Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism

Toxicology in Vitro

Volumn 22, Issue 6, 2008, Pages 1461-1468

  Sai, Yan ^a   Wu, Qiang ^a   Le, Weidong ^b   Ye, Feng ^a   Li, Yunpeng ^a   Dong, Zhaojun ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Endogenous dopamine; Oxidative stress; Parkinson's disease; Rotenone

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); DOPAMINE; ENZYME; PROTEIN; REACTIVE OXYGEN METABOLITE; ROTENONE; SELEGILINE; TYROSINE 3 MONOOXYGENASE; VANOXERINE; VESICULAR MONOAMINE TRANSPORTER 2;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL STRAIN; CELL TRANSPORT; CELL VIABILITY; CYTOPLASM; CYTOTOXICITY; DOPAMINE METABOLISM; DOPAMINERGIC NERVE CELL; ENVIRONMENTAL EXPOSURE; NONHUMAN; OXIDATIVE STRESS;

ANIMALS; BIOLOGICAL TRANSPORT; CELL DEATH; CELL SURVIVAL; CYTOPLASM; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; INSECTICIDES; NEURONS; OXIDATIVE STRESS; PC12 CELLS; RATS; REACTIVE OXYGEN SPECIES; ROTENONE;

RATTUS;

EID: 49149102041     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.04.019     Document Type: Article

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