Effects of morphine analgesia in ventilated preterm neonates: Primary outcomes from the NEOPAIN randomised trial

Lancet

Volumn 363, Issue 9422, 2004, Pages 1673-1682

  Anand, K J S ^a,b,k   Hall, R Whit ^a   Desai, Nirmala ^c   Shephard, Barbara ^d   Bergqvist, Lena L ^e   Young, Thomas E ^f   Boyle, Elaine M ^g   Carbajal, Ricardo ^h   Bhutani, Vinod K ⁱ   Moore, Mary Beth ^a   Kronsberg, Shari S ^j   Barton, Bruce A ^j  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^d TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^f UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF EDINBURGH   (United Kingdom)

^h CENTRE HOSPITALIER INTERCOMMUNAL   (France)

ⁱ PENNSYLVANIA HOSPITAL   (United States)

^j MARYLAND MEDICAL RESEARCH INSTITUTE   (United States)

^k ARKANSAS CHILDREN S HOSPITAL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE;

ANALGESIA; ARTICLE; ARTIFICIAL VENTILATION; BRAIN HEMORRHAGE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; DRUG EFFECT; HUMAN; INFUSION SYSTEM; LEUKOMALACIA; NEWBORN; NEWBORN CARE; NEWBORN DEATH; PAIN; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TREATMENT OUTCOME;

EID: 2442691352     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(04)16251-X     Document Type: Article

References (50)

1. Anand KJS, International Evidence-Based Group for Neonatal Pain. Consensus statement for the prevention and management of pain in the newborn. Arch Pediatr Adolesc Med 2001; 155: 173-80.
2. American Academy of Pediatrics Committee on Fetus and Newborn, Committee on Drugs. Section on Anesthesiology, Section on Surgery, Canadian Paediatric Society, Fetus and Newborn Committee. Prevention and management of pain and stress in the neonate. Pediatrics 2000; 105: 454-61.
3. Kennedy KA, Tyson JE. Narcotic analgesia for ventilated newborns: are placebo-controlled trials ethical and necessary? J Pediatr. 134:1999;127-129
4. Pokela ML. Pain relief can reduce hypoxemia in distressed neonates during routine treatment procedures. Pediatrics. 93:1994;379-383
5. Goldstein RF, Brazy JE. Narcotic sedation stabilizes arterial blood pressure fluctuations in sick premature infants. J Perinatol. 11:1991;365-371
6. Orsini AJ, Leef KH, Costarino A, Dettorre MD, Stefano JL. Routine use of fentanyl infusions for pain and stress reduction in infants with respiratory distress syndrome. J Pediatr. 129:1996;140-145
7. Barker DP, Rutter N. Stress, severity of illness, and outcome in ventilated preterm infants. Arch Dis Child Fetal Neonatal Ed. 75:1996;F187-F190
8. Dyke MP, Kohan R, Evans S. Morphine increases synchronous ventilation in preterm infants. J Paediatr Child Health. 31:1995;176-179
9. Anand KJS, McIntosh N, Lagercrantz H, Young TE, Vasa RK, Barton BA. Analgesia and sedation in ventilated preterm neonates: results from the pilot NOPAIN trial. Arch Pediatr Adolesc Med. 153:1999;331-338
10. Quinn MW, Wild J, Dean HG, et al. Randomised double-blind controlled trial of effect of morphine on catecholamine concentrations in ventilated preterm babies. Lancet. 342:1993;324-327
11. Simons SHP, van Dijk M, van Lingen RA, et al. Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial. JAMA. 290:2003;2419-2427
12. Pokela ML. Effect of opioid-induced analgesia on beta-endorphin, cortisol and glucose responses in neonates with cardiorespiratory problems. Biol Neonate. 64:1993;360-367
13. Barker DP, Simpson J, Pawula M, Barrett DA, Shaw PN, Rutter N. Randomised, double blind trial of two loading dose regimens of diamorphine in ventilated newborn infants. Arch Dis Child Fetal Neonatal Ed. 73:1995;F22-F26
14. Simons SHP, van Dijk M, Anand KJS, Roofthooft D, van Lingen RA, Tibboel D. Do we still hurt newborn babies? A prospective study of procedural pain and analgesia in neonates. Arch Pediatr Adolesc Med. 157:2003;1058-1064
15. Barker DP, Rutter N. Exposure to invasive procedures in neonatal intensive care unit admissions. Arch Dis Child Fetal Neonatal Ed. 72:1995;F47-F48
16. Johnston CC, Collinge JM, Henderson SJ, Anand KJS. A cross-sectional survey of pain and pharmacological analgesia in Canadian neonatal intensive care units. Clin J Pain. 13:1997;308-312
17. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1, 500 gm. J Pediatr. 92:1978;529-534
18. Ment LR, Bada HS, Barnes P, et al. Practice parameter - neuroimaging of the neonate: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 58:2002;1726-1738
19. Bhat R, Abu-Harb M, Chari G, Gulati A. Morphine metabolism in acutely ill preterm newborn infants. J Pediatr. 120:1992;795-799
20. Barrett DA, Barker DP, Rutter N, Pawula M, Shaw PN. Morphine, morphine-6-glucuronide and morphine-3-glucuronide pharmacokinetics in newborn infants receiving diamorphine infusions. Br J Clin Pharmacol. 41:1996;531-537
21. Barrett DA, Elias-Jones AC, Rutter N, Shaw PN, Davis SS. Morphine kinetics after diamorphine infusion in premature neonates. Br J Clin Pharmacol. 32:1991;31-37
22. Hartley R, Green M, Quinn M, Levene MI. Pharmacokinetics of morphine infusion in premature neonates. Arch Dis Child. 69:1993;55-58
23. Bhat R, Chari G, Gulati A, Aldana O, Velamati R, Bhargava H. Pharmacokinetics of a single dose of morphine in preterm infants during the first week of life. J Pediatr. 117:1990;477-481
24. Scott CS, Riggs KW, Ling EW, et al. Morphine pharmacokinetics and pain assessment in premature newborns. J Pediatr. 135:1999;423-429
25. Zahorodny W, Rom C, Whitney W, et al. The neonatal withdrawal inventory: a simplified score of newborn withdrawal. J Dev Behav Pediatr. 19:1998;89-93
26. Cunningham N. Inclusion of the nonverbal patient: a matter of moral emergency. Pain Forum. 8:1999;110-112
27. Perlman JM, Rollins N. Surveillance protocol for the detection of intracranial abnormalities in premature neonates. Arch Pediatr Adolesc Med. 154:2000;822-826
28. Maalouf EF, Duggan PJ, Counsell SJ, et al. Comparison of findings on cranial ultrasound and magnetic resonance imaging in preterm infants. Pediatrics. 107:2001;719-727
29. Volpe JJ. Neurobiology of periventricular leukomalacia in the premature infant. Pediatr Res. 50:2001;553-562
30. Kahn DJ, Richardson DK, Gray JE, et al. Variation among neonatal intensive care units in narcotic administration. Arch Pediatr Adolesc Med. 152:1998;844-851
31. Sabatino G, Quartulli L, Di Fabio S, Ramenghi LA. Hemodynamic effects of intravenous morphine infusion in ventilated preterm babies. Early Hum Dev. 47:1997;263-270
32. Quinn MW, Otoo F, Rushforth JA, et al. Effect of morphine and pancuronium on the stress response in ventilated preterm infants. Early Hum Dev. 30:1992;241-248
33. Saarenmaa E, Huttunen P, Leppaluoto J, Meretoja O, Fellman V. Advantages of fentanyl over morphine in analgesia for ventilated newborn infants after birth: a randomized trial. J Pediatr. 134:1999;144-150
34. Wu YW, Colford JM. Jr. Chorioamnionitis as a risk factor for cerebral palsy: a meta-analysis. JAMA. 284:2000;1417-1424
35. Bass WT, Schultz SJ, Burke BL, White LE, Khan JH, Karlowicz MG. Indices of hemodynamic and respiratory functions in premature infants at risk for the development of cerebral white matter injury. J Perinatol. 22:2002;64-71
36. Baud O, Foix-L'Helias L, Kaminski M, et al. Antenatal glucocorticoid treatment and cystic periventricular leukomalacia in very premature infants. N Engl J Med. 341:1999;1190-1196
37. Anand KJS. Clinical importance of pain and stress in preterm neonates. Biol Neonate. 73:1998;1-9
38. McIntosh N. Pain in the newborn, a possible new starting point. Eur J Pediatr. 156:1997;173-177
39. van Dijk M, Bouwmeester NJ, Duivenvoorden HJ, et al. Efficacy of continuous versus intermittent morphine administration after major surgery in 0-3-year-old infants; a double-blind randomized controlled trial. Pain. 98:2002;305-313
40. Bouwmeester NJ, Anand KJS, van Dijk M, Hop WC, Boomsma F, Tibboel D. Hormonal and metabolic stress responses after major surgery in children aged 0-3 years: a double-blind, randomized trial comparing the effects of continuous versus intermittent morphine. Br J Anaesth. 87:2001;390-399
41. Lazzara A, Ahmann P, Dykes F, Brann AW Jr, Schwartz J. Clinical predictability of intraventricular hemorrhage in preterm infants. Pediatrics. 65:1980;30-34
42. Volpe JJ. Brain injury in the premature infant: neuropathology, clinical aspects, pathogenesis, and prevention. Clin Perinatol. 24:1997;567-587
43. Grunau RE, Holsti L, Whitfield MF, Ling E. Are twitches, startles, and body movements pain indicators in extremely low birth weight infants? Clin J Pain. 16:2000;37-45
44. Stevens BJ, Johnston CC, Horton L. Multidimensional pain assessment in premature neonates: a pilot study. J Obstet Gynecol Neonatal Nurs. 22:1993;531-541
45. Howard VA, Thurber FW. The interpretation of infant pain: physiological and behavioral indicators used by NICU nurses. J Pediatr Nurs. 13:1998;164-174
46. De Paoli AG, Morley C, Davis PG. Nasal CPAP for neonates: what do we know in? Arch Dis Child Fetal Neonatal Ed ; 88. 2003:2003;F168-F172
47. Greenough A, Milner AD, Dimitriou G. Synchronized mechanical ventilation for respiratory support in newborn infants. (Cochrane Review). In: The Cochrane Library, Issue 1, 2003. Oxford: Update Software: CD000456.
48. Richardson DK, Zupancic JA, Escobar GJ, Ogino M, Pursley DM, Mugford M. A critical review of cost reduction in neonatal intensive care: II strategies for reduction. J Perinatol. 21:2001;121-127
49. Bhutta AT, Rovnaghi CR, Simpson PM, Gosset JM, Scalzo FM, Anand KJS. Interactions of inflammatory pain and morphine treatment in infant rats: long-term behavioral effects. Physiol Behav. 73:2001;51-58
50. Vaccarino AL, Couret LCJr. Relationship between hypothalamic-pituitary- adrenal activity and blockade of tolerance to morphine analgesia by pain: a strain comparison. Pain. 63:1995;385-389