Hypoxia-inducible factor-1α downregulation by small interfering RNA inhibits proliferation, induces apoptosis, and enhances radiosensitivity in chemical hypoxic human hepatoma SMMC-7721 cells

Cancer Biotherapy and Radiopharmaceuticals

Volumn 26, Issue 5, 2011, Pages 565-571

  Yang, Wei ^a   Sun, Ting ^a   Cao, Jianping ^a   Fan, Saijun ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

hepatoma; HIF 1; hypoxia; radiosensitivity; siRNA

Indexed keywords

BETA ACTIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN BCL 2; SMALL INTERFERING RNA; SURVIVIN; VASCULOTROPIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROLIFERATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; MOLECULARLY TARGETED THERAPY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; RADIOSENSITIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; WESTERN BLOTTING;

APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL GROWTH PROCESSES; CELL HYPOXIA; CELL LINE, TUMOR; COBALT; DOWN-REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER NEOPLASMS; RADIATION TOLERANCE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 80054685625     PISSN: 10849785     EISSN: 15578852     Source Type: Journal    
DOI: 10.1089/cbr.2011.0955     Document Type: Article

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