The involvement of microRNAs in type 2 diabetes

Biochemical Society Transactions

Volumn 38, Issue 6, 2010, Pages 1565-1570

  Ferland McCollough, David ^a   Ozanne, Susan E ^b   Siddle, Kenneth ^b   Willisand, Anne E ^a   Bushell, Martin ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

cell dysfunction; Insulin resistance; microRNA (miRNA); Type 2 diabetes

Indexed keywords

FATTY ACID SYNTHASE; GLUCOSE TRANSPORTER 4; INSULIN; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROSTAGLANDIN E SYNTHASE; PROTEIN KINASE B; SNARE PROTEIN; SYNAPTOBREVIN 2;

APOPTOSIS; CHROMOSOME 10; CONFERENCE PAPER; DOWN REGULATION; HUMAN; INSULIN RESISTANCE; INSULIN SYNTHESIS; LIVER; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; SKELETAL MUSCLE; UPREGULATION; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; ANIMALS; DIABETES MELLITUS, TYPE 2; GENE EXPRESSION REGULATION; GLUCOSE; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; LIPID METABOLISM; MICRORNAS; MUSCLE, SKELETAL; OBESITY;

EID: 78649727507     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0381565     Document Type: Conference Paper

References (39)

1. Ribbing, J., Hamrén, B., Svensson, M.K. and Karlsson, M.O. (2010) A model for glucose, insulin, and β-cell dynamics in subjects with insulin resistance and patients with type 2 diabetes. J. Clin. Pharmacol. 50, 861-872
2. Steppan, C.M., Bailey, S.T., Bhat, S., Brown, E.J., Banerjee, R.R., Wright, C.M., Patel, H.R., Ahima, R.S. and Lazar, M.A. (2001) The hormone resistin links obesity to diabetes. Nature 409, 307-312
3. Shulman, G.I. (2000) Cellular mechanisms of insulin resistance. J. Clin. Invest. 106, 171-176
4. Raz, I., Eldor, R., Cernea, S. and Shafrir, E. (2005) Diabetes: insulin resistance and derangements in lipid metabolismCure through intervention in fat transport and storage. Diabetes Metab. Res. Rev. 21, 3-14
5. Kong, Y.W., Cannell, I.G., de Moor, C.H., Hill, K., Garside, P.G., Hamilton, T.L., Meijer, H.A., Dobbyn, H.C., Stoneley, M., Spriggs, K.A. et al. (2008) The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene. Proc. Natl. Acad. Sci. U.S.A. 105, 8866-8871
6. Griffiths-Jones, S., Saini, H.K., van Dongen, S. and Enright, A.J. (2008) miRBase: tools for microRNA genomics. Nucleic Acids Res. 36, D154-D158
7. Miranda, K.C., Huynh, T., Tay, Y., Ang, Y.S., Tam, W.L., Thomson, A.M., Lim, B. and Rigoutsos, I. (2006) A pattern-based method for the identification of microRNA binding sites and their corresponding heteroduplexes. Cell 126, 1203-1217
8. Mendell, J.T. (2005) MicroRNAs: critical regulators of development, cellular physiology and malignancy. Cell Cycle 4, 1179-1184
9. Xie, H., Lim, B. and Lodish, H.F. (2009) MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes 58, 1050-1057
10. Ling, H.-Y., Ou, H.-S., Feng, S.-D., Zhang, X.-Y., Tuo, Q.-H., Chen, L.-X., Zhu, B.-Y., Gao, Z.-P., Tang, C.-K., Yin, W.-D. et al. (2009) Changes in microRNA profile and effects of miR-320 in insulin-resistant 3T3-L1 adipocytes. Clin. Exp. Pharmacol. Physiol. 9, e32-e39
11. Lewis, G.F., Carpentier, A., Adeli, K. and Giacca, A. (2002) Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr. Rev. 23, 201-229
12. Ortega, F.J., Moreno-Navarrete, J.M., Pardo, G., Sabater, M., Hummel, M., Ferrer, A., Rodriguez-Hermosa, J.I., Ruiz, B., Ricart, W., Peral, B. and Fernandez-Real, J.M. (2010) MiRNA expression profile of human subcutaneous adipose and during adipocyte differentiation. PLoS ONE 5, e9022
13. Herrera, B.M., Lockstone, H.E., Taylor, J.M., Ria, M., Barrett, A., Collins, S., Kaisaki, P., Argoud, K., Fernandez, C., Travers, M.E. et al. (2010) Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes. Diabetologia 53, 1099-1109
14. Herrera, B.M., Lockstone, H.E., Taylor, J.M., Wills, Q.F., Kaisaki, P.J., Barrett, A., Camps, C., Fernandez, C., Ragoussis, J., Gauguier, D. et al. (2009) MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 diabetes. BMC Med. Genomics 2, 54
15. Takanabe, R., Ono, K., Abe, Y., Takaya, T., Horie, T., Wada, H., Kita, T., Satoh, N., Shimatsu, A. and Hasegawa, K. (2008) Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet. Biochem. Biophys. Res. Commun. 376, 728-732
16. He, A., Zhu, L., Gupta, N., Chang, Y. and Fang, F. (2007) Overexpression of micro ribonucleic acid 29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes. Mol. Endocrinol. 21, 2785-2794
17. Nitz, I., Fisher, E., Grallert, H., Li, Y., Gieger, C., Rubin, D., Boeing, H., Spranger, J., Lindner, I., Schreiber, S. et al. (2007) Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations. J. Clin. Endocrinol. Metab. 92, 3183-3188
18. Fisher, E., Nitz, I., Lindner, I., Rubin, D., Boeing, H., Mohlig, M., Hampe, J., Schreiber, S., Schrezenmeir, J. and Doring, F. (2007) Candidate gene association study of type 2 diabetes in a nested case-control study of the EPIC-Potsdam cohort: role of fat assimilation. Mol. Nutr. Food Res. 51, 185-191
19. Nakanishi, N., Nakagawa, Y., Tokushige, N., Aoki, N., Matsuzaka, T., Ishii, K., Yahagi, N., Kobayashi, K., Yatoh, S., Takahashi, A. et al. (2009) The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice. Biochem. Biophys. Res. Commun. 385, 492-496
20. Tiniakos, D.G., Vos, M.B. and Brunt, E.M. (2010) Nonalcoholic fatty liver disease: pathology and pathogenesis. Annu. Rev. Pathol. 5, 145-171
21. Garofalo, M., Di Leva, G., Romano, G., Nuovo, G., Suh, S.S., Ngankeu, A., Taccioli, C., Pichiorri, F., Alder, H., Secchiero, P. et al. (2009) miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. Cancer Cell 16, 498-509
22. Stiles, B., Wang, Y., Stahl, A., Bassilian, S., Lee, W.P., Kim, Y.J., Sherwin, R., Devaskar, S., Lesche, R., Magnuson, M.A. and Wu, H. (2004) Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity. Proc. Natl. Acad. Sci. U.S.A. 101, 2082-2087
23. Jennewein, C., von Knethen, A., Schmid, T. and Brune, B. (2010) MicroRNA-27b contributes to lipopolysaccharide-mediated peroxisome proliferator-activated receptor γ (PPARγ ) mRNA destabilization. J. Biol. Chem. 285, 11846-11853
24. Karbiener, M., Fischer, C., Nowitsch, S., Opriessnig, P., Papak, C., Ailhaud, G., Dani, C., Amri, E.Z. and Scheideler, M. (2009) microRNA miR-27b impairs human adipocyte differentiation and targets PPARγ. Biochem. Biophys. Res. Commun. 390, 247-251
25. Westerbacka, J., Kolak, M., Kiviluoto, T., Arkkila, P., Siren, J., Hamsten, A., Fisher, R.M. and Yki-Jarvinen, H. (2007) Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects. Diabetes 56, 2759-2765
26. Poy, M.N., Spranger, M. and Stoffel, M. (2007) microRNAs and the regulation of glucose and lipid metabolism. Diabetes Obes. Metab. 9 (Suppl. 2), 67-73
27. Gallagher, I.J., Scheele, C., Keller, P., Nielsen, A.R., Remenyi, J., Fischer, C.P., Roder, K., Babraj, J., Wahlestedt, C., Hutvagner, G. et al. (2010) Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes. Genome Med. 2, 9
28. Huang, B., Qin, W., Zhao, B., Shi, Y., Yao, C., Li, J., Xiao, H. and Jin, Y. (2009) MicroRNA expression profiling in diabetic GK rat model. Acta Biochim. Biophys. Sin. 41, 472-477
29. Keren, A., Tamir, Y. and Bengal, E. (2006) The p38 MAPK signaling pathway: a major regulator of skeletal muscle development. Mol. Cell. Endocrinol. 252, 224-230
30. Igarashi, M., Wakasaki, H., Takahara, N., Ishii, H., Jiang, Z.Y., Yamauchi, T., Kuboki, K., Meier, M., Rhodes, C.J. and King, G.L. (1999) Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J. Clin. Invest. 103, 185-195
31. Guo, C., Sah, J.F., Beard, L., Willson, J.K., Markowitz, S.D. and Guda, K. (2008) The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosomes Cancer 47, 939-946
32. Newsholme, P., Keane, D., Welters, H.J. and Morgan, N.G. (2007) Life and death decisions of the pancreatic β-cell: the role of fatty acids. Clin. Sci. 112, 27-42
33. Prentki, M. and Nolan, C.J. (2006) Islet β cell failure in type 2 diabetes. J. Clin. Invest. 116, 1802-1812
34. Poy, M.N., Hausser, J., Trajkovski, M., Braun, M., Collins, S., Rorsman, P., Zavolan, M. and Stoffel, M. (2009) miR-375 maintains normal pancreatic α- and β-cell mass. Proc. Natl. Acad. Sci. U.S.A. 106, 5813-5818
35. Poy, M.N., Eliasson, L., Krutzfeldt, J., Kuwajima, S., Ma, X., Macdonald, P.E., Pfeffer, S., Tuschl, T., Rajewsky, N., Rorsman, P. and Stoffel, M. (2004) A pancreatic islet-specific microRNA regulates insulin secretion. Nature 432, 226-230
36. Zhao, E., Keller, M.P., Rabaglia, M.E., Oler, A.T., Stapleton, D.S., Schueler, K.L., Neto, E.C., Moon, J.Y., Wang, P., Wang, I.M. et al. (2009) Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice. Mamm. Genome 20, 476-485
37. El Ouaamari, A., Baroukh, N., Martens, G.A., Lebrun, P., Pipeleers, D. and van Obberghen, E. (2008) miR-375 targets 3′-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic β-cells. Diabetes 57, 2708-2717
38. Lovis, P., Roggli, E., Laybutt, D.R., Gattesco, S., Yang, J.Y., Widmann, C., Abderrahmani, A. and Regazzi, R. (2008) Alterations in microRNA expression contribute to fatty acid-induced pancreatic β-cell dysfunction. Diabetes 57, 2728-2736
39. Lovis, P., Gattesco, S. and Regazzi, R. (2008) Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs. Biol. Chem. 389, 305-312