The role of Aurora A in hypoxia-inducible factor 1α-promoting malignant phenotypes of hepatocelluar carcinoma

Cell Cycle

Volumn 12, Issue 17, 2013, Pages 2849-2866

  Cui, Shi Yun ^a   Huang, Jia Yuan ^a   Chen, Yi Tian ^a   Song, Hai Zhu ^a   Huang, Gui Chun ^a   De, Wei ^b   Wang, Rui ^a   Chen, Long Bang ^a  

^a NANJING UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Aurora A; Hepatocelluar carcinoma; Hypoxia inducible factor 1 ; Malignant phenotype; Promoter

Indexed keywords

AURORA A KINASE; HISTONE ACETYLTRANSFERASE PCAF; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; SHORT HAIRPIN RNA;

ADULT; AGED; ARTICLE; CANCER GROWTH; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KNOCKOUT GENE; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR INVASION;

AURORA A; HEPATOCELLUAR CARCINOMA; HYPOXIA-INDUCIBLE FACTOR 1Α; MALIGNANT PHENOTYPE; PROMOTER;

AGED; APOPTOSIS; AURORA KINASE A; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CELL HYPOXIA; CELL MOVEMENT; CELL PROLIFERATION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KAPLAN-MEIER ESTIMATE; LIVER NEOPLASMS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOTYPE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TUMOR STEM CELL ASSAY;

EID: 84883572013     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.25916     Document Type: Article

References (47)

1. Herszényi L, Tulassay Z. Epidemiology of gastrointestinal and liver tumors. Eur Rev Med Pharmacol Sci 2010; 14:249-58; PMID:20496531
2. Tang ZY. Hepatocellular carcinoma-cause, treatment and metastasis. World J Gastroenterol 2001; 7:445-54; PMID:11819809
3. Pan H, Fu X, Huang W. Molecular mechanism of liver cancer. Anticancer Agents Med Chem 2011; 11:493-9; PMID:21554201; http://dx.doi.org/10.2174/ 187152011796011073
4. Semenza GL. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci 2012; 33:207-14; PMID:22398146; http://dx.doi.org/10.1016/j.tips.2012.01.005
5. Wu XZ, Xie GR, Chen D. Hypoxia and hepatocellular carcinoma: The therapeutic target for hepatocellular carcinoma. J Gastroenterol Hepatol 2007; 22:1178-82; PMID:17559361; http://dx.doi.org/10.1111/j.1440-1746.2007.04997.x
6. Adams JM, Difazio LT, Rolandelli RH, Luján JJ, Haskó G, Csóka B, Selmeczy Z, Németh ZH. HIF-1: a key mediator in hypoxia. Acta Physiol Hung 2009; 96:19-28; PMID:19264039; http://dx.doi.org/10.1556/ APhysiol.96.2009.1.2
7. Lu X, Kang Y. Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clin Cancer Res 2010; 16:5928-35; PMID:20962028; http://dx.doi.org/10.1158/1078-0432.CCR-10-1360
8. Rohwer N, Cramer T. Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways. Drug Resist Updat 2011; 14:191-201; PMID:21466972; http://dx.doi.org/10.1016/j.drup.2011.03.001
9. Vordermark D, Brown JM. Endogenous markers of tumor hypoxia predictors of clinical radiation resistance? Strahlenther Onkol 2003; 179:801-11; PMID:14652668; http://dx.doi.org/10.1007/s00066-003-1150-9
10. Kishimoto K, Yoshida S, Ibaragi S, Yoshioka N, Okui T, Hu GF, Sasaki A. Hypoxia-induced up-regulation of angiogenin, besides VEGF, is related to progression of oral cancer. Oral Oncol 2012; 48:1120-7; PMID:22694909; http://dx.doi.org/10.1016/j.oraloncology.2012.05.009
11. Krishnamachary B, Berg-Dixon S, Kelly B, Agani F, Feldser D, Ferreira G, Iyer N, LaRusch J, Pak B, Taghavi P, et al. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res 2003; 63:1138-43; PMID:12615733
12. Liu XH, Yu EZ, Li YY, Kagan E. HIF-1alpha has an anti-apoptotic effect in human airway epithelium that is mediated via Mcl-1 gene expression. J Cell Biochem 2006; 97:755-65; PMID:16229017; http://dx.doi.org/10.1002/jcb.20683
13. Chen N, Chen X, Huang R, Zeng H, Gong J, Meng W, Lu Y, Zhao F, Wang L, Zhou Q. BCL-xL is a target gene regulated by hypoxia-inducible factor-1alpha. J Biol Chem 2009; 284:10004-12; PMID:19211554; http://dx.doi.org/10.1074/jbc. M805997200
14. Chen YQ, Zhao CL, Li W. Effect of hypoxiainducible factor-1alpha on transcription of survivin in non-small cell lung cancer. J Exp Clin Cancer Res 2009; 28:29; PMID:19245702; http://dx.doi.org/10.1186/1756-9966-28-29
15. Saeki T, Ouchi M, Ouchi T. Physiological and oncogenic Aurora-A pathway. Int J Biol Sci 2009; 5:758-62; PMID:20011137; http://dx.doi.org/10.7150/ijbs.5. 758
16. Wang R, Wang JH, Chu XY, Geng HC, Chen LB. Expression of STK15 mRNA in hepatocellular carcinoma and its prognostic significance. Clin Biochem 2009; 42:641-7; PMID:19232520; http://dx.doi.org/10.1016/j.clinbiochem.2009.01.023
17. Gao P, Wang R, Shen JJ, Lin F, Wang X, Dong K, Zhang HZ. Hypoxia-inducible enhancer/alpha-fetoprotein promoter-driven RNA interference targeting STK15 suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells. Cancer Sci 2008; 99:2209-17; PMID:18803637; http://dx.doi.org/10.1111/j.1349-7006.2008.00941.x
18. Klein A, Flügel D, Kietzmann T. Transcriptional regulation of serine/threonine kinase-15 (STK15) expression by hypoxia and HIF-1. Mol Biol Cell 2008; 19:3667-75; PMID:18562694; http://dx.doi.org/10.1091/mbc.E08-01-0042
19. Mabjeesh NJ, Amir S. Hypoxia-inducible factor (HIF) in human tumorigenesis. Histol Histopathol 2007; 22:559-72; PMID:17330811
20. Brahimi-Horn C, Pouysségur J. The role of the hypoxia-inducible factor in tumor metabolism growth and invasion. Bull Cancer 2006; 93:E73-80; PMID:16935775
21. Gordan JD, Simon MC. Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev 2007; 17:71-7; PMID:17208433; http://dx.doi.org/10.1016/j.gde.2006.12.006
22. Tatsuka M, Sato S, Kanda A, Miki T, Kamata N, Kitajima S, Kudo Y, Takata T. Oncogenic role of nuclear accumulated Aurora-A. Mol Carcinog 2009; 48:810-20; PMID:19204928; http://dx.doi.org/10.1002/mc.20525
23. Brahimi-Horn MC, Pouysségur J. Harnessing the hypoxia-inducible factor in cancer and ischemic disease. Biochem Pharmacol 2007; 73:450-7; PMID:17101119; http://dx.doi.org/10.1016/j.bcp.2006.10.013
24. Goda N, Kanai M. Hypoxia-inducible factors and their roles in energy metabolism. Int J Hematol 2012; 95:457-63; PMID:22535382; http://dx.doi.org/10. 1007/s12185-012-1069-y
25. Semenza GL. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci 2012; 33:207-14; PMID:22398146; http://dx.doi.org/10.1016/j.tips.2012.01.005
26. Chen L, Endler A, Shibasaki F. Hypoxia and angiogenesis: regulation of hypoxia-inducible factors via novel binding factors. Exp Mol Med 2009; 41:849-57; PMID:19942820; http://dx.doi.org/10.3858/emm.2009.41.12.103
27. Seeber LM, Horrée N, Vooijs MA, Heintz AP, van der Wall E, Verheijen RH, van Diest PJ. The role of hypoxia inducible factor-1alpha in gynecological cancer. Crit Rev Oncol Hematol 2011; 78:173-84; PMID:20627616; http://dx.doi.org/10.1016/j.critrevonc.2010.05.003
28. Furlan D, Sahnane N, Carnevali I, Cerutti R, Uccella S, Bertolini V, Chiaravalli AM, Capella C. Up-regulation and stabilization of HIF-1alpha in colorectal carcinomas. Surg Oncol 2007; 16(Suppl 1):S25-7; PMID:18023174; http://dx.doi.org/10.1016/j.suronc.2007.10.014
29. Wan XB, Fan XJ, Huang PY, Dong D, Zhang Y, Chen MY, Xiang J, Xu J, Liu L, Zhou WH, et al. Aurora-A activation, correlated with hypoxia-inducible factor-1α, promotes radiochemoresistance and predicts poor outcome for nasopharyngeal carcinoma. Cancer Sci 2012; 103:1586-94; PMID:22587416; http://dx.doi.org/10.1111/j.1349-7006.2012.02332.x
30. Sun W, Shen ZY, Zhang H, Fan YZ, Zhang WZ, Zhang JT, Lu XS, Ye C. Overexpression of HIF-1α in primary gallbladder carcinoma and its relation to vasculogenic mimicry and unfavourable prognosis. Oncol Rep 2012; 27:1990-2002; PMID:22470047
31. Munipalle PC, Viswanath YK, Davis PA, Scoones D. Prognostic value of hypoxia inducible factor 1α in esophageal squamous cell carcinoma. Dis Esophagus 2011; 24:177-81; PMID:21073615; http://dx.doi.org/10.1111/j.1442-2050. 2010.01122.x
32. Qiu MZ, Han B, Luo HY, Zhou ZW, Wang ZQ, Wang FH, et al. Expressions of hypoxia-inducible factor-1α and hexokinase-II in gastric adenocarcinoma: the impact on prognosis and correlation to clinicopathologic features. Tumour Biol 2001; 32:159-66; http://dx.doi.org/10.1007/s13277-010-0109-6
33. Kimbro KS, Simons JW. Hypoxia-inducible factor-1 in human breast and prostate cancer. Endocr Relat Cancer 2006; 13:739-49; PMID:16954428; http://dx.doi.org/10.1677/erc.1.00728
34. Eckert AW, Schutze A, Lautner MH, Taubert H, Schubert J, Bilkenroth U. HIF-1alpha is a prognostic marker in oral squamous cell carcinomas. Int J Biol Markers 2010; 25:87-92; PMID:20544685
35. Cummins EP, Taylor CT. Hypoxia-responsive transcription factors. Pflugers Arch 2005; 450:363-71;PMID:16007431; http://dx.doi.org/10.1007/s00424-005-1413- 7
36. Liu F, Wang P, Jiang X, Tan G, Qiao H, Jiang H, Krissansen GW, Sun X. Antisense hypoxiainducible factor 1alpha gene therapy enhances the therapeutic efficacy of doxorubicin to combat hepatocellular carcinoma. Cancer Sci 2008; 99:2055-61; PMID:19016766
37. Yang W, Sun T, Cao J, Fan S. Hypoxia-inducible factor-1α downregulation by small interfering RNA inhibits proliferation, induces apoptosis, and enhances radiosensitivity in chemical hypoxic human hepatoma SMMC-7721 cells. Cancer Biother Radiopharm 2011; 26:565-71; PMID:21950556; http://dx.doi.org/10.1089/cbr.2011.0955
38. Huang Y, Yu J, Yan C, Hou J, Pu J, Zhang G, Fu Z, Wang X. Effect of small interfering RNA targeting hypoxia-inducible factor-1α on radiosensitivity of PC3 cell line. Urology 2012; 79:e17-24; PMID:22196409; http://dx.doi.org/10. 1016/j.urology.2011.10.024
39. Zhou H, Fei W, Bai Y, Zhu S, Luo E, Chen K, Hu J. RNA interference-mediated downregulation of hypoxia-inducible factor-1α inhibits angiogenesis and survival of oral squamous cell carcinoma in vitro and in vivo. Eur J Cancer Prev 2012; 21:289-99; PMID:22113109; http://dx.doi.org/10. 1097/CEJ.0b013e32834dbbda
40. Gillespie DL, Flynn JR, Ragel BT, Arce-Larreta M, Kelly DA, Tripp SR, Jensen RL. Silencing of HIF-1alpha by RNA interference in human glioma cells in vitro and in vivo. Methods Mol Biol 2009; 487:283-301; PMID:19301653; http://dx.doi.org/10.1007/978-1-60327-547-7-14
41. Mizuno T, Nagao M, Yamada Y, Narikiyo M, Ueno M, Miyagishi M, Taira K, Nakajima Y. Small interfering RNA expression vector targeting hypoxiainducible factor 1 alpha inhibits tumor growth in hepatobiliary and pancreatic cancers. Cancer Gene Ther 2006; 13:131-40; PMID:16096651; http://dx.doi.org/10.1038/sj. cgt.7700871
42. Choi SH, Shin HW, Park JY, Yoo JY, Kim Y, Ro WS, Yun CO, Han KH. Effects of the knockdown of hypoxia inducible factor-1α expression by adenovirus-mediated shRNA on angiogenesis and tumor growth in hepatocellular carcinoma cell lines. Korean J Hepatol 2010; 16:280-7; PMID:20924210; http://dx.doi.org/10.3350/kjhep.2010.16.3.280
43. Zhou Q, Lui VW, Yeo W. Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma. Future Oncol 2011; 7:1149-67; PMID:21992728; http://dx.doi.org/10.2217/fon.11.95
44. Psyrri A, Arkadopoulos N, Vassilakopoulou M, Smyrniotis V, Dimitriadis G. Pathways and targets in hepatocellular carcinoma. Expert Rev Anticancer Ther 2012; 12:1347-57; PMID:23176622; http://dx.doi.org/10.1586/era.12.113
45. Wang X, Lu N, Niu B, Chen X, Xie J, Cheng N. Overexpression of Aurora-A enhances invasion and matrix metalloproteinase-2 expression in esophageal squamous cell carcinoma cells. [P.]. Mol Cancer Res 2012; 10:588-96; PMID:22522455; http://dx.doi.org/10.1158/1541-7786.MCR-11-0416
46. Wan XB, Long ZJ, Yan M, Xu J, Xia LP, Liu L, Zhao Y, Huang XF, Wang XR, Zhu XF, et al. Inhibition of Aurora-A suppresses epithelial-mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells. Carcinogenesis 2008; 29:1930-7; PMID:18667445; http://dx.doi.org/10.1093/ carcin/bgn176
47. Yao JE, Yan M, Guan Z, Pan CB, Xia LP, Li CX, Wang LH, Long ZJ, Zhao Y, Li MW, et al. Aurora-A down-regulates IkappaBalpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival. Mol Cancer 2009; 8:95; PMID:19891769; http://dx.doi.org/10.1186/1476-4598-8-95