MicroRNA-106b induces mitochondrial dysfunction and insulin resistance in C2C12 myotubes by targeting mitofusin-2

Molecular and Cellular Endocrinology

Volumn 381, Issue 1-2, 2013, Pages 230-240

  Zhang, Ying ^a   Yang, Lei ^b,c   Gao, Yuan Fu ^a   Fan, Zhong Min ^a   Cai, Xiao Yi ^a   Liu, Meng Yuan ^a   Guo, Xi Rong ^b,c   Gao, Chun Lin ^a   Xia, Zheng Kun ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b WOMEN S HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^c NANJING MEDICAL UNIVERSITY   (China)

Author keywords

C2C12 myotubes; Insulin resistance; MicroRNA 106b; Mitochondrial function; Mitofusin 2; Peroxisome proliferator activated receptor gamma coactivator 1

Indexed keywords

ESTROGEN RELATED RECEPTOR ALPHA; LUCIFERASE; MICRORNA; MICRORNA 106B; MITOFUSIN 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; BINDING SITE; CELL LINE; CELL STRAIN C2C12; CONTROLLED STUDY; DOWN REGULATION; DRUG TARGETING; ENZYME ASSAY; GENE OVEREXPRESSION; GENE TARGETING; IMMUNOBLOTTING; INSULIN RESISTANCE; LOSS OF FUNCTION MUTATION; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRION; MOUSE; MUSCLE MITOCHONDRION; MUTATIONAL ANALYSIS; MYOTUBE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; UPREGULATION;

3′ UNTRANSLATED REGION; 3′ UTR; C2C12 MYOTUBES; DHE; DIHYDROETHIDIUM; DMEM; DULBECCO'S MODIFIED EAGLE'S MEDIUM; ECL; ENHANCED CHEMILUMINESCENCE; ERR-Α; ESTROGEN-RELATED RECEPTOR-Α; FACS; FLUORESCENCE ASSISTED CELL SORTING; GLUCOSE TRANSPORTER 4; GLUT4; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RESISTANCE; IRS-1; MFN2; MICRORNA-106B; MICRORNAS; MIR-106B; MIRNAS; MITOCHONDRIAL DNA; MITOCHONDRIAL FUNCTION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOFUSIN-2; MTDNA; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR-1Α; PGC-1Α; REACTIVE OXYGEN SPECIES; ROS; SDS-PAGE; SODIUM DODECYL SULFATE-POLYACRYLAMIDE ELECTROPHORESIS; T2DM; TNF-Α; TUMOR NECROSIS FACTOR-Α; TYPE 2 DIABETES MELLITUS; ΔΨ;

3' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; GLUCOSE; GTP PHOSPHOHYDROLASES; INSULIN; INSULIN RESISTANCE; MICE; MICRORNAS; MITOCHONDRIA, MUSCLE; MUSCLE FIBERS, SKELETAL; ORGANELLE SHAPE; RECEPTORS, ESTROGEN; RNA INTERFERENCE; TRANSCRIPTION FACTORS;

EID: 84883550464     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2013.08.004     Document Type: Article

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