Cardiac sympathetic nerve function in congestive heart failure

Circulation

Volumn 93, Issue 9, 1996, Pages 1667-1676

  Eisenhofer, Graeme ^a,e   Friberg, Peter ^c   Rundqvist, Bengt ^c   Quyyumi, Arshed A ^b   Lambert, Gavin ^d   Kaye, David M ^d   Kopin, Irwin J ^a   Goldstein, David S ^a   Esler, Murray D ^d  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

heart failure; nervous system, autonomic; norepinephrine; radioisotopes

Indexed keywords

3,4 DIHYDROXYPHENYLETHYLENE GLYCOL; ADRENERGIC RECEPTOR; DOPA; HEART RECEPTOR; NORADRENALIN; TYROSINE 3 MONOOXYGENASE;

ADRENERGIC STIMULATION; ADULT; AGED; ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; FEMALE; HEART NERVE; HUMAN; MAJOR CLINICAL STUDY; MALE; NORADRENALIN BLOOD LEVEL; NORADRENALIN RELEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SYMPATHETIC NERVE;

EID: 0029876322     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.93.9.1667     Document Type: Article

References (40)

1. Thomas JA, Marks BH. Plasma norepinephrine in congestive heart failure. Am J Cardiol. 1978;41:233-243.
2. Davis D, Baily R, Zelis GJ. Abnormalities in systemic norepinephrine kinetics in human congestive heart failure. Am J Physiol. 1988; 254:760-766.
3. Abraham WT, Hensen J, Schrier RW. Elevated plasma noradrenaline concentrations in patients with low-output cardiac failure: dependence on increased noradrenaline secretion rates. Clin Sci. 1990;79:429-435.
4. Leimbach WN, Wallin BG, Victor RG, Aylward PE, Sundlöf G, Mark AL. Direct evidence from intraneural recordings for increased central sympathetic outflow in patients with heart failure. Circulation. 1986;73:913-919.
5. Hasking GJ, Esler MD, Jennings GL, Burton D, Johns JA, Korner PI. Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity. Circulation. 1986;73:615-621.
6. Meredith IT, Eisenhofer G, Lambert GW, Dewar EM, Jennings GL, Esler MD. Cardiac sympathetic nervous activity in congestive heart failure: evidence for increased neuronal norepinephrine release and preserved neuronal uptake. Circulation. 1993;88: 136-145.
7. Kaye DM, Lambert GW, Lefkovits J, Morris M, Jennings G, Esler MD. Neurochemical evidence of cardiac sympathetic activation and increased central nervous system norepinephrine turnover in severe congestive heart failure. J Am Coll Cardiol 1994;23:570-578.
8. Bristow MR, Ginsburg R, Minobe W, Cubicciotti RS, Sageman WS, Lurie K, Billingham ME, Harrison DC, Stinson EB. Decreased catecholamine sensitivity and β-adrenergic receptor density in failing human hearts. N Engl J Med. 1982;307:205-211.
9. Brodde OE. Beta-adrenoceptors in cardiac disease. Pharmacol Ther. 1993;60:405-430.
10. Chidsey CA, Braunwald E, Morrow AG, Mason DT. Myocardial norepinephrine concentrations in man: effects of reserpine and of congestive heart failure. N Engl J Med. 1963;269:653-659.
11. DeQuattro V, Nagatsu T, Mendez A, Verska J. Determinants of cardiac noradrenaline depletion in human congestive failure. Cardiovasc Res. 1973;7:344-350.
12. Borchard F. The adrenergic nerves of the normal and hypertrophied heart. In: Bargmann W, Doerr W, eds. Normal and Pathological Anatomy. Stuttgart, Germany: Georg Thieme Publishers; 1978;33:1-68.
13. Petch MC, Nayler WG. Concentration of catecholamines in human cardiac muscle. Br Heart J. 1979;41:340-344.
14. Sole MJ, Helke CJ, Jacobowitz DM. Increased dopamine in the failing hamster heart: transvesicular transport of dopamine limits the rate of norepinephrine synthesis. Am J Cardiol. 1982;49: 1682-1690.
15. Pierpoint GL, Francis GS, DeMaster EG, Olivari MT, Ring WS, Goldenberg IF, Reynolds S, Cohn JN. Heterogenous myocardial catecholamine concentrations in patients with congestive heart failure. Am J Cardiol. 1987;60:316-321.
16. Rose CP, Burgess JH, Cousineau D. Tracer norepinephrine kinetics in coronary circulation of patients with heart failure secondary to chronic pressure and volume overload. J Clin Invest. 1985; 76:1740-1747.
17. Himura Y, Felten SY, Kashiki M, Lewandowski TJ, Delehanty JM, Liang C-S. Cardiac noradrenergic nerve terminal abnormalities in dogs with experimental congestive heart failure. Circulation. 1993; 88:1299-1309.
18. Liang C-S, Fan T-HM, Sullebarger JT, Sakamoto S. Decreased adrenergic neuronal uptake activity in experimental right heart failure: a chamber-specific contributor to beta-adrenoceptor downregulation. J Clin Invest. 1989;84:1267-1275.
19. Beau SL, Saffitz JE. Transmural heterogeneity of norepinephrine uptake in failing human hearts. J Am Coll Cardiol. 1994;23:579-585.
20. Böhm M, Larosée K, Schwinger RHG, Erdmann E. Evidence for reduction of norepinephrine uptake sites in the failing human heart. J Am Coll Cardiol. 1995;25:146-153.
21. Braunwald E. Pathophysiology of heart failure. In: Braunwald E, ed. Heart Disease: A Textbook of Cardiovascular Medicine. Philadelphia, Pa: WB Saunders Co; 1988:426-448.
22. Port JD, Gilbert EM, Larrabee P, Mealey P, Volkman K, Ginsburg R, Hershberger RE, Murray J, Bristow MR. Neurotransmitter depletion compromises the ability of indirect-acting amines to provide inotropic support in the failing human heart. Circulation. 1990;81:929-938.
23. Eisenhofer G, Smolich JJ, Cox HS, Esler M. Neuronal reuptake of norepinephrine and production of dihydroxyphenylglycol by cardiac sympathetic nerves in the anesthetized dog. Circulation. 1991;84: 1354-1363.
24. Eisenhofer G, Esler MD, Meredith IT, Dart A, Cannon RO, Quyyumi AA, Lambert G, Chin J, Jennings GL, Goldstein DS. Sympathetic nervous function in human heart as assessed by cardiac spillovers of dihydroxyphenylglycol and norepinephrine. Circulation. 1992;85:1775-1785.
25. Eisenhofer G, Smolich JJ, Esler MD. Increased cardiac production of dihydroxyphenylalanine (DOPA) during sympathetic stimulation in anesthetized dogs. Neurochem Int. 1992;21:37-44.
26. Eisenhofer G, Goldstein DS, Stull R, Keiser HR, Sunderland T, Murphy DL, Kopin IJ. Simultaneous liquid-chromatographic determination of 3,4-dihydroxyphenylglycol, catecholamines, and 3,4-dihydroxyphenylalanine in plasma, and their responses to inhibition of monoamine oxidase. Clin Chem. 1986;32:2030-2033.
27. Lenders JWM, Eisenhofer G, Armando I, Keiser HR, Goldstein DS, Kopin IJ. Determination of metanephrines in plasma by liquid chromatography with electrochemical detection. Clin Chem. 1993; 39:97-103.
28. Karoum F. Mass fragmentography in the analysis of biogenic amines: a clinical, physiological, and pharmacological evaluation. In: Parvez S, Nagatsu T, Nagatsu I, Parvez H, eds. Methods in Biogenic Amine Research. New York, NY: Elsevier; 1983:237-255.
29. Esler M, Jennings G, Korner P, Blombery P, Sacharias N, Leonard P. Measurement of total and organ-specific norepinephrine kinetics in humans. Am J Physiol. 1984;247:E21-E28.
30. Eisenhofer G, Rundqvist B, Äneman A, Friberg P, Dakak N, Kopin IJ, Jacobs M-C, Lenders JWM. Regional release and removal of catecholamines and extraneuronal metabolism to metanephrines. J Clin Endocrinol Metab. 1995;80:3009-3017.
31. Eisenhofer G. Plasma normetanephrine for examination of extraneuronal uptake and metabolism of noradrenaline in rats. Naunyn Schmiedebergs Arch Pharmacol. 1994;349:259-269.
32. Goldstein DS, Brush JE, Eisenhofer G, Stull R, Esler M. In vivo measurement of neuronal uptake of norepinephrine in the human heart. Circulation. 1988;78:41-48.
33. Grossman E, Chang PC, Hoffman A, Tamrat M, Kopin IJ, Goldstein DS. Forearm kinetics of plasma norepinephrine: dependence on regional blood flow and the site of infusion of the tracer. Am J Physiol. 1991;260:R946-R952.
34. Chang PC, Kriek E, van der Krogt JA, van Brummelen P. Does regional norepinephrine spillover represent local sympathetic activity? Hypertension. 1991;18:56-66.
35. Sole MJ, Lo C-M, Laird CW, Sonnenblick EH, Wurtman RJ. Norepinephrine turnover in the heart and spleen of the cardiomyopathic Syrian hamster. Circ Res. 1975;37:855-862.
36. Stute N, Trendelenburg U. The outward transport of axoplasmic noradrenaline induced by a rise of the sodium concentration in the adrenergic nerve endings of the rat vas deferens. Naunyn Schmiedebergs Arch Pharmacol. 1984;327:124-132.
37. Pool PE, Covell JW, Levitt M, Gigg J, Braunwald E. Reduction of cardiac tyrosine hydroxylase activity in experimental congestive heart failure: its role in the depletion of cardiac norepinephrine stores. Circ Res. 1967;20:349-353.
38. Rundquist B, Eisenhofer G, Dakak NA, Elam M, Waagstein F, Friberg P. Cardiac noradrenergic function one year following cardiac transplantation. Blood Pressure. 1993;2:252-261.
39. Meredith IT, Esler MD, Cox HS, Lambert GW, Jennings GL, Eisenhofer G. Biochemical evidence of sympathetic denervation of the heart in pure autonomic failure. Clin Auton Res. 1991;1:187-194.
40. Eisenhofer G, Brush JE, Cannon RO, Stull R, Kopin IJ, Goldstein DS. Plasma dihydroxyphenylalanine and total body and regional noradrenergic activity in humans. J Clin Endocrinol Metab. 1989;68: 247-255.