Alpha-synuclein potentiates Ca2+ influx through voltage-dependent Ca2+ channels

NeuroReport

Volumn 17, Issue 18, 2006, Pages 1883-1886

  Adamczyk, Agata ^a   Strosznajder, Joanna B ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

Author keywords

Alpha synuclein; Ca2+ infux; Synaptoneurosomes; Voltage dependent Ca2+ channels

Indexed keywords

ALPHA SYNUCLEIN; CALCIUM CHANNEL N TYPE; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; OMEGA CONOTOXIN GVIA; RESVERATROL; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; MALE; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTOSOME;

ALPHA-SYNUCLEIN; ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CARBON ISOTOPES; CEREBRAL CORTEX; ENZYME INHIBITORS; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; NEURONS; NITROARGININE; OMEGA-CONOTOXIN GVIA; RATS; RATS, WISTAR; SYNAPTOSOMES;

EID: 33845773459     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e3280115185     Document Type: Article

References (22)

1. Maroteaux L, Campanelli JT, Scheller RH. Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci 1988; 8:2804-2815.
2. Alves da Costa C. Recent advances on alpha-synuclein cell biology: functions and dysfunctions. Curr Mol Med 2003; 3:17-24.
3. Baba M, Nakajo S, Tu PH, Tomita T, Nakaya K, Lee VM, et al. Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 1998; 152:879-884.
4. Dickson DW, Liu W, Hardy J, Farrer M, Mehta N, Uitti R, et al. Widespread alterations of alpha-synuclein in multiple system atrophy. Am J Pathol 1999; 155:1241-1251.
5. Tu PH, Galvin JE, Baba M, Giasson B, Tomita T, Leight S, et al. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein. Ann Neurol 1998; 44:415-422.
6. Bodles AM, Guthrie DJ, Harriott P, Campbell P, Irvine GB. Toxicity of non-amyloid beta component of Alzheimer's disease amyloid, and N-terminal fragments thereof, correlates to formation of beta-sheet structure and fibrils. Eur J Biochem 2000; 267:2186-2194.
7. Sung JY, Park SM, Lee CH, Um JW, Lee HJ, Kim J, et al. Proteolytic cleavage of extracellular secreted alpha-synuclein via matrix metalloproteinases. J Biol Chem 2005; 280:25216-25224.
8. Adamczyk A, Kaźmierczak A, Strosznajder JB. α-Synuclein and its neurotoxic fragment inhibit dopamine uptake into rat striatal synaptosomes. Relationship to nitric oxide. Neurochem Int 2006; 49:407-412.
9. Kawahara M, Kuroda Y, Arispe N, Rojas E. Alzheimer's beta-amyloid, human islet amylin, and prion protein fragment evoke intracellular free calcium elevations by a common mechanism in a hypothalamic GnRH neuronal cell line. J Biol Chem 2000; 275:14077-14083.
10. Pierrot N, Ghisdal P, Caumont AS, Octave JN. Intraneuronal amyloid-beta 1-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death. J Neurochem 2004; 88:1140-1150.
11. Mandal PK, Pettegrew JW, Masliah E, Hamilton RL, Mandal R. Interaction between Aβ peptide and α-synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease. Neurochem Res 2006; 31:1153-1162.
12. 2+ channels: a possible involvement of free radicals. J Neurochem 1997; 68:265-271.
13. Hollingsworth EB, McNeal ET, Burton JL, Williams RJ, Daly JW, Creveling CR. Biochemical characterization of a filtered synapto-neurosome preparation from guinea pig cerebral cortex: cyclic adenosine 3′:5′- monophosphate-generating systems, receptors, and enzymes. J Neurosci 1985; 5:2240-2253.
14. 2+-dependent, and carbachol-mediated arachidonic acid release from rat brain cortex membrane. J Neurochem 1991; 57:1198-1206.
15. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985;260:3440-3450.
16. 2+ influx into cerebrocortical synaptoneurosomes exclusively through L-type channel. Neurobiol Aging 1998; 19:S48.
17. 2+) channel activity by beta-amyloid-(1-40) in rat cortical synaptosomes and cultured cortical neurons. Modulation by the proinflammatory cytokine interleukin-1beta. J Biol Chem 2000; 275:4713-4718.
18. Desole MS, Kim WK, Rabin RA, Laychock SG. Nitric oxide reduces depolarization-induced calcium influx in PC12 cells by a cyclic GMP-mediated mechanism. Neuropharmacology 1994; 33:193-198.
19. 2+ in cultured rat forebrain neurons. Brain Res 1992; 592:310-316.
20. Ikeda J, Ochiai K, Morita I, Murota S. Endogenous nitric oxide blocks calcium influx induced by glutamate in neurons containing NADPH diaphorase. Neurosci Lett 1993; 158:193-196.
21. 2+ channels in mouse cerebral cortical neurons. Brain Res Mol Brain Res 1998; 54:133-140.
22. Kiedrowski L, Costa E, Wroblewski JT. Sodium nitroprusside inhibits N-methyl-D-aspartate-evoked calcium influx via a nitric oxide- and cGMP-independent mechanism. Mol Pharmacol 1992; 41:779-784.