Cajanol, a novel anticancer agent from Pigeonpea [Cajanus cajan (L.) Millsp.] roots, induces apoptosis in human breast cancer cells through a ROS-mediated mitochondrial pathway

Chemico-Biological Interactions

Volumn 188, Issue 1, 2010, Pages 151-160

  Luo, Meng ^a   Liu, Xia ^a   Zu, Yuangang ^a   Fu, Yujie ^a   Zhang, Su ^a   Yao, Liping ^a   Efferth, Thomas ^b  

^a NORTHEAST FORESTRY UNIVERSITY   (China)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Anticancer activity; Apoptosis; Cajanol; Cell cycle arrest; MCF 7

Indexed keywords

5 HYDROXY 3 (4 HYDROXY 2 METHOXYPHENYL) 7 METHOXY 4 CHROMANONE; CASPASE 3; CASPASE 9; CYTOCHROME C; DNA; FLAVANONE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CAJANOL; ISOFLAVONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL GROWTH; CELL NUCLEUS; CELL STRAIN MCF 7; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME RELEASE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PIGEONPEA; PLANT ROOT; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TIME; WESTERN BLOTTING; BREAST TUMOR; CAJANUS; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; FEMALE; FLOW CYTOMETRY; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BREAST NEOPLASMS; CAJANUS; CELL LINE, TUMOR; FEMALE; FLOW CYTOMETRY; HUMANS; ISOFLAVONES; MITOCHONDRIA; PLANT ROOTS; REACTIVE OXYGEN SPECIES;

CAJANUS CAJAN;

EID: 77956173448     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.07.009     Document Type: Article

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