The nonsteroidal anti-inflammatory drug indomethacin induces heterogeneity in lipid membranes: Potential implication for its diverse biological action

PLoS ONE

Volumn 5, Issue 1, 2010, Pages

  Zhou, Yong ^a   Hancock, John F ^a   Lichtenberger, Lenard M ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; DIOLEOYLPHOSPHATIDYLCHOLINE; DIPALMITOYLPHOSPHATIDYLCHOLINE; FLUORESCENT DYE; INDOMETACIN; LIPOSOME; MEMBRANE LIPID; NONSTEROID ANTIINFLAMMATORY AGENT;

ARTICLE; ARTIFICIAL MEMBRANE; BIOLOGICAL ACTIVITY; CELL COMMUNICATION; CELL FUNCTION; FLUORESCENCE RESONANCE ENERGY TRANSFER; LIPID MEMBRANE; MEMBRANE MODEL; PHASE SEPARATION; METABOLISM;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; FLUORESCENCE RESONANCE ENERGY TRANSFER; INDOMETHACIN; LIPOSOMES; MEMBRANE LIPIDS;

EID: 77952472956     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008811     Document Type: Article

References (26)

1. Soh JW, Weinstein IB (2003) Role of COX-independent targets of NSAIDs and related compounds in cancer prevention and treatment. Prog Exp Tumor Res 37: 261-285.
2. Stadler P, Armstrong D, Margalith D, Saraga E, Stolte M, et al. (1991) Diclofenac delays healing of gastroduodenal mucosal lesions. Double-blind, placebo-controlled endoscopic study in healthy volunteers. Dig Dis Sci 36: 594-600.
3. Gerli R, Paolucci C, Gresele P, Bistoni O, Fiorucci S, et al. (1998) Salicylates inhibit adhesion and transmigration of T lymphocytes by preventing integrin activation induced by contact with endothelial cells. Blood 92: 2389-2398.
4. Chan TA, Morin PJ, Vogelstein B, Kinzler KW (1998) Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis. Proc Natl Acad Sci U S A 95: 681-686.
5. Takada Y, Bhardwaj A, Potdar P, Aggarwal BB (2004) Nonsteroidal antiinflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-9258.
6. Zhou Y, Raphael RM (2005) Effect of salicylate on the elasticity, bending stiffness, and strength of SOPC membranes. Biophys J 89: 1789-1801.
7. Lichtenberger LM, Zhou Y, Dial EJ, Raphael RM (2006) NSAID injury to the gastrointestinal tract: evidence that NSAIDs interact with phospholipids to weaken the hydrophobic surface barrier and induce the formation of unstable pores in membranes. J Pharm Pharmacol 58: 1421-1428.
8. Lichtenberger LM, Wang ZM, Romero JJ, Ulloa C, Perez JC, et al. (1995) Nonsteroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids: insight into the mechanism and reversal of NSAID-induced gastrointestinal injury. Nat Med 1: 154-158.
9. Gennis RB (1989) Biomembranes: Molecular Structure and Function; Cantor C, editor. New York, NY: Springer-Verlag.
10. Lasoner E, Weringa WD (1990) An NMR and DSC study of the interaction of phospholipid vesciles with some anti-inflammatory agents. J Colloid Int Sci 139: 469-478.
11. Hancock JF (2006) Lipid rafts: contentious only from simplistic standpoints. Nat Rev Mol Cell Biol 7: 456-462.
12. Hancock JF (2003) Ras proteins: different signals from different locations. Nat Rev Mol Cell Biol 4: 373-384.
13. Hancock JF, Parton RG (2005) Ras plasma membrane signalling platforms. Biochem J 389: 1-11.
14. Plowman SJ, Muncke C, Parton RG, Hancock JF (2005) H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton. Proc Natl Acad Sci U S A 102: 15500-15505.
15. Abe M, Sevanian A (2006) The Effect of Oxygen Exposure on Erythrocyte Phospholipid Composition. The Tohoku Journal of Experimental Medicine 135: 205-211.
16. Silva LC, de Almeida RF, Castro BM, Fedorov A, Prieto M (2007) Ceramide-domain formation and collapse in lipid rafts: membrane reorganization by an apoptotic lipid. Biophys J 92: 502-516.
17. Leidy C, Wolkers WF, Jorgensen K, Mouritsen OG, Crowe JH (2001) Lateral organization and domain formation in a two-component lipid membrane system. Biophys J 80: 1819-1828.
18. Silvius JR (2003) Fluorescence energy transfer reveals microdomain formation at physiological temperatures in lipid mixtures modeling the outer leaflet of the plasma membrane. Biophys J 85: 1034-1045.
19. Spink CH, Yeager MD, Feigenson GW (1990) Partitioning behavior of indocarbocyanine probes between coexisting gel and fluid phases in model membranes. Biochim Biophys Acta 1023: 25-33.
20. Sklar LA, Miljanich GP, Dratz EA (1979) Phospholipid lateral phase separation and the partition of cis-parinaric acid and trans-parinaric acid among aqueous, solid lipid, and fluid lipid phases. Biochemistry 18: 1707-1716.
21. Bakht O, Pathak P, London E (2007) Effect of the structure of lipids favoring disordered domain formation on the stability of cholesterol-containing ordered domains (lipid rafts): identification of multiple raft-stabilization mechanisms. Biophys J 93: 4307-4318.
22. Lucio M, Bringezu F, Reis S, Lima JL, Brezesinski G (2008) Binding of nonsteroidal anti-inflammatory drugs to DPPC: structure and thermodynamic aspects. Langmuir 24: 4132-4139.
23. Lichtenberg D, Goni FM, Heerklotz H (2005) Detergent-resistant membranes should not be identified with membrane rafts. Trends Biochem Sci 30: 430-436.
24. Keller S, Tsamaloukas A, Heerklotz H (2005) A quantitative model describing the selective solubilization of membrane domains. J Am Chem Soc 127: 11469-11476.
25. Prior IA, Harding A, Yan J, Sluimer J, Parton RG, et al. (2001) GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nat Cell Biol 3: 368-375.
26. Aouad SM, Cohen LY, Sharif-Askari E, Haddad EK, Alam A, et al. (2004) Caspase-3 is a component of Fas death-inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas-mediated cell death. J Immunol 172: 2316-2323.