-
1
-
-
84855172814
-
The pathogenesis of rheumatoid arthritis
-
McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N. Engl. J. Med. 365(23), 2205-2219 (2011).
-
(2011)
N. Engl. J. Med
, vol.365
, Issue.23
, pp. 2205-2219
-
-
McInnes, I.B.1
Schett, G.2
-
2
-
-
77957196913
-
Rheumatoid arthritis
-
Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet 376(9746), 1094-1108 (2010).
-
(2010)
Lancet
, vol.376
, Issue.9746
, pp. 1094-1108
-
-
Scott, D.L.1
Wolfe, F.2
Huizinga, T.W.3
-
4
-
-
0014233443
-
Amethopterin (methotrexate) in connective tissue disease-psoriasis and polyarthritis
-
Kersley GD. Amethopterin (methotrexate) in connective tissue disease-psoriasis and polyarthritis. Ann. Rheum. Dis. 27, 64-66 (1968).
-
(1968)
Ann. Rheum. Dis
, vol.27
, pp. 64-66
-
-
Kersley, G.D.1
-
5
-
-
84885376558
-
Methotrexate for rheumatoid arthritis
-
Suarez-Almazor ME, Belseck E, Shea B, Wells G, Tugwell P. Methotrexate for rheumatoid arthritis. Cochrane Database Syst. Rev. 2, CD000957 (2000).
-
(2000)
Cochrane Database Syst. Rev
, vol.2
-
-
Suarez-Almazor, M.E.1
Belseck, E.2
Shea, B.3
Wells, G.4
Tugwell, P.5
-
6
-
-
0033509413
-
Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis
-
Nakashima-Matsushita N, Homma T, Yu S et al. Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis. Arthritis Rheum. 42(8), 1609-1616 (1999).
-
(1999)
Arthritis Rheum
, vol.42
, Issue.8
, pp. 1609-1616
-
-
Nakashima-Matsushita, N.1
Homma, T.2
Yu, S.3
-
7
-
-
58249094867
-
Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients
-
van der Heijden JW, Oerlemans R, Dijkmans BAC et al. Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients. Arthritis Rheum. 60(1), 12-21 (2009).
-
(2009)
Arthritis Rheum
, vol.60
, Issue.1
, pp. 12-21
-
-
Van Der Heijden, J.W.1
Oerlemans, R.2
Dijkmans, B.A.C.3
-
8
-
-
39449121672
-
Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis
-
Wessels JA, Huizinga TW, Guchelaar HJ. Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis. Rheumatology (Oxford) 47(3), 249-255 (2008).
-
(2008)
Rheumatology (Oxford)
, vol.47
, Issue.3
, pp. 249-255
-
-
Wessels, J.A.1
Huizinga, T.W.2
Guchelaar, H.J.3
-
9
-
-
0037207972
-
Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68
-
Montesinos MC, Desai A, Delano D et al. Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68. Arthritis Rheum. 48(1), 240-247 (2003).
-
(2003)
Arthritis Rheum
, vol.48
, Issue.1
, pp. 240-247
-
-
Montesinos, M.C.1
Desai, A.2
Delano, D.3
-
10
-
-
0031985832
-
The efficacy of folic acid and folinic acid in reducing methotrexate gastrointestinal toxicity in rheumatoid arthritis. A meta-analysis of randomized controlled trials
-
Ortiz Z, Shea B, Suarez-Almazor ME, Moher D, Wells GA, Tugwell P. The efficacy of folic acid and folinic acid in reducing methotrexate gastrointestinal toxicity in rheumatoid arthritis. A meta-analysis of randomized controlled trials. J. Rheumatol. 25(1), 36-43 (1998).
-
(1998)
J. Rheumatol
, vol.25
, Issue.1
, pp. 36-43
-
-
Ortiz, Z.1
Shea, B.2
Suarez-Almazor, M.E.3
Moher, D.4
Wells, G.A.5
Tugwell, P.6
-
11
-
-
0022137053
-
Weekly pulse methotrexate in rheumatoid arthritis. Clinical and immunologic effects in a randomized, double-blind study
-
Andersen PA, West SG, O'Dell JR, Via CS, Claypool RG, Kotzin BL. Weekly pulse methotrexate in rheumatoid arthritis. Clinical and immunologic effects in a randomized, double-blind study. Ann. Intern. Med. 103(4), 489-496 (1985).
-
(1985)
Ann. Intern. Med
, vol.103
, Issue.4
, pp. 489-496
-
-
Andersen, P.A.1
West, S.G.2
O'Dell, J.R.3
Via, C.S.4
Claypool, R.G.5
Kotzin, B.L.6
-
12
-
-
0021923633
-
Efficacy of low-dose methotrexate in rheumatoid arthritis
-
Weinblatt ME, Coblyn JS, Fox DA et al. Efficacy of low-dose methotrexate in rheumatoid arthritis. N. Engl. J. Med. 312(13), 818-822 (1985).
-
(1985)
N. Engl. J. Med
, vol.312
, Issue.13
, pp. 818-822
-
-
Weinblatt, M.E.1
Coblyn, J.S.2
Fox, D.A.3
-
13
-
-
0021794435
-
Comparison of low-dose oral pulse methotrexate and placebo in the treatment of rheumatoid arthritis. A controlled clinical trial
-
Williams HJ, Willkens RF, Samuelson CO et al. Comparison of low-dose oral pulse methotrexate and placebo in the treatment of rheumatoid arthritis. A controlled clinical trial. Arthritis Rheum. 28(7), 721-730 (1985).
-
(1985)
Arthritis Rheum
, vol.28
, Issue.7
, pp. 721-730
-
-
Williams, H.J.1
Willkens, R.F.2
Samuelson, C.O.3
-
14
-
-
0025633939
-
Adverse experience with methotrexate during 176 weeks of a longterm prospective trial in patients with rheumatoid arthritis
-
Furst DE, Erikson N, Clute L, Koehnke R, Burmeister LF, Kohler JA. Adverse experience with methotrexate during 176 weeks of a longterm prospective trial in patients with rheumatoid arthritis. J. Rheumatol. 17(12), 1628-1635 (1990).
-
(1990)
J. Rheumatol
, vol.17
, Issue.12
, pp. 1628-1635
-
-
Furst, D.E.1
Erikson, N.2
Clute, L.3
Koehnke, R.4
Burmeister, L.F.5
Kohler, J.A.6
-
15
-
-
0027587502
-
A short-term randomized controlled study with methotrexate in rheumatoid arthritis
-
Pinheiro GR, Helfenstein Júnior M, Ferraz MB, Atra E. [A short-term randomized controlled study with methotrexate in rheumatoid arthritis]. Rev. Assoc. Med. Bras. 39(2), 91-94 (1993).
-
(1993)
Rev. Assoc. Med. Bras
, vol.39
, Issue.2
, pp. 91-94
-
-
Pinheiro, G.R.1
Helfenstein Jr., M.2
Ferraz, M.B.3
Atra, E.4
-
16
-
-
0036021133
-
Effectiveness profiles and dose dependent retention of traditional disease modifying antirheumatic drugs for rheumatoid arthritis. An observational study
-
Aletaha D, Smolen JS. Effectiveness profiles and dose dependent retention of traditional disease modifying antirheumatic drugs for rheumatoid arthritis. An observational study. J. Rheumatol. 29(8), 1631-1638 (2002).
-
(2002)
J. Rheumatol
, vol.29
, Issue.8
, pp. 1631-1638
-
-
Aletaha, D.1
Smolen, J.S.2
-
17
-
-
67549101312
-
Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: A systematic review of the literature
-
Visser K, van der Heijde D. Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature. Ann. Rheum. Dis. 68(7), 1094-1099 (2009).
-
(2009)
Ann. Rheum. Dis
, vol.68
, Issue.7
, pp. 1094-1099
-
-
Visser, K.1
Van Der Heijde, D.2
-
18
-
-
38149057526
-
Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: Results of a six-month, multicenter, randomized, double-blind, controlled, Phase IV trial
-
Braun J, Kästner P, Flaxenberg P et al. Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: results of a six-month, multicenter, randomized, double-blind, controlled, Phase IV trial. Arthritis Rheum. 58(1), 73-81 (2008).
-
(2008)
Arthritis Rheum
, vol.58
, Issue.1
, pp. 73-81
-
-
Braun, J.1
Kästner, P.2
Flaxenberg, P.3
-
19
-
-
0033596065
-
Leflunomide Rheumatoid Arthritis Investigators Group. Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate
-
Strand V, Cohen S, Schiff M et al. Leflunomide Rheumatoid Arthritis Investigators Group. Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Arch. Intern. Med. 159(21), 2542-2550 (1999).
-
(1999)
Arch. Intern. Med
, vol.159
, Issue.21
, pp. 2542-2550
-
-
Strand, V.1
Cohen, S.2
Schiff, M.3
-
20
-
-
77953696525
-
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs
-
Smolen JS, Landewe R, Breedveld FC et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs. Ann. Rheum. Dis. 69(6), 964-975 (2010).
-
(2010)
Ann. Rheum. Dis
, vol.69
, Issue.6
, pp. 964-975
-
-
Smolen, J.S.1
Landewe, R.2
Breedveld, F.C.3
-
21
-
-
84871089146
-
Induction therapy with a combination of DMARDs is better than methotrexate monotherapy: First results of the tREACH trial
-
de Jong PH, Hazes JM, Barendregt PJ et al. Induction therapy with a combination of DMARDs is better than methotrexate monotherapy: first results of the tREACH trial. Ann. Rheum. Dis. 72(1), 72-78 (2013).
-
(2013)
Ann. Rheum. Dis
, vol.72
, Issue.1
, pp. 72-78
-
-
De Jong, P.H.1
Hazes, J.M.2
Barendregt, P.J.3
-
22
-
-
0032804664
-
Mechanism of action for leflunomide in rheumatoid arthritis
-
Fox RI, Herrmann ML, Frangou CG et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin. Immunol. 93(3), 198-208 (1999).
-
(1999)
Clin. Immunol
, vol.93
, Issue.3
, pp. 198-208
-
-
Fox, R.I.1
Herrmann, M.L.2
Frangou, C.G.3
-
23
-
-
0033802451
-
Leflunomide and rheumatoid arthritis: A systematic review of effectiveness, safety and cost implications
-
Hewitson PJ, Debroe S, McBride A, Milne R. Leflunomide and rheumatoid arthritis: a systematic review of effectiveness, safety and cost implications. J. Clin. Pharm. Ther. 25(4), 295-302 (2000).
-
(2000)
J. Clin. Pharm. Ther
, vol.25
, Issue.4
, pp. 295-302
-
-
Hewitson, P.J.1
Debroe, S.2
McBride, A.3
Milne, R.4
-
24
-
-
0038657686
-
Leflunomide for the treatment of rheumatoid arthritis: A systematic review and meta-analysis
-
Osiri M, Shea B, Robinson V et al. Leflunomide for the treatment of rheumatoid arthritis: a systematic review and meta-analysis. J. Rheumatol. 30(6), 1182-1190 (2003).
-
(2003)
J. Rheumatol
, vol.30
, Issue.6
, pp. 1182-1190
-
-
Osiri, M.1
Shea, B.2
Robinson, V.3
-
26
-
-
0033053835
-
Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: A double-blind, randomised, multicentre trial
-
European Leflunomide Study Group
-
Smolen JS, Kalden JR, Scott DL et al. European Leflunomide Study Group. Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial. Lancet 353(9149), 259-266 (1999).
-
(1999)
Lancet
, vol.353
, Issue.9149
, pp. 259-266
-
-
Smolen, J.S.1
Kalden, J.R.2
Scott, D.L.3
-
27
-
-
6744262231
-
A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis
-
Emery P, Breedveld FC, Lemmel EM et al. A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis. Rheumatology (Oxford) 39(6), 655-665 (2000).
-
(2000)
Rheumatology (Oxford)
, vol.39
, Issue.6
, pp. 655-665
-
-
Emery, P.1
Breedveld, F.C.2
Lemmel, E.M.3
-
28
-
-
0034827629
-
Treatment of active rheumatoid arthritis with leflunomide: Two year follow up of a double blind, placebo controlled trial versus sulfasalazine
-
Scott DL, Smolen JS, Kalden JR et al. Treatment of active rheumatoid arthritis with leflunomide: two year follow up of a double blind, placebo controlled trial versus sulfasalazine. Ann. Rheum. Dis. 60(10), 913-923 (2001).
-
(2001)
Ann. Rheum. Dis
, vol.60
, Issue.10
, pp. 913-923
-
-
Scott, D.L.1
Smolen, J.S.2
Kalden, J.R.3
-
29
-
-
0034123087
-
Treatment with leflunomide slows radiographic progression of rheumatoid arthritis: Results from three randomized controlled trials of leflunomide in patients with active rheumatoid arthritis
-
Leflunomide Rheumatoid Arthritis Investigators Group
-
Sharp JT, Strand V, Leung H, Hurley F, Loew-Friedrich I. Leflunomide Rheumatoid Arthritis Investigators Group. Treatment with leflunomide slows radiographic progression of rheumatoid arthritis: results from three randomized controlled trials of leflunomide in patients with active rheumatoid arthritis. Arthritis Rheum. 43(3), 495-505 (2000).
-
(2000)
Arthritis Rheum
, vol.43
, Issue.3
, pp. 495-505
-
-
Sharp, J.T.1
Strand, V.2
Leung, H.3
Hurley, F.4
Loew-Friedrich, I.5
-
30
-
-
0028792355
-
Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis. Results of a randomized, placebo-controlled, Phase II study
-
Mladenovic V, Domljan Z, Rozman B et al. Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis. Results of a randomized, placebo-controlled, Phase II study. Arthritis Rheum. 38(11), 1595-1603 (1995).
-
(1995)
Arthritis Rheum
, vol.38
, Issue.11
, pp. 1595-1603
-
-
Mladenovic, V.1
Domljan, Z.2
Rozman, B.3
-
31
-
-
18044400396
-
Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate. Utilization of Leflunomide in the Treatment of Rheumatoid Arthritis Trial Investigator Group
-
Cohen S, Cannon GW, Schiff M et al. Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate. Utilization of Leflunomide in the Treatment of Rheumatoid Arthritis Trial Investigator Group. Arthritis Rheum. 44(9), 1984-1992 (2001).
-
(2001)
Arthritis Rheum
, vol.44
, Issue.9
, pp. 1984-1992
-
-
Cohen, S.1
Cannon, G.W.2
Schiff, M.3
-
32
-
-
0028998289
-
A review of its pharmacological properties and therapeutic efficacy in the treatment of rheumatoid arthritis
-
Rains CP, Noble S, Faulds D. Sulfasalazine. A review of its pharmacological properties and therapeutic efficacy in the treatment of rheumatoid arthritis. Drugs 50(1), 137-156 (1995).
-
(1995)
Drugs
, vol.50
, Issue.1
, pp. 137-156
-
-
Rains, C.P.1
Noble, S.2
Sulfasalazine, F.D.3
-
33
-
-
0030855717
-
Sulphasalazine in the treatment of rheumatoid arthritis
-
Box SA, Pullar T. Sulphasalazine in the treatment of rheumatoid arthritis. Br. J. Rheumatol. 36(3), 382-386 (1997).
-
(1997)
Br. J. Rheumatol
, vol.36
, Issue.3
, pp. 382-386
-
-
Box, S.A.1
Pullar, T.2
-
34
-
-
0036126746
-
Regulation of human B cell function by sulfasalazine and its metabolites
-
Hirohata S, Ohshima N, Yanagida T, Aramaki K. Regulation of human B cell function by sulfasalazine and its metabolites. Int. Immunopharmacol. 2(5), 631-640 (2002).
-
(2002)
Int. Immunopharmacol
, vol.2
, Issue.5
, pp. 631-640
-
-
Hirohata, S.1
Ohshima, N.2
Yanagida, T.3
Aramaki, K.4
-
35
-
-
0028223925
-
Effect of sulfasalazine on B cell hyperactivity in patients with rheumatoid arthritis
-
Imai F, Suzuki T, Ishibashi T, Tanaka M, Akiyama Y, Dohi Y. Effect of sulfasalazine on B cell hyperactivity in patients with rheumatoid arthritis. J. Rheumatol. 21(4), 612-615 (1994).
-
(1994)
J. Rheumatol
, vol.21
, Issue.4
, pp. 612-615
-
-
Imai, F.1
Suzuki, T.2
Ishibashi, T.3
Tanaka, M.4
Akiyama, Y.5
Dohi, Y.6
-
36
-
-
0032032469
-
Sulfasalazine: A potent and specific inhibitor of nuclear factor kappa B
-
Wahl C, Liptay S, Adler G, Schmid RM. Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J. Clin. Invest. 101(5), 1163-1174 (1998).
-
(1998)
J. Clin. Invest
, vol.101
, Issue.5
, pp. 1163-1174
-
-
Wahl, C.1
Liptay, S.2
Adler, G.3
Schmid, R.M.4
-
37
-
-
0031458257
-
Rapid induction of neutrophil apoptosis by sulfasalazine: Implications of reactive oxygen species in the apoptotic process
-
Akahoshi T, Namai R, Sekiyama N, Tanaka S, Hosaka S, Kondo H. Rapid induction of neutrophil apoptosis by sulfasalazine: implications of reactive oxygen species in the apoptotic process. J. Leukoc. Biol. 62(6), 817-826 (1997).
-
(1997)
J. Leukoc. Biol
, vol.62
, Issue.6
, pp. 817-826
-
-
Akahoshi, T.1
Namai, R.2
Sekiyama, N.3
Tanaka, S.4
Hosaka, S.5
Kondo, H.6
-
38
-
-
0033696206
-
The antiinflammatory drug sulfasalazine inhibits tumor necrosis factor alpha expression in macrophages by inducing apoptosis
-
Rodenburg RJ, Ganga A, van Lent PL, van de Putte LB, van Venrooij WJ. The antiinflammatory drug sulfasalazine inhibits tumor necrosis factor alpha expression in macrophages by inducing apoptosis. Arthritis Rheum. 43(9), 1941-1950 (2000).
-
(2000)
Arthritis Rheum
, vol.43
, Issue.9
, pp. 1941-1950
-
-
Rodenburg, R.J.1
Ganga, A.2
Van Lent, P.L.3
Van De Putte, L.B.4
Van Venrooij, W.J.5
-
39
-
-
0032846648
-
Sulfasalazine treatment for rheumatoid arthritis: A meta-analysis of 15 randomized trials
-
Weinblatt ME, Reda D, Henderson W et al. Sulfasalazine treatment for rheumatoid arthritis: a meta-analysis of 15 randomized trials. J. Rheumatol. 26(10), 2123-2130 (1999).
-
(1999)
J. Rheumatol
, vol.26
, Issue.10
, pp. 2123-2130
-
-
Weinblatt, M.E.1
Reda, D.2
Henderson, W.3
-
40
-
-
84921430385
-
Sulfasalazine for rheumatoid arthritis
-
Suarez-Almazor ME, Belseck E, Shea B, Wells G, Tugwell P. Sulfasalazine for rheumatoid arthritis. Cochrane Database Syst. Rev. 2, CD000958 (2000).
-
(2000)
Cochrane Database Syst. Rev
, vol.2
-
-
Suarez-Almazor, M.E.1
Belseck, E.2
Shea, B.3
Wells, G.4
Tugwell, P.5
-
41
-
-
0024604643
-
Effects of hydroxychloroquine and sulphasalazine on progression of joint damage in rheumatoid arthritis
-
van der Heijde DM, van Riel PL, Nuver-Zwart IH, Gribnau FW, vad de Putte LB. Effects of hydroxychloroquine and sulphasalazine on progression of joint damage in rheumatoid arthritis. Lancet 1(8646), 1036-1038 (1989).
-
(1989)
Lancet
, vol.1
, Issue.8646
, pp. 1036-1038
-
-
Van Der Heijde, D.M.1
Van Riel, P.L.2
Nuver-Zwart, I.H.3
Gribnau, F.W.4
Vad De Putte, L.B.5
-
42
-
-
80053954998
-
Rheumatoid arthritis and pregnancy: Safety considerations in pharmacological management
-
Makol A, Wright K, Amin S. Rheumatoid arthritis and pregnancy: safety considerations in pharmacological management. Drugs 71(15), 1973-1987 (2011).
-
(2011)
Drugs
, vol.71
, Issue.15
, pp. 1973-1987
-
-
Makol, A.1
Wright, K.2
Amin, S.3
-
43
-
-
0036105568
-
Radiographic outcome after three years of patients with early erosive rheumatoid arthritis treated with intramuscular methotrexate or parenteral gold. Extension of a one-year double-blind study in 174 patients
-
Rau R, Herborn G, Menninger H, Sangha O. Radiographic outcome after three years of patients with early erosive rheumatoid arthritis treated with intramuscular methotrexate or parenteral gold. Extension of a one-year double-blind study in 174 patients. Rheumatology (Oxford) 41(2), 196-204 (2002).
-
(2002)
Rheumatology (Oxford)
, vol.41
, Issue.2
, pp. 196-204
-
-
Rau, R.1
Herborn, G.2
Menninger, H.3
Sangha, O.4
-
44
-
-
0035003318
-
Comparative study of intramuscular gold and methotrexate in a rheumatoid arthritis population from a socially deprived area
-
Hamilton J, McInnes IB, Thomson EA et al. Comparative study of intramuscular gold and methotrexate in a rheumatoid arthritis population from a socially deprived area. Ann. Rheum. Dis. 60(6), 566-572 (2001).
-
(2001)
Ann. Rheum. Dis
, vol.60
, Issue.6
, pp. 566-572
-
-
Hamilton, J.1
McInnes, I.B.2
Thomson, E.A.3
-
45
-
-
18644373869
-
A 48-week, randomized, double-blind, double-observer, placebo-controlled multicenter trial of combination methotrexate and intramuscular gold therapy in rheumatoid arthritis: Results of the METGO study
-
Lehman AJ, Esdaile JM, Klinkhoff AV et al. A 48-week, randomized, double-blind, double-observer, placebo-controlled multicenter trial of combination methotrexate and intramuscular gold therapy in rheumatoid arthritis: results of the METGO study. Arthritis Rheum. 52(5), 1360-1370 (2005).
-
(2005)
Arthritis Rheum
, vol.52
, Issue.5
, pp. 1360-1370
-
-
Lehman, A.J.1
Esdaile, J.M.2
Klinkhoff, A.V.3
-
46
-
-
0034959008
-
Molecular mechanisms of action of gold in treatment of rheumatoid arthritis - An update
-
Burmester GR. [Molecular mechanisms of action of gold in treatment of rheumatoid arthritis - an update]. Zeitschrift für Rheumatologie 60(3), 167-173 (2001).
-
(2001)
Zeitschrift für Rheumatologie
, vol.60
, Issue.3
, pp. 167-173
-
-
Burmester, G.R.1
-
47
-
-
79959543141
-
Study of anti-inflammatory action of aurothiomalate, an inhibitor of NF-kB
-
Belsky YP, Ivanova AN, Danilets MG et al. Study of anti-inflammatory action of aurothiomalate, an inhibitor of NF-kB. Bull. Exp. Biol. Med. 151(2), 190-193 (2011).
-
(2011)
Bull. Exp. Biol. Med
, vol.151
, Issue.2
, pp. 190-193
-
-
Belsky, Y.P.1
Ivanova, A.N.2
Danilets, M.G.3
-
48
-
-
77952946900
-
Aurothiomalate inhibits cyclooxygenase 2, matrix metalloproteinase 3, and interleukin-6 expression in chondrocytes by increasing MAPK phosphatase 1 expression and decreasing p38 phosphorylation: MAPK phosphatase 1 as a novel target for antirheumatic drugs
-
Nieminen R, Korhonen R, Moilanen T, Clark AR, Moilanen E. Aurothiomalate inhibits cyclooxygenase 2, matrix metalloproteinase 3, and interleukin-6 expression in chondrocytes by increasing MAPK phosphatase 1 expression and decreasing p38 phosphorylation: MAPK phosphatase 1 as a novel target for antirheumatic drugs. Arthritis Rheum. 62(6), 1650-1659 (2010).
-
(2010)
Arthritis Rheum
, vol.62
, Issue.6
, pp. 1650-1659
-
-
Nieminen, R.1
Korhonen, R.2
Moilanen, T.3
Clark, A.R.4
Moilanen, E.5
-
49
-
-
0036709080
-
Gold sodium thiomalate suppresses the differentiation and function of human dendritic cells from peripheral blood monocytes
-
Wang ZY, Morinobu A, Kawano S, Saegusa J, Wang B, Kumagai S. Gold sodium thiomalate suppresses the differentiation and function of human dendritic cells from peripheral blood monocytes. Clin. Exp. Rheumatol. 20(5), 683-688 (2002).
-
(2002)
Clin. Exp. Rheumatol
, vol.20
, Issue.5
, pp. 683-688
-
-
Wang, Z.Y.1
Morinobu, A.2
Kawano, S.3
Saegusa, J.4
Wang, B.5
Kumagai, S.6
-
51
-
-
0029929327
-
A 10 year follow up of parenteral gold therapy in patients with rheumatoid arthritis
-
Bendix G, Bjelle A. A 10 year follow up of parenteral gold therapy in patients with rheumatoid arthritis. Ann. Rheum. Dis. 55(3), 169-176 (1996).
-
(1996)
Ann. Rheum. Dis
, vol.55
, Issue.3
, pp. 169-176
-
-
Bendix, G.1
Bjelle, A.2
-
52
-
-
84921431065
-
Antimalarials for treating rheumatoid arthritis
-
Suarez-Almazor ME, Belseck E, Shea B, Homik J, Wells G, Tugwell P. Antimalarials for treating rheumatoid arthritis. Cochrane Database Syst. Rev. 4, CD000959 (2000).
-
(2000)
Cochrane Database Syst. Rev
, vol.4
-
-
Suarez-Almazor, M.E.1
Belseck, E.2
Shea, B.3
Homik, J.4
Wells, G.5
Tugwell, P.6
-
53
-
-
79955017501
-
Re-evaluation of antimalarials in treating rheumatic diseases: Re-appreciation and insights into new mechanisms of action
-
Katz SJ, Russell AS. Re-evaluation of antimalarials in treating rheumatic diseases: re-appreciation and insights into new mechanisms of action. Curr. Opin. Rheumatol. 23(3), 278-281 (2011).
-
(2011)
Curr. Opin. Rheumatol
, vol.23
, Issue.3
, pp. 278-281
-
-
Katz, S.J.1
Russell, A.S.2
-
54
-
-
0031936182
-
Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds
-
Macfarlane DE, Manzel L. Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds. J. Immunol. 160(3), 1122-1131 (1998).
-
(1998)
J. Immunol
, vol.160
, Issue.3
, pp. 1122-1131
-
-
Macfarlane, D.E.1
Manzel, L.2
-
55
-
-
0025058790
-
Sulphasalazine versus hydroxychloroquine in rheumatoid arthritis: 3-year follow-up
-
van der Heijde DM, van Riel PL, Nuver-Zwart IH, van de Putte LB. Sulphasalazine versus hydroxychloroquine in rheumatoid arthritis: 3-year follow-up. Lancet 335(8688), 539 (1990).
-
(1990)
Lancet
, vol.335
, Issue.8688
, pp. 539
-
-
Van Der Heijde, D.M.1
Van Riel, P.L.2
Nuver-Zwart, I.H.3
Van De Putte, L.B.4
-
56
-
-
0031789546
-
Long-term effectiveness of antimalarial drugs in rheumatic diseases
-
Avina-Zubieta JA, Galindo-Rodriguez G, Newman S, Suarez-Almazor ME, Russell AS. Long-term effectiveness of antimalarial drugs in rheumatic diseases. Ann. Rheum. Dis. 57(10), 582-587 (1998).
-
(1998)
Ann. Rheum. Dis
, vol.57
, Issue.10
, pp. 582-587
-
-
Avina-Zubieta, J.A.1
Galindo-Rodriguez, G.2
Newman, S.3
Suarez-Almazor, M.E.4
Russell, A.S.5
-
57
-
-
77953093167
-
Rates and predictors of hydroxychloroquine retinal toxicity in patients with rheumatoid arthritis and systemic lupus erythematosus
-
Wolfe F, Marmor MF. Rates and predictors of hydroxychloroquine retinal toxicity in patients with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Care Res. 62(6), 775-784 (2010).
-
(2010)
Arthritis Care Res
, vol.62
, Issue.6
, pp. 775-784
-
-
Wolfe, F.1
Marmor, M.F.2
-
58
-
-
67549096874
-
Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with a focus on rheumatoid arthritis: Integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative
-
Visser K, Katchamart W, Loza E et al. Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with a focus on rheumatoid arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative. Ann. Rheum. Dis. 68(7), 1086-1093 (2009).
-
(2009)
Ann. Rheum. Dis
, vol.68
, Issue.7
, pp. 1086-1093
-
-
Visser, K.1
Katchamart, W.2
Loza, E.3
-
59
-
-
84860511740
-
Conventional combination treatment versus biological treatment in methotrexate-refractory early rheumatoid arthritis: 2 year follow-up of the randomised, non-blinded, parallel-group Swefot trial
-
van Vollenhoven RF, Geborek P, Forslind K et al. Conventional combination treatment versus biological treatment in methotrexate-refractory early rheumatoid arthritis: 2 year follow-up of the randomised, non-blinded, parallel-group Swefot trial. Lancet 379(9827), 1712-1720 (2012).
-
(2012)
Lancet
, vol.379
, Issue.9827
, pp. 1712-1720
-
-
Van Vollenhoven, R.F.1
Geborek, P.2
Forslind, K.3
-
60
-
-
9244247260
-
Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications
-
O'Dell JR, Haire CE, Erikson N et al. Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications. N. Engl. J. Med. 334(20), 1287-1291 (1996).
-
(1996)
N. Engl. J. Med
, vol.334
, Issue.20
, pp. 1287-1291
-
-
O'Dell, J.R.1
Haire, C.E.2
Erikson, N.3
-
61
-
-
0036096084
-
Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications: Results of a two-year, randomized, double-blind, placebo-controlled trial
-
O'Dell JR, Leff R, Paulsen G et al. Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications: results of a two-year, randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 46(5), 1164-1170 (2002).
-
(2002)
Arthritis Rheum
, vol.46
, Issue.5
, pp. 1164-1170
-
-
O'Dell, J.R.1
Leff, R.2
Paulsen, G.3
-
62
-
-
67549142546
-
Efficacy and toxicity of methotrexate (MTX) monotherapy versus MTX combination therapy with non-biological disease-modifying antirheumatic drugs in rheumatoid arthritis: A systematic review and meta-analysis
-
Katchamart W, Trudeau J, Phumethum V, Bombardier C. Efficacy and toxicity of methotrexate (MTX) monotherapy versus MTX combination therapy with non-biological disease-modifying antirheumatic drugs in rheumatoid arthritis: a systematic review and meta-analysis. Ann. Rheum. Dis. 68(7), 1105-1112 (2009).
-
(2009)
Ann. Rheum. Dis
, vol.68
, Issue.7
, pp. 1105-1112
-
-
Katchamart, W.1
Trudeau, J.2
Phumethum, V.3
Bombardier, C.4
-
63
-
-
78049509056
-
Early combination disease-modifying antirheumatic drug therapy and tight disease control improve long-term radiologic outcome in patients with early rheumatoid arthritis: The 11-year results of the Finnish Rheumatoid Arthritis Combination Therapy trial
-
Rantalaiho V, Korpela M, Laasonen L et al. Early combination disease-modifying antirheumatic drug therapy and tight disease control improve long-term radiologic outcome in patients with early rheumatoid arthritis: the 11-year results of the Finnish Rheumatoid Arthritis Combination Therapy trial. Arthritis Res. Ther. 12(3), R122 (2010).
-
(2010)
Arthritis Res. Ther
, vol.12
, Issue.3
-
-
Rantalaiho, V.1
Korpela, M.2
Laasonen, L.3
-
64
-
-
0033535754
-
Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: A randomised trial
-
FIN-RACo trial group
-
Möttönen T, Hannonen P, Leirisalo-Repo M et al. FIN-RACo trial group. Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: a randomised trial. Lancet 353(9164), 1568-1573 (1999).
-
(1999)
Lancet
, vol.353
, Issue.9164
, pp. 1568-1573
-
-
Möttönen, T.1
Hannonen, P.2
Leirisalo-Repo, M.3
-
65
-
-
84865655947
-
A randomized comparative effectiveness study of oral triple therapy versus etanercept plus methotrexate in early aggressive rheumatoid arthritis: The Treatment of Early Aggressive Rheumatoid Arthritis trial
-
Moreland LW, O'Dell JR, Paulus HE et al. A randomized comparative effectiveness study of oral triple therapy versus etanercept plus methotrexate in early aggressive rheumatoid arthritis: the Treatment of Early Aggressive Rheumatoid Arthritis trial. Arthritis Rheum. 64(9), 2824-2835 (2012).
-
(2012)
Arthritis Rheum
, vol.64
, Issue.9
, pp. 2824-2835
-
-
Moreland, L.W.1
O'Dell, J.R.2
Paulus, H.E.3
-
66
-
-
68049124945
-
Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial
-
van Vollenhoven RF, Ernestam S, Geborek P et al. Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial. Lancet 374(9688), 459-466 (2009).
-
(2009)
Lancet
, vol.374
, Issue.9688
, pp. 459-466
-
-
Van Vollenhoven, R.F.1
Ernestam, S.2
Geborek, P.3
-
67
-
-
84880753128
-
Therapies for active rheumatoid arthritis after methotrexate failure
-
O'Dell JR, Mikuls TR, Taylor TH et al. Therapies for active rheumatoid arthritis after methotrexate failure. N. Engl. J. Med. 369(4), 307-318 (2013).
-
(2013)
N. Engl. J. Med
, vol.369
, Issue.4
, pp. 307-318
-
-
O'Dell, J.R.1
Mikuls, T.R.2
Taylor, T.H.3
-
68
-
-
0036049943
-
Analysis of improvements, full responses, remission and toxicity in rheumatoid patients treated with step-up combination therapy (methotrexate, cyclosporin A, sulphasalazine) or monotherapy for three years
-
Ferraccioli GF, Gremese E, Tomietto P, Favret G, Damato R, Di Poi E. Analysis of improvements, full responses, remission and toxicity in rheumatoid patients treated with step-up combination therapy (methotrexate, cyclosporin A, sulphasalazine) or monotherapy for three years. Rheumatology (Oxford) 41(8), 892-898 (2002).
-
(2002)
Rheumatology (Oxford)
, vol.41
, Issue.8
, pp. 892-898
-
-
Ferraccioli, G.F.1
Gremese, E.2
Tomietto, P.3
Favret, G.4
Damato, R.5
Di Poi, E.6
-
69
-
-
2642530610
-
Combination leflunomide and methotrexate (MTX) therapy for patients with active rheumatoid arthritis failing MTX monotherapy: Open-label extension of a randomized, double-blind, placebo controlled trial
-
Kremer J, Genovese M, Cannon GW et al. Combination leflunomide and methotrexate (MTX) therapy for patients with active rheumatoid arthritis failing MTX monotherapy: open-label extension of a randomized, double-blind, placebo controlled trial. J. Rheumatol. 31(8), 1521-1531 (2004).
-
(2004)
J. Rheumatol
, vol.31
, Issue.8
, pp. 1521-1531
-
-
Kremer, J.1
Genovese, M.2
Cannon, G.W.3
-
70
-
-
0037027427
-
Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate. A randomized, double-blind, placebo-controlled trial
-
Kremer JM, Genovese MC, Cannon GW et al. Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate. A randomized, double-blind, placebo-controlled trial. Ann. Intern. Med. 137(9), 726-733 (2002).
-
(2002)
Ann. Intern. Med
, vol.137
, Issue.9
, pp. 726-733
-
-
Kremer, J.M.1
Genovese, M.C.2
Cannon, G.W.3
-
71
-
-
80555128924
-
Liver toxicity is rare in rheumatoid arthritis patients using combination therapy with leflunomide and methotrexate
-
Alves JA, Fialho SC Morato EF et al. Liver toxicity is rare in rheumatoid arthritis patients using combination therapy with leflunomide and methotrexate. Rev. Bras. Reumatol. 51(2), 141-144 (2011).
-
(2011)
Rev. Bras. Reumatol
, vol.51
, Issue.2
, pp. 141-144
-
-
Alves, J.A.1
Fialho, S.C.2
Morato, E.F.3
-
72
-
-
0033509841
-
Pharmacokinetics, safety, and efficacy of combination treatment with methotrexate and leflunomide in patients with active rheumatoid arthritis
-
Weinblatt ME, Kremer JM, Coblyn JS et al. Pharmacokinetics, safety, and efficacy of combination treatment with methotrexate and leflunomide in patients with active rheumatoid arthritis. Arthritis Rheum. 42(7), 1322-1328 (1999).
-
(1999)
Arthritis Rheum
, vol.42
, Issue.7
, pp. 1322-1328
-
-
Weinblatt, M.E.1
Kremer, J.M.2
Coblyn, J.S.3
-
73
-
-
0026579862
-
Comparison of auranofin, methotrexate, and the combination of both in the treatment of rheumatoid arthritis. A controlled clinical trial
-
Williams HJ, Ward JR, Reading JC et al. Comparison of auranofin, methotrexate, and the combination of both in the treatment of rheumatoid arthritis. A controlled clinical trial. Arthritis Rheum. 35(3), 259-269 (1992).
-
(1992)
Arthritis Rheum
, vol.35
, Issue.3
, pp. 259-269
-
-
Williams, H.J.1
Ward, J.R.2
Reading, J.C.3
-
74
-
-
0027430830
-
Radiographic assessment of disease progression in rheumatoid arthritis patients enrolled in the cooperative systematic studies of the rheumatic diseases program randomized clinical trial of methotrexate, auranofin, or a combination of the two
-
López-Méndez A, Daniel WW, Reading JC, Ward JR, Alarcón GS. Radiographic assessment of disease progression in rheumatoid arthritis patients enrolled in the cooperative systematic studies of the rheumatic diseases program randomized clinical trial of methotrexate, auranofin, or a combination of the two. Arthritis Rheum. 36(10), 1364-1369 (1993).
-
(1993)
Arthritis Rheum
, vol.36
, Issue.10
, pp. 1364-1369
-
-
López-Méndez, A.1
Daniel, W.W.2
Reading, J.C.3
Ward, J.R.4
Alarcón, G.S.5
-
75
-
-
0029022389
-
Combination therapy with cyclosporine and methotrexate in severe rheumatoid arthritis. The Methotrexate-Cyclosporine Combination Study Group
-
Tugwell P, Pincus T, Yocum D et al. Combination therapy with cyclosporine and methotrexate in severe rheumatoid arthritis. The Methotrexate-Cyclosporine Combination Study Group. N. Engl. J. Med. 333(3), 137-141 (1995).
-
(1995)
N. Engl. J. Med
, vol.333
, Issue.3
, pp. 137-141
-
-
Tugwell, P.1
Pincus, T.2
Yocum, D.3
-
76
-
-
15144356729
-
Combination treatment of severe rheumatoid arthritis with cyclosporine and methotrexate for forty-eight weeks: An open-label extension study. The Methotrexate-Cyclosporine Combination Study Group
-
Stein CM, Pincus T, Yocum D et al. Combination treatment of severe rheumatoid arthritis with cyclosporine and methotrexate for forty-eight weeks: an open-label extension study. The Methotrexate-Cyclosporine Combination Study Group. Arthritis Rheum. 40(10), 1843-1851 (1997).
-
(1997)
Arthritis Rheum
, vol.40
, Issue.10
, pp. 1843-1851
-
-
Stein, C.M.1
Pincus, T.2
Yocum, D.3
-
77
-
-
33646468228
-
Combination treatment with methotrexate, cyclosporine, and intraarticular betamethasone compared with methotrexate and intraarticular betamethasone in early active rheumatoid arthritis: An investigator-initiated, multicenter, randomized, double-blind, parallel-group, placebo-controlled study
-
Hetland ML, Stengaard-Pedersen K, Junker P et al. Combination treatment with methotrexate, cyclosporine, and intraarticular betamethasone compared with methotrexate and intraarticular betamethasone in early active rheumatoid arthritis: an investigator-initiated, multicenter, randomized, double-blind, parallel-group, placebo-controlled study. Arthritis Rheum. 54(5), 1401-1409 (2006).
-
(2006)
Arthritis Rheum
, vol.54
, Issue.5
, pp. 1401-1409
-
-
Hetland, M.L.1
Stengaard-Pedersen, K.2
Junker, P.3
-
78
-
-
0037377961
-
Cyclosporin A monotherapy versus cyclosporin A and methotrexate combination therapy in patients with early rheumatoid arthritis: A double blind randomised placebo controlled trial
-
Gerards AH, Landewé RB, Prins APA et al. Cyclosporin A monotherapy versus cyclosporin A and methotrexate combination therapy in patients with early rheumatoid arthritis: a double blind randomised placebo controlled trial. Ann. Rheum. Dis. 62(4), 291-296 (2003).
-
(2003)
Ann. Rheum. Dis
, vol.62
, Issue.4
, pp. 291-296
-
-
Gerards, A.H.1
Landewé, R.B.2
Prins, A.P.A.3
-
79
-
-
33644686282
-
Combination of cyclosporine and leflunomide versus single therapy in severe rheumatoid arthritis
-
Karanikolas G, Charalambopoulos D, Andrianakos A, Antoniades C, Katsilambros N. Combination of cyclosporine and leflunomide versus single therapy in severe rheumatoid arthritis. J. Rheumatol. 33(3), 486-489 (2006).
-
(2006)
J. Rheumatol
, vol.33
, Issue.3
, pp. 486-489
-
-
Karanikolas, G.1
Charalambopoulos, D.2
Andrianakos, A.3
Antoniades, C.4
Katsilambros, N.5
-
80
-
-
0028572390
-
Combination of methotrexate and sulphasalazine vs methotrexate alone: A randomized open clinical trial in rheumatoid arthritis patients resistant to sulphasalazine therapy
-
Haagsma CJ, van Riel PL, de Rooij DJ et al. Combination of methotrexate and sulphasalazine vs methotrexate alone: a randomized open clinical trial in rheumatoid arthritis patients resistant to sulphasalazine therapy. Br. J. Rheumatol. 33(11), 1049-1055 (1994).
-
(1994)
Br. J. Rheumatol
, vol.33
, Issue.11
, pp. 1049-1055
-
-
Haagsma, C.J.1
Van Riel, P.L.2
De Rooij, D.J.3
-
81
-
-
0032957015
-
Combination therapy in early rheumatoid arthritis: A randomised, controlled, double blind 52 week clinical trial of sulphasalazine and methotrexate compared with the single components
-
Dougados M, Combe B, Cantagrel A et al. Combination therapy in early rheumatoid arthritis: a randomised, controlled, double blind 52 week clinical trial of sulphasalazine and methotrexate compared with the single components. Ann. Rheum. Dis. 58(4), 220-225 (1999).
-
(1999)
Ann. Rheum. Dis
, vol.58
, Issue.4
, pp. 220-225
-
-
Dougados, M.1
Combe, B.2
Cantagrel, A.3
-
82
-
-
33846864259
-
Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid arthritis with a suboptimal response to sulfasalazine: Results from the double-blind placebo-controlled MASCOT study
-
Capell HA, Madhok R, Porter DR et al. Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid arthritis with a suboptimal response to sulfasalazine: results from the double-blind placebo-controlled MASCOT study. Ann. Rheum. Dis. 66(2), 235-241 (2007).
-
(2007)
Ann. Rheum. Dis
, vol.66
, Issue.2
, pp. 235-241
-
-
Capell, H.A.1
Madhok, R.2
Porter, D.R.3
-
83
-
-
0028148788
-
Combination therapy with methotrexate and chloroquine in rheumatoid arthritis. A multicenter randomized placebo-controlled trial
-
Ferraz MB, Pinheiro GR, Helfenstein M et al. Combination therapy with methotrexate and chloroquine in rheumatoid arthritis. A multicenter randomized placebo-controlled trial. Scand. J. Rheumatol. 23(5), 231-236 (1994).
-
(1994)
Scand. J. Rheumatol
, vol.23
, Issue.5
, pp. 231-236
-
-
Ferraz, M.B.1
Pinheiro, G.R.2
Helfenstein, M.3
-
84
-
-
0036791895
-
Combination therapy with methotrexate and hydroxychloroquine for rheumatoid arthritis increases exposure to methotrexate
-
Carmichael SJ, Beal J, Day RO, Tett SE. Combination therapy with methotrexate and hydroxychloroquine for rheumatoid arthritis increases exposure to methotrexate. J. Rheumatol. 29(10), 2077-2083 (2002).
-
(2002)
J. Rheumatol
, vol.29
, Issue.10
, pp. 2077-2083
-
-
Carmichael, S.J.1
Beal, J.2
Day, R.O.3
Tett, S.E.4
-
85
-
-
0026643335
-
Comparison of azathioprine, methotrexate, and the combination of both in the treatment of rheumatoid arthritis. A controlled clinical trial
-
Willkens RF, Urowitz MB, Stablein DM et al. Comparison of azathioprine, methotrexate, and the combination of both in the treatment of rheumatoid arthritis. A controlled clinical trial. Arthritis Rheum. 35(8), 849-856 (1992).
-
(1992)
Arthritis Rheum
, vol.35
, Issue.8
, pp. 849-856
-
-
Willkens, R.F.1
Urowitz, M.B.2
Stablein, D.M.3
-
86
-
-
0029566876
-
Comparison of azathioprine, methotrexate, and the combination of the two in the treatment of rheumatoid arthritis. A forty-eight-week controlled clinical trial with radiologic outcome assessment
-
Willkens RF, Sharp JT, Stablein D, Marks C, Wortmann R. Comparison of azathioprine, methotrexate, and the combination of the two in the treatment of rheumatoid arthritis. A forty-eight-week controlled clinical trial with radiologic outcome assessment. Arthritis Rheum. 38(12), 1799-1806 (1995).
-
(1995)
Arthritis Rheum
, vol.38
, Issue.12
, pp. 1799-1806
-
-
Willkens, R.F.1
Sharp, J.T.2
Stablein, D.3
Marks, C.4
Wortmann, R.5
-
87
-
-
32444441470
-
Treatment of early seropositive rheumatoid arthritis: Doxycycline plus methotrexate versus methotrexate alone
-
O'Dell JR, Elliott JR, Mallek JA et al. Treatment of early seropositive rheumatoid arthritis: doxycycline plus methotrexate versus methotrexate alone. Arthritis Rheum. 54(2), 621-627 (2006).
-
(2006)
Arthritis Rheum
, vol.54
, Issue.2
, pp. 621-627
-
-
O'Dell, J.R.1
Elliott, J.R.2
Mallek, J.A.3
-
88
-
-
27744516900
-
Therapeutic effects of the combination of methotrexate and bucillamine in early rheumatoid arthritis: A multicenter, double-blind, randomized controlled study
-
Ichikawa Y, Saito T, Yamanaka H et al. Therapeutic effects of the combination of methotrexate and bucillamine in early rheumatoid arthritis: a multicenter, double-blind, randomized controlled study. Mod. Rheumatol. 15(5), 323-328 (2005).
-
(2005)
Mod. Rheumatol
, vol.15
, Issue.5
, pp. 323-328
-
-
Ichikawa, Y.1
Saito, T.2
Yamanaka, H.3
-
89
-
-
11344269738
-
When a DMARD fails, should patients switch to sulfasalazine or add sulfasalazine to continuing leflunomide?
-
Dougados M, Emery P, Lemmel EM, Zerbini CA, Brin S, van Riel P. When a DMARD fails, should patients switch to sulfasalazine or add sulfasalazine to continuing leflunomide? Ann. Rheum. Dis. 64(1), 44-51 (2005).
-
(2005)
Ann. Rheum. Dis
, vol.64
, Issue.1
, pp. 44-51
-
-
Dougados, M.1
Emery, P.2
Lemmel, E.M.3
Zerbini, C.A.4
Brin, S.5
Van Riel, P.6
-
90
-
-
0032854478
-
Cyclosporin and sulfasalazine combination in the treatment of early rheumatoid arthritis
-
Rojkovich B, Hodinka L, Balint G et al. Cyclosporin and sulfasalazine combination in the treatment of early rheumatoid arthritis. Scand. J. Rheumatol. 28(4), 216-221 (1999).
-
(1999)
Scand. J. Rheumatol
, vol.28
, Issue.4
, pp. 216-221
-
-
Rojkovich, B.1
Hodinka, L.2
Balint, G.3
-
91
-
-
0027379482
-
Hydroxychloroquine and sulphasalazine alone and in combination in rheumatoid arthritis: A randomised double blind trial
-
Faarvang KL, Egsmose C, Kryger P, Pødenphant J, Ingeman-Nielsen M, Hansen TM. Hydroxychloroquine and sulphasalazine alone and in combination in rheumatoid arthritis: a randomised double blind trial. Ann. Rheum. Dis. 52(10), 711-715 (1993).
-
(1993)
Ann. Rheum. Dis
, vol.52
, Issue.10
, pp. 711-715
-
-
Faarvang, K.L.1
Egsmose, C.2
Kryger, P.3
Pødenphant, J.4
Ingeman-Nielsen, M.5
Hansen, T.M.6
-
92
-
-
27744514865
-
Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial
-
Goekoop-Ruiterman YP, de Vries-Bouwstra JK, Allaart CF et al. Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial. Arthritis Rheum. 52(11), 3381-3390 (2005).
-
(2005)
Arthritis Rheum
, vol.52
, Issue.11
, pp. 3381-3390
-
-
Goekoop-Ruiterman, Y.P.1
De Vries-Bouwstra, J.K.2
Allaart, C.F.3
-
93
-
-
38149067809
-
Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): A double-blind, randomised controlled trial
-
Buttgereit F, Doering G, Schaeffler A et al. Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial. Lancet 371(9608), 205-214 (2008).
-
(2008)
Lancet
, vol.371
, Issue.9608
, pp. 205-214
-
-
Buttgereit, F.1
Doering, G.2
Schaeffler, A.3
-
94
-
-
84859832981
-
2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis
-
Singh JA, Furst DE, Bharat A et al. 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res. 64(5), 625-639 (2012).
-
(2012)
Arthritis Care Res
, vol.64
, Issue.5
, pp. 625-639
-
-
Singh, J.A.1
Furst, D.E.2
Bharat, A.3
-
95
-
-
80051611724
-
Cardiovascular safety of anti-TNF-alpha therapies: Facts and unsettled issues
-
Cacciapaglia F, Navarini L, Menna P, Salvatorelli E, Minotti G, Afeltra A. Cardiovascular safety of anti-TNF-alpha therapies: facts and unsettled issues. Autoimmun. Rev. 10(10), 631-635 (2011).
-
(2011)
Autoimmun. Rev
, vol.10
, Issue.10
, pp. 631-635
-
-
Cacciapaglia, F.1
Navarini, L.2
Menna, P.3
Salvatorelli, E.4
Minotti, G.5
Afeltra, A.6
-
96
-
-
79952012771
-
Tumour necrosis factor antagonists and the risk of cardiovascular disease in patients with rheumatoid arthritis: A systematic literature review
-
Westlake SL, Colebatch AN, Baird J et al. Tumour necrosis factor antagonists and the risk of cardiovascular disease in patients with rheumatoid arthritis: a systematic literature review. Rheumatology (Oxford) 50(3), 518-531 (2011).
-
(2011)
Rheumatology (Oxford)
, vol.50
, Issue.3
, pp. 518-531
-
-
Westlake, S.L.1
Colebatch, A.N.2
Baird, J.3
-
97
-
-
33750608851
-
Tumor necrosis factor antagonists: Different kinetics and/or mechanisms of action may explain differences in the risk for developing granulomatous infection
-
Furst DE, Wallis R, Broder M, Beenhouwer DO. Tumor necrosis factor antagonists: different kinetics and/or mechanisms of action may explain differences in the risk for developing granulomatous infection. Semin. Arthritis Rheum. 36(3), 159-167 (2006).
-
(2006)
Semin. Arthritis Rheum
, vol.36
, Issue.3
, pp. 159-167
-
-
Furst, D.E.1
Wallis, R.2
Broder, M.3
Beenhouwer, D.O.4
-
98
-
-
72949116165
-
A network meta-analysis of randomized controlled trials of biologics for rheumatoid arthritis: A Cochrane overview
-
Singh JA, Christensen R, Wells GA et al. A network meta-analysis of randomized controlled trials of biologics for rheumatoid arthritis: a Cochrane overview. CMAJ 181(11), 787-796 (2009).
-
(2009)
CMAJ
, vol.181
, Issue.11
, pp. 787-796
-
-
Singh, J.A.1
Christensen, R.2
Wells, G.A.3
-
99
-
-
84869210810
-
Mixed treatment comparison of the treatment discontinuations of biologic disease-modifying antirheumatic drugs in adults with rheumatoid arthritis
-
Desai RJ, Hansen RA, Rao JK et al. Mixed treatment comparison of the treatment discontinuations of biologic disease-modifying antirheumatic drugs in adults with rheumatoid arthritis. Ann. Pharmacother. 46(11), 1491-1505 (2012).
-
(2012)
Ann. Pharmacother
, vol.46
, Issue.11
, pp. 1491-1505
-
-
Desai, R.J.1
Hansen, R.A.2
Rao, J.K.3
-
100
-
-
84855833408
-
Systematic review and meta-analysis of the efficacy and safety of existing TNF blocking agents in treatment of rheumatoid arthritis
-
Aaltonen KJ, Virkki LM, Malmivaara A, Konttinen YT, Nordström DC, Blom M. Systematic review and meta-analysis of the efficacy and safety of existing TNF blocking agents in treatment of rheumatoid arthritis. PLoS ONE 7(1), e30275 (2012).
-
(2012)
PLoS ONE
, vol.7
, Issue.1
-
-
Aaltonen, K.J.1
Virkki, L.M.2
Malmivaara, A.3
Konttinen, Y.T.4
Nordström, D.C.5
Blom, M.6
-
101
-
-
84874656491
-
Immunogenicity of anti-TNF biologic therapies for rheumatoid arthritis
-
van Schouwenburg PA, Rispens T, Wolbink GJ. Immunogenicity of anti-TNF biologic therapies for rheumatoid arthritis. Nat. Rev. Rheumatol. 9(3), 164-172 (2013).
-
(2013)
Nat. Rev. Rheumatol
, vol.9
, Issue.3
, pp. 164-172
-
-
Van Schouwenburg, P.A.1
Rispens, T.2
Wolbink, G.J.3
-
102
-
-
84867405325
-
Drug retention rates and relevant risk factors for drug discontinuation due to adverse events in rheumatoid arthritis patients receiving anticytokine therapy with different target molecules
-
Sakai R, Tanaka M, Nanki T et al. Drug retention rates and relevant risk factors for drug discontinuation due to adverse events in rheumatoid arthritis patients receiving anticytokine therapy with different target molecules. Ann. Rheum. Dis. 71(11), 1820-1826 (2012).
-
(2012)
Ann. Rheum. Dis
, vol.71
, Issue.11
, pp. 1820-1826
-
-
Sakai, R.1
Tanaka, M.2
Nanki, T.3
-
103
-
-
84863760529
-
Survival of TNF-alpha antagonists in rheumatoid arthritis: A long-term study
-
Markatseli TE, Alamanos Y, Saougou I, Voulgari PV, Drosos AA. Survival of TNF-alpha antagonists in rheumatoid arthritis: a long-term study. Clin. Exp. Rheumatol. 30(1), 31-38 (2012).
-
(2012)
Clin. Exp. Rheumatol
, vol.30
, Issue.1
, pp. 31-38
-
-
Markatseli, T.E.1
Alamanos, Y.2
Saougou, I.3
Voulgari, P.V.4
Drosos, A.A.5
-
104
-
-
84861811932
-
Longterm retention of tumor necrosis factor - A inhibitor therapy in a large italian cohort of patients with rheumatoid arthritis from the GISEA registry: An appraisal of predictors
-
Iannone F, Gremese E, Atzeni F et al. Longterm retention of tumor necrosis factor-a inhibitor therapy in a large italian cohort of patients with rheumatoid arthritis from the GISEA registry: an appraisal of predictors. J. Rheumatol. 39(6), 1179-1184 (2012).
-
(2012)
J. Rheumatol
, vol.39
, Issue.6
, pp. 1179-1184
-
-
Iannone, F.1
Gremese, E.2
Atzeni, F.3
-
105
-
-
70449725246
-
Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritis
-
Radstake TR, Svenson M, Eijsbouts AM et al. Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritis. Ann. Rheum. Dis. 68(11), 1739-1745 (2009).
-
(2009)
Ann. Rheum. Dis
, vol.68
, Issue.11
, pp. 1739-1745
-
-
Radstake, T.R.1
Svenson, M.2
Eijsbouts, A.M.3
-
106
-
-
79960935860
-
Influence of immunogenicity on the efficacy of long-term treatment with infliximab in rheumatoid arthritis
-
Pascual-Salcedo D, Plasencia C, Ramiro S et al. Influence of immunogenicity on the efficacy of long-term treatment with infliximab in rheumatoid arthritis. Rheumatology (Oxford) 50(8), 1445-1452 (2011).
-
(2011)
Rheumatology (Oxford)
, vol.50
, Issue.8
, pp. 1445-1452
-
-
Pascual-Salcedo, D.1
Plasencia, C.2
Ramiro, S.3
-
107
-
-
34347267600
-
Clinical response to adalimumab: Relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis
-
Bartelds GM, Wijbrandts CA, Nurmohamed MT et al. Clinical response to adalimumab: relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis. Ann. Rheum. Dis. 66(7), 921-926 (2007).
-
(2007)
Ann. Rheum. Dis
, vol.66
, Issue.7
, pp. 921-926
-
-
Bartelds, G.M.1
Wijbrandts, C.A.2
Nurmohamed, M.T.3
-
108
-
-
79953906254
-
Development of antidrug antibodies against adalimumab and association with disease activity and treatment failure during long-term follow-up
-
Bartelds GM, Krieckaert CLM, Nurmohamed MT et al. Development of antidrug antibodies against adalimumab and association with disease activity and treatment failure during long-term follow-up. JAMA 305(14), 1460-1468 (2011).
-
(2011)
JAMA
, vol.305
, Issue.14
, pp. 1460-1468
-
-
Bartelds, G.M.1
Krieckaert, C.L.M.2
Nurmohamed, M.T.3
-
109
-
-
74849094402
-
Direct comparison of treatment responses, remission rates, and drug adherence in patients with rheumatoid arthritis treated with adalimumab, etanercept, or infliximab: Results from eight years of surveillance of clinical practice in the nationwide Danish DANBIO registry
-
Hetland ML, Christensen IJ, Tarp U et al. Direct comparison of treatment responses, remission rates, and drug adherence in patients with rheumatoid arthritis treated with adalimumab, etanercept, or infliximab: results from eight years of surveillance of clinical practice in the nationwide Danish DANBIO registry. Arthritis Rheum. 62(1), 22-32 (2010).
-
(2010)
Arthritis Rheum
, vol.62
, Issue.1
, pp. 22-32
-
-
Hetland, M.L.1
Christensen, I.J.2
Tarp, U.3
-
110
-
-
84873115118
-
A randomised efficacy and discontinuation study of etanercept versus adalimumab (RED SEA) for rheumatoid arthritis: A pragmatic, unblinded, non-inferiority study of first TNF inhibitor use: Outcomes over 2 years
-
Jobanputra P, Maggs F, Deeming A et al. A randomised efficacy and discontinuation study of etanercept versus adalimumab (RED SEA) for rheumatoid arthritis: a pragmatic, unblinded, non-inferiority study of first TNF inhibitor use: outcomes over 2 years. BMJ Open 2(6), e001395 (2012).
-
(2012)
BMJ Open
, vol.2
, Issue.6
-
-
Jobanputra, P.1
Maggs, F.2
Deeming, A.3
-
111
-
-
37349006854
-
The number needed to treat for adalimumab, etanercept, and infliximab based on ACR50 response in three randomized controlled trials on established rheumatoid arthritis: A systematic literature review
-
Kristensen LE, Christensen R, Bliddal H, Geborek P, Danneskiold- Samsøe B, Saxne T. The number needed to treat for adalimumab, etanercept, and infliximab based on ACR50 response in three randomized controlled trials on established rheumatoid arthritis: a systematic literature review. Scand. J. Rheumatol. 36(6), 411-417 (2007).
-
(2007)
Scand. J. Rheumatol
, vol.36
, Issue.6
, pp. 411-417
-
-
Kristensen, L.E.1
Christensen, R.2
Bliddal, H.3
Geborek, P.4
Danneskiold- Samsøe, B.5
Saxne, T.6
-
112
-
-
84866104476
-
Golimumab in patients with active rheumatoid arthritis who have previous experience with tumour necrosis factor inhibitors: Results of a long-term extension of the randomised, double-blind, placebo-controlled GO-AFTER study through week 160
-
Smolen JS, Kay J, Landewé RB et al. Golimumab in patients with active rheumatoid arthritis who have previous experience with tumour necrosis factor inhibitors: results of a long-term extension of the randomised, double-blind, placebo-controlled GO-AFTER study through week 160. Ann. Rheum. Dis. 71(10), 1671-1679 (2012).
-
(2012)
Ann. Rheum. Dis
, vol.71
, Issue.10
, pp. 1671-1679
-
-
Smolen, J.S.1
Kay, J.2
Landewé, R.B.3
-
113
-
-
78650459480
-
Anti-tumor necrosis factor - A antibodies induce regulatory macrophages in an Fc region-dependent manner
-
Vos AC, Wildenberg ME, Duijvestein M, Verhaar AP, van den Brink GR, Hommes DW. Anti-tumor necrosis factor-a antibodies induce regulatory macrophages in an Fc region-dependent manner. Gastroenterology 140(1), 221-230 (2011).
-
(2011)
Gastroenterology
, vol.140
, Issue.1
, pp. 221-230
-
-
Vos, A.C.1
Wildenberg, M.E.2
Duijvestein, M.3
Verhaar, A.P.4
Van Den Brink, G.R.5
Hommes, D.W.6
-
114
-
-
80052977037
-
A mixed treatment comparison of the short-term efficacy of biologic disease modifying anti-rheumatic drugs in established rheumatoid arthritis
-
Turkstra E, Ng S-K, Scuffham PA. A mixed treatment comparison of the short-term efficacy of biologic disease modifying anti-rheumatic drugs in established rheumatoid arthritis. Curr. Med. Res. Opin. 27(10), 1885-1897 (2011).
-
(2011)
Curr. Med. Res. Opin
, vol.27
, Issue.10
, pp. 1885-1897
-
-
Turkstra, E.1
Ng, S.-K.2
Scuffham, P.A.3
-
115
-
-
79953018875
-
Adverse effects of biologics: A network meta-analysis and Cochrane overview
-
Singh JA, Wells GA, Christensen R et al. Adverse effects of biologics: a network meta-analysis and Cochrane overview. Cochrane Database Syst. Rev. 2, CD008794 (2011).
-
(2011)
Cochrane Database Syst. Rev
, vol.2
-
-
Singh, J.A.1
Wells, G.A.2
Christensen, R.3
-
116
-
-
0023694150
-
Correlation of plasma interleukin 1 levels with disease activity in rheumatoid arthritis
-
Eastgate JA, Symons JA, Wood NC, Grinlinton FM, di Giovine FS, Duff GW. Correlation of plasma interleukin 1 levels with disease activity in rheumatoid arthritis. Lancet 2(8613), 706-709 (1988).
-
(1988)
Lancet
, vol.2
, Issue.8613
, pp. 706-709
-
-
Eastgate, J.A.1
Symons, J.A.2
Wood, N.C.3
Grinlinton, F.M.4
Di Giovine, F.S.5
Duff, G.W.6
-
117
-
-
34447318083
-
The efficacy of inhibiting tumour necrosis factor alpha and interleukin 1 in patients with rheumatoid arthritis: A meta-analysis and adjusted indirect comparisons
-
Nixon R, Bansback N, Brennan A. The efficacy of inhibiting tumour necrosis factor alpha and interleukin 1 in patients with rheumatoid arthritis: a meta-analysis and adjusted indirect comparisons. Rheumatology (Oxford) 46(7), 1140-1147 (2007).
-
(2007)
Rheumatology (Oxford)
, vol.46
, Issue.7
, pp. 1140-1147
-
-
Nixon, R.1
Bansback, N.2
Brennan, A.3
-
118
-
-
34047174085
-
A pilot study of IL-1 inhibition by anakinra in acute gout
-
So A, De Smedt T, Revaz S, Tschopp J. A pilot study of IL-1 inhibition by anakinra in acute gout. Arthritis Res. Ther. 9(2), R28 (2007).
-
(2007)
Arthritis Res. Ther
, vol.9
, Issue.2
-
-
So, A.1
De Smedt, T.2
Revaz, S.3
Tschopp, J.4
-
119
-
-
39749175570
-
Successful treatment of resistant pseudogout with anakinra
-
McGonagle D, Tan AL, Madden J, Emery P, McDermott MF. Successful treatment of resistant pseudogout with anakinra. Arthritis Rheum. 58(2), 631-633 (2008).
-
(2008)
Arthritis Rheum
, vol.58
, Issue.2
, pp. 631-633
-
-
McGonagle, D.1
Tan, A.L.2
Madden, J.3
Emery, P.4
McDermott, M.F.5
-
120
-
-
84876744340
-
Anakinra in adult onset still's disease: Long term treatment in patients resistant to conventional therapy
-
Giampietro C, Ridene M, Lequerre T et al. Anakinra in adult onset still's disease: long term treatment in patients resistant to conventional therapy. Arthritis Care Res. (Hoboken) 65(5), 822-826 (2012).
-
(2012)
Arthritis Care Res. (Hoboken)
, vol.65
, Issue.5
, pp. 822-826
-
-
Giampietro, C.1
Ridene, M.2
Lequerre, T.3
-
121
-
-
73849134001
-
Blocking interleukin-1 in rheumatic diseases
-
Goldbach-Mansky R. Blocking interleukin-1 in rheumatic diseases. Ann. NY Acad. Sci. 1182, 111-123 (2009).
-
(2009)
Ann. NY Acad. Sci
, vol.1182
, pp. 111-123
-
-
Goldbach-Mansky, R.1
-
122
-
-
84863228835
-
Sustained response and prevention of damage progression in patients with neonatal-onset multisystem inflammatory disease treated with anakinra: A cohort study to determine three- and five-year outcomes
-
Sibley CH, Plass N, Snow J et al. Sustained response and prevention of damage progression in patients with neonatal-onset multisystem inflammatory disease treated with anakinra: a cohort study to determine three- and five-year outcomes. Arthritis Rheum. 64(7), 2375-2386 (2012).
-
(2012)
Arthritis Rheum
, vol.64
, Issue.7
, pp. 2375-2386
-
-
Sibley, C.H.1
Plass, N.2
Snow, J.3
-
123
-
-
52149099504
-
IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: Results from a 24-week multicentre randomised placebo-controlled trial
-
Emery P, Keystone E, Tony HP et al. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial. Ann. Rheum. Dis. 67(11), 1516-1523 (2008).
-
(2008)
Ann. Rheum. Dis
, vol.67
, Issue.11
, pp. 1516-1523
-
-
Emery, P.1
Keystone, E.2
Tony, H.P.3
-
124
-
-
84870514601
-
Tocilizumab (TCZ) monotherapy is superior to adalimumab (ADA) monotherapy in reducing disease activity in patients with rheumatoid arthritis(RA): 24-week data from the phase 4 ADACTA trial
-
Gabay C, Emery P, van Vollenhoven R. Tocilizumab (TCZ) monotherapy is superior to adalimumab (ADA) monotherapy in reducing disease activity in patients with rheumatoid arthritis(RA): 24-week data from the phase 4 ADACTA trial. Ann. Rheum. Dis. 71(Suppl. 3), 152 (2012).
-
(2012)
Ann. Rheum. Dis
, vol.71
, Issue.SUPPL. 3
, pp. 152
-
-
Gabay, C.1
Emery, P.2
Van Vollenhoven, R.3
-
125
-
-
84858124911
-
Cost-effectiveness of adalimumab, etanercept, and tocilizumab as first-line treatments for moderate-to-severe rheumatoid arthritis
-
Soini EJ, Hallinen TA, Puolakka K, Vihervaara V, Kauppi MJ. Cost-effectiveness of adalimumab, etanercept, and tocilizumab as first-line treatments for moderate-to-severe rheumatoid arthritis. J. Med. Econ. 15(2), 340-351 (2012).
-
(2012)
J. Med. Econ
, vol.15
, Issue.2
, pp. 340-351
-
-
Soini, E.J.1
Hallinen, T.A.2
Puolakka, K.3
Vihervaara, V.4
Kauppi, M.J.5
-
126
-
-
60149100932
-
Masked early symptoms of pneumonia in patients with rheumatoid arthritis during tocilizumab treatment: A report of two cases
-
Fujiwara H, Nishimoto N, Hamano Y et al. Masked early symptoms of pneumonia in patients with rheumatoid arthritis during tocilizumab treatment: a report of two cases. Mod. Rheumatol. 19(1), 64-68 (2009).
-
(2009)
Mod. Rheumatol
, vol.19
, Issue.1
, pp. 64-68
-
-
Fujiwara, H.1
Nishimoto, N.2
Hamano, Y.3
-
127
-
-
84857238587
-
Effectiveness of disease-modifying antirheumatic drug co-therapy with methotrexate and leflunomide in rituximab-treated rheumatoid arthritis patients: Results of a 1-year follow-up study from the CERERRA collaboration
-
Chatzidionysiou K, Lie E, Nasonov E et al. Effectiveness of disease-modifying antirheumatic drug co-therapy with methotrexate and leflunomide in rituximab-treated rheumatoid arthritis patients: results of a 1-year follow-up study from the CERERRA collaboration. Ann. Rheum. Dis. 71(3), 374-377 (2012).
-
(2012)
Ann. Rheum. Dis
, vol.71
, Issue.3
, pp. 374-377
-
-
Chatzidionysiou, K.1
Lie, E.2
Nasonov, E.3
-
128
-
-
82955195732
-
Comparative effectiveness of rituximab in combination with either methotrexate or leflunomide in the treatment of rheumatoid arthritis
-
Narváez J, Díaz-Torné C, Ruiz JM et al. Comparative effectiveness of rituximab in combination with either methotrexate or leflunomide in the treatment of rheumatoid arthritis. Semin. Arthritis Rheum. 41(3), 401-405 (2011).
-
(2011)
Semin. Arthritis Rheum
, vol.41
, Issue.3
, pp. 401-405
-
-
Narváez, J.1
Díaz-Torné, C.2
Ruiz, J.M.3
-
129
-
-
84866773063
-
Rituximab is more effective than second anti-TNF therapy in rheumatoid arthritis patients and previous TNFa blocker failure
-
Kekow J, Mueller-Ladner U, Schulze-Koops H. Rituximab is more effective than second anti-TNF therapy in rheumatoid arthritis patients and previous TNFa blocker failure. Biologics 6, 191-199 (2012).
-
(2012)
Biologics
, vol.6
, pp. 191-199
-
-
Kekow, J.1
Mueller-Ladner, U.2
Schulze-Koops, H.3
-
130
-
-
84881479853
-
Long-term safety of rituximab in rheumatoid arthritis: 9.5-year follow-up of the global clinical trial programme with a focus on adverse events of interest in RA patients
-
(Epub ahead of print)
-
van Vollenhoven RF, Emery P, Bingham CO et al. Long-term safety of rituximab in rheumatoid arthritis: 9.5-year follow-up of the global clinical trial programme with a focus on adverse events of interest in RA patients. Ann. Rheum. Dis. (2012) (Epub ahead of print).
-
(2012)
Ann. Rheum. Dis
-
-
Van Vollenhoven, R.F.1
Emery, P.2
Bingham, C.O.3
-
131
-
-
80052777262
-
Rituximab-associated progressive multifocal leukoencephalopathy in rheumatoid arthritis
-
Clifford DB, Ances B, Costello C et al. Rituximab-associated progressive multifocal leukoencephalopathy in rheumatoid arthritis. Arch. Neurol. 68(9), 1156-1164 (2011).
-
(2011)
Arch. Neurol
, vol.68
, Issue.9
, pp. 1156-1164
-
-
Clifford, D.B.1
Ances, B.2
Costello, C.3
-
132
-
-
84865315420
-
Progressive multifocal leukoencephalopathy associated with immunosuppressive therapy in rheumatic diseases: Evolving role of biologic therapies
-
Molloy ES, Calabrese LH. Progressive multifocal leukoencephalopathy associated with immunosuppressive therapy in rheumatic diseases: evolving role of biologic therapies. Arthritis Rheum. 64(9), 3043-3051 (2012).
-
(2012)
Arthritis Rheum
, vol.64
, Issue.9
, pp. 3043-3051
-
-
Molloy, E.S.1
Calabrese, L.H.2
-
133
-
-
84871813585
-
Head-to-head comparison of subcutaneous abatacept versus adalimumab for rheumatoid arthritis: Findings of a Phase IIIb, multinational, prospective, randomized study
-
Weinblatt ME, Schiff M, Valente R et al. Head-to-head comparison of subcutaneous abatacept versus adalimumab for rheumatoid arthritis: findings of a Phase IIIb, multinational, prospective, randomized study. Arthritis Rheum. 65(1), 28-38 (2013).
-
(2013)
Arthritis Rheum
, vol.65
, Issue.1
, pp. 28-38
-
-
Weinblatt, M.E.1
Schiff, M.2
Valente, R.3
-
134
-
-
47949106400
-
Efficacy and safety of abatacept or infliximab vs placebo in ATTEST: A Phase III, multi-centre, randomised, double-blind, placebo-controlled study in patients with rheumatoid arthritis and an inadequate response to methotrexate
-
Schiff M, Keiserman M, Codding C et al. Efficacy and safety of abatacept or infliximab vs placebo in ATTEST: a Phase III, multi-centre, randomised, double-blind, placebo-controlled study in patients with rheumatoid arthritis and an inadequate response to methotrexate. Ann. Rheum. Dis. 67(8), 1096-1103 (2008).
-
(2008)
Ann. Rheum. Dis
, vol.67
, Issue.8
, pp. 1096-1103
-
-
Schiff, M.1
Keiserman, M.2
Codding, C.3
-
135
-
-
84861805344
-
Indirect treatment comparison of abatacept with methotrexate versus other biologic agents for active rheumatoid arthritis despite methotrexate therapy in the United kingdom
-
Guyot P, Taylor PC, Christensen R et al. Indirect treatment comparison of abatacept with methotrexate versus other biologic agents for active rheumatoid arthritis despite methotrexate therapy in the United kingdom. J. Rheumatol. 39(6), 1198-1206 (2012).
-
(2012)
J. Rheumatol
, vol.39
, Issue.6
, pp. 1198-1206
-
-
Guyot, P.1
Taylor, P.C.2
Christensen, R.3
-
136
-
-
79957790183
-
Efficacy and safety of leflunomide or methotrexate plus subcutaneous tumour necrosis factor-alpha blocking agents in rheumatoid arthritis
-
Benucci M, Saviola G, Baiardi P, Manfredi M, Sarzi-Puttini P, Atzeni F. Efficacy and safety of leflunomide or methotrexate plus subcutaneous tumour necrosis factor-alpha blocking agents in rheumatoid arthritis. Int. J. Immunopathol. Pharmacol. 24(1), 269-274 (2011).
-
(2011)
Int. J. Immunopathol. Pharmacol
, vol.24
, Issue.1
, pp. 269-274
-
-
Benucci, M.1
Saviola, G.2
Baiardi, P.3
Manfredi, M.4
Sarzi-Puttini, P.5
Atzeni, F.6
-
137
-
-
77950862612
-
Comparison of combination therapies in the treatment of rheumatoid arthritis: Leflunomide-anti-TNF-alpha versus methotrexate-anti-TNF-alpha
-
De Stefano R, Frati E, Nargi F et al. Comparison of combination therapies in the treatment of rheumatoid arthritis: leflunomide-anti-TNF-alpha versus methotrexate-anti-TNF-alpha. Clin. Rheumatol. 29(5), 517-524 (2010).
-
(2010)
Clin. Rheumatol
, vol.29
, Issue.5
, pp. 517-524
-
-
De Stefano, R.1
Frati, E.2
Nargi, F.3
-
138
-
-
10744223002
-
Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: Double-blind randomised controlled trial
-
Klareskog L, van der Heijde D, de Jager JP et al. Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial. Lancet 363(9410), 675-681 (2004).
-
(2004)
Lancet
, vol.363
, Issue.9410
, pp. 675-681
-
-
Klareskog, L.1
Van Der Heijde, D.2
De Jager, J.P.3
-
139
-
-
31044442965
-
The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment
-
Breedveld FC, Weisman MH, Kavanaugh AF et al. The PREMIER study: a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis Rheum. 54(1), 26-37 (2006).
-
(2006)
Arthritis Rheum
, vol.54
, Issue.1
, pp. 26-37
-
-
Breedveld, F.C.1
Weisman, M.H.2
Kavanaugh, A.F.3
-
140
-
-
2942537697
-
Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
-
Edwards JC, Szczepanski L, Szechinski J et al. Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N. Engl. J. Med. 350(25), 2572-2581 (2004).
-
(2004)
N. Engl. J. Med
, vol.350
, Issue.25
, pp. 2572-2581
-
-
Edwards, J.C.1
Szczepanski, L.2
Szechinski, J.3
-
141
-
-
33749363027
-
Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
-
Maini RN, Taylor PC, Szechinski J et al. Double-blind randomized
-
(2006)
Arthritis Rheum
, vol.54
, Issue.9
, pp. 2817-2829
-
-
Maini, R.N.1
Taylor, P.C.2
Szechinski, J.3
-
142
-
-
77953122551
-
Indirect comparison of tocilizumab and other biologic agents in patients with rheumatoid arthritis and inadequate response to disease-modifying antirheumatic drugs
-
Bergman GJD, Hochberg MC, Boers M, Wintfeld N, Kielhorn A, Jansen JP. Indirect comparison of tocilizumab and other biologic agents in patients with rheumatoid arthritis and inadequate response to disease-modifying antirheumatic drugs. Semin. Arthritis Rheum. 39(6), 425-441 (2010).
-
(2010)
Semin. Arthritis Rheum
, vol.39
, Issue.6
, pp. 425-441
-
-
Bergman, G.J.D.1
Hochberg, M.C.2
Boers, M.3
Wintfeld, N.4
Kielhorn, A.5
Jansen, J.P.6
-
143
-
-
78751704593
-
Indirect comparisons of the efficacy of biological antirheumatic agents in rheumatoid arthritis in patients with an inadequate response to conventional disease-modifying antirheumatic drugs or to an anti-tumour necrosis factor agent: A meta-analysis
-
Salliot C, Finckh A, Katchamart W et al. Indirect comparisons of the efficacy of biological antirheumatic agents in rheumatoid arthritis in patients with an inadequate response to conventional disease-modifying antirheumatic drugs or to an anti-tumour necrosis factor agent: a meta-analysis. Ann. Rheum. Dis. 70(2), 266-271 (2011).
-
(2011)
Ann. Rheum. Dis
, vol.70
, Issue.2
, pp. 266-271
-
-
Salliot, C.1
Finckh, A.2
Katchamart, W.3
-
144
-
-
84877602545
-
Induction therapy with adalimumab plus methotrexate for 24 weeks followed by methotrexate monotherapy up to week 48 versus methotrexate therapy alone for DMARD-naive patients with early rheumatoid arthritis: HIT HARD, an investigator-initiated study
-
Detert J, Bastian H, Listing J et al. Induction therapy with adalimumab plus methotrexate for 24 weeks followed by methotrexate monotherapy up to week 48 versus methotrexate therapy alone for DMARD-naive patients with early rheumatoid arthritis: HIT HARD, an investigator-initiated study. Ann. Rheum. Dis. 72(6), 844-850 (2012).
-
(2012)
Ann. Rheum. Dis
, vol.72
, Issue.6
, pp. 844-850
-
-
Detert, J.1
Bastian, H.2
Listing, J.3
-
145
-
-
84887419853
-
Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in early rheumatoid arthritis: 2-year quality-of-life results of the randomised, controlled, SWEFOT trial
-
(Epub ahead of print)
-
Karlsson JA, Neovius M, Nilsson JÅ et al. Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in early rheumatoid arthritis: 2-year quality-of-life results of the randomised, controlled, SWEFOT trial. Ann. Rheum. Dis. (2012) (Epub ahead of print).
-
(2012)
Ann. Rheum. Dis
-
-
Karlsson, J.A.1
Neovius, M.2
Nilsson, J.Å.3
-
146
-
-
48149100741
-
Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): A randomised, double-blind, parallel treatment trial
-
Emery P, Breedveld FC, Hall S et al. Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial. Lancet 372(9636), 375-382 (2008).
-
(2008)
Lancet
, vol.372
, Issue.9636
, pp. 375-382
-
-
Emery, P.1
Breedveld, F.C.2
Hall, S.3
-
147
-
-
24944498854
-
Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition
-
Genovese MC, Becker JC, Schiff M et al. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition. N. Engl. J. Med. 353(11), 1114-1123 (2005).
-
(2005)
N. Engl. J. Med
, vol.353
, Issue.11
, pp. 1114-1123
-
-
Genovese, M.C.1
Becker, J.C.2
Schiff, M.3
-
148
-
-
33746961890
-
Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, Phase III trial evaluating primary efficacy and safety at twenty-four weeks
-
Cohen SB, Emery P, Greenwald MW et al. Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, Phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum. 54(9), 2793-2806 (2006).
-
(2006)
Arthritis Rheum
, vol.54
, Issue.9
, pp. 2793-2806
-
-
Cohen, S.B.1
Emery, P.2
Greenwald, M.W.3
-
149
-
-
1542313935
-
Lack of response to anakinra in rheumatoid arthritis following failure of tumor necrosis factor alpha blockade
-
Buch MH, Bingham SJ, Seto Y et al. Lack of response to anakinra in rheumatoid arthritis following failure of tumor necrosis factor alpha blockade. Arthritis Rheum. 50(3), 725-728 (2004).
-
(2004)
Arthritis Rheum
, vol.50
, Issue.3
, pp. 725-728
-
-
Buch, M.H.1
Bingham, S.J.2
Seto, Y.3
-
150
-
-
84870328782
-
The efficacy of biologic agents in patients with rheumatoid arthritis and an inadequate response to tumour necrosis factor inhibitors: A systematic review
-
Moots RJ, Naisbett-Groet B. The efficacy of biologic agents in patients with rheumatoid arthritis and an inadequate response to tumour necrosis factor inhibitors: a systematic review. Rheumatology (Oxford) 51(12), 2252-2261 (2012).
-
(2012)
Rheumatology (Oxford)
, vol.51
, Issue.12
, pp. 2252-2261
-
-
Moots, R.J.1
Naisbett-Groet, B.2
-
151
-
-
84863846460
-
Comparative effectiveness and safety of biological treatment options after tumour necrosis factor a inhibitor failure in rheumatoid arthritis: Systematic review and indirect pairwise meta-analysis
-
Schoels M, Aletaha D, Smolen JS, Wong JB. Comparative effectiveness and safety of biological treatment options after tumour necrosis factor a inhibitor failure in rheumatoid arthritis: systematic review and indirect pairwise meta-analysis. Ann. Rheum. Dis. 71(8), 1303-1308 (2012).
-
(2012)
Ann. Rheum. Dis
, vol.71
, Issue.8
, pp. 1303-1308
-
-
Schoels, M.1
Aletaha, D.2
Smolen, J.S.3
Wong, J.B.4
-
152
-
-
84872238508
-
Systematic review and network meta-analysis of combination and monotherapy treatments in disease-modifying antirheumatic drug-experienced patients with rheumatoid arthritis: Analysis of American College of Rheumatology criteria scores 20, 50, and 70
-
Orme ME, Macgilchrist KS, Mitchell S, Spurden D, Bird A. Systematic review and network meta-analysis of combination and monotherapy treatments in disease-modifying antirheumatic drug-experienced patients with rheumatoid arthritis: analysis of American College of Rheumatology criteria scores 20, 50, and 70. Biologics 6, 429-464 (2012).
-
(2012)
Biologics
, vol.6
, pp. 429-464
-
-
Orme, M.E.1
Macgilchrist, K.S.2
Mitchell, S.3
Spurden, D.4
Bird, A.5
-
153
-
-
84855352586
-
A mixed treatment comparison of the efficacy of anti-TNF agents in rheumatoid arthritis for methotrexate non-responders demonstrates differences between treatments: A Bayesian approach
-
Schmitz S, Adams R, Walsh CD, Barry M, FitzGerald O. A mixed treatment comparison of the efficacy of anti-TNF agents in rheumatoid arthritis for methotrexate non-responders demonstrates differences between treatments: a Bayesian approach. Ann. Rheum. Dis. 71(2), 225-230 (2012).
-
(2012)
Ann. Rheum. Dis
, vol.71
, Issue.2
, pp. 225-230
-
-
Schmitz, S.1
Adams, R.2
Walsh, C.D.3
Barry, M.4
Fitzgerald, O.5
-
154
-
-
84862165188
-
Cost utility of tumour necrosis factor - A inhibitors for rheumatoid arthritis: An application of Bayesian methods for evidence synthesis in a Markov model
-
Nguyen CM, Bounthavong M, Mendes MA et al. Cost utility of tumour necrosis factor-a inhibitors for rheumatoid arthritis: an application of Bayesian methods for evidence synthesis in a Markov model. Pharmacoeconomics 30(7), 575-593 (2012).
-
(2012)
Pharmacoeconomics
, vol.30
, Issue.7
, pp. 575-593
-
-
Nguyen, C.M.1
Bounthavong, M.2
Mendes, M.A.3
-
155
-
-
79955556837
-
Comparison of certolizumab pegol with other anticytokine agents for treatment of rheumatoid arthritis: A multiple-treatment Bayesian metaanalysis
-
Launois R, Avouac B, Berenbaum F et al. Comparison of certolizumab pegol with other anticytokine agents for treatment of rheumatoid arthritis: a multiple-treatment Bayesian metaanalysis. J. Rheumatol. 38(5), 835-845 (2011).
-
(2011)
J. Rheumatol
, vol.38
, Issue.5
, pp. 835-845
-
-
Launois, R.1
Avouac, B.2
Berenbaum, F.3
-
156
-
-
84857410587
-
Lack of head-to-head trials and fair control arms: Randomized controlled trials of biologic treatment for rheumatoid arthritis
-
Estellat C, Ravaud P. Lack of head-to-head trials and fair control arms: randomized controlled trials of biologic treatment for rheumatoid arthritis. Arch. Intern. Med. 172(3), 237-244 (2012).
-
(2012)
Arch. Intern. Med
, vol.172
, Issue.3
, pp. 237-244
-
-
Estellat, C.1
Ravaud, P.2
-
157
-
-
84875715149
-
Tabalumab in patients with rheumatoid arthritis with an inadequate response to methotrexate and naive to biologic therapy
-
Genovese MC, Bojin S, Biagini I et al. Tabalumab in patients with rheumatoid arthritis with an inadequate response to methotrexate and naive to biologic therapy. Arthritis Rheum. 65(4), 880-889 (2013).
-
(2013)
Arthritis Rheum
, vol.65
, Issue.4
, pp. 880-889
-
-
Genovese, M.C.1
Bojin, S.2
Biagini, I.3
-
158
-
-
84934435776
-
From whole monoclonal antibodies to single domain antibodies: Think small
-
Teillaud JL. From whole monoclonal antibodies to single domain antibodies: think small. Methods Mol. Biol. 911, 3-13 (2012).
-
(2012)
Methods Mol. Biol
, vol.911
, pp. 3-13
-
-
Teillaud, J.L.1
-
159
-
-
84864662570
-
Kinase inhibition - A new approach to the treatment of rheumatoid arthritis
-
Fox DA. Kinase inhibition - a new approach to the treatment of rheumatoid arthritis. N. Engl. J. Med. 367(6), 565-567 (2012).
-
(2012)
N. Engl. J. Med
, vol.367
, Issue.6
, pp. 565-567
-
-
Fox, D.A.1
-
160
-
-
84873731179
-
Kinase inhibition in rheumatoid arthritis: A big advance?
-
Miossec P. Kinase inhibition in rheumatoid arthritis: a big advance? Lancet 381(9865), 429-431 (2013).
-
(2013)
Lancet
, vol.381
, Issue.9865
, pp. 429-431
-
-
Miossec, P.1
-
161
-
-
84866862357
-
Intracellular signaling transduction pathways. Potential targets in the treatment of rheumatic diseases
-
Frommer KW, Geyer M, Firestein GS. [Intracellular signaling transduction pathways. Potential targets in the treatment of rheumatic diseases]. Z. Rheumatol. 71(6), 460-467 (2012).
-
(2012)
Z. Rheumatol
, vol.71
, Issue.6
, pp. 460-467
-
-
Frommer, K.W.1
Geyer, M.2
Firestein, G.S.3
-
162
-
-
84872011053
-
Kinase inhibitors: A new class of antirheumatic drugs
-
Kyttaris VC. Kinase inhibitors: a new class of antirheumatic drugs. Drug Des. Devel. Ther. 6, 245-250 (2012).
-
(2012)
Drug Des. Devel. Ther
, vol.6
, pp. 245-250
-
-
Kyttaris, V.C.1
-
163
-
-
59649127763
-
Inhibition of p38: Has the fat lady sung?
-
Genovese MC. Inhibition of p38: has the fat lady sung? Arthritis Rheum. 60(2), 317-320 (2009).
-
(2009)
Arthritis Rheum
, vol.60
, Issue.2
, pp. 317-320
-
-
Genovese, M.C.1
-
164
-
-
0141788311
-
Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653
-
Nishikawa M, Myoui A, Tomita T, Takahi K, Nampei A, Yoshikawa H. Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653. Arthritis Rheum. 48(9), 2670-2681 (2003).
-
(2003)
Arthritis Rheum
, vol.48
, Issue.9
, pp. 2670-2681
-
-
Nishikawa, M.1
Myoui, A.2
Tomita, T.3
Takahi, K.4
Nampei, A.5
Yoshikawa, H.6
-
165
-
-
75749115980
-
Efficacy and safety of pamapimod in patients with active rheumatoid arthritis receiving stable methotrexate therapy
-
Alten RE, Zerbini C, Jeka S et al. Efficacy and safety of pamapimod in patients with active rheumatoid arthritis receiving stable methotrexate therapy. Ann. Rheum. Dis. 69(2), 364-367 (2010).
-
(2010)
Ann. Rheum. Dis
, vol.69
, Issue.2
, pp. 364-367
-
-
Alten, R.E.1
Zerbini, C.2
Jeka, S.3
-
166
-
-
59649114148
-
Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis
-
Cohen SB, Cheng TT, Chindalore V et al. Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis. Arthritis Rheum. 60(2), 335-344 (2009).
-
(2009)
Arthritis Rheum
, vol.60
, Issue.2
, pp. 335-344
-
-
Cohen, S.B.1
Cheng, T.T.2
Chindalore, V.3
-
167
-
-
66049086274
-
Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double-blind, placebo-controlled clinical studies
-
Damjanov N, Kauffman RS, Spencer-Green GT. Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum. 60(5), 1232-1241 (2009).
-
(2009)
Arthritis Rheum
, vol.60
, Issue.5
, pp. 1232-1241
-
-
Damjanov, N.1
Kauffman, R.S.2
Spencer-Green, G.T.3
-
168
-
-
79955563297
-
A 24-week, randomized, double-blind, placebo-controlled, parallel group study of the efficacy of oral SCIO-469, a p38 mitogen-activated protein kinase inhibitor, in patients with active rheumatoid arthritis
-
Genovese MC, Cohen SB, Wofsy D et al. A 24-week, randomized, double-blind, placebo-controlled, parallel group study of the efficacy of oral SCIO-469, a p38 mitogen-activated protein kinase inhibitor, in patients with active rheumatoid arthritis. J. Rheumatol. 38(5), 846-854 (2011).
-
(2011)
J. Rheumatol
, vol.38
, Issue.5
, pp. 846-854
-
-
Genovese, M.C.1
Cohen, S.B.2
Wofsy, D.3
-
169
-
-
62849094732
-
Selectivity and therapeutic inhibition of kinases: To be or not to be?
-
Ghoreschi K, Laurence A, O'Shea JJ. Selectivity and therapeutic inhibition of kinases: to be or not to be? Nat. Immunol. 10(4), 356-360 (2009).
-
(2009)
Nat. Immunol
, vol.10
, Issue.4
, pp. 356-360
-
-
Ghoreschi, K.1
Laurence, A.2
O'Shea, J.J.3
-
170
-
-
75749092187
-
"Go upstream, young man": Lessons learned from the p38 saga
-
Hammaker D, Firestein GS. "Go upstream, young man": lessons learned from the p38 saga. Ann. Rheum. Dis. 69(Suppl. 1), I77-I82 (2010).
-
(2010)
Ann. Rheum. Dis
, vol.69
, Issue.SUPPL. 1
-
-
Hammaker, D.1
Firestein, G.S.2
-
171
-
-
84865663791
-
Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: Advantages of targeting upstream kinases MKK-3 or MKK-6
-
Guma M, Hammaker D, Topolewski K et al. Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6. Arthritis Rheum. 64(9), 2887-2895 (2012).
-
(2012)
Arthritis Rheum
, vol.64
, Issue.9
, pp. 2887-2895
-
-
Guma, M.1
Hammaker, D.2
Topolewski, K.3
-
172
-
-
84857239335
-
The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: Autocrine role of type i interferon
-
Rosengren S, Corr M, Firestein GS, Boyle DL. The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon. Ann. Rheum. Dis. 71(3), 440-447 (2012).
-
(2012)
Ann. Rheum. Dis
, vol.71
, Issue.3
, pp. 440-447
-
-
Rosengren, S.1
Corr, M.2
Firestein, G.S.3
Boyle, D.L.4
-
173
-
-
79955673696
-
CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes
-
Migita K, Komori A, Torigoshi T et al. CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes. Arthritis Res. Ther. 13(3), R72 (2011).
-
(2011)
Arthritis Res. Ther
, vol.13
, Issue.3
-
-
Migita, K.1
Komori, A.2
Torigoshi, T.3
-
174
-
-
84861827087
-
The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-g and interleukin-17 production by human CD4+ T cells
-
Maeshima K, Yamaoka K, Kubo S et al. The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-g and interleukin-17 production by human CD4+ T cells. Arthritis Rheum. 64(6), 1790-1798 (2012).
-
(2012)
Arthritis Rheum
, vol.64
, Issue.6
, pp. 1790-1798
-
-
Maeshima, K.1
Yamaoka, K.2
Kubo, S.3
-
175
-
-
39749164515
-
Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis
-
Milici AJ, Kudlacz EM, Audoly L, Zwillich S, Changelian P. Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis. Arthritis Res. Ther. 10(1), R14 (2008).
-
(2008)
Arthritis Res. Ther
, vol.10
, Issue.1
-
-
Milici, A.J.1
Kudlacz, E.M.2
Audoly, L.3
Zwillich, S.4
Changelian, P.5
-
176
-
-
84866156845
-
A Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone
-
Kremer JM, Cohen S, Wilkinson BE et al. A Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone. Arthritis Rheum. 64(4), 970-981 (2012).
-
(2012)
Arthritis Rheum
, vol.64
, Issue.4
, pp. 970-981
-
-
Kremer, J.M.1
Cohen, S.2
Wilkinson, B.E.3
-
177
-
-
67650093218
-
The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo
-
Kremer JM, Bloom BJ, Breedveld FC et al. The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo. Arthritis Rheum. 60(7), 1895-1905 (2009).
-
(2009)
Arthritis Rheum
, vol.60
, Issue.7
, pp. 1895-1905
-
-
Kremer, J.M.1
Bloom, B.J.2
Breedveld, F.C.3
-
178
-
-
84857761516
-
Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs
-
Fleischmann R, Cutolo M, Genovese MC et al. Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs. Arthritis Rheum. 64(3), 617-629 (2012).
-
(2012)
Arthritis Rheum
, vol.64
, Issue.3
, pp. 617-629
-
-
Fleischmann, R.1
Cutolo, M.2
Genovese, M.C.3
-
179
-
-
84860388892
-
Phase II study of tofacitinib (CP-690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate
-
Tofacitinib Study Investigators
-
Tanaka Y, Suzuki M, Nakamura H, Toyoizumi S, Zwillich SH; Tofacitinib Study Investigators. Phase II study of tofacitinib (CP-690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate. Arthritis Care Res. 63(8), 1150-1158 (2011).
-
(2011)
Arthritis Care Res
, vol.63
, Issue.8
, pp. 1150-1158
-
-
Tanaka, Y.1
Suzuki, M.2
Nakamura, H.3
Toyoizumi, S.4
Zwillich, S.H.5
-
180
-
-
75749127860
-
Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690, 550, an orally active Janus kinase (JAK) inhibitor: Results from a randomised, double-blind, placebo-controlled trial
-
Coombs JH, Bloom BJ, Breedveld FC et al. Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial. Ann. Rheum. Dis. 69(2), 413-416 (2010).
-
(2010)
Ann. Rheum. Dis
, vol.69
, Issue.2
, pp. 413-416
-
-
Coombs, J.H.1
Bloom, B.J.2
Breedveld, F.C.3
-
181
-
-
84864716411
-
Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis
-
Fleischmann R, Kremer J, Cush J et al. Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis. N. Engl. J. Med. 367(6), 495-507 (2012).
-
(2012)
N. Engl. J. Med
, vol.367
, Issue.6
, pp. 495-507
-
-
Fleischmann, R.1
Kremer, J.2
Cush, J.3
-
182
-
-
84864703156
-
Tofacitinib or adalimumab versus placebo in rheumatoid arthritis
-
van Vollenhoven RF, Fleischmann R, Cohen S et al. Tofacitinib or adalimumab versus placebo in rheumatoid arthritis. N. Engl. J. Med. 367(6), 508-519 (2012).
-
(2012)
N. Engl. J. Med
, vol.367
, Issue.6
, pp. 508-519
-
-
Van Vollenhoven, R.F.1
Fleischmann, R.2
Cohen, S.3
-
183
-
-
84873707288
-
Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: A randomised Phase 3 trial
-
Burmester GR, Blanco R, Charles-Schoeman C et al. Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised Phase 3 trial. Lancet 381(9865), 451-460 (2013).
-
(2013)
Lancet
, vol.381
, Issue.9865
, pp. 451-460
-
-
Burmester, G.R.1
Blanco, R.2
Charles-Schoeman, C.3
-
184
-
-
84875905545
-
Tofacitinib, an oral janus kinase inhibitor, in the treatment of rheumatoid arthritis: Open-label, long-term extension safety and efficacy up to 48 months
-
Wollenhaupt J, Silverfield JC, Lee EB. Tofacitinib, an oral janus kinase inhibitor, in the treatment of rheumatoid arthritis: open-label, long-term extension safety and efficacy up to 48 months. Arthritis Rheum. 64(Suppl.10), S548-S549 (2012).
-
(2012)
Arthritis Rheum
, vol.64
, Issue.SUPPL. 10
-
-
Wollenhaupt, J.1
Silverfield, J.C.2
Lee, E.B.3
-
185
-
-
84879640235
-
Tofacitinib (CP-690,550), an oral janus kinase inhibitor: Analysis of malignancies across the rheumatoid arthritis clinical programme
-
Mariette X, Curtis JR, Lee EB. Tofacitinib (CP-690,550), an oral janus kinase inhibitor: analysis of malignancies across the rheumatoid arthritis clinical programme. Ann. Rheum. Dis. 71(Suppl. 3), 199 (2012).
-
(2012)
Ann. Rheum. Dis
, vol.71
, Issue.SUPPL. 3
, pp. 199
-
-
Mariette, X.1
Curtis, J.R.2
Lee, E.B.3
-
186
-
-
84879626651
-
Cardiovascular safety findings in rheumatoid arthritis patients treated with tofacitinib (CP-690,550), a novel, oral JAK inhibitor
-
Charles-Schoeman C, Wicker P, Sechtem U. Cardiovascular safety findings in rheumatoid arthritis patients treated with tofacitinib (CP-690,550), a novel, oral JAK inhibitor. Ann. Rheum. Dis. 71(Suppl. 3), 201 (2012).
-
(2012)
Ann. Rheum. Dis
, vol.71
, Issue.SUPPL. 3
, pp. 201
-
-
Charles-Schoeman, C.1
Wicker, P.2
Sechtem, U.3
-
187
-
-
84865013186
-
Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis
-
Sandborn WJ, Ghosh S, Panes J et al. Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis. N. Engl. J. Med. 367(7), 616-624 (2012).
-
(2012)
N. Engl. J. Med
, vol.367
, Issue.7
, pp. 616-624
-
-
Sandborn, W.J.1
Ghosh, S.2
Panes, J.3
-
188
-
-
84874284072
-
24-week results of a blinded Phase 2b dose-ranging study of baricitinib, an oral janus kinase 1/januse kinase 2 inhibitor, in combination with traditional disease modifying antirheumatic drugs in patients with rheumatoid arthritis
-
Genovese MC, Keystone E, Taylor PC. 24-week results of a blinded Phase 2b dose-ranging study of baricitinib, an oral janus kinase 1/januse kinase 2 inhibitor, in combination with traditional disease modifying antirheumatic drugs in patients with rheumatoid arthritis. Arthritis Rheum. 64(Suppl. 10), S1049-S1050 (2012).
-
(2012)
Arthritis Rheum
, vol.64
, Issue.SUPPL. 10
-
-
Genovese, M.C.1
Keystone, E.2
Taylor, P.C.3
-
189
-
-
84863393110
-
A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
-
Verstovsek S, Mesa RA, Gotlib J et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N. Engl. J. Med. 366(9), 799-807 (2012).
-
(2012)
N. Engl. J. Med
, vol.366
, Issue.9
, pp. 799-807
-
-
Verstovsek, S.1
Mesa, R.A.2
Gotlib, J.3
-
190
-
-
84874667135
-
Selective JAK1 inhibition in the treatment of rheumatoid arthritis: Proof of concept with GLPG0634
-
Vanhouette F, Mazur M, van der Aa A. Selective JAK1 inhibition in the treatment of rheumatoid arthritis: proof of concept with GLPG0634. Arthritis Rheum. 64(Suppl. 10), S1051 (2012).
-
(2012)
Arthritis Rheum
, vol.64
, Issue.SUPPL. 10
-
-
Vanhouette, F.1
Mazur, M.2
Van Der Aa, A.3
-
191
-
-
84875877083
-
Coadministration of ASP015K, a novel janus kinase inhibitor with methotrexate demonstrates tolerability and lack of pharmaco-kinetic interactions in patients with rheumatoid arthritis
-
Zhu T, Oda K, Valluri U. Coadministration of ASP015K, a novel janus kinase inhibitor with methotrexate demonstrates tolerability and lack of pharmaco-kinetic interactions in patients with rheumatoid arthritis. Arthritis Rheum. 64(Suppl. 10), S569 (2012).
-
(2012)
Arthritis Rheum
, vol.64
, Issue.SUPPL. 10
-
-
Zhu, T.1
Oda, K.2
Valluri, U.3
-
192
-
-
78650294662
-
An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: A three-month randomized, placebo-controlled, Phase i study in patients with active rheumatoid arthritis that did not respond to biologic agents
-
Genovese MC, Kavanaugh A, Weinblatt ME et al. An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month randomized, placebo-controlled, Phase I study in patients with active rheumatoid arthritis that did not respond to biologic agents. Arthritis Rheum. 63(2), 337-345 (2011).
-
(2011)
Arthritis Rheum
, vol.63
, Issue.2
, pp. 337-345
-
-
Genovese, M.C.1
Kavanaugh, A.2
Weinblatt, M.E.3
-
193
-
-
55849114400
-
Treatment of rheumatoid arthritis with a Syk kinase inhibitor: A twelve-week, randomized, placebo-controlled trial
-
Weinblatt ME, Kavanaugh A, Burgos-Vargas R et al. Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trial. Arthritis Rheum. 58(11), 3309-3318 (2008).
-
(2008)
Arthritis Rheum
, vol.58
, Issue.11
, pp. 3309-3318
-
-
Weinblatt, M.E.1
Kavanaugh, A.2
Burgos-Vargas, R.3
-
194
-
-
77957333252
-
An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis
-
Weinblatt ME, Kavanaugh A, Genovese MC, Musser TK, Grossbard EB, Magilavy DB. An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis. N. Engl. J. Med. 363(14), 1303-1312 (2010).
-
(2010)
N. Engl. J. Med
, vol.363
, Issue.14
, pp. 1303-1312
-
-
Weinblatt, M.E.1
Kavanaugh, A.2
Genovese, M.C.3
Musser, T.K.4
Grossbard, E.B.5
Magilavy, D.B.6
-
195
-
-
84877732792
-
Concomitant iguratimod therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate: A randomized, double-blind, placebo-controlled trial
-
Ishiguro N, Yamamoto K, Katayama K et al. Concomitant iguratimod therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate: a randomized, double-blind, placebo-controlled trial. Mod. Rheumatol. 23(3), 430-439 (2012).
-
(2012)
Mod. Rheumatol
, vol.23
, Issue.3
, pp. 430-439
-
-
Ishiguro, N.1
Yamamoto, K.2
Katayama, K.3
-
196
-
-
34249720998
-
Cytokines in the pathogenesis of rheumatoid arthritis
-
McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat. Rev. Immunol. 7(6), 429-442 (2007).
-
(2007)
Nat. Rev. Immunol
, vol.7
, Issue.6
, pp. 429-442
-
-
McInnes, I.B.1
Schett, G.2
-
197
-
-
84863964840
-
-
(8th Edition). Garland Science, Taylor & Francis Group, LLC, Florence, KY, USA
-
Murphy KP. Janeways's Immunobiology (8th Edition). Garland Science, Taylor & Francis Group, LLC, Florence, KY, USA (2012)
-
(2012)
Janeways's Immunobiology
-
-
Murphy, K.P.1
-
198
-
-
84874402383
-
Tofacitinib (CP-690,550) in patients with rheumatoid arthritis on methotrexate: 12-month data from a 24-month Phase 3 randomized radiographic study
-
van der Heijde D, Tanaka Y, Fleischmann R. Tofacitinib (CP-690,550) in patients with rheumatoid arthritis on methotrexate: 12-month data from a 24-month Phase 3 randomized radiographic study. Arthritis Rheum. 65(3), 559-570 (2013).
-
(2013)
Arthritis Rheum
, vol.65
, Issue.3
, pp. 559-570
-
-
Van Der Heijde, D.1
Tanaka, Y.2
Fleischmann, R.3
-
199
-
-
84883571770
-
Remission rates with tofacitinib treatment in rheumatoid arthritis: A comparison of various remission criteria
-
Smolen JS, Aletaha D, Gruben D. Remission rates with tofacitinib treatment in rheumatoid arthritis: a comparison of various remission criteria. Arthritis Rheum. 64(Suppl. 10), S334 (2012).
-
(2012)
Arthritis Rheum
, vol.64
, Issue.SUPPL. 10
-
-
Smolen, J.S.1
Aletaha, D.2
Gruben, D.3
-
202
-
-
84883585668
-
-
US FDA approval of etanercept for rheumatoid arthritis.www.fda.gov/ downloads/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ ApprovalApplications/TherapeuticBiologicApplications/ucm088659.pdf
-
US FDA Approval of Etanercept for Rheumatoid Arthritis
-
-
|