Anti-inflammatory and analgesic effects of the sesquiterpene lactone budlein A in mice: Inhibition of cytokine production-dependent mechanism

European Journal of Pharmacology

Volumn 562, Issue 1-2, 2007, Pages 155-163

  Valério, Daniel A R ^a   Cunha, Thiago M ^a   Arakawa, Nilton S ^a   Lemos, Henrique P ^a   Da Costa, Fernando B ^a   Parada, Carlos A ^a   Ferreira, Sergio H ^a   Cunha, Fernando Q ^a   Verri Jr , Waldiceu A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Asteraceae; Budlein A; Chemokine; Cytokine; Hyperalgesia; Hypernociception; Inflammation; Neutrophil migration; Nociception; Oedema; Pain; Sesquiterpene lactones; Viguiera robusta

Indexed keywords

ACETIC ACID; BUDLEIN A; CARRAGEENAN; CHEMOKINE; CYTOKINE; DEXAMETHASONE; DOPAMINE; FREUND ADJUVANT; INDOMETACIN; INTERLEUKIN 1BETA; MYELOPEROXIDASE; PROSTAGLANDIN E2; SESQUITERPENE LACTONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG MECHANISM; INFLAMMATION; MALE; MOUSE; NEUTROPHIL; NOCICEPTION; NONHUMAN; PAW EDEMA; PLANT; PRIORITY JOURNAL; VIGUIERA ROBUSTA; WRITHING TEST;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTERACEAE; BEHAVIOR, ANIMAL; CARRAGEENAN; CELL MOVEMENT; CYTOKINES; DINOPROSTONE; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; FREUND'S ADJUVANT; HINDLIMB; INFLAMMATION; LACTONES; MALE; MICE; MOLECULAR STRUCTURE; NEUTROPHILS; PAIN; PERITONEAL CAVITY; SESQUITERPENES; SIGNAL TRANSDUCTION; SKIN;

EID: 33947544247     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.01.029     Document Type: Article

References (51)

1. Abil'daeva A.Z., Pak R.N., Kulyiasov A.T., and Adekenov S.M. Anti-inflammatory effect of arglabin and 11,13-dihydro-13-dimethylaminoarglabin hydrochloride. Eksp. Klin. Farmakol 67 (2004) 37-39
2. Ahmed M., Rahman M.T., Alimuzzaman M., and Shilpi J.A. Analgesic sesquiterpene dilactone from Mikania cordata. Fitoterapia 72 (2001) 919-921
3. Baeuerle P.A., and Baltimore D. NF-kappa B: ten years after. Cell 87 (1996) 13-20
4. Baeuerle P.A., and Henkel T. Function and activation of NF-kappa B in the immune system. Annu. Rev. Immunol. 12 (1994) 141-179
5. Barnes P.J. How corticosteroids control inflammation: Quintiles Prize Lecture 2005. Br. J. Pharmacol. 148 (2006) 245-254
6. Bradley P.P., Priebat D.A., Christensen R.D., and Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J. Invest. Dermatol. 78 (1982) 206-209
7. Canetti C., Silva J.S., Ferreira S.H., and Cunha F.Q. Tumour necrosis factor-alpha and leukotriene B(4) mediate the neutrophil migration in immune inflammation. Br. J. Pharmacol. 134 (2001) 1619-1628
8. Casagrande R., Georgetti S.R., Verri Jr. W.A., Dorta D.J., dos Santos A.C., and Fonseca M.J. Protective effect of topical formulations containing quercetin against UVB-induced oxidative stress in hairless mice. J. Photochem. Photobiol., B Biol. 84 (2006) 21-27
9. Chen C.H., Yang L.M., Lee T.T., Shen Y.C., Zhang D.C., Pan D.J., McPhail A.T., McPhail D.R., Liu S.Y., Li D.H., et al. Antitumor agents-CLI. Bis(helenalinyl)glutarate and bis(isoalantodiol-B)glutarate, potent inhibitors of human DNA topoisomerase II. Bioorg. Med. Chem. 2 (1994) 137-145
10. Collier H.O., Dinneen L.C., Johnson C.A., and Schneider C. The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br. J. Pharmacol. Chemother. 32 (1968) 295-310
11. Cunha F.Q., Lorenzetti B.B., Poole S., and Ferreira S.H. Interleukin-8 as a mediator of sympathetic pain. Br. J. Pharmacol. 104 (1991) 765-767
12. Cunha F.Q., Poole S., Lorenzetti B.B., and Ferreira S.H. The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br. J. Pharmacol. 107 (1992) 660-664
13. Cunha T.M., Verri Jr. W.A., Vivancos G.G., Moreira I.F., Reis S., Parada C.A., Cunha F.Q., and Ferreira S.H. An electronic pressure-meter nociception paw test for mice. Braz. J. Med. Biol. Res. 37 (2004) 401-407
14. Cunha T.M., Verri Jr. W.A., Silva J.S., Poole S., Cunha F.Q., and Ferreira S.H. A cascade of cytokines mediates mechanical inflammatory hypernociception in mice. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 1755-1760
15. Da Costa F.B., Schorr K., Arakawa N.S., Schilling E.E., and Spring O. Infraspecific variation in the chemistry of glandular trichomes of two Brazilian Viguiera populations. J. Braz. Chem. Soc. 12 (2001) 403-407
16. Damre A.A., Damre A.S., and Saraf M.N. Evaluation of sesquiterpene lactone fraction of Saussurea lappa on transudative, exudative and proliferative phases of inflammation. Phytother. Res. 17 (2003) 722-725
17. De Vivar A.R., Diaz C.G.E., Bratoeff E.A., and Jimenez L. The germacranolides of Viguiera buddleiaeformis structures of budlein-A and -B. Phytochemistry 15 (1976) 525-529
18. Feltenstein M.W., Schuhly W., Warnick J.E., Fischer N.H., and Sufka K.J. Anti-inflammatory and anti-hyperalgesic effects of sesquiterpene lactones from Magnolia and Bear's foot. Pharmacol. Biochem. Behav. 79 (2004) 299-302
19. Ferreira S.H., Lorenzetti B.B., Bristow A.F., and Poole S. Interleukin-1 beta as a potent hyperalgesic agent antagonized by a tripeptide analogue. Nature 334 (1988) 698-700
20. Ferreira S.H., Cunha F.Q., Lorenzetti B.B., Michelin M.A., Perretti M., Flower R.J., and Poole S. Role of lipocortin-1 in the anti-hyperalgesic actions of dexamethasone. Br. J. Pharmacol. 121 (1997) 883-888
21. French L.A., and Galicich J.H. The use of steroids for control of cerebral edema. Clin. Neurosurg. 10 (1964) 212-223
22. Goldman G., Welbourn R., Kobzik L., Valeri C.R., Shepro D., and Hechtman H.B. Lavage with leukotriene B4 induces lung generation of tumor necrosis factor-alpha that in turn mediates neutrophil diapedesis. Surgery 113 (1993) 297-303
23. Guardia T., Juarez A.O., Guerreiro E., Guzman J.A., and Pelzer L. Anti-inflammatory activity and effect on gastric acid secretion of dehydroleucodine isolated from Artemisia douglasiana. J. Ethnopharmacol. 88 (2003) 195-198
24. Gudis K., and Sakamoto C. The role of cyclooxygenase in gastric mucosal protection. Dig. Dis. Sci. 50 Suppl. 1 (2005) S16-S23
25. Hehner S.P., Heinrich M., Bork P.M., Vogt M., Ratter F., Lehmann V., Schulze-Osthoff K., Droge W., and Schmitz M.L. Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta. J. Biol. Chem. 273 (1998) 1288-1297
26. Heinrich M., Robles M., West J.E., Ortiz de Montellano B.R., and Rodriguez E. Ethnopharmacology of Mexican asteraceae (Compositae). Annu. Rev. Pharmacol. Toxicol. 38 (1998) 539-565
27. Huacuja R.L., Carranco A., Guzman S.A., and Guerrero C. Inactivation of SH groups with sesquiterpene lactones: effects on nuclear decondensation pattern/motility induced by heparin in human spermatozoa. Adv. Contracept. Deliv. Syst. 9 (1993) 97-106
28. Jain N.K., and Kulkarni S.K. Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in mice and rats. J. Ethnopharmacol. 68 (1999) 251-259
29. Limet R., and Lecomte J. Inhibitory action of indomethacin on generalized edema induced by dextran in rats. Arch. Int. Pharmacodyn. Ther. 171 (1968) 109-115
30. May M.J., and Ghosh S. Signal transduction through NF-kappa B. Immunol. Today 19 (1998) 80-88
31. Meshnick S.R. Artemisinin: mechanisms of action, resistance and toxicity. Int. J. Parasitol. 32 (2002) 1655-1660
32. Okugawa H., Ueda R., Matsumoto K., Kawanishi K., and Kato K. Effects of sesquiterpenoids from "Oriental incenses" on acetic acid-induced writhing and D2 and 5-HT2A receptors in rat brain. Phytomedicine 7 (2000) 417-422
33. Parada C.A., Vivancos G.G., Tambeli C.H., Cunha F.Q., and Ferreira S.H. Activation of presynaptic NMDA receptors coupled to NaV1.8-resistant sodium channel C-fibers causes retrograde mechanical nociceptor sensitization. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 2923-2928
34. Pickman A.K. Antifungal activity of sesquiterpene lactones. Biochem. Syst. Ecol. 12 (1984) 13-18
35. Recio M.C., Giner R.M., Uriburu L., Manez S., Cerda M., De la Fuente J.R., and Rios J.L. In vivo activity of pseudoguaianolide sesquiterpene lactones in acute and chronic inflammation. Life Sci. 66 (2000) 2509-2518
36. Ribeiro R.A., Vale M.L., Thomazzi S.M., Paschoalato A.B., Poole S., Ferreira S.H., and Cunha F.Q. Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice. Eur. J. Pharmacol. 387 (2000) 111-118
37. Rosland J.H., Hunskaar S., and Hole K. Diazepam attenuates morphine antinociception test-dependently in mice. Pharmacol. Toxicol. 66 (1990) 382-386
38. Rüngeler P., Castro V., Mora G., Gören N., Vichnewski W., Pahl H.L., Merfort I., and Schmidt T.J. Inhibition of transcription factor NF-_B by sesquiterpene lactones: a proposed molecular mechanism of action. Bioorg. Med. Chem. 7 (1999) 2343-2352
39. Sayers T.J., Wiltrout T.A., Bull C.A., Denn A.C., Pilaro A.M., and Lokesh B. Effect of cytokines on polymorphonuclear neutrophil infiltration in the mouse. Prostaglandin- and leukotriene-independent induction of infiltration by IL-1 and tumor necrosis factor. J. Immunol. 141 (1988) 1670-1677
40. Secco D.D., Paron J.A., de Oliveira S.H., Ferreira S.H., Silva J.S., and Cunha F.Q. Neutrophil migration in inflammation: nitric oxide inhibits rolling, adhesion and induces apoptosis. Nitric Oxide 9 (2003) 153-164
41. Siedle B., Garcia-Pineres A.J., Murillo R., Schulte-Monting J., Castro V., Rungeler P., Klaas C.A., Da Costa F.B., Kisiel W., and Merfort I. Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB. J. Med. Chem. 47 (2004) 6042-6054
42. Silvan A.M., Abad M.J., Bermejo P., and Villar A. Inhibition by hydroxyachillin, sesquiterpene lactone from Tanacetum microphyllum, of PMA-induced mouse ear oedema. Inflamm. Res. 45 (1996) 289-292
43. Souza M.H., Lemos H.P., Oliveira R.B., and Cunha F.Q. Gastric damage and granulocyte infiltration induced by indomethacin in tumour necrosis factor receptor 1 (TNF-R1) or inducible nitric oxide synthase (iNOS) deficient mice. Gut 53 (2004) 791-796
44. Verri Jr. W.A., Schivo I.R., Cunha T.M., Liew F.Y., Ferreira S.H., and Cunha F.Q. Interleukin-18 induces mechanical hypernociception in rats via endothelin acting on ETB receptors in a morphine-sensitive manner. J. Pharmacol. Exp. Ther. 310 (2004) 710-717
45. Verri Jr. W.A., Molina R.O., Schivo I.R., Cunha T.M., Parada C.A., Poole S., Ferreira S.H., and Cunha F.Q. Nociceptive effect of subcutaneously injected interleukin-12 is mediated by endothelin (ET) acting on ETB receptors in rats. J. Pharmacol. Exp. Ther. 315 (2005) 609-615
46. Verri Jr. W.A., Cunha T.M., Parada C.A., Poole S., Cunha F.Q., and Ferreira S.H. Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development?. Pharmacol. Ther. 112 (2006) 116-138
47. Verri Jr. W.A., Cunha T.M., Parada C.A., Wei X.Q., Ferreira S.H., Liew F.Y., and Cunha F.Q. IL-15 mediates immune inflammatory hypernociception by triggering a sequential release of IFN-{gamma}, endothelin, and prostaglandin. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 9721-9725
48. Verri, W.A., Jr., Cunha, T.M., Parada, C.A., Poole, S., Liew, F.Y., Ferreira, S.H., Cunha F.Q., in press. Antigen-induced inflammatory mechanical hypernociception in mice is mediated by IL-18. Brain Behav. Immun. doi:10.1016/j.bbi.2006.11.005.
49. Vivancos G.G., Verri Jr. W.A., Cunha T.M., Schivo I.R., Parada C.A., Cunha F.Q., and Ferreira S.H. An electronic pressure-meter nociception paw test for rats. Braz. J. Med. Biol. Res. 37 (2004) 391-399
50. Wallace J.L., McKnight G.W., and Bell C.J. Adaptation of rat gastric mucosa to aspirin requires mucosal contact. Am. J. Physiol. 268 (1995) G134-G138
51. Winter C.A., Risley E.A., and Nuss G.W. Carrageenan-induced edema in hind paw of the rat as an assay for antiinflammatory drugs. Proc. Soc. Exp. Biol. Med. 111 (1962) 544-547