Neurodevelopmental implications of the use of sedation and analgesia in neonates

Clinics in Perinatology

Volumn 40, Issue 3, 2013, Pages 559-573

  Davidson, Andrew ^a   Flick, Randall P ^b  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

^b MAYO CLINIC   (United States)

Author keywords

Analgesia; Neonates; Neurodevelopment; Neurotoxicity; Sedation

Indexed keywords

4 AMINOBUTYRIC ACID; ANESTHETIC AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; BRAIN DERIVED NEUROTROPHIC FACTOR; BUPRENORPHINE; CHLORAL HYDRATE; DEXMEDETOMIDINE; DIAZEPAM; FENTANYL; ISOFLURANE; KETAMINE; METHADONE; MIDAZOLAM; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OPIATE; SEDATIVE AGENT; TRAMADOL;

ANALGESIA; BRAIN DEVELOPMENT; DRUG EXPOSURE; DRUG SAFETY; DRUG USE; EXPERIMENTAL ANIMAL; GABAERGIC SYSTEM; GENERAL ANESTHESIA; HUMAN; LEARNING DISORDER; NERVE CELL NECROSIS; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROANATOMY; NEWBORN CARE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; REGIONAL ANESTHESIA; REVIEW; RISK FACTOR; RODENT; SEDATION;

ANALGESIA; NEONATES; NEURODEVELOPMENT; NEUROTOXICITY; SEDATION;

ANALGESIA, OBSTETRICAL; ANALGESICS; ANALGESICS, OPIOID; ANESTHESIA, OBSTETRICAL; ANESTHETICS, GENERAL; ANIMALS; BARBITURATES; BENZODIAZEPINES; BRAIN; CHILD DEVELOPMENT; HUMANS; HYPNOTICS AND SEDATIVES; INFANT, NEWBORN; PAIN MANAGEMENT;

EID: 84882916135     PISSN: 00955108     EISSN: 15579840     Source Type: Journal    
DOI: 10.1016/j.clp.2013.05.009     Document Type: Review

References (73)

1. Quimby K.L., Katz J., Bowman R.E. Behavioral consequences in rats from chronic exposure to 10 PPM halothane during early development. Anesth Analg 1975, 54(5):628-633.
2. Uemura E., Levin E.D., Bowman R.E. Effects of halothane on synaptogenesis and learning behavior in rats. Exp Neurol 1985, 89(3):520-529.
3. Ikonomidou C., Bosch F., Miksa M., et al. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 1999, 283(5398):70-74.
4. Jevtovic-Todorovic V., Hartman R.E., Izumi Y., et al. Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. JNeurosci 2003, 23(3):876-882.
5. Yon J.H., Daniel-Johnson J., Carter L.B., et al. Anesthesia induces neuronal cell death in the developing rat brain via the intrinsic and extrinsic apoptotic pathways. Neuroscience 2005, 135(3):815-827.
6. Hayashi H., Dikkes P., Soriano S.G. Repeated administration of ketamine may lead to neuronal degeneration in the developing rat brain. Paediatr Anaesth 2002, 12(9):770-774.
7. Kodama M., Satoh Y., Otsubo Y., et al. Neonatal desflurane exposure induces more robust neuroapoptosis than do isoflurane and sevoflurane and impairs working memory. Anesthesiology 2011, 115(5):1-13.
8. Istaphanous G.K., Howard J., Nan X., et al. Comparison of the neuroapoptotic properties of equipotent anesthetic concentrations of desflurane, isoflurane, or sevoflurane in neonatal mice. Anesthesiology 2011, 114(3):578-587.
9. Liang G., Ward C., Peng J., et al. Isoflurane causes greater neurodegeneration than an equivalent exposure of sevoflurane in the developing brain of neonatal mice. Anesthesiology 2010, 112(6):1325-1334.
10. Lu Y., Wu X., Dong Y., et al. Anesthetic sevoflurane causes neurotoxicity differently in neonatal naive and Alzheimer disease transgenic mice. Anesthesiology 2010, 112(6):1404.
11. Fredriksson A., Ponten E., Gordh T., et al. Neonatal exposure to a combination of N-methyl-D-aspartate and gamma-aminobutyric acid type A receptor anesthetic agents potentiates apoptotic neurodegeneration and persistent behavioral deficits. Anesthesiology 2007, 107(3):427-436.
12. Stratmann G. Neurotoxicity of anesthetic drugs in the developing brain. Anesth Analg 2011, 113(5):1170-1179.
13. Stratmann G., Sall J.W., May L.D., et al. Isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats. Anesthesiology 2009, 110(4):834-848.
14. Shih J., May L.D.V., Gonzalez H.E., et al. Delayed environmental enrichment reverses sevoflurane-induced memory impairment in rats. Anesthesiology 2012, 116(3):586.
15. Slikker W., Zou X., Hotchkiss C.E., et al. Ketamine-induced neuronal cell death in the perinatal rhesus monkey. Toxicol Sci 2007, 98(1):145-158.
16. Brambrink A.M., Evers A.S., Avidan M.S., et al. Ketamine-induced neuroapoptosis in the fetal and neonatal rhesus macaque brain. Anesthesiology 2012, 116(2):372.
17. Paule M.G., Li M., Allen R.R., et al. Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys. Neurotoxicol Teratol 2011, 33(2):220-230.
18. Brambrink A.M., Evers A.S., Avidan M.S., et al. Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain. Anesthesiology 2010, 112:834-841.
19. Briner A., De Roo M., Dayer A., et al. Volatile anesthetics rapidly increase dendritic spine density in the rat medial prefrontal cortex during synaptogenesis. Anesthesiology 2010, 112(3):546-556.
20. De Roo M., Klauser P., Briner A., et al. Anesthetics rapidly promote synaptogenesis during a critical period of brain development. PLoS One 2009, 4(9):e7043.
21. Vutskits L., Gascon E., Tassonyi E., et al. Effect of ketamine on dendritic arbor development and survival of immature GABAergic neurons invitro. Toxicol Sci 2006, 91(2):540-549.
22. Vutskits L., Gascon E., Tassonyi E., et al. Clinically relevant concentrations of propofol but not midazolam alter invitro dendritic development of isolated gamma-aminobutyric acid-positive interneurons. Anesthesiology 2005, 102(5):970-976.
23. Lemkuil B.P., Head B.P., Pearn M.L., et al. Isoflurane neurotoxicity is mediated by p75ntr-rhoa activation and actin depolymerization. Anesthesiology 2011, 114(1):49-57.
24. Sall J.W., Stratmann G., Leong J., et al. Isoflurane inhibits growth but does not cause cell death in hippocampal neural precursor cells grown in culture. Anesthesiology 2009, 110(4):826-833.
25. Soriano S.G., Liu Q., Li J., et al. Ketamine activates cell cycle signaling and apoptosis in the neonatal rat brain. Anesthesiology 2010, 112(5):1155-1163.
26. Sanchez V., Feinstein S.D., Lunardi N., et al. General anesthesia causes long-term impairment of mitochondrial morphogenesis and synaptic transmission in developing rat brain. Anesthesiology 2011, 115(5):992-1002.
27. Head B.P., Patel H.H., Niesman I.R., et al. Inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system. Anesthesiology 2009, 110(4):813-825.
28. Sanders R.D., Xu J., Shu Y., et al. Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats. Anesthesiology 2009, 110(5):1077-1085.
29. Ma D., Williamson P., Januszewski A., et al. Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain. Anesthesiology 2007, 106(4):746-753.
30. Wang C., Sadovova N., Hotchkiss C., et al. Blockade of N-methyl-D-aspartate receptors by ketamine produces loss of postnatal day 3 monkey frontal cortical neurons in culture. Toxicol Sci 2006, 91(1):192.
31. Braun S., Gaza N., Werdehausen R., et al. Ketamine induces apoptosis via the mitochondrial pathway in human lymphocytes and neuronal cells. Br J Anaesth 2010, 105(3):347-354.
32. Liu J.-R., Liu Q., Li J., et al. Noxious stimulation attenuates ketamine-induced neuroapoptosis in the developing rat brain. Anesthesiology 2012, 117(1):64-71.
33. Anand K.J., Garg S., Rovnaghi C.R., et al. Ketamine reduces the cell death following inflammatory pain in newborn rat brain. Pediatr Res 2007, 62(3):283-290.
34. Bittigau P., Sifringer M., Genz K., et al. Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proc Natl Acad Sci USA 2002, 99(23):15089-15094.
35. Ikonomidou C., Bittigau P., Ishimaru M.J., et al. Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome. Science 2000, 287(5455):1056.
36. Fredriksson A., Archer T., Alm H., et al. Neurofunctional deficits and potentiated apoptosis by neonatal NMDA antagonist administration. Behav Brain Res 2004, 153(2):367-376.
37. Xu H., Liu Z.Q., Liu Y., et al. Administration of midazolam in infancy does not affect learning and memory of adult mice. Clin Exp Pharmacol Physiol 2009, 36(12):1144-1148.
38. Cattano D., Straiko M.M., Olney J.W. Chloral hydrate induces and lithium prevents neuroapoptosis in the infant mouse brain. Anesthesiology 2008, 109:A315.
39. Tachibana K., Hashimoto T., Kato R., et al. Long-lasting effects of neonatal pentobarbital administration on spatial learning and hippocampal synaptic plasticity. Brain Res 2009, 1388:69-76.
40. Kim J.S., Kondratyev A., Tomita Y., et al. Neurodevelopmental impact of antiepileptic drugs and seizures in the immature brain. Epilepsia 2007, 48(Suppl 5):19-26.
41. Sanders R.D., Sun P., Patel S., et al. Dexmedetomidine provides cortical neuroprotection: impact on anaesthetic-induced neuroapoptosis in the rat developing brain. Acta Anaesthesiol Scand 2009, 54(6):710-716.
42. Tachibana K., Hashimoto T., Kato R., et al. Neonatal administration with dexmedetomidine does not impair the rat hippocampal synaptic plasticity later in adulthood. Paediatr Anaesth 2012, 22(7):713-719.
43. Wang Y., Han T.Z. Prenatal exposure to heroin in mice elicits memory deficits that can be attributed to neuronal apoptosis. Neuroscience 2009, 160(2):330-338.
44. Slamberova R., Schindler C.J., Pometlova M., et al. Prenatal morphine exposure differentially alters learning and memory in male and female rats. Physiol Behav 2001, 73(1-2):93-103.
45. Lin C.S., Tao P.L., Jong Y.J., et al. Prenatal morphine alters the synaptic complex of postsynaptic density 95 with N-methyl-D-aspartate receptor subunit in hippocampal CA1 subregion of rat offspring leading to long-term cognitive deficits. Neuroscience 2009, 158(4):1326-1337.
46. McPherson R.J., Gleason C., Mascher-Denen M., et al. Anew model of neonatal stress which produces lasting neurobehavioral effects in adult rats. Neonatology 2007, 92(1):33-41.
47. Boasen J.F., McPherson R.J., Hays S.L., et al. Neonatal stress or morphine treatment alters adult mouse conditioned place preference. Neonatology 2009, 95(3):230-239.
48. Rozisky J.R., Medeiros L.F., Adachi L.S., et al. Morphine exposure in early life increases nociceptive behavior in a rat formalin tonic pain model in adult life. Brain Res 2011, 1367:122-129.
49. Hammer R.P., Ricalde A.A., Seatriz J.V. Effects of opiates on brain development. Neurotoxicology 1989, 10(3):475-483.
50. Tempel A. Visualization of mu opiate receptor downregulation following morphine treatment in neonatal rat brain. Brain Res Dev Brain Res 1991, 64(1-2):19-26.
51. Wu V.W., Mo Q., Yabe T., et al. Perinatal opioids reduce striatal nerve growth factor content in rat striatum. Eur J Pharmacol 2001, 414(2-3):211-214.
52. Dawson G., Dawson S.A., Goswami R. Chronic exposure to kappa-opioids enhances the susceptibility of immortalized neurons (F-11kappa 7) to apoptosis-inducing drugs by a mechanism that may involve ceramide. JNeurochem 1997, 68(6):2363-2370.
53. Rizzi S., Ori C., Jevtovic-Todorovic V. Timing versus duration: determinants of anesthesia-induced developmental apoptosis in the young mammalian brain. Ann N Y Acad Sci 2010, 1199:43-51.
54. Bouman N.H., Koot H.M., Hazebroek F.W. Long-term physical, psychological, and social functioning of children with esophageal atresia. JPediatr Surg 1999, 34(3):399-404.
55. Chacko J., Ford W.D., Haslam R. Growth and neurodevelopmental outcome in extremely-low-birth-weight infants after laparotomy. Pediatr Surg Int 1999, 15(7):496-499.
56. Doyle L.W., Callanan C., Carse E., et al. Surgery and the tiny baby: sensorineural outcome at 5 years of age. JPaediatr Child Health 1996, 32(2):167-172.
57. Laing S., Walker K., Ungerer J., et al. Early development of children with major birth defects requiring newborn surgery. JPaediatr Child Health 2011, 47(3):140-147.
58. Gischler S.J., Mazer P., Duivenvoorden H.J., et al. Interdisciplinary structural follow-up of surgical newborns: a prospective evaluation. JPediatr Surg 2009, 44(7):1382-1389.
59. Ludman L., Spitz L., Lansdown R. Intellectual development at 3 years of age of children who underwent major neonatal surgery. JPediatr Surg 1993, 28(2):130-134.
60. Walker K., Halliday R., Holland A.J., et al. Early developmental outcome of infants with infantile hypertrophic pyloric stenosis. JPediatr Surg 2010, 45(12):2369-2372.
61. Wilder R.T., Flick R.P., Sprung J., et al. Early exposure to anesthesia and learning disabilities in a population-based birth cohort. Anesthesiology 2009, 110(4):796-804.
62. Flick R.P., Katusic S.K., Colligan R.C., et al. Cognitive and behavioral outcomes after early exposure to anesthesia and surgery. Pediatrics 2011, 128(5):e1053-e1061.
63. Sprung J., Flick R.P., Katusic S.K., et al. Attention-deficit/hyperactivity disorder after early exposure to procedures requiring general anesthesia. Mayo Clin Proc 2012, 87(2):120-129.
64. Di Maggio C., Sun L., Kakavuoli A., et al. Aretrospective cohort study of the association of anesthesia and hernia repair surgery with behavioral and developmental disorders in young children. JNeurosurg Anesthesiol 2009, 21:286-291.
65. Di Maggio C., Sun L., Li G. Early childhood exposure to anesthesia and risk of developmental and behavioral disorders in a sibling birth cohort. Anesth Analg 2011, 113(5):1143-1151.
66. Hansen T.G., Pedersen J.K., Henneberg S.W., et al. Academic performance in adolescence after inguinal hernia repair in infancy: a nationwide cohort study. Anesthesiology 2011, 114(5):1076-1085.
67. Block R.I., Thomas J.J., Bayman E.O., et al. Are anesthesia and surgery during infancy associated with altered academic performance during childhood?. Anesthesiology 2012, 117(3):494-503.
68. Bartels M., Althoff R.R., Boomsma D.I. Anesthesia and cognitive performance in children: no evidence for a causal relationship. Twin Res Hum Genet 2009, 12(3):246-253.
69. Ing C., DiMaggio C., Whitehouse A., et al. Long-term differences in language and cognitive function after childhood exposure to anesthesia. Pediatrics 2012, 130(3):e476-e485.
70. Anand K.J., Hall R.W., Desai N., et al. Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial. Lancet 2004, 363(9422):1673-1682.
71. Hall R.W., Kronsberg S.S., Barton B.A., et al. Morphine, hypotension, and adverse outcomes among preterm neonates: who's to blame? Secondary results from the NEOPAIN trial. Pediatrics 2005, 115(5):1351-1359.
72. Sprung J., Flick R.P., Wilder R.T., et al. Anesthesia for cesarean delivery and learning disabilities in a population-based birth cohort. Anesthesiology 2009, 111(2):302-310.
73. Flick R.P., Lee K., Hofer R.E., et al. Neuraxial labor analgesia for vaginal delivery and its effects on childhood learning disabilities. Anesth Analg 2011, 112(6):1424-1431.