Expressions of hypoxia-inducible factor-1α and hexokinase-II in gastric adenocarcinoma: The impact on prognosis and correlation to clinicopathologic features

Tumor Biology

Volumn 32, Issue 1, 2011, Pages 159-166

  Qiu, Miao Zhen ^a   Han, Bing ^a   Luo, Hui Yan ^a   Zhou, Zhi Wei ^a   Wang, Zhi Qiang ^a   Wang, Feng Hua ^a   Li, Yu Hong ^a   Xu, Rui Hua ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

Gastric adenocarcinoma; HIF 1 ; HK II; Immunohistochemistry; Survival

Indexed keywords

HEXOKINASE; HEXOKINASE ISOENZYME; HYPOXIA INDUCIBLE FACTOR 1ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; GASTRECTOMY; GENETIC CORRELATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; STOMACH ADENOCARCINOMA; TUMOR VOLUME;

EID: 78751584845     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-010-0109-6     Document Type: Article

References (37)

1. F Kamangar GM Dores WF Anderson 2006 Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world J Clin Oncol 10 2137 50 10.1200/JCO.2005.05.2308 (Pubitemid 46655601)
2. CV Dang GL Semenza 1999 Oncogenic alterations of metabolism Trends Biochem Sci 24 68 72 1:CAS:528:DyaK1MXltFCgsr4%3D 10.1016/S0968-0004(98)01344-9 10098401 (Pubitemid 29346576)
3. RA Gatenby HB Kessler JS Rosenblum LR Coia PJ Moldofsky WH Hartz GJ Broder 1998 Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy Int J Radiat Oncol Biol Phys 14 831 8
4. GL Wang BH Jiang EA Rue GL Semenza 1995 Hypoxia-inducible factor-1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension Proc Natl Acad Sci U S A 92 5510 4 1:CAS:528:DyaK2MXmtFOgs7k%3D 10.1073/pnas.92.12. 5510 7539918
5. NV Iyer LE Kotch F Agani SW Leung E Laughner RH Wenger M Gassmann JD Gearhart AM Lawler AY Yu GL Semenza 1998 Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha Genes Dev 12 149 62 1:CAS:528:DyaK1cXnsVOqsQ%3D%3D 10.1101/gad.12.2.149 9436976
6. G Helmlinger F Yuan M Dellian RK Jain 1997 Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation Nat Med 3 177 82 1:CAS:528:DyaK2sXpsVOktw%3D%3D 10.1038/nm0297-177 9018236 (Pubitemid 27064702)
7. D Feldser F Agani NV Iyer B Pak G Ferreira GL Semenza 1999 Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2 Cancer Res 59 3915 8 1:CAS:528:DyaK1MXlsVOlt70%3D 10463582
8. DA Elson HE Ryan JW Snow R Johnson JM Arbeit 2000 Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes dring multi-stage epidermal carcinogenesis and wound healing Cancer Res 60 6189 95 1:CAS:528:DC%2BD3cXotV2ltr4%3D 11085544
9. O Stoeltzing MF McCarty JS Wey F Fan W Liu A Belcheva CD Bucana GL Semenza LM Ellis 2004 Role of hypoxia-inducible factor 1 alpha in gastric cancer cell growth, angiogenesis, and vessel maturation J Natl Cancer Inst 96 946 56 1:CAS:528:DC%2BD2cXltVWmtb0%3D 10.1093/jnci/djh168 15199114
10. MJ Sweeney J Ashmore HP Morris G Weber 1963 Comparative biochemistry hepatomas. IV. isotope studies of glucose and fructose metabolism in liver tumors of different growth rate Cancer Res 23 995 1002 1:CAS:528: DyaF2cXhvVOhtQ%3D%3D 14050771
11. D Burk M Woods J Hunter 1967 On the significance of glucolysis for cancer growth, with special reference to Morris rat hepatomas J Natl Cancer Inst 38 839 63 1:CAS:528:DyaF2sXkslWktro%3D 4381692
12. Y Shinohara J Ichihara H Terada 1991 Remarkably enhanced expression of the type II hexokinase in rat hepatoma cell line AH130 FEBS Lett 291 55 7 1:CAS:528:DyaK3MXmt12nsLc%3D 10.1016/0014-5793(91)81102-E 1936251
13. V Adams W Kempf S Hassam J Briner 1995 Determination of hexokinase isoenzyme I and II composition by RT-PCR: increased hexokinase isoenzyme II in human renal cell carcinoma Biochem Mol Med 54 53 8 1:CAS:528:DyaK2MXks12ks7o%3D 10.1006/bmme.1995.1008 7551817
14. A Rempel P Bannasch D Mayer 1994 Differences in expression and intracellular distribution of hexokinase isoenzymes in rat liver cells of different transformation stages Biochim Biophys Acta 1219 660 8 7948023
15. MM Katabi HL Chan SE Karp G Batist 1999 HexokinasetypeII: a novel tumor-specific promoter for gene-targeted therapy differentially expressed and regulated in human cancer cells Hum Gene Ther 10 155 64 1:CAS:528: DyaK1MXhtVKntbw%3D 10.1089/10430349950018959 10022541 (Pubitemid 29070630)
16. BL Ebert JD Firth PJ Ratcliffe 1995 Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences J Biol Chem 270 29083 9 1:CAS:528:DyaK2MXpvVOhtbk%3D 10.1074/jbc.270.36.21021 7493931
17. SP Mathupala A Rempel PL Pedersen 1997 Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase J Bioenerg Biomembr 29 339 43 1:CAS:528:DyaK2sXnt1Oksrs%3D 10.1023/A:1022494613613 9387094 (Pubitemid 27498413)
18. V Srinivas I Leshchinsky N Sang MP King A Minchenko J Caro 2001 Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway J Biol Chem 276 21995 8 1:CAS:528:DC%2BD3MXkvVant74%3D 10.1074/jbc.C100177200 11342528
19. S Yasuda S Arii A Mori N Isobe W Yang H Oe A Fujimoto Y Yonenaga H Sakashita M Imamura 2004 Hexokinase II and VEGF expression in liver tumors: correlation with hypoxia-inducible factor 1 alpha and its significance J Hepatol 40 117 23 1:CAS:528:DC%2BD3sXps1Ogtr4%3D 10.1016/S0168-8278(03)00503-8 14672622 (Pubitemid 38064720)
20. MC Brahimi-Horn J Chiche J Pouysségur 2007 Hypoxia signalling controls metabolic demand Curr Opin Cell Biol 19 223 9 1:CAS:528: DC%2BD2sXjt1Sksro%3D 10.1016/j.ceb.2007.02.003 17303407 (Pubitemid 46386401)
21. GL Semenza 2002 HIF-1 and tumor progression: pathophysiology and therapeutics Trends Mol Med 8 S62 7 1:CAS:528:DC%2BD38XitlGhsb8%3D 10.1016/S1471-4914(02)02317-1 11927290 (Pubitemid 34297081)
22. H Zhong AM De Marzo E Laughner M Lim DA Hilton D Zagzag P Buechler WB Isaacs GL Semenza JW Simons 1999 Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases Cancer Res 59 5830 5 1:CAS:528:DyaK1MXnslygsr0%3D 10582706
23. P Birner B Gatterbauer G Oberhuber M Schindl K Rössler A Prodinger H Budka JA Hainfellner 2001 Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangigenesis Cancer 92 165 71 1:STN:280:DC%2BD3MzovVOquw%3D%3D 10.1002/1097-0142(20010701)92:1<165::AID- CNCR1305>3.0.CO;2-F 11443623 (Pubitemid 32623053)
24. R Bos H Zhong CF Hanrahan EC Mommers GL Semenza HM Pinedo MD Abeloff JW Simons PJ van Diest E van der Wall 2001 Levels of hypoxia-inducible factor-1alpha during breast carcinogenesis J Natl Cancer Inst 93 309 14 1:STN:280:DC%2BD3M7psFCgsA%3D%3D 10.1093/jnci/93.4.309 11181778
25. P Birner M Schindl A Obermair G Breitenecker G Oberhuber 2001 Hypoxia-inducible factor 1alpha expression in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy Clin Cancer Res 7 1661 8 1:CAS:528:DC%2BD3MXltV2hs74%3D 11410504
26. T Matsuyama K Nakanishi T Hayashi Y Yoshizumi S Aiko Y Sugiura T Tanimoto M Uenoyama Y Ozeki T Maehara 2005 Expression of hypoxia-inducible factor-1alpha in esophageal squamous cell carcinoma Cancer Sci 96 176 82 1:CAS:528: DC%2BD2MXjsFWgtL4%3D 10.1111/j.1349-7006.2005.00025.x 15771621 (Pubitemid 40575919)
27. DM Aebersold P Burri KT Beer J Laissue V Djonov RH Greiner GL Semenza 2001 Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer Cancer Res 61 2911 6 1:CAS:528:DC%2BD3MXivFGqsr8%3D 11306467
28. DM Brizel SP Scully JM Harrelson LJ Layfield JM Bean LR Prosnitz MW Dewhirst 1996 Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma Cancer Res 56 941 3 1:CAS:528: DyaK28XhtlKks7Y%3D 8640781
29. JM Brown AJ Giaccia 1998 The unique physiology of solid tumors: opportunities (and problems) for cancer therapy Cancer Res 58 1408 16 1:STN:280:DyaK1c7ps1Ggsw%3D%3D 9537241
30. Y Sumiyoshi Y Kakeji A Egashira K Mizokami H Orita Y Maehara 2006 Overexpression of hypoxia-inducible factor 1alpha and p53 is a marker for an unfavorable prognosis in gastric cancer Clin Cancer Res 12 5112 7 1:CAS:528:DC%2BD28XovF2gs7w%3D 10.1158/1078-0432.CCR-05-2382 16951228 (Pubitemid 44453338)
31. MI Koukourakis A Giatromanolaki J Skarlatos L Corti S Blandamura M Piazza KC Gatter AL Harris 2001 Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy Cancer Res 61 1830 2 1:CAS:528:DC%2BD3MXit1Ohurk%3D 11280732
32. R Bos P van der Groep AE Greijer A Shvarts S Meijer HM Pinedo GL Semenza PJ van Diest E van der Wall 2003 Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma Cancer 97 1573 81 10.1002/cncr.11246 12627523 (Pubitemid 36297788)
33. K Nakanishi S Hiroi S Tominaga S Aida H Kasamatsu S Matsuyama T Matsuyama T Kawai 2005 Expression of hypoxia-inducible factor-1alpha protein predicts survival in patients with transitional cell carcinoma of the upper urinary tract Clin Cancer Res 11 2583 90 1:CAS:528:DC%2BD2MXivFKisrY%3D 10.1158/1078-0432. CCR-04-1685 15814637 (Pubitemid 40569457)
34. D Cabuk G Basaran C Celikel F Dane PF Yumuk MS Iyikesici M Ekenel NS Turhal 2007 Vascular endothelial growth factor, hypoxia-inducible factor 1 alpha and CD34 expressions in early-stage gastric tumors: relationship with pathological factors and prognostic impact on survival Oncology 72 111 7 1:CAS:528:DC%2BD2sXhtlyksLvM 10.1159/000111118 18025805 (Pubitemid 350249138)
35. H Lu RA Forbes A Verma 2002 Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis J Biol Chem 277 23111 5 1:CAS:528:DC%2BD38XltF2nsr4%3D 10.1074/jbc.M202487200 11943784 (Pubitemid 34952134)
36. PL Pedersen S Mathupala A Rempel JF Geschwind YH Ko 2002 Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention Biochim Biophys Acta 1555 14 20 1:CAS:528:DC%2BD38Xms1yhtr8%3D 10.1016/S0005-2728(02)00248-7 12206885 (Pubitemid 35245999)
37. M Rho J Kim CD Jee YM Lee HE Lee MA Kim HS Lee WH Kim 2007 Expression of type 2 hexokinase and mitochondria-related genes in gastric carcinoma tissues and cell lines Anticancer Res 27 251 8 1:CAS:528:DC%2BD2sXjs1WnsLo%3D 17352240