Analysis of nonhuman N-glycans as the minor constituents in recombinant monoclonal antibody pharmaceuticals

Analytical Chemistry

Volumn 84, Issue 5, 2012, Pages 2373-2379

  Maeda, Eiki ^a   Kita, Soichiro ^b   Kinoshita, Mitsuhiro ^b   Urakami, Koji ^a   Hayakawa, Takao ^b   Kakehi, Kazuaki ^b  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b KINKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL APPLICATION; CLONE SELECTION; CULTURE MEDIA; DEVELOPMENT STAGES; IMMUNOGENICITY; LASER INDUCED FLUORESCENCE DETECTION; MAMMALIAN CELL LINES; MINOR CONSTITUENTS; N-GLYCANS; N-GLYCOLYLNEURAMINIC ACID; N-LINKED GLYCANS; PRODUCT CHARACTERISTICS; PRODUCTION PROCESS; RECOMBINANT MONOCLONAL ANTIBODY; TIME OF FLIGHT MASS SPECTROMETRY;

ANIMAL CELL CULTURE; CAPILLARY ELECTROPHORESIS; DISEASES; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PATIENT TREATMENT; SAFETY TESTING;

MONOCLONAL ANTIBODIES;

GALACTOSE; MONOCLONAL ANTIBODY; N GLYCOLOYLNEURAMINIC ACID; N-GLYCOLYLNEURAMINIC ACID; NEURAMINIC ACID DERIVATIVE; POLYSACCHARIDE; RECOMBINANT PROTEIN;

ARTICLE; CAPILLARY ELECTROPHORESIS; CARBOHYDRATE ANALYSIS; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; GENETICS; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; LASER; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS;

ANTIBODIES, MONOCLONAL; CARBOHYDRATE SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS, CAPILLARY; GALACTOSE; GLYCOSYLATION; LASERS; MOLECULAR SEQUENCE DATA; NEURAMINIC ACIDS; POLYSACCHARIDES; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84857852410     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac300234a     Document Type: Article

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