Identification of p10 as a neurotoxic product generated from the proteolytic cleavage of the neuronal Cdk5 activator

Journal of Cellular Biochemistry

Volumn 111, Issue 5, 2010, Pages 1359-1366

  Chew, Jenny ^a   Chen, Minghui Jessica ^b   Lee, Alan Yiu Wah ^a   Peng, Zhao Feng ^a,c   Chong, Kevin Wai Yin ^a   He, Lisheng ^d   Bay, Boon Huat ^a   Ng, Jian Ming Jeremy ^b   Qi, Robert Z ^d   Cheung, Nam Sang ^b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b UNIVERSITY OF TASMANIA   (Australia)

^c CHINA UNIVERSITY OF GEOSCIENCES   (China)

^d HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Alzheimer's disease; cyclin dependent kinase 5; neurodegeneration; neuronal death; p10; p35

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYCLIN DEPENDENT KINASE 5; LACTACYSTIN; PROTEIN P10; PROTEIN P25; PROTEIN P35; STAUROSPORINE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL FRACTIONATION; CELL ORGANELLE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; MOUSE; MYRISTYLATION; NERVE CELL; NERVE CELL STIMULATION; NEUROBLASTOMA CELL; NEUROFIBRILLARY TANGLE; NEUROMODULATION; NEUROTOXICITY; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN CLEAVAGE; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CASPASES; CELLS, CULTURED; HYDROLYSIS; MICE; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; NEURONS; PEPTIDE FRAGMENTS; PEPTIDE HYDROLASES;

EID: 78649884714     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22864     Document Type: Article

References (38)

1. Bence NF, Sampat RM, Kopito RR,. 2001. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 292: 1552-1555.
2. Berg L, Mckeel DW, Jr., Miller JP, Baty J, Marris JC,. 1993. Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older. Arch Neurol 50: 349-358.
3. Camins A, Verdaguer E, Folch J, Canudas AM, Pallàs M,. 2006. The role of CDK5/P25 formation/inhibition in neurodegeneration. Drug News Perspect 19: 453-460.
4. Cheng K, Li Z, Fu WY, Wang JH, Fu KY, Ip NY,. 2002. Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35. J Biol Chem 277: 31988-31993.
5. Cheung NS, Pascoe CJ, Giardina SF, John CA, Beart PM,. 1998. Micromolar L -glutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, excitotoxic injury in cultured cortical neurons. Neuropharmacology 37: 1419-1429.
6. Cheung NS, Choy MS, Halliwell B, Teo TS, Bay BH, Lee AY, Qi RZ, Koh VH, Whiteman M, Koay ES, Chiu LL, Zhu HJ, Wong KP, Beart PM, Cheng HC,. 2004a. Lactacystin-induced apoptosis of cultured mouse cortical neurons is associated with accumulation of PTEN to the detergent-resistant membrane fraction. Cell Mol Life Sci 61: 1926-1934.
7. Cheung NS, Koh CH, Bay BH, Qi RZ, Choy MS, Li QT, Wong KP, Whiteman M,. 2004b. Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons. Biochem Biophys Res Commun 315: 408-417.
8. Chua BT, Guo K, Li P,. 2000. Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases. J Biol Chem 275: 5131-5135.
9. Dhavan R, Tsai LH,. 2001. A decade of Cdk5. Nat Rev Mol Cell Biol 2: 749-759.
10. Fu X, Choi Y, Qu D, Yu Y, Cheung NS, Qi RZ,. 2006. Identification of nuclear import mechanisms for the neuronal Cdk5 activator. J Biol Chem 281: 39014-39021.
11. Gong CX, Iqbal K,. 2008. Hyperphosphorylation of microtubule-associated protein tau: A promising therapeutic target for Alzheimer disease. Curr Med Chem 15: 2321-2328.
12. Halliwell B,. 2002. Hypothesis: Proteasomal dysfunction: A primary event in neurogeneration that leads to nitrative and oxidative stress and subsequent cell death. Ann NY Acad Sci 962: 182-194.
13. Hashiguchi M, Saito T, Hisanaga S, Hashiguchi T,. 2002. Truncation of Cdk5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau. J Biol Chem 277: 44525-44530.
14. Ishiguro K, Kobayashi S, Omore A, Takamatsu M, Yonekura S, Anzai K, Imahori K, Uchida T,. 1994. Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain. FEBS Lett 342: 203-208. (Pubitemid 24115197)
15. Keller JN, Hanni KB, Markesbery WR,. 2000. Impaired proteasome function in Alzheimer's disease. J Neurochem 75: 436-439.
16. Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttila T,. 2002a. Influence of phosphorylation of p35, an activator of cyclin-dependent kinase (Cdk5), on the proteolysis of p35. Mol Brain Res 106: 50-56. (Pubitemid 35223279)
17. Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttila T,. 2002b. Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau phosphorylation. Biochem Biophys Res Commun 298: 693-698.
18. Kusakawa G, Saito T, Onuki R, Ishiguro K, Kishimoto T, Hisanaga S,. 2000. Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25. J Biol Chem 275: 17166-17172.
19. Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH,. 2000. Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 405: 360-364.
20. Liu F, Iqbal K, Grundke-Iqbal I, Gong CX,. 2002. Involvement of aberrant glycosylation in phosphorylation of tau by Cdk5 and GSK-3beta. FEBS Lett 530: 209-214.
21. Lund ET, McKenna R, Evans DB, Sharma SK, Mathews WR,. 2001. Characterization of the in vitro phosphorylation of human tau by tau protein kinase II using mass spectrometry. J Neurochem 76: 1221-1232.
22. Maccioni RB, Munoz JP, Barbeito L,. 2001. The molecular basis of Alzheimer's disease and other neurodegenerative disorders. Arch Med Res 32: 367-381.
23. McGinnis KM, Gnegy ME, Park YH, Mukerjee N, Wang KK,. 1999. Procaspase-3 and poly(ADP)ribose polymerase are calpain substrates. Biochem Biophys Res Commun 263: 94-99.
24. Nath R, Davis M, Probert AW, Kupina NC, Ren X, Schielke GP, Wang KK,. 2000. Processing of Cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells. Biochem Biophys Res Commun 274: 16-21.
25. Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, Gaynor K, LaFrancois J, Wang L, Kondo T, Davies P, Burns M, Veeranna, Nixon R, Dickson D, Matsuoka Y, Ahlijanian M, Lau LF, Duff K,. 2003. Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron 38: 555-565.
26. Paglini G, Peris L, Diez-Guerra J, Quiroga S, Careres A,. 2001. The Cdk5-p35 kinase associates with the Golgi apparatus and regulates membrane traffic. EMBO Rep 2: 1139-1144.
27. Pasquini LA, Moreno MB, Adamo AM, Pasquini JM, Soto EF,. 2000. Lactacystin, a specific inhibitor of the proteasome, induces apoptosis and activates caspase-3 in cultured cerebellar granule cells. J Neurosci Res 59: 601-611.
28. Patrick GN, Zhou P, Kwon YT, Howley PM, Tsai LH,. 1998. p35, the neuronal-specific activator of cyclin-dependent kinase 5 is degraded by the ubiquitin-proteosome pathway. J Biol Chem 273: 24057-24064.
29. Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH,. 1999. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402: 615-622.
30. Patzke H, Tsai LH,. 2002. Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. J Biol Chem 277: 8054-8060.
31. Poon RY, Lew J, Hunter T,. 1997. Identification of functional domains in the neuronal Cdk5 activator protein. 272: 5703-5708.
32. Qiu JH, Asai A, Chi S, Saito N, Hamada H, Kirino T,. 2000. Proteasome inhibitors induce cytochrome c-caspase-3-like protease-mediated apoptosis in cultured cortical neurons. J Neurosci 20: 259-265.
33. Sobue K, Agarwal-Mawal A, Li W, Sun W, Miura Y, Paudel HK,. 2000. Interaction of neuronal Cdc2-like protein kinase with microtubule-associated protein tau. J Biol Chem 275: 16673-16680.
34. Sun KH, de Pablo Y, Vincent F, Johnson EO, Chavers AK, Shah K,. 2008. Novel genetic tools reveal Cdk5's major role in Golgi fragmentation in Alzheimer's disease. Mol Biol Cell 19: 3052-3069.
35. Takashima A, Murayama M, Ysutake K, Takahashi H, Yokoyama M, Ishiguro K,. 2001. Involvement of cyclin dependent kinase 5 activator p25 on tau phosphorylation in mouse brain. Neurosci Lett 306: 37-40.
36. Tang D, Chun AC, Zhang M, Wang JH,. 1997. Cyclin-dependent kinase 5 (Cdk5) activation domain of neuronal Cdk5 activator. Evidence of the existence of cyclin fold in neuronal Cdk5a activator. J Biol Chem 272: 12318-12327.
37. Tsai LH, Lee MS, Cruz J,. 2004. Cdk5, a therapeutic target for Alzheimer's disease? Biochim Biophys Acta 1697: 137-142. (Pubitemid 38326767)
38. Town T, Zolton J, Shaffner R, Schnell B, Crescentini R, Wu Y, Zeng J, DelleDonne A, Obregon D, Tan J, Mullan M,. 2002. p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro. J Neurosci Res 69: 362-372.