Alpha-synuclein inhibits poly (ADP-ribose) polymerase-1 (PARP-1) activity via NO-dependent pathway

Folia Neuropathologica

Volumn 47, Issue 3, 2009, Pages 247-251

  Adamczyk, Agata ^a   Kaźmierczak, Anna ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

Author keywords

Alpha synuclein; Brain; Nitric oxide; Poly (ADP ribose) polymerase 1

Indexed keywords

ALPHA SYNUCLEIN; N(G) NITROARGININE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NITRIC OXIDE SYNTHASE;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE OVEREXPRESSION; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PROTEIN DETERMINATION; PROTEIN PROTEIN INTERACTION; RAT; SYNAPSE VESICLE; TISSUE HOMOGENATE; TRANSCRIPTION REGULATION;

EID: 70350362348     PISSN: 16414640     EISSN: 1509572X     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Adamczyk A, Jesko H, Strosznajder RP. Alzheimer's disease related peptides affected cholinergic receptor mediated poly(ADPribose) polymerase activity in the hippocampus. Folia Neuropathol 2005; 43: 139-142.
2. Adamczyk A, Kacprzak M, Kazmierczak A. Alpha-synuclein decreases arachidonic acid incorporation into rat striatal synaptoneurosomes. Folia Neuropathol 2007; 45: 230-235.
3. Adamczyk A, Kazmierczak A, Strosznajder JB. Alpha-synuclein and its neurotoxic fragment inhibit dopamine uptake into rat striatal synaptosomes. Relationship to nitric oxide. Neurochem Int 2006; 49: 407-412.
4. Adamczyk A, Czapski GA, Kazmierczak A, Strosznajder JB. Alpha-Synuclein Alters NMDA Receptor-Dependent Signal Transduction. (9th International Conference AD/PD 2009, Prague, Czech Republik, March 11-15, 2009). Neurodegener Dis 2009; 1835.
5. Adamczyk A, Strosznajder JB. Alpha-synuclein potentiates Ca2+ influx through voltage-dependent Ca2+ channels. Neuroreport 2006; 7: 1883-1886.
6. Buchman VL, Ninkina N. Modulation of alpha-synuclein expression in transgenic animals for modelling synucleinopathies-is the juice worth the squeeze? Neurotox Res 2008; 14: 329-341.
7. Clayton DF, George JM. Synucleins in synaptic plasticity and neurodegenerative disorders. J Neurosci Res 1999; 58: 120-129.
8. Clayton DF, George JM. The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends Neurosci 1998; 21: 249-254.
9. Cookson MR. Alpha-Synuclein and neuronal cell death. Molecular Neurodegener 2009; 4: 9.
10. El-Agnaf OM, Salem SA, Paleologou KE, Curran MD, Gibson MJ, Court JA, Schlossmacher MG, Allsop D. Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease. FASEB J 2006; 20: 419-425.
11. Gentile A, Amadoro G, Corsetti V, Ciotti MT, Serafino A, Calissano P. Spontaneous aggregation and altered intracellular distribution of endogenous alpha-synuclein during neuronal apoptosis. J Alzheimers Dis 2008; 13: 151-160.
12. Goers J, Manning-Bog AB, McCormack AL, Millett IS, Doniach S, Di Monte DA, Uversky VN, Fink AL. Nuclear localization of alphasynuclein and its interaction with histones. Biochemistry 2003; 42: 8465-8471.
13. Kontopoulos E, Parvin JD, Feany MB. Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum Mol Genet 2006; 15: 3012-3023.
14. Lavedan C. The synuclein family. Genome Res 1998; 8: 871-880.
15. Lee HJ, Suk JE, Bae EJ, Lee JH, Paik SR, Lee SJ. Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein. Int J Biochem Cell Biol 2008; 40: 1835-1849.
16. Lee HJ, Patel S, Lee SJ. Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. J Neurosci 2005; 25: 6016-6024.
17. Liu G, Zhang C, Yin J, Li X, Cheng F, Li Y, Yang H, Uéda K, Chan P, Yu S. Alpha-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently downregulates complex i activity. Neurosci Lett 2009a; 454: 187-192.
18. Liu J, Zhang JP, Shi M, Quinn T, Bradner J, Beyer R, Chen S, Zhang J. Rab11a and HSP90 regulate recycling of extracellular alphasynuclein. J Neurosci 2009b; 29: 1480-1485.
19. Maroteaux L, Campanelli JT, Scheller RH. Synuclein: a neuronspecific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci 1988; 8: 2804-2815.
20. Norris EH, Giasson BI, Lee VM. Alpha-synuclein: normal function and role in neurodegenerative diseases. Curr Top Dev Biol 2004; 60, 17-54.
21. Petermann E, Keil C, Oei SL. Importance of poly(ADP-ribose) polymerases in the regulation of DNA-dependent processes. Cell Mol Life Sci 2005; 62: 731-738.
22. Pytlowany M, Strosznajder JB, Jesko H, Cakala M, Strosznajder RP. Molecular mechanism of PC12 cell death evoked by sodium nitroprusside, a nitric oxide donor. Acta Biochim Pol 2008; 55: 339-347.
23. Schell H, Hasegawa T, Neumann M, Kahle PJ. Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice. Neuroscience 2009; 160: 796-804.
24. Sidhu A, Wersinger C, Vernier P. Does alpha-synuclein modulate dopaminergic synaptic content and tone at the synapse? FASEB J 2004; 18: 637-647.
25. Sidorkina O, Espey MG, Miranda KM, Wink DA, Laval J. Inhibition of poly(ADP-ribose) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species. Free Radic Biol Med 2003; 35: 1431-1438.
26. Strosznajder RP, Jesko H, Adamczyk A. Effect of aging and oxidative/ genotoxic stress on poly(ADP-ribose) polymerase-1 activity in rat brain. Acta Biochim Polon 2005b; 52: 909-914.
27. Strosznajder RP, Jesko H, Zambrzycka A. Poly(ADP-ribose) polymerase: the nuclear target in signal transduction and its role in brain ischemia-reperfusion injury. Mol Neurobiol 2005a; 31: 149-167.
28. Sung JY, Park SM, Lee CH, Um JW, Lee HJ, Kim J, Oh YJ, Lee ST, Paik SR, Chung KC. Proteolytic cleavage of extracellular secreted alpha-synuclein via matrix metalloproteinases. J Biol Chem 2005; 280: 25216-25224.
29. Szabó C. Poly(ADP-ribose) polymerase activation by reactive nitrogen species - relevance for the pathogenesis of inflammation. Nitric Oxide 2006; 14: 169-179.
30. Virág L. Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies. Curr Vasc Pharmacol 2005; 3: 209-214.
31. Xu S, Zhou M, Yu S, Cai Y, Zhang A, Uéda K, Chan P. Oxidative stress induces nuclear translocation of C-terminus of alpha-synuclein in dopaminergic cells. Biochem Biophys Res Commun 2006; 342: 330-335.
32. Yu S, Li X, Liu G, Han J, Zhang C, Li Y, Xu S, Liu C, Gao Y, Yang H, Uéda K, Chan P. Extensive nuclear localization of alpha-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody. Neuroscience 2007; 145: 539-555.
33. Zhang L, Zhang C, Zhu Y, Cai Q, Chan P, Uéda K, Yu S, Yang H. Semi-quantitative analysis of alpha-synuclein in subcellular pools of rat brain neurons: an immunogold electron microscopic study using a C-terminal specific monoclonal antibody. Brain Res 2008; 1244: 40-52.
34. Zhang J, Pieper A, Snyder SH. Poly(ADP-ribose) synthetase activation: an early indicator of neurotoxic DNA damage. J Neurochem 1995; 65: 1411-1414.