Membrane permeabilization by non-steroidal anti-inflammatory drugs

Biochemical and Biophysical Research Communications

Volumn 323, Issue 3, 2004, Pages 1032-1039

  Tomisato, Wataru ^a,b   Tanaka, Ken Ichiro ^a   Katsu, Takashi ^b   Kakuta, Hiroki ^b   Sasaki, Kenji ^b   Tsutsumi, Shinji ^a   Hoshino, Tatsuya ^a   Aburaya, Mayuko ^a   Li, Daiwei ^b   Tsuchiya, Tomofusa ^b   Suzuki, Keitarou ^a   Yokomizo, Kazumi ^a   Mizushima, Tohru ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

Cytotoxicity; Gastric mucosal cells; Intracellular Ca 2+ level; Membrane fluidity; Membrane permeabilization; NSAIDs

Indexed keywords

CALCEIN; CALCIUM; CELECOXIB; FLUFENAMIC ACID; FLURBIPROFEN; LIPOSOME; MEFENAMIC ACID; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL DEATH; CELL PERMEABILIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; HEMOLYSIS; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; CALCIUM; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTRIC MUCOSA; GUINEA PIGS; LIPOSOMES; MALE; MEMBRANE FLUIDITY;

EID: 4544249375     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.08.205     Document Type: Article

References (45)

1. W.E. Smalley, W.A. Ray, J.R. Daugherty, and M.R. Griffin Nonsteroidal anti-inflammatory drugs and the incidence of hospitalizations for peptic ulcer disease in elderly persons Am. J. Epidemiol. 141 1995 539 545
2. C.J. Hawkey Nonsteroidal anti-inflammatory drug gastropathy Gastroenterology 119 2000 521 535
3. C.H. Barrier, and B.I. Hirschowitz Controversies in the detection and management of nonsteroidal antiinflammatory drug-induced side effects of the upper gastrointestinal tract Arthritis Rheum. 32 1989 926 932
4. S.E. Gabriel, L. Jaakkimainen, and C. Bombardier Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs. A meta-analysis Ann. Intern. Med. 115 1991 787 796
5. J.F. Fries, S.R. Miller, P.W. Spitz, C.A. Williams, H.B. Hubert, and D.A. Bloch Toward an epidemiology of gastropathy associated with nonsteroidal antiinflammatory drug use Gastroenterology 96 1989 647 655
6. J.H. Kurata, and D.E. Abbey The effect of chronic aspirin use on duodenal and gastric ulcer hospitalizations J. Clin. Gastroenterol. 12 1990 260 266
7. G. Singh Recent considerations in nonsteroidal anti-inflammatory drug gastropathy Am. J. Med. 105 1998 31S 38S
8. J.R. Vane, and R.M. Botting Mechanism of action of anti-inflammatory drugs Scand. J. Rheumatol. Suppl. 102 1996 9 21
9. T.A. Miller Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms Am. J. Physiol. 245 1983 G601 G623
10. M. Ligumsky, E.M. Golanska, D.G. Hansen, and G.J. Kauffman Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in rat Gastroenterology 84 1983 756 761
11. M. Ligumsky, M. Sestieri, F. Karmeli, J. Zimmerman, E. Okon, and D. Rachmilewitz Rectal administration of nonsteroidal antiinflammatory drugs. Effect on rat gastric ulcerogenicity and prostaglandin E2 synthesis Gastroenterology 1990 1245 1249
12. L.M. Lichtenberger Where is the evidence that cyclooxygenase inhibition is the primary cause of nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal injury? Topical injury revisited Biochem. Pharmacol. 61 2001 631 637
13. L.M. Lichtenberger, Z.M. Wang, J.J. Romero, C. Ulloa, J.C. Perez, M.N. Giraud, and J.C. Barreto Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids: insight into the mechanism and reversal of NSAID-induced gastrointestinal injury Nat. Med. 1 1995 154 158
14. S. Somasundaram, S. Rafi, J. Hayllar, G. Sigthorsson, M. Jacob, A.B. Price, A. Macpherson, T. Mahmod, D. Scott, J.M. Wrigglesworth, and I. Bjarnason Mitochondrial damage: a possible mechanism of the “topical phase of NSAID induced injury to the rat intestine Gut 41 1997 344 353
15. W. Tomisato, S. Tsutsumi, K. Rokutan, T. Tsuchiya, and T. Mizushima NSAIDs induce both necrosis and apoptosis in guinea pig gastric mucosal cells in primary culture Am. J. Physiol. Gastrointest. Liver Physiol. 281 2001 G1092 1100
16. W. Tomisato, S. Tsutsumi, T. Hoshino, H.J. Hwang, M. Mio, T. Tsuchiya, and T. Mizushima Role of direct cytotoxic effects of NSAIDs in the induction of gastric lesions Biochem. Pharmacol. 67 2004 575 585
17. X.H. Liu, S. Yao, A. Kirschenbaum, and A.C. Levine NS398, a selective cyclooxygenase-2 inhibitor, induces apoptosis and down-regulates bcl-2 expression in LNCaP cells Cancer Res. 58 1998 4245 4249
18. P. Schwenger, P. Bellosta, I. Vietor, C. Basilico, E.Y. Skolnik, and J. Vilcek Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation Proc. Natl. Acad. Sci. USA 94 1997 2869 2873
19. M.N. Giraud, C. Motta, J.J. Romero, G. Bommelaer, and L.M. Lichtenberger Interaction of indomethacin and naproxen with gastric surface-active phospholipids: a possible mechanism for the gastric toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs) Biochem. Pharmacol. 57 1999 247 254
20. B.S. Anand, J.J. Romero, S.K. Sanduja, and L.M. Lichtenberger Phospholipid association reduces the gastric mucosal toxicity of aspirin in human subjects Am. J. Gastroenterol. 94 1999 1818 1822
21. H. Aki, and M. Yamamoto Biothermodynamic characterization of erythrocyte hemolysis induced by phenothiazine derivatives and anti-inflammatory drugs Biochem. Pharmacol. 39 1990 396 398
22. K. Rokutan, M. Yamada, J. Torigoe, and T. Saito Transforming growth factor-beta inhibits proliferation and maturation of cultured guinea pig gastric pit cells Am. J. Physiol. 275 1998 G526 533
23. S. Tsutsumi, W. Tomisato, T. Takano, K. Rokutan, T. Tsuchiya, and T. Mizushima Gastric irritant-induced apoptosis in guinea pig gastric mucosal cells in primary culture Biochim. Biophys. Acta 1589 2002 168 180
24. T. Hoshino, S. Tsutsumi, W. Tomisato, H.J. Hwang, T. Tsuchiya, and T. Mizushima Prostaglandin E2 protects gastric mucosal cells from apoptosis via EP2 and EP4 receptor activation J. Biol. Chem. 278 2003 12752 12758
25. W. Tomisato, T. Hoshino, S. Tsutsumi, T. Tsuchiya, and T. Mizushima Maturation-associated increase in sensitivity of cultured guinea pig gastric pit cells to hydrogen peroxide Dig. Dis. Sci. 47 2002 2125 2133
26. B.B. Wolf, and D.R. Green Suicidal tendencies: apoptotic cell death by caspase family proteinases J. Biol. Chem. 274 1999 20049 20052
27. T. Katsu, M. Kuroko, T. Morikawa, K. Sanchika, H. Yamanaka, S. Shinoda, and Y. Fujita Interaction of wasp venom mastoparan with biomembranes Biochim. Biophys. Acta 1027 1990 185 190
28. T. Katsu, H. Kobayashi, T. Hirota, Y. Fujita, K. Sato, and U. Nagai Structureâ€"activity relationship of gramicidin S analogues on membrane permeability Biochim. Biophys. Acta 899 1987 159 170
29. T. Katsu Application of calcein-loaded liposomes for the determination of membrane channel size Biol. Pharm. Bull. 22 1999 978 980
30. R.R.C. New Liposomes: A Practical Approach 1990 IRL Press Oxford
31. M. Makise, S. Mima, T. Katsu, T. Tsuchiya, and T. Mizushima Acidic phospholipids inhibit the DNA-binding activity of DnaA protein, the initiator of chromosomal DNA replication in Escherichia coli Mol. Microbiol. 46 2002 245 256
32. J.P. Kao, A.T. Harootunian, and R.Y. Tsien Photochemically generated cytosolic calcium pulses and their detection by fluo-3 J. Biol. Chem. 264 1989 8179 8184
33. J. Vane Towards a better aspirin Nature 367 1994 215 216
34. S. Orrenius, B. Zhivotovsky, and P. Nicotera Regulation of cell death: the calcium-apoptosis link Nat. Rev. Mol. Cell Biol. 4 2003 552 565
35. W.J. Murdoch Differential effects of indomethacin on the sheep ovary: prostaglandin biosynthesis, intracellular calcium, apoptosis, and ovulation Prostaglandins 52 1996 497 506
36. 2+ on indomethacin-induced injury to rabbit dispersed gastric mucosal cells Can. J. Physiol. Pharmacol. 72 1994 63 69
37. 2+-ATPases: a plausible link with its anti-tumour effect and cardiovascular risks Biochem. J. 366 2002 831 837
38. 2+ movement and cell proliferation in human osteoblasts Biochem. Pharmacol. 67 2004 1123 1130
39. S. Fiorucci, E. Antonelli, G. Migliorati, L. Santucci, O. Morelli, B. Federici, and A. Morelli TNFalpha processing enzyme inhibitors prevent aspirin-induced TNFalpha release and protect against gastric mucosal injury in rats Aliment. Pharmacol. Ther. 12 1998 1139 1153
40. R.A. Levine, J. Nandi, and R.L. King Aspirin potentiates prestimulated acid secretion and mobilizes intracellular calcium in rabbit parietal cells J. Clin. Invest. 86 1990 400 408
41. U.K. Murthy, and R.A. Levine Aspirin induces morphological transformation to the secretory state in isolated rabbit parietal cells Gastroenterology 101 1991 404 409
42. S. Tsutsumi, T. Gotoh, W. Tomisato, S. Mima, T. Hoshino, H.J. Hwang, H. Takenaka, T. Tsuchiya, M. Mori, and T. Mizushima Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis Cell Death Differ. 11 2004 1009 1016
43. S. Nozaki, G.W. Sledge Jr., and H. Nakshatri Repression of GADD153/CHOP by NF-kappaB: a possible cellular defense against endoplasmic reticulum stress-induced cell death Oncogene 20 2001 2178 2185
44. H. Zinszner, M. Kuroda, X. Wang, N. Batchvarova, R.T. Lightfoot, H. Remotti, J.L. Stevens, and D. Ron CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum Genes Dev. 12 1998 982 995
45. J.T. Chou, and P.C. Jurs Computer-assisted computation of partition coefficients from molecular structures using fragment constants J. Chem. Inf. Comput. Sci. 19 1979 172 178