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Volumn 42, Issue 7, 1999, Pages 1322-1328

Pharmacokinetics, safety, and efficacy of combination treatment with methotrexate and leflunomide in patients with active rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

LEFLUNOMIDE; METHOTREXATE;

EID: 0033509841     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(199907)42:7<1322::AID-ANR4>3.0.CO;2-P     Document Type: Article
Times cited : (278)

References (20)
  • 1
    • 0033053835 scopus 로고    scopus 로고
    • Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: A double-blind, randomised, multicentre trial
    • Smolen JS, Kalden JR, Scott DL, Rozman B, Kvien TK, Larsen A, et al. Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial. Lancet 1999;353:259-66.
    • (1999) Lancet , vol.353 , pp. 259-266
    • Smolen, J.S.1    Kalden, J.R.2    Scott, D.L.3    Rozman, B.4    Kvien, T.K.5    Larsen, A.6
  • 2
    • 0029591467 scopus 로고
    • The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis
    • Cherwinski HM, Cohn RG, Cheung P, Webster DJ, Xu YZ, Caulfield JP, et al. The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis. J Pharmacol Exp Ther 1995;275:1043-9.
    • (1995) J Pharmacol Exp Ther , vol.275 , pp. 1043-1049
    • Cherwinski, H.M.1    Cohn, R.G.2    Cheung, P.3    Webster, D.J.4    Xu, Y.Z.5    Caulfield, J.P.6
  • 5
    • 0031865023 scopus 로고    scopus 로고
    • Mechanism of action of leflunomide in rheumatoid arthritis
    • Fox RI. Mechanism of action of leflunomide in rheumatoid arthritis. J Rheumatol 1998;25 Suppl 53:S20-6.
    • (1998) J Rheumatol , vol.25 , Issue.53 SUPPL.
    • Fox, R.I.1
  • 7
    • 0029959051 scopus 로고    scopus 로고
    • Rationale for combination therapy of rheumatoid arthritis based on pathophysiology
    • Harris ED. Rationale for combination therapy of rheumatoid arthritis based on pathophysiology. J Rheumatol 1996;23 Suppl 44:2-4.
    • (1996) J Rheumatol , vol.23 , Issue.44 SUPPL. , pp. 2-4
    • Harris, E.D.1
  • 8
    • 0030462249 scopus 로고    scopus 로고
    • Molecular therapeutics: Methotrexate and its mechanism of action
    • Cronstein BN. Molecular therapeutics: methotrexate and its mechanism of action. Arthritis Rheum 1996;39:1951-60.
    • (1996) Arthritis Rheum , vol.39 , pp. 1951-1960
    • Cronstein, B.N.1
  • 9
    • 0032528186 scopus 로고    scopus 로고
    • Immunosuppressive properties of methotrexate: Apoptosis and clonal deletion of activated peripheral T cells
    • Genestier L, Paillot R, Fournel S, Ferraro C, Miossec P, Revillard J. Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells. J Clin Invest 1998;102:322-8.
    • (1998) J Clin Invest , vol.102 , pp. 322-328
    • Genestier, L.1    Paillot, R.2    Fournel, S.3    Ferraro, C.4    Miossec, P.5    Revillard, J.6
  • 10
    • 0023945481 scopus 로고
    • The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
    • Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
    • (1988) Arthritis Rheum , vol.31 , pp. 315-324
    • Arnett, F.C.1    Edworthy, S.M.2    Bloch, D.A.3    McShane, D.J.4    Fries, J.F.5    Cooper, N.S.6
  • 11
    • 0028813226 scopus 로고
    • Validity and reliability of the twenty-eight-joint count for the assessment of rheumatoid arthritis activity
    • Smolen JS, Breedveld FC, Eberl G, Jones I, Leeming M, Wylie GL, et al. Validity and reliability of the twenty-eight-joint count for the assessment of rheumatoid arthritis activity. Arthritis Rheum 1995;38:38-43.
    • (1995) Arthritis Rheum , vol.38 , pp. 38-43
    • Smolen, J.S.1    Breedveld, F.C.2    Eberl, G.3    Jones, I.4    Leeming, M.5    Wylie, G.L.6
  • 12
    • 0021046385 scopus 로고
    • Assessment of patient satisfaction in activities of daily living using a modified Stanford Health Assessment Questionnaire
    • Pincus T, Summey JA, Soraci SA Jr, Wallston KA, Hummon NP. Assessment of patient satisfaction in activities of daily living using a modified Stanford Health Assessment Questionnaire. Arthritis Rheum 1983;26:1346-53.
    • (1983) Arthritis Rheum , vol.26 , pp. 1346-1353
    • Pincus, T.1    Summey, J.A.2    Soraci S.A., Jr.3    Wallston, K.A.4    Hummon, N.P.5
  • 13
    • 0027238592 scopus 로고
    • The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials
    • Felson DT, Anderson JJ, Boers M, Bombardier C, Chernoff M, Fried B, et al. The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials. Arthritis Rheum 1993;36:729-40.
    • (1993) Arthritis Rheum , vol.36 , pp. 729-740
    • Felson, D.T.1    Anderson, J.J.2    Boers, M.3    Bombardier, C.4    Chernoff, M.5    Fried, B.6
  • 14
    • 0019407824 scopus 로고
    • Preliminary criteria for clinical remission in rheumatoid arthritis
    • Pinals RS, Masi AT, Larsen RA, and the Subcommittee for Criteria of Remission in Rheumatoid Arthritis of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteria for clinical remission in rheumatoid arthritis. Arthritis Rheum 1981;24:1308-15.
    • (1981) Arthritis Rheum , vol.24 , pp. 1308-1315
    • Pinals, R.S.1    Masi, A.T.2    Larsen, R.A.3
  • 16
    • 0026643335 scopus 로고
    • Comparison of azathioprine, methotrexate, and the combination of both in the treatment of rheumatoid arthritis: A controlled clinical trial
    • Willkens RF, Urowitz MB, Stablein DM, McKendry RJR Jr, Berger RG, Box JH, et al. Comparison of azathioprine, methotrexate, and the combination of both in the treatment of rheumatoid arthritis: a controlled clinical trial. Arthritis Rheum 1992;35:849-56.
    • (1992) Arthritis Rheum , vol.35 , pp. 849-856
    • Willkens, R.F.1    Urowitz, M.B.2    Stablein, D.M.3    McKendry R.J.R., Jr.4    Berger, R.G.5    Box, J.H.6
  • 17
    • 0026579862 scopus 로고
    • Comparison of auranofin, methotrexate, and the combination of both in the treatment of rheumatoid arthritis: A controlled clinical trial
    • Williams HJ, Ward JR, Reading JC, Brooks RH, Clegg DO, Skosey JL, et al. Comparison of auranofin, methotrexate, and the combination of both in the treatment of rheumatoid arthritis: a controlled clinical trial. Arthritis Rheum 1992;35:259-69.
    • (1992) Arthritis Rheum , vol.35 , pp. 259-269
    • Williams, H.J.1    Ward, J.R.2    Reading, J.C.3    Brooks, R.H.4    Clegg, D.O.5    Skosey, J.L.6
  • 18
    • 9244247260 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications
    • O'Dell JR, Haire CE, Erikson N, Drymalski W, Palmer W, Eckhoff PJ, et al. Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications. N Engl J Med 1996;334: 1287-91.
    • (1996) N Engl J Med , vol.334 , pp. 1287-1291
    • O'Dell, J.R.1    Haire, C.E.2    Erikson, N.3    Drymalski, W.4    Palmer, W.5    Eckhoff, P.J.6
  • 19
    • 0029022389 scopus 로고
    • Combination therapy with cyclosporine and methotrexate in severe rheumatoid arthritis
    • Tugwell P, Pincus T, Yocum D, Stein M, Gluck O, Kraag G, et al. Combination therapy with cyclosporine and methotrexate in severe rheumatoid arthritis. N Engl J Med 1995;333:137-41.
    • (1995) N Engl J Med , vol.333 , pp. 137-141
    • Tugwell, P.1    Pincus, T.2    Yocum, D.3    Stein, M.4    Gluck, O.5    Kraag, G.6


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