor activation increases cyclic AMP in area CA1 of the hippocampus via calcium/calmodulin stimulation of adenylyl cyclase. J. Neurochem. 61 (1993) 1933-1942
3. Climent E., Pascual M., Renau-Piqueras J., and Guerri C. Ethanol exposure enhances cell death in the developing cerebral cortex: role of brain-derived neurotrophic factor and its signaling pathways. J. Neurosci. Res. 68 (2002) 213-225
4. Cross T.G., Scheel-Toellner D., Henriquez N.V., Deacon E., Salmon M., and Lord J.M. Serine/threonine protein kinases and apoptosis. Exp. Cell Res. 256 (2000) 34-41
5. Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., and Greenberg M.E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91 (1997) 231-241
6. Deng X., Xiao L., Lang W., Gao F., Ruvolo P., and May Jr. W.S. Novel role for JNK as a stress-activated Bcl2 kinase. J. Biol. Chem. 276 (2001) 23681-23688
7. Green D.R., and Reed J.C. Mitochondria and apoptosis. Science 281 (1998) 1309-1312
8. Han J.Y., Joo Y., Kim Y.S., Lee Y.K., Kim H.J., Cho G.J., Choi W.S., and Kang S.S. Ethanol induces cell death by activating caspase-3 in the rat cerebral cortex. Mol. Cells 20 (2005) 189-195
9. Harada H., Becknell B., Wilm M., Mann M., Huang L.J.S., Taylor S.S., Scott J.D., and Korsmeyer S.J. Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol. Cell 3 (1999) 413-422
10. Hoffman P.L., Rabe C.S., Moses F., and Tabakoff B. N-methyl-d-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production. J. Neurochem. 52 (1989) 1937-1940
11. Ikonomidou C., Bittigau P., Ishimaru M.J., Wozniak D.F., Koch C., Genz K., Price M.T., Stefovska V., Horster F., Tenkova T., Dikranian K., and Olney J.W. Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome. Science 287 (2000) 1056-1060
12. Kuan C.Y., Yang D.D., Samanta Roy D.R., Davis R.J., Rakic P., and Flavell R.A. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22 (1999) 667-676
13. Lee Y.J., and Shukla S.D. Pro- and anti-apoptotic roles of c-Jun N-terminal kinase (JNK) in ethanol and acetaldehyde exposed rat hepatocytes. Eur. J. Pharmacol. 508 (2005) 31-45
14. Lei K., Nimnual A., Zong W.X., Kennedy N.J., Flavell R.A., Thompson C.B., Bar-Sagi D., and Davis R.J. The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol. Cell Biol. 22 (2002) 4929-4942
15. Liu J., Tian Z., Gao B., and Kunos G. Dose-dependent activation of antiapoptotic and proapoptotic pathways by ethanol treatment in human vascular endothelial cells. J. Biol. Chem. 277 (2002) 20927-20933
16. Luo J., West J.R., and Pantazis N.J. Nerve growth factor and basic fibroblast growth factor protect rat cerebellar granule cells in culture against ethanol-induced cell death. Alcohol Clin. Exp. Res. 21 (1997) 1108-1120
17. Maldonado F., and Hanks S.K. A cDNA clone encoding human cAMP-dependent protein kinase catalytic subunit C alpha. Nucleic Acids Res. 16 (1988) 8189-8190
18. McAlhany Jr. R.E., West J.R., and Miranda R.C. Glial-derived neurotrophic factor (GDNF) prevents ethanol-induced apoptosis and JUN kinase phosphorylation. Brain Res. Dev. Brain Res. 119 (2000) 209-216
19. Nutt D.J. Addiction: brain mechanisms and their treatment implications. Lancet 347 (1996) 31-36
20. Olney J.W., Tenkova T., Dikranian K., Muglia L.J., Jermakowicz W.J., D'Sa C., and Roth K.A. Ethanol-induced caspase-3 activation in the in vivo developing mouse brain. Neurobiol. Dis. 9 (2002) 205-219
21. Pearson G., Robinson F., Beers Gibson T., Xu B.E., Karandikar M., Berman K., and Cobb M.H. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22 (2001) 153-183
22. Vaudry D., Rousselle C., Basille M., Falluel-Morel A., Pamantung T.F., Fontaine M., Fournier A., Vaudry H., and Gonzalez B.J. Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 6398-6403
23. Yang E., Zha J., Jockel J., Boise L.H., Thompson C.B., and Korsmeyer S.J. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80 (1995) 285-291
24. Young C., Klocke B.J., Tenkova T., Choi J., Labruyere J., Qin Y.Q., Holtzman D.M., Roth K.A., and Olney J.W. Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain. Cell Death Differ. 10 (2003) 1148-1155
25. Zha J., Harada H., Yang E., Jockel J., and Korsmeyer S.J. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 87 (1996) 619-628