Abnormalities of retinal metabolism in diabetes or experimental galactosemia: V. Relationship between protein kinase C and APTases

Diabetes

Volumn 47, Issue 3, 1998, Pages 464-469

  Kowiuru, Renu A ^a,c   Jirousek, Michael R ^b   Stramm, Lawrence ^b   Farid, Nagy ^b   Engerman, Ronald L ^a   Kern, Timothy S ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALLOXAN; GALACTOSE; GLYCOSYLATED HEMOGLOBIN; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; RUBOXISTAURIN; UNCLASSIFIED DRUG;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DIABETIC RETINOPATHY; ENZYME ACTIVITY; GALACTOSEMIA; GLUCOSE BLOOD LEVEL; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; RETINA BLOOD VESSEL; SCIATIC NERVE; TISSUE METABOLISM;

EID: 0031891448     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.47.3.464     Document Type: Article

References (35)

1. Engerman RL, Kern TS: Diabetic retinopathy: is it a consequence of hyper-glycemia? Diabet Med 2:200-203,1985
2. Engerman RL, Kern TS: Hyperglycemia as a cause of diabetic retinopathy. Metabolism 35 (Suppl. l):20-23,1986
3. Shiba T, Inoguchi T, Sportsman JR, Heath WF, Bursell S, King GL: Correlation of diacylglycerol and protein kinase C in rat retina to retinal circulation. Am J Physiol 265:E783-E793,1993
4. Presta M, Maier JAM, Ragnotti G: The mitogenic signalling pathway but not plasminogen activator inducing pathway of basic flbroblast growth factor is mediated through protein kinase C in fetal bovine aortic endothellal cells. J Cell Biol 109:1877-1884,1989
5. Hachiya HL, Takayama S, White MF, King GL: Regulation of insulin receptor internalization in vascular endothelial cells by insulin and phorbol ester. J Biol chem 262:6417-6424,1987
6. Montesano R, Orci L: Tumor-promoting phorbol esters induce angiogenesis in vitro. Cell 42:469-477,1985
7. Murphy TL, Sakamoto T, Hinton DR, Spee C, Gundimeda U, Soriano D, Gopalkhshna R, Ryan SJ: Migration of retinal pigment epithelium cells in vitro is regulated by protein kinase C. Exp Eye Res 60:683-695,1995
8. Clark JD, Lin LL, Kriz RW, Ramesha CS, Sultzman LA, Lin AY, Milona N, Knopf JL: A novel arachidonic acid-selective cytosolic PLA2 contains a cal-cium-dependent translocation domain with homology to PKC and GAP. Cell 65:1043-1051,1991
9. Sharma K, Danoff TM, DePiero A, Ziyadeh FN: Enhanced expression of inducible nitric oxide synthase in murine macrophages and glomerular mesangial cells by elevated glucose levels: possible mediation via protein kinase C. Biochem Biopkys Res Comm 207:80-88,1995
10. Xia P, Kramer RM, King GL Identification of the mechanism for the inhibition of Na,K-adenosine triphosphaiase by hyperglycemia involving activation of pro-tein kinase C and cytosolic phospholipase A2, J Clin Invest 96:733-740,1995
11. Feschenko MS, Sweadner KJ: Structural basis for species-specific differences in the phosphorylation of Na,K-ATPase by protein kinase C. J Biol Chem 270:14072-14077,1995
12. II and diacylglycerol levels in aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci USA 89:11059-11063,1992
13. Ishii H, Jirousek MR, Koya D, Takagi C, Xia P, Clermont A, Bursell S-E, Kem TS, Ballas LM, Heath WF, Stramm LE, Feener EP, King GL Amelioration of vas-cular dysfunctions in diabetic rats by an oral PKC βinhibitor. Science 272:728-731, 1996
14. Craven PA, DeRubertis FD: Protein kinase C is activated in glomeruli from streptozotocin diabetic rats: possible mediation by glucose. J Clin Invest 83:1667-1675,1989
15. Lee T-S, MacGregor LC, Fluharty SJ, King GL: Differential regulation of pro-tein kinase C and (Na,K)-adenosine triphosphatase activities by elevated glu-cose levels in retinal capillary endothelial cells. J Clin Invest 83:90-94,1989
16. Kim J, Rushovich EH, Thomas TP, Ueda T, Agranoff BW, Greene DA: Diminished specific activity of cytosolic protein kinase C in sciatic nerve of strep-tozocin-induced diabetic rats and its correction by dietary myo-inositol Dia-betes 40:1545-1554,1991
17. Lee T-S, Saltsman KA, Ohashi H, King GL: Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the devel-opment of diabetic vascular complications. Proc Natl Acad Sci USA 86:5141-5145,1989
18. Xia P, Inoguchi T, Kern TS, Engerman RL, Oates PJ, King GL: Characteri-zation of the mechanism for the chronic activation of diacylglycerol-pro-tein kinase C pathway in diabetes and hypergalactosemia. Diabetes 43:1122-1129,1994
19. Tamoki T, Nomoto H, Takahashi I, Kato Y, Morimoto M, Tomita F: Stau-rosporin, a potent inhibitor of phospholipid/calcium dependent protein kinase. Biochem Biophys Res Comm 135:397-402,1986
20. Andrejauskas-Buchdunger E, Regenass U: Differential inhibition of the epi-dermal growth factor-, platelet-derived growth factor-, and protein kinase C- mediated signal transduction pathways by the staurosporine derivative CGP 41251. Cancer Res 52:5353-5358,1992
21. Kowluru RA, Bitensky MW, Kowluru A, Dembo M, Keaton PA, Buican T: Reversible sodium pump defect and swelling in the diabetic rat erythrocyte: effects on filterability and implications for microangiopathy. Proc Natl Acad Sci USA 86:3327-3331,1989
22. Greene DA, Lattimer SA: Protein kinase C agonists acutely normalize decreased ouabain-inhibitable respiration in diabetic rabbit nerve: implications for (Na, K)-ATPase regulation and diabetic complications. Diabetes 35:242-245,1986
23. Clermont AC, Takagi C, Jirousek MR, Bursell S-E, King GL: A PKC beta isoform selective antagonist normalized retinal blood flow in STZ diabetic rats: first report of an oral agent selective for the PKC beta isoenzyme (Abstract). Invest Ophthalmol Vis Sci 36:8173, 1995
24. Cuthbertson RA, Mandel TE: Anatomy of the mouse retina: endothelial cell-pericyte ratio and capillary distribution. Invest Ophthalmol Vis Sci 27:1659-1664,1986
25. Williams B, Schlier RW: Characterization of glucose-induced in situ protein kinase C activity in cultured vascular smooth muscle cells. Diabetes 41:1464-1472,1992
26. Kern TS, Kowluru R, Engerman RL: Abnormalities of retinal metabolism in dia-betes or galactosemia: ATPases and glutathione. Invest Ophthalmol Vis Sci 35:2962-2967,1994
27. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein. Anal Biochem 72:248-258,1974
28. Stahl WL: The Na,K-ATPase of nervous tissue. Neurochem Int 8:449-476, 1986
29. Greene DA, Lattimer SA: Impaired energy utilization and Na-K-ATPase in dia-betic peripheral nerve. Am J Physiol 246:E311-E318,1984
30. Borghini I, Geering K, Gjinovci A, Wollheim CB: In vivo phosphorylation of the Na,K-ATPase alpha subunit in sciatic nerves of control and diabetic rats: effects of protein kinase modulators. Proc Natl Acad Sci USA 1994:6211-6215,1994
31. Lowndes JM, Hokin-Nearverson M, Bertics PJ: Kinetics of phosphorylation of Na/K-ATPase by protein kinase C.Biochem Btophys Acta 1052:143-151,1990
32. Kern TS, Kowluru R, Engerman RL: Correction of retinal dysmetabolism in dia-betic rats and galactosemic rats by antioxidants, calcium channel blocker, or aldose reductase inhibitor (Abstract). In 15th International Diabetes Federation Congress, Kobe, Japan, 2994, p. 369
33. Kowluru RA, Kern TS, Engerman RL, Armstrong D: Abnormalities of retinal metabolism in diabetes or experimental galactosemia. III. Effects of antioxi-dants. Diabetes 45:1233-1237,1996
34. +-ATPase defects in diabetic rats (Abstract). Diabetes 46 (Suppl. 1):31A, 1997
35. Kern TS, Engerman RL: Capillary lesions develop in retina rather than cere-bral cortex in diabetes and experimental galactosemia. Arch Ophthalmol 114:306-310, 1996