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Volumn 126, Issue 5, 2013, Pages 591-603

Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease

Author keywords

DOPAC; DOPAL; dopamine; DOPET; monoamine oxidase; Parkinson's disease

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 3,4 DIHYDROXYPHENYLETHYLENE GLYCOL; ALDEHYDE DEHYDROGENASE; CATECHOL DERIVATIVE; CATECHOLAMINE; DOPA; NORADRENALIN; VESICULAR MONOAMINE TRANSPORTER 2;

EID: 84883195985     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12345     Document Type: Article
Times cited : (166)

References (52)
  • 1
    • 79960686500 scopus 로고    scopus 로고
    • Oxidation of 3,4-dihydroxyphenylacetaldehyde, a toxic dopaminergic metabolite, to a semiquinone radical and an ortho-quinone
    • Anderson D. G., Mariappan S. V., Buettner G. R., and, Doorn J. A., (2011) Oxidation of 3,4-dihydroxyphenylacetaldehyde, a toxic dopaminergic metabolite, to a semiquinone radical and an ortho-quinone. J. Biol. Chem. 286, 26978-26986.
    • (2011) J. Biol. Chem. , vol.286 , pp. 26978-26986
    • Anderson, D.G.1    Mariappan, S.V.2    Buettner, G.R.3    Doorn, J.A.4
  • 3
    • 0036784071 scopus 로고    scopus 로고
    • Kinetics and crystal structure of catechol-o-methyltransferase complex with co-substrate and a novel inhibitor with potential therapeutic application
    • Bonifacio M. J., Archer M., Rodrigues M. L., Matias P. M., Learmonth D. A., Carrondo M. A., and, Soares-Da-Silva P., (2002) Kinetics and crystal structure of catechol-o-methyltransferase complex with co-substrate and a novel inhibitor with potential therapeutic application. Mol. Pharmacol. 62, 795-805.
    • (2002) Mol. Pharmacol. , vol.62 , pp. 795-805
    • Bonifacio, M.J.1    Archer, M.2    Rodrigues, M.L.3    Matias, P.M.4    Learmonth, D.A.5    Carrondo, M.A.6    Soares-Da-Silva, P.7
  • 4
    • 0141638380 scopus 로고    scopus 로고
    • 3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: Implications for Parkinson's disease pathogenesis
    • Burke W. J., Li S. W., Williams E. A., Nonneman R., and, Zahm D. S., (2003) 3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson's disease pathogenesis. Brain Res. 989, 205-213.
    • (2003) Brain Res. , vol.989 , pp. 205-213
    • Burke, W.J.1    Li, S.W.2    Williams, E.A.3    Nonneman, R.4    Zahm, D.S.5
  • 5
    • 9144224220 scopus 로고    scopus 로고
    • Neurotoxicity of MAO metabolites of catecholamine neurotransmitters: Role in neurodegenerative diseases
    • Burke W. J., Li S. W., Chung H. D., et al,. (2004) Neurotoxicity of MAO metabolites of catecholamine neurotransmitters: role in neurodegenerative diseases. Neurotoxicology 25, 101-115.
    • (2004) Neurotoxicology , vol.25 , pp. 101-115
    • Burke, W.J.1    Li, S.W.2    Chung, H.D.3
  • 6
    • 38149073317 scopus 로고    scopus 로고
    • Aggregation of alpha-synuclein by DOPAL, the monoamine oxidase metabolite of dopamine
    • Burke W. J., Kumar V. B., Pandey N., et al,. (2008) Aggregation of alpha-synuclein by DOPAL, the monoamine oxidase metabolite of dopamine. Acta Neuropathol. 115, 193-203.
    • (2008) Acta Neuropathol. , vol.115 , pp. 193-203
    • Burke, W.J.1    Kumar, V.B.2    Pandey, N.3
  • 7
    • 34547467082 scopus 로고    scopus 로고
    • Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration
    • Caudle W. M., Richardson J. R., Wang M. Z., et al,. (2007) Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration. J. Neurosci. 27, 8138-8148.
    • (2007) J. Neurosci. , vol.27 , pp. 8138-8148
    • Caudle, W.M.1    Richardson, J.R.2    Wang, M.Z.3
  • 8
    • 49449097043 scopus 로고    scopus 로고
    • Incidental Lewy body disease and preclinical Parkinson disease
    • DelleDonne A., Klos K. J., Fujishiro H., et al,. (2008) Incidental Lewy body disease and preclinical Parkinson disease. Arch. Neurol. 65, 1074-1080.
    • (2008) Arch. Neurol. , vol.65 , pp. 1074-1080
    • Delledonne, A.1    Klos, K.J.2    Fujishiro, H.3
  • 9
    • 0035969842 scopus 로고    scopus 로고
    • Genetic dissection of retinoid dehydrogenases
    • Duester G., (2001) Genetic dissection of retinoid dehydrogenases. Chem. Biol. Interact. 130-132, 469-480.
    • (2001) Chem. Biol. Interact. , vol.130-132 , pp. 469-480
    • Duester, G.1
  • 10
    • 34250928307 scopus 로고
    • Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system
    • Ehringer H., and, Hornykiewicz O., (1960) Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system. Wien. Klin. Wochenschr. 38, 1236-1239.
    • (1960) Wien. Klin. Wochenschr. , vol.38 , pp. 1236-1239
    • Ehringer, H.1    Hornykiewicz, O.2
  • 12
    • 4143144205 scopus 로고    scopus 로고
    • Catecholamine metabolism: A contemporary view with implications for physiology and medicine
    • Eisenhofer G., Kopin I. J., and, Goldstein D. S., (2004) Catecholamine metabolism: a contemporary view with implications for physiology and medicine. Pharmacol. Rev. 56, 331-349.
    • (2004) Pharmacol. Rev. , vol.56 , pp. 331-349
    • Eisenhofer, G.1    Kopin, I.J.2    Goldstein, D.S.3
  • 13
    • 84872171338 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease
    • Fitzmaurice A. G., Rhodes S. L., Lulla A., et al,. (2012) Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease. Proc. Natl Acad. Sci. USA 110, 636-641.
    • (2012) Proc. Natl Acad. Sci. USA , vol.110 , pp. 636-641
    • Fitzmaurice, A.G.1    Rhodes, S.L.2    Lulla, A.3
  • 15
    • 0348109455 scopus 로고    scopus 로고
    • ALDH1 mRNA: Presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia
    • Galter D., Buervenich S., Carmine A., Anvret M., and, Olson L., (2003) ALDH1 mRNA: presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia. Neurobiol. Dis. 14, 637-647.
    • (2003) Neurobiol. Dis. , vol.14 , pp. 637-647
    • Galter, D.1    Buervenich, S.2    Carmine, A.3    Anvret, M.4    Olson, L.5
  • 17
    • 84864705194 scopus 로고    scopus 로고
    • Stress, allostatic load, catecholamines, and other neurotransmitters in neurodegenerative diseases
    • Goldstein D. S., (2012) Stress, allostatic load, catecholamines, and other neurotransmitters in neurodegenerative diseases. Cell. Mol. Neurobiol. 32, 661-666.
    • (2012) Cell. Mol. Neurobiol. , vol.32 , pp. 661-666
    • Goldstein, D.S.1
  • 18
    • 0036138672 scopus 로고    scopus 로고
    • Kinetic model for the fate of the sympathoneural imaging agent 6-[18F]fluorodopamine in the human heart: A novel means to assess cardiac sympathetic neuronal function
    • Goldstein D. S., Katzper M., Linares O. A., and, Kopin I. J., (2002) Kinetic model for the fate of the sympathoneural imaging agent 6-[18F]fluorodopamine in the human heart: a novel means to assess cardiac sympathetic neuronal function. Naunyn-Schmiedeberg's Arch. Pharmacol. 365, 38-49.
    • (2002) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.365 , pp. 38-49
    • Goldstein, D.S.1    Katzper, M.2    Linares, O.A.3    Kopin, I.J.4
  • 20
    • 84861547965 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers of central catecholamine deficiency in Parkinson's disease and other synucleinopathies
    • Goldstein D. S., Holmes C., and, Sharabi Y., (2012a) Cerebrospinal fluid biomarkers of central catecholamine deficiency in Parkinson's disease and other synucleinopathies. Brain 135, 1900-1913.
    • (2012) Brain , vol.135 , pp. 1900-1913
    • Goldstein, D.S.1    Holmes, C.2    Sharabi, Y.3
  • 21
    • 84870587197 scopus 로고    scopus 로고
    • Vesicular uptake blockade generates the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde in PC12 Cells: Relevance to the pathogenesis of Parkinson disease
    • Goldstein D. S., Sullivan P., Cooney A., Jinsmaa Y., Sullivan R., Gross D. J., Holmes C., Kopin I. J., and, Sharabi Y., (2012b) Vesicular uptake blockade generates the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde in PC12 Cells: relevance to the pathogenesis of Parkinson disease. J. Neurochem. 123, 932-943.
    • (2012) J. Neurochem. , vol.123 , pp. 932-943
    • Goldstein, D.S.1    Sullivan, P.2    Cooney, A.3    Jinsmaa, Y.4    Sullivan, R.5    Gross, D.J.6    Holmes, C.7    Kopin, I.J.8    Sharabi, Y.9
  • 23
    • 66149143952 scopus 로고    scopus 로고
    • Protective actions of the vesicular monoamine transporter 2 (VMAT2) in monoaminergic neurons
    • Guillot T. S., and, Miller G. W., (2009) Protective actions of the vesicular monoamine transporter 2 (VMAT2) in monoaminergic neurons. Mol. Neurobiol. 39, 149-170.
    • (2009) Mol. Neurobiol. , vol.39 , pp. 149-170
    • Guillot, T.S.1    Miller, G.W.2
  • 24
    • 49549112268 scopus 로고    scopus 로고
    • Reduced vesicular storage of dopamine exacerbates methamphetamine-induced neurodegeneration and astrogliosis
    • Guillot T. S., Shepherd K. R., Richardson J. R., Wang M. Z., Li Y., Emson P. C., and, Miller G. W., (2008) Reduced vesicular storage of dopamine exacerbates methamphetamine-induced neurodegeneration and astrogliosis. J. Neurochem. 106, 2205-2217.
    • (2008) J. Neurochem. , vol.106 , pp. 2205-2217
    • Guillot, T.S.1    Shepherd, K.R.2    Richardson, J.R.3    Wang, M.Z.4    Li, Y.5    Emson, P.C.6    Miller, G.W.7
  • 25
    • 0028258283 scopus 로고
    • Improved assay for plasma dihydroxyphenylacetic acid and other catechols using high-performance liquid chromatography with electrochemical detection
    • Holmes C., Eisenhofer G., and, Goldstein D. S., (1994) Improved assay for plasma dihydroxyphenylacetic acid and other catechols using high-performance liquid chromatography with electrochemical detection. J. Chromatogr. B Biomed. Appl. 653, 131-138.
    • (1994) J. Chromatogr. B Biomed. Appl. , vol.653 , pp. 131-138
    • Holmes, C.1    Eisenhofer, G.2    Goldstein, D.S.3
  • 26
    • 77951749932 scopus 로고    scopus 로고
    • Contamination of the norepinephrine prodrug droxidopa by dihydroxyphenylacetaldehyde
    • Holmes C., Whittaker N., Heredia-Moya J., and, Goldstein D. S., (2010) Contamination of the norepinephrine prodrug droxidopa by dihydroxyphenylacetaldehyde. Clin. Chem. 56, 832-838.
    • (2010) Clin. Chem. , vol.56 , pp. 832-838
    • Holmes, C.1    Whittaker, N.2    Heredia-Moya, J.3    Goldstein, D.S.4
  • 27
    • 0031682676 scopus 로고    scopus 로고
    • Biochemical aspects of Parkinson's disease
    • Hornykiewicz O., (1998) Biochemical aspects of Parkinson's disease. Neurology 51, S2-S9.
    • (1998) Neurology , vol.51
    • Hornykiewicz, O.1
  • 28
    • 0035840318 scopus 로고    scopus 로고
    • 3,4-Dihydroxyphenylacetaldehyde and hydrogen peroxide generate a hydroxyl radical: Possible role in Parkinson's disease pathogenesis
    • Li S. W., Lin T. S., Minteer S., and, Burke W. J., (2001) 3,4-Dihydroxyphenylacetaldehyde and hydrogen peroxide generate a hydroxyl radical: possible role in Parkinson's disease pathogenesis. Brain Res. Mol. Brain Res. 93, 1-7.
    • (2001) Brain Res. Mol. Brain Res. , vol.93 , pp. 1-7
    • Li, S.W.1    Lin, T.S.2    Minteer, S.3    Burke, W.J.4
  • 29
    • 11844269889 scopus 로고    scopus 로고
    • Intracellular dopamine oxidation mediates rotenone-induced apoptosis in PC12 cells
    • Liu H. Q., Zhu X. Z., and, Weng E. Q., (2005) Intracellular dopamine oxidation mediates rotenone-induced apoptosis in PC12 cells. Acta Pharmacol. Sin. 26, 17-26.
    • (2005) Acta Pharmacol. Sin. , vol.26 , pp. 17-26
    • Liu, H.Q.1    Zhu, X.Z.2    Weng, E.Q.3
  • 30
    • 29744442267 scopus 로고    scopus 로고
    • Gene expression profiling of sporadic Parkinson's disease substantia nigra pars compacta reveals impairment of ubiquitin-proteasome subunits, SKP1A, aldehyde dehydrogenase, and chaperone HSC-70
    • Mandel S., Grunblatt E., Riederer P., Amariglio N., Jacob-Hirsch J., Rechavi G., and, Youdim M. B., (2005) Gene expression profiling of sporadic Parkinson's disease substantia nigra pars compacta reveals impairment of ubiquitin-proteasome subunits, SKP1A, aldehyde dehydrogenase, and chaperone HSC-70. Ann. N. Y. Acad. Sci. 1053, 356-375.
    • (2005) Ann. N. Y. Acad. Sci. , vol.1053 , pp. 356-375
    • Mandel, S.1    Grunblatt, E.2    Riederer, P.3    Amariglio, N.4    Jacob-Hirsch, J.5    Rechavi, G.6    Youdim, M.B.7
  • 31
    • 34249794888 scopus 로고    scopus 로고
    • Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenyla cetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: The role of aldehyde dehydrogenase
    • Marchitti S. A., Deitrich R. A., and, Vasiliou V., (2007) Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenyla cetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase. Pharmacol. Rev. 59, 125-150.
    • (2007) Pharmacol. Rev. , vol.59 , pp. 125-150
    • Marchitti, S.A.1    Deitrich, R.A.2    Vasiliou, V.3
  • 32
    • 0028787768 scopus 로고
    • An endogenous dopaminergic neurotoxin: Implication for Parkinson's disease
    • Mattammal M. B., Haring J. H., Chung H. D., Raghu G., and, Strong R., (1995) An endogenous dopaminergic neurotoxin: implication for Parkinson's disease. Neurodegeneration 4, 271-281.
    • (1995) Neurodegeneration , vol.4 , pp. 271-281
    • Mattammal, M.B.1    Haring, J.H.2    Chung, H.D.3    Raghu, G.4    Strong, R.5
  • 33
    • 0033030440 scopus 로고    scopus 로고
    • Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson's disease
    • Miller G. W., Erickson J. D., Perez J. T., Penland S. N., Mash D. C., Rye D. B., and, Levey A. I., (1999) Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson's disease. Exp. Neurol. 156, 138-148.
    • (1999) Exp. Neurol. , vol.156 , pp. 138-148
    • Miller, G.W.1    Erickson, J.D.2    Perez, J.T.3    Penland, S.N.4    Mash, D.C.5    Rye, D.B.6    Levey, A.I.7
  • 34
    • 80255133088 scopus 로고    scopus 로고
    • Dopamine transporter and vesicular monoamine transporter knockout mice: Implications for Parkinson's disease
    • Miller G. W., Wang Y. M., Gainetdinov R. R., and, Caron M. G., (2001) Dopamine transporter and vesicular monoamine transporter knockout mice: implications for Parkinson's disease. Methods Mol. Med. 62, 179-190.
    • (2001) Methods Mol. Med. , vol.62 , pp. 179-190
    • Miller, G.W.1    Wang, Y.M.2    Gainetdinov, R.R.3    Caron, M.G.4
  • 35
    • 84861651595 scopus 로고    scopus 로고
    • A molecular signature in blood identifies early Parkinson's disease
    • Molochnikov L., Rabey J. M., Dobronevsky E., et al,. (2012) A molecular signature in blood identifies early Parkinson's disease. Mol. Neurodegener. 7, 26.
    • (2012) Mol. Neurodegener. , vol.7 , pp. 26
    • Molochnikov, L.1    Rabey, J.M.2    Dobronevsky, E.3
  • 36
    • 75749084489 scopus 로고    scopus 로고
    • In vivo measurement of vesicular monoamine transporter type 2 density in Parkinson disease with (18)F-AV-133
    • Okamura N., Villemagne V. L., Drago J., et al,. (2010) In vivo measurement of vesicular monoamine transporter type 2 density in Parkinson disease with (18)F-AV-133. J. Nucl. Med. 51, 223-228.
    • (2010) J. Nucl. Med. , vol.51 , pp. 223-228
    • Okamura, N.1    Villemagne, V.L.2    Drago, J.3
  • 37
    • 78650789638 scopus 로고    scopus 로고
    • The neurotoxicity of DOPAL: Behavioral and stereological evidence for its role in Parkinson disease pathogenesis
    • Panneton W. M., Kumar V. B., Gan Q., Burke W. J., and, Galvin J. E., (2010) The neurotoxicity of DOPAL: behavioral and stereological evidence for its role in Parkinson disease pathogenesis. PLoS ONE 5, e15251.
    • (2010) PLoS ONE , vol.5
    • Panneton, W.M.1    Kumar, V.B.2    Gan, Q.3    Burke, W.J.4    Galvin, J.E.5
  • 38
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos M. H., Lavedan C., Leroy E., et al,. (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276, 2045-2047.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3
  • 40
    • 35848959042 scopus 로고    scopus 로고
    • Lipid peroxidation products inhibit dopamine catabolism yielding aberrant levels of a reactive intermediate
    • Rees J. N., Florang V. R., Anderson D. G., and, Doorn J. A., (2007) Lipid peroxidation products inhibit dopamine catabolism yielding aberrant levels of a reactive intermediate. Chem. Res. Toxicol. 20, 1536-1542.
    • (2007) Chem. Res. Toxicol. , vol.20 , pp. 1536-1542
    • Rees, J.N.1    Florang, V.R.2    Anderson, D.G.3    Doorn, J.A.4
  • 41
    • 67651005418 scopus 로고    scopus 로고
    • Protein reactivity of 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite, is dependent on both the aldehyde and the catechol
    • Rees J. N., Florang V. R., Eckert L. L., and, Doorn J. A., (2009) Protein reactivity of 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite, is dependent on both the aldehyde and the catechol. Chem. Res. Toxicol. 22, 1256-1263.
    • (2009) Chem. Res. Toxicol. , vol.22 , pp. 1256-1263
    • Rees, J.N.1    Florang, V.R.2    Eckert, L.L.3    Doorn, J.A.4
  • 42
    • 49149102041 scopus 로고    scopus 로고
    • Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism
    • Sai Y., Wu Q., Le W., Ye F., Li Y., and, Dong Z., (2008) Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism. Toxicol. In Vitro 22, 1461-1468.
    • (2008) Toxicol. in Vitro , vol.22 , pp. 1461-1468
    • Sai, Y.1    Wu, Q.2    Le, W.3    Ye, F.4    Li, Y.5    Dong, Z.6
  • 43
    • 70549084415 scopus 로고    scopus 로고
    • Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
    • Satake W., Nakabayashi Y., Mizuta I., et al,. (2009) Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat. Genet. 41, 1303-1307.
    • (2009) Nat. Genet. , vol.41 , pp. 1303-1307
    • Satake, W.1    Nakabayashi, Y.2    Mizuta, I.3
  • 44
    • 0242300619 scopus 로고    scopus 로고
    • Alpha-Synuclein locus triplication causes Parkinson's disease
    • Singleton A. B., Farrer M., Johnson J., et al,. (2003) alpha-Synuclein locus triplication causes Parkinson's disease. Science 302, 841.
    • (2003) Science , vol.302 , pp. 841
    • Singleton, A.B.1    Farrer, M.2    Johnson, J.3
  • 45
    • 0034108225 scopus 로고    scopus 로고
    • Inhibition of brain vesicular monoamine transporter (VMAT2) enhances 1-methyl-4-phenylpyridinium neurotoxicity in vivo in rat striata
    • Staal R. G., and, Sonsalla P. K., (2000) Inhibition of brain vesicular monoamine transporter (VMAT2) enhances 1-methyl-4-phenylpyridinium neurotoxicity in vivo in rat striata. J. Pharmacol. Exp. Ther. 293, 336-342.
    • (2000) J. Pharmacol. Exp. Ther. , vol.293 , pp. 336-342
    • Staal, R.G.1    Sonsalla, P.K.2
  • 47
    • 80053567505 scopus 로고    scopus 로고
    • Distribution of vesicular monoamine transporter 2 protein in human brain: Implications for brain imaging studies
    • Tong J., Boileau I., Furukawa Y., Chang L.-J., Wilson A. A., Houle S., and, Kish S. J., (2011) Distribution of vesicular monoamine transporter 2 protein in human brain: implications for brain imaging studies. J. Cereb. Blood Flow Metab. 31, 2065-2075.
    • (2011) J. Cereb. Blood Flow Metab. , vol.31 , pp. 2065-2075
    • Tong, J.1    Boileau, I.2    Furukawa, Y.3    Chang, L.-J.4    Wilson, A.A.5    Houle, S.6    Kish, S.J.7
  • 48
    • 84862303338 scopus 로고    scopus 로고
    • Dysregulated dopamine storage increases the vulnerability to alpha-synuclein in nigral neurons
    • Ulusoy A., Bjorklund T., Buck K., and, Kirik D., (2012) Dysregulated dopamine storage increases the vulnerability to alpha-synuclein in nigral neurons. Neurobiol. Dis. 47, 367-377.
    • (2012) Neurobiol. Dis. , vol.47 , pp. 367-377
    • Ulusoy, A.1    Bjorklund, T.2    Buck, K.3    Kirik, D.4
  • 49
    • 0031458923 scopus 로고    scopus 로고
    • Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine
    • Wang Y. M., Gainetdinov R. R., Fumagalli F., Xu F., Jones S. R., Bock C. B., Miller G. W., Wightman R. M., and, Caron M. G., (1997) Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. Neuron 19, 1285-1296.
    • (1997) Neuron , vol.19 , pp. 1285-1296
    • Wang, Y.M.1    Gainetdinov, R.R.2    Fumagalli, F.3    Xu, F.4    Jones, S.R.5    Bock, C.B.6    Miller, G.W.7    Wightman, R.M.8    Caron, M.G.9
  • 50
    • 40749153440 scopus 로고    scopus 로고
    • Proteome analysis of human substantia nigra in Parkinson's disease
    • Werner C. J., Heyny-von Haussen R., Mall G., and, Wolf S., (2008) Proteome analysis of human substantia nigra in Parkinson's disease. Proteome Sci. 6, 8.
    • (2008) Proteome Sci. , vol.6 , pp. 8
    • Werner, C.J.1    Heyny-Von Haussen, R.2    Mall, G.3    Wolf, S.4
  • 51
    • 84857466337 scopus 로고    scopus 로고
    • Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: Implications for Parkinson's disease
    • Wey M., Fernandez E., Martinez P. A., Sullivan P., Goldstein D. S., and, Strong R., (2012) Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's disease. PLoS ONE 7, e31522.
    • (2012) PLoS ONE , vol.7
    • Wey, M.1    Fernandez, E.2    Martinez, P.A.3    Sullivan, P.4    Goldstein, D.S.5    Strong, R.6


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