Quality assurance of monoclonal antibody pharmaceuticals based on their charge variants using microchip isoelectric focusing method

Journal of Chromatography A

Volumn 1309, Issue , 2013, Pages 76-83

  Kinoshita, Mitsuhiro ^a   Nakatsuji, Yuki ^a   Suzuki, Shigeo ^a   Hayakawa, Takao ^a   Kakehi, Kazuaki ^a  

^a KINKI UNIVERSITY   (Japan)

Author keywords

Antibody; Charge variant; Isoelectric focusing; Microchip

Indexed keywords

CAPILLARY ISOELECTRIC FOCUSING; CHARGE VARIANTS; COMPLEX CHARACTERISTICS; ISOELECTRIC FOCUSING; MICROCHIP; MICROCHIP ELECTROPHORESIS; MONOCLONAL ANTIBODIES (MAB); REGULATORY EVALUATION;

ANTIBODIES; CAPILLARY ELECTROPHORESIS; MONOCLONAL ANTIBODIES; QUALITY ASSURANCE;

MICROPROCESSOR CHIPS;

ARGININE; BEVACIZUMAB; CETUXIMAB; HYDROXYPROPYLMETHYLCELLULOSE; MONOCLONAL ANTIBODY; POLYMER; TRANSFERRIN; TRASTUZUMAB; UREA;

ACCURACY; ADSORPTION; ANIMAL CELL; ARTICLE; CAPILLARY ELECTROPHORESIS; CONTROLLED STUDY; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; HYDROPHOBICITY; INTERMETHOD COMPARISON; ISOELECTRIC FOCUSING; LIMIT OF DETECTION; MICROCHIP ELECTROPHORESIS; NONHUMAN; PH; PRIORITY JOURNAL; PROCESS OPTIMIZATION; REPRODUCIBILITY; SOLUBILITY; SURFACE PROPERTY;

EID: 84883208534     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2013.08.021     Document Type: Article

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