Interaction of nonsteroidal anti-inflammatory drugs with membranes: In vitro assessment and relevance for their biological actions

Progress in Lipid Research

Volumn 52, Issue 4, 2013, Pages 571-584

  Pereira Leite, Catarina ^a   Nunes, Cláudia ^a   Reis, Salette ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

Biological membranes; Membrane model systems; Nonsteroidal anti inflammatory drugs; Pharmacokinetic properties; Therapeutic and toxic actions

Indexed keywords

ACETYLSALICYLIC ACID; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; IBUPROFEN; INDOMETACIN; LIPOSOME; MEFENAMIC ACID; NABUMETONE; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM;

ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIPYRETIC ACTIVITY; ARTICLE; ARTIFICIAL MEMBRANE; CARDIOTOXICITY; CARDIOVASCULAR SYMPTOM; CELL CULTURE; CHEMICAL INTERACTION; DIFFUSION; DIGESTIVE SYSTEM INJURY; DRUG ABSORPTION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG MEMBRANE INTERACTION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG STRUCTURE; ENZYME INHIBITION; GASTROINTESTINAL SYMPTOM; HUMAN; HYDROPHILICITY; IN VITRO STUDY; KIDNEY INJURY; LARGE UNILAMELLAR VESICLE; LIPID BILAYER; LIPID MONOLAYER; LIPOPHILICITY; LIVER TOXICITY; MEMBRANE BIOLOGY; MICELLE; MOLECULAR DYNAMICS; MULTILAMELLAR LIPID VESICLE; PASSIVE DIFFUSION; PH; PRIORITY JOURNAL; SMALL UNILAMELLAR VESICLE; SUPPORTED LIPID BILAYER;

ADENOSINE TRIPHOSPHATE; ATP; BIOLOGICAL MEMBRANES; CARDIOVASCULAR; COX; COX-2 SELECTIVE INHIBITORS; COXIBS; CV; CYCLOOXYGENASE; DIPALMITOYLPHOSPHATIDYLCHOLINE; DPPC; GASTROINTESTINAL; GI; GIANT UNILAMELLAR VESICLES; GUVS; LANGMUIR-BLODGETT; LARGE UNILAMELLAR VESICLES; LB; LIPOXYGENASE; LOX; LUVS; MD; MEMBRANE MODEL SYSTEMS; MICROSOMAL PROSTAGLANDIN E SYNTHASE-1; MLVS; MOLECULAR DYNAMICS; MPGES-1; MULTILAMELLAR LIPID VESICLES; NITRIC OXIDE-RELEASING NONSTEROIDAL ANTI-INFLAMMATORY DRUGS; NO-NSAIDS; NONSTEROIDAL ANTI-INFLAMMATORY DRUGS; NSAIDS; PC-NSAIDS; PG; PHARMACOKINETIC PROPERTIES; PHOSPHATIDYLCHOLINE-ASSOCIATED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS; PROSTAGLANDIN; SLB; SMALL UNILAMELLAR VESICLES; SUPPORTED LIPID BILAYERS; SUVS; THERAPEUTIC AND TOXIC ACTIONS; THROMBOXANE; TX;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL MEMBRANE; HUMANS; LIPID BILAYERS; MITOCHONDRIA; MOLECULAR DYNAMICS SIMULATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; UNILAMELLAR LIPOSOMES;

EID: 84883616305     PISSN: 01637827     EISSN: 18732194     Source Type: Journal    
DOI: 10.1016/j.plipres.2013.08.003     Document Type: Review

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