Molecular mechanisms of action of gold treatment in rheumatoid arthritis - An update;Molekulare wirkungsmechanismen von gold bei der behandlung der rheumatoiden arthritis - Ein update

Zeitschrift fur Rheumatologie

Volumn 60, Issue 3, 2001, Pages 167-173

  Burmester, G R ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Gold; Immune system; Macrophages; Rheumatoid arthritis; Signal transduction

Indexed keywords

GOLD; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN KAPPA CHAIN; INTERLEUKIN 1; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN PRESENTATION; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME INHIBITION; GENE CONTROL; IMMUNE RESPONSE; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ANTIGEN PRESENTATION; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; CYTOKINES; HUMANS; LYMPHOCYTE ACTIVATION; MACROPHAGES; ORGANOGOLD COMPOUNDS; SIGNAL TRANSDUCTION;

EID: 0034959008     PISSN: 03401855     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003930170065     Document Type: Review

References (17)

1. Gold, the Noble metal and the paradoxes of its toxicology
2. Wirkmechanismen yon gold bei der behandlung der rheumatoiden arthritis
3. The immunologic homunculus in rheumatoid arthritis
4. Tissue gold concentration in a rheumatoid arthritic receiving chrysotherapy
5. Gold and D-penicillamine induce vasculitis and up-regulate mRNA for IL-4 in the Brown Norway rat: Sup- port for a role for Th2 cell activity
6. Immunosuppressive effect of gold on IgG subclasses and IgE; evidence for sparing of Th2 responses
7. Synergistic inhibition of human B cell activation by gold sodium thiomalate and auranofin
8. Gold inhibition of the second complement component by lymphokine-stimulated human monocytes
9. The antirheumatic drug disodium authiomalate inhibits CD4+ T cell recognition of peptides containing two or more cysteine residues
10. The antirheumatic drug gold, a coin with two faces: Au(I) and Au(II). Desired and undesired effects on the immune system
11. Activation of goldreactive T lymphocytes in rheumatoid arthritis patients treated with gold
12. Differential influences of gold sodium thiomalate and bucillamine on the generation of CD14+ monocyte-lineage cells from bone marrow of rheumatoid arthritis patients
13. Intramuscular gold decreases cytokine expression and macrophage numbers in the rheumatoid synovial membrane
14. In vitro modulation of cytokine, cytokine inhibitor, and prostaglandin E release from blood mononuclear cells and synovial fibroblasts by antirheumatic drugs
15. Inhibition of IL-6 and IL-8 induction from cultured rheumatoid synovial fibroblasts by treatment with aurothioglucose
16. Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase
17. Inhibition of MMPs in rheumatoid arthritis and the crystallographic mode of a peptide inhibitor