Tephrosia sinapou ethyl acetate extract inhibits inflammatory pain in mice: Opioid receptor dependent inhibition of TNFα and IL-1β production

Pharmaceutical Biology

Volumn 51, Issue 10, 2013, Pages 1262-1271

  Martinez, Renata M ^a   Zarpelon, Ana C ^a   Cardoso, Renato D R ^a   Vicentini, Fabiana T M C ^b   Georgetti, Sandra R ^a   Baracat, Marcela M ^a   Andrei, Cesar C ^a   Moreira, Isabel C ^c   Verri Jr , Waldiceu A ^a   Casagrande, Rubia ^a  

^a STATE UNIVERSITY OF LONDRINA   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSIDADE TECNOLÓGICA FEDERAL DO PARANÁ   (Brazil)

Author keywords

Abdominal contortions; Cytokine; Hot plate; Hyperalgesia; Morphine; Myeloperoxidase; Neutrophil recruitment; Nociception; Writhing test

Indexed keywords

ACETIC ACID ETHYL ESTER; ALANINE AMINOTRANSFERASE; ANALGESIC AGENT; ASPARTATE AMINOTRANSFERASE; INTERLEUKIN 1BETA; MORPHINE; MYELOPEROXIDASE; NALOXONE; PLANT EXTRACT; TEPHROSIA SINAPOU EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; COLORIMETRY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; FABACEAE; HYPERALGESIA; INFLAMMATORY PAIN; LEUKOCYTE MIGRATION INHIBITION; MALE; MECHANICAL HYPERALGESIA; MOUSE; NONHUMAN; ROTAROD TEST; TEPHROSIA SINAPOU; THERMAL HYPERALGESIA;

ACETATES; ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERALGESIA; INTERLEUKIN-1BETA; MALE; MICE; NARCOTIC ANTAGONISTS; NEUTROPHIL INFILTRATION; PAIN; PAIN THRESHOLD; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PLANTS, MEDICINAL; RECEPTORS, OPIOID; SIGNAL TRANSDUCTION; SOLVENTS; TEPHROSIA; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84883249175     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2013.786099     Document Type: Article

References (60)

1. Allen C, Sievers J, Berry M, Jenner S. (1981). Experimental studies on cerebellar foliation. II. A morphometric analysis of cerebellar fissuration defects and growth retardation after neonatal treatment with 6-OHDA in the rat. J Comp Neurol 20: 771-83.
2. Andel H, Klune G, Andel D, et al. (2000). Propofol without muscle relaxants for conventional or fiberoptic nasotracheal intubation: A dose-finding study. Anesth Analg 91: 458-61.
3. Andrei CC, Ferreira DT, Faccione M, et al. (2000). C-Prenylflavonoids from roots of Tephrosia tunicata. Phytochemistry 55: 799-804.
4. Andrei G, Snoeck R, Vandeputte M, De Clercq E. (1997). Activities of various compounds against murine and primate polyomaviruses. Antimicrob Agents Chemother 41: 587-93.
5. Anjaneyulu M, Chopra K. (2003). Quercetin, a bioflavonoid, attenuates thermal hyperalgesia in a mouse model of diabetic neuropathic pain. Prog Neuropsychopharmacol Biol Psychiatr 27: 1001-5.
6. Arriaga AM, Lima JQ, Vasconcelos JN, et al. (2009a). Unequivocal assignments of flavonoids from Tephrosia sp. (Fabaceae). Magn Reson Chem 47: 537-40.
7. Arriaga AM, Lima JQ, Vasconcelos JN, et al. (2009b). Antioxidant and larvicidal activities of Tephrosia egregia Sandw against Aedes aegypti. Nat Prod Commun 4: 529-30.
8. Arroio A, Honório KM, Weber KC, et al. (2004). A theoretical study on the chemopreventive activity of flavonoid compounds. Internet Electron J Mol Des 3: 781-8.
9. Bisgaard H, Kristensen JK. (1985). Leukotriene B4 produces hyperalgesia in humans. Prostaglandins 30: 791-7.
10. Carvalho TT, Flauzino T, Otaguiri ES, et al. (2011). Granulocyte-Colony Stimulating Factor (G-CSF) induces mechanical hyperalgesia via spinal activation of MAP kinases and PI(3)K in mice. Pharmacol Biochem Behav 98: 188-95.
11. Casagrande R, Georgetti SR, Verri Jr WA, et al. (2006). Protective effect of topical formulations containing quercetin against UVBinduced oxidative stress in hairless mice. J Photochem Photobiol B 84: 21-7.
12. Chou TC, Chang LP, Li CY, et al. (2003). The antiinflammatory and analgesic effects of baicalin in carrageenan-evoked thermal hyperalgesia. Anesth Analg 97: 1724-9.
13. Clark JD, Shi X, Li X, et al. (2007). Morphine reduces local cytokine expression and neutrophil infiltration after incision. Mol Pain 2007: 28-40.
14. Cunha TM, Roman-Campos D, Lotufo CM, et al. (2010a). Morphine peripheral analgesia depends on activation of the PI3Kgamma/AKT/nNOS/NO/KATP signaling pathway. Proc Natl Acad Sci USA 107: 4442-7.
15. Cunha TM, Talbot J, Pinto LG, et al. (2010b). Caspase-1 is involved in the genesis of inflammatory hypernociception by contributing to peripheral IL-1b maturation. Mol Pain 6: 63-73.
16. Cunha TM, Verri Jr WA. (2006). Neutrophils: Are they hyperalgesic or anti-hyperalgesic? J Leukoc Biol 80: 727-8
17. Cunha TM, Verri Jr WA, Schivo IR, et al. (2008b). Crucial role of neutrophils in the development of mechanical inflammatory hypernociception. J Leukoc Biol 83: 824-32.
18. Cunha TM, Verri Jr WA, Silva JS, et al. (2005). A cascade of cytokines mediates mechanical inflammatory hypernociception in mice. Proc Natl Acad Sci USA 102: 1755-60.
19. Cunha TM, Verri Jr WA, Valério DA, et al. (2008a). Role of cytokines in mediating mechanical hypernociception in a model of delayed-type hypersensitivity in mice. Eur J Pain 12: 1059-68.
20. Cunha TM, Verri Jr WA, Vivancos GG, et al. (2004). An electronic pressure-meter nociception paw test for mice. Braz J Med Biol Res 37: 401-7.
21. Delporte C, Backhouse N, Inostroza V, et al. (2007). Analgesic activity of Ugni molinae (murtilla) in mice models of acute pain. J Ethnopharmacol 112: 162-5.
22. Georgetti SR, Casagrande R, Vicentini FTMC, et al. (2006). Evaluation of the antioxidant activity of soybean extract by different in vitro methods and investigation of this activity after its incorporation in topical formulations. Eur J Pharm Biopharm 64: 99-106.
23. Gold MS, Reichling DB, Shuster MJ, Levine JD. (1996a). Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors. Proc Natl Acad Sci USA 93: 1108-12.
24. Gold MS, Shuster MJ, Levine JD. (1996b). Role of a Ca(2+)-dependent slow afterhyperpolarization in prostaglandin E2-induced sensitization of cultured rat sensory neurons. Neurosci Lett 205: 161-4.
25. Guerrero AT, Verri Jr WA, Cunha TM, et al. (2008). Involvement of LTB4 in zymosan-induced joint nociception in mice: Participation of neutrophils and PGE2. J Leukoc Biol 83: 122-30.
26. Jang DS, Park EJ, Kang YH, et al. (2003). Potential cancer chemopreventive flavonoids from the stems of Tephrosia sinapou. J Nat Prod 66: 1166-70.
27. Kandhare AD, Raygude KS, Ghosh P, et al. (2012). Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy. Fitoterapia 83: 650-9.
28. Khatri A, Garg A, Agrawal SS. (2009). Evaluation of hepatoprotective activity of aerial parts of Tephrosia purpurea L. and stem bark of Tecomella undulata. J Ethnopharmacol 122: 1-5.
29. Khasar SG, Gold MS, Levine JD. (1998). A tetrodotoxin-resistant sodium current mediates inflammatory pain in the rat. Neurosci Lett 256: 17-20.
30. Le Bars D, Gozariu M, Cadden SW. (2001). Animal models of nociception. Pharmacol Rev 53: 597-652.
31. Levine JD, Lau W, Kwiat G, Goetzl EJ. (1984). Leukotriene B4 produces hyperalgesia that is dependent on polymorphonuclear leukocytes. Science 225: 743-5.
32. Loscalzo LM, Wasowski C, Paladini AC, Marder M. (2008). Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur J Pharmacol 580: 306-13.
33. Loscalzo LM, Yow TT, Wasowski C, et al. (2011). Hesperidin induces antinociceptive effect in mice and its aglycone, hesperetin, binds to m-opioid receptor and inhibits GIRK1/2 currents. Pharmacol Biochem Behav 99: 333-41.
34. Martin JL, Koodie L, Krishnan AG, et al. (2010). Chronic morphine administration delays wound healing by inhibiting immune cell recruitment to the wound site. Am J Pathol 176: 786-99.
35. Niassy B, Lobstein A, Um BH, et al. (2005). Flavonoids from Tephrosia deflexa and T. albifoliolis. Biochem Systemat Eco 33: 309-12.
36. Pavão-de-Souza GF, Zarpelon AC, Tedeschi GC, et al. (2012). Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI(3)K and microglia in mice. Pharmacol Biochem Behav 101: 320-8.
37. Pezzuto JM, Song LL, Lee SK, et al. (1999). Bioassay methods useful for activity-guided isolation of natural product cancer chemopreventive agents. In: Hostettmann K, Gupta MP, Marston A, eds. Chemistry, Biological and Pharmacological Properties of Medicinal Plants from the Americas. Amsterdam, Netherlands: Harwood Academic, 81-110.
38. Ribeiro WH, Vasconcelos JN, Arriaga AM, et al. (2006). Tephrosia toxicaria pers essential oil: Chemical composition and larvicidal activity. Nat Prod Commun 1: 391-4.
39. Rittner HL, Mousa SA, Labuz D, et al. (2006). Selective local PMN recruitment by CXCL1 or CXCL2/3 injection does not cause inflammatory pain. J Leukoc Biol 79: 1022-32.
40. Safieh-Garabedian B, Poole S, Allchorne A, et al. (1995). Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia. Br J Pharmacol 115: 1265-75.
41. Saleem M, Ahmed Su, Alam A, Sultana S. (2001). Tephrosia purpurea alleviates phorbol ester-induced tumor promotion response in murine skin. Pharmacol Res 43: 135-44.
42. Ting E, Guerrero AT, Cunha TM, et al. (2008). Role of complement C5a in mechanical inflammatory hypernociception: Potential use of C5a receptor antagonists to control inflammatory pain. Br J Pharmacol 153: 1043-53.
43. Valério DA, Cunha TM, Arakawa NS, et al. (2007). Anti-inflammatory and analgesic effects of the sesquiterpene lactone budlein A in mice: Inhibition of cytokine production-dependent mechanism. Eur J Pharmacol 562: 155-63.
44. Valério DA, Ferreira FI, Cunha TM, et al. (2009a). Fructose-1,6- bisphosphate reduces inflammatory pain-like behaviour in mice: Role of adenosine acting on A1 receptors. Br J Pharmacol 158: 558-68.
45. Valério DA, Georgetti SR, Magro DA, et al. (2009b). Quercetin reduces inflammatory pain: Inhibition of oxidative stress and cytokine production. J Nat Prod 72: 1975-9.
46. Valsecchi AE, Franchi S, Panerai AE, et al. (2008). Genistein, a natural phytoestrogen from soy, relieves neuropathic pain following chronic constriction sciatic nerve injury in mice: Anti-inflammatory and antioxidant activity. J Neurochem 107: 230-40.
47. Vasconcelos JN, Lima JQ, Lemos TLG, et al. (2009). Estudo químico e biológico de Tephrosia toxicaria Pers. Quím Nova 15: 1-5.
48. Verri Jr WA, Cunha TM, Ferreira SH, et al. (2007b). Role of IL-15 in antigen-induced neutrophil migration by triggering IL-18 production. Eur J Immunol 37: 3373-80.
49. Verri Jr WA, Cunha TM, Magro DA, et al. (2008a). Role of IL-18 in overt pain-like behaviour in mice. Eur J Pharmacol 588: 207-12.
50. Verri Jr WA, Cunha TM, Magro DA, et al. (2009). Targeting endothelin ETA and ETB receptors inhibits antigen-induced neutrophil migration and mechanical hypernociception in mice. Naunyn Schmiedebergs Arch Pharmacol 379: 271-9.
51. Verri Jr WA, Cunha TM, Parada CA, et al. (2006a). IL-15 mediates immune inflammatory hypernociception by triggering a sequential release of IFN-gamma, endothelin, and prostaglandin. Proc Natl Acad Sci USA 103: 9721-5.
52. Verri Jr WA, Cunha TM, Parada CA, et al. (2006b). Hypernociceptive role of cytokines and chemokines: Target for analgesic drug development? Pharmacol Ther 112: 116-38
53. Verri Jr WA, Cunha TM, Poole S, et al. (2007a). Cytokine inhibitors and pain control. Rev Bras Reumatol 47: 341-53.
54. Verri Jr WA, Guerrero AT, Fukada SY, et al. (2008b). IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice. Proc Natl Acad Sci USA 105: 2723-8.
55. Verri Jr WA, Molina RO, Schivo IR, et al. (2005). Nociceptive effect of subcutaneously injected interleukin-12 is mediated by endothelin (ET) acting on ETB receptors in rats. J Pharmacol Exp Ther 315: 609-15.
56. Verri Jr WA, Schivo IR, Cunha TM, et al. (2004). Interleukin-18 induces mechanical hypernociception in rats via endothelin acting on ETB receptors in a morphine-sensitive manner. J Pharmacol Exp Ther 310: 710-17.
57. Verri Jr WA, Souto FO, Vieira SM, et al. (2010). IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy. Ann Rheum Dis 69: 1697-703.
58. Wang J, Barke RA, Charboneau R, Roy S. (2005). Morphine impairs host innate immune response and increases susceptibility to Streptococcus pneumoniae lung infection. J Immunol 174: 426-34.
59. Yenesew A, Kiplagat JT, Derese S, et al. (2006). Two unusual rotenoid derivatives, 7a-O-methyl-12a-hydroxydeguelol and spiro-13-homo- 13-oxaelliptone, from the seeds of Derris trifoliate. Phytochemistry 67: 988-91.
60. Zimmermann M. (1983). Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16: 109-10.