Extracellular alpha-synuclein induces calpain-dependent overactivation of cyclin-dependent kinase 5 in vitro

FEBS Letters

Volumn 587, Issue 18, 2013, Pages 3135-3141

  Czapski, Grzegorz A ^a   Ga̧ssowska, Magdalena ^a   Wilkaniec, Anna ^a   Cieślik, Magdalena ^a   Adamczyk, Agata ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

Author keywords

Alpha synuclein; Calpain; Cyclin dependent kinase 5; p35; Parkinson's disease; Phosphorylation

Indexed keywords

ALPHA SYNUCLEIN; CALPAIN; CYCLIN DEPENDENT KINASE 5; PROTEIN P25; PROTEIN P35; TYROSINE;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY TEST; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RAT;

ALPHA-SYNUCLEIN; CALPAIN; CYCLIN-DEPENDENT KINASE 5; P35; PARKINSON'S DISEASE; PHOSPHORYLATION;

ALPHA-SYNUCLEIN; ANIMALS; APOPTOSIS; CALCIUM; CALPAIN; CYCLIN-DEPENDENT KINASE 5; ENZYME ACTIVATION; EXTRACELLULAR SPACE; GENE EXPRESSION REGULATION; PC12 CELLS; PHOSPHORYLATION; PHOSPHOTRANSFERASES; PROTEIN KINASE INHIBITORS; RATS; SIGNAL TRANSDUCTION;

EID: 84883487726     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.07.053     Document Type: Article

References (41)

1. A. Adamczyk, and A. Kaźmierczak Alpha-synuclein inhibits poly (ADP-ribose) polymerase-1 (PARP-1) activity via NO-dependent pathway Folia Neuropathol. 47 2009 247 251
2. 2+ channels NeuroReport 17 2006 1883 1886
3. A. Adamczyk Effect of N-methyl-d-aspartate (NMDA) receptor antagonists on alpha-synuclein-evoked neuronal nitric oxide synthase activation in the rat brain Pharmacol. Rep. 61 2009 1078 1085
4. A. Adamczyk Alpha-synuclein decreases arachidonic acid incorporation into rat striatal synaptoneurosomes Folia Neuropathol. 45 2007 230 235
5. A. Adamczyk Alpha-synuclein induced cell death in mouse hippocampal (HT22) cells is mediated by nitric oxide-dependent activation of caspase-3 FEBS Lett. 584 2010 3504 3508
6. D. Alvira Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease Parkinsonism Relat. Disord. 14 2008 309 313
7. E. Avraham Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation J. Biol. Chem. 282 2007 12842 12850
8. L. Chagniel Striatal inhibition of calpains prevents levodopa-induced neurochemical changes and abnormal involuntary movements in the hemiparkinsonian rat model Neurobiol. Dis. 45 2012 645 655
9. F. Cheng The role of alpha-synuclein in neurotransmission and synaptic plasticity J. Chem. Neuroanat. 42 2011 242 248
10. J. Chew Identification of p10 as a neurotoxic product generated from the proteolytic cleavage of the neuronal Cdk5 activator J. Cell. Biochem. 111 2010 1359 1366
11. G.A. Czapski Alterations of cyclin dependent kinase 5 expression and phosphorylation in amyloid precursor protein (APP)-transfected PC12 cells FEBS Lett. 585 2011 1243 1248
12. P. Desplats Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein Proc. Natl. Acad. Sci. USA 106 2009 13010 13015
13. M.J. Diógenes Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation J. Neurosci. 32 2012 11750 11762
14. S.L. Green Cyclin-dependent protein kinase 5 activity increases in rat brain following ischemia Neurochem. Int. 31 1997 617 623
15. L.A. Greene, and A.S. Tischler Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth-factor Proc. Natl. Acad. Sci. USA 73 1976 2424 2428
16. L.A. Greene PC12 pheochromocytoma cells: culture, nerve growth factor treatment, and experimental exploitation Methods Enzymol. 147 1987 207 216
17. C. Hansen Alpha-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells J. Clin. Invest. 121 2011 715 725
18. S.-I. Hisanaga, and K. Ishiguro The kinase activity of Cdk5 and its regulation N.Y. Ip, L.-H. Tsai, Cyclin depenent kinase 5 (Cdk5) 2008 Springer US New York 171 190
19. K.A. Jellinger Lewy body-related alpha-synucleinopathy in the aged human brain J. Neural. Transm. 111 2004 1219 1235
20. A. Kaźmierczak Alpha-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells Neurochem. Int. 53 2008 263 269
21. A. Kaźmierczak A novel mechanism of non-Abeta component of Alzheimer's disease amyloid (NAC) neurotoxicity. Interplay between p53 protein and cyclin-dependent kinase 5 (Cdk5) Neurochem. Int. 58 2011 206 214
22. J.H. Lee Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death J. Cell Sci. 120 2007 2259 2271
23. J.Y. Li Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation Nat. Med. 14 2008 501 503
24. O. Marques, and T.F. Outeiro Alpha-synuclein: from secretion to dysfunction and death Cell Death Dis. 3 2012 e350
25. B. Menn Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models PLoS One 5 2010 e12117
26. I. Mikolaenko Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA) J. Neuropathol. Exp. Neurol. 64 2005 156 162
27. Y. Miyamoto Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through non-receptor tyrosine kinase Fyn J. Neurosci. 28 2008 8326 8337
28. K. Murayama Neural cell lines L.C. Doerin, Protocols for neural cell culture 2001 Springer Science and Business Media LLC New York 219
29. C. Pacheco An extracellular mechanism that can explain the neurotoxic effects of alpha-synuclein aggregates in the brain Front. Physiol. 3 2012 297
30. D. Qu Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease Neuron 55 2007 37 52
31. E. Rubio de la Torre Combined kinase inhibition modulates parkin inactivation Hum. Mol. Genet. 18 2009 809 823
32. Y. Sasaki Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex Neuron 35 2002 907 920
33. V. Shukla A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model miceed FASEB J. 27 2012 174 186
34. P.D. Smith Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease Proc. Natl. Acad. Sci. USA 100 2003 13650 13655
35. L. Stefanis Alpha-synuclein in Parkinson's disease Cold Spring Harb. Perspect. Med. 2 2012 a009399
36. M. Takahashi Cyclin-dependent kinase 5 (Cdk5) associated with Lewy bodies in diffuse Lewy body disease Brain Res. 862 2000 253 256
37. K. Vekrellis, and L. Stefanis Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies Expert. Opin. Ther. Targets 16 2012 421 432
38. J. Wang Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors Nat. Neurosci. 6 2003 1039 1047
39. A.S. Wong Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease Nat. Cell Biol. 13 2011 568 579
40. J. Zhang Cdk5 phosphorylates p53 and regulates its activity J. Neurochem. 81 2002 307 313
41. L.R. Zukerberg Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth Neuron 26 2000 633 646