Wheezing in Older Children

Kendig and Chernick's Disorders of the Respiratory Tract in Children

Volumn , Issue , 2012, Pages 699-735

  Kercsmar, Carolyn M ^a,b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882894616     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-1-4377-1984-0.00047-4     Document Type: Chapter

References (101)

1. Z. Allakhverdi, M.R. Comeau and H.K. Jessup (2007) Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J Exp Med. 204 253-258.
2. D.W. Cockcroft (2010) Direct challenge tests: Airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest 138 18S-24S.
3. A.M. Fitzpatrick, W.G. Teague and D.A. Meyers National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program (2011) Heterogeneity of severe asthma in childhood: Confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol. 127 382-389. for the
4. S.T. Holgate (2007) Epithelium dysfunction in asthma. J Allergy Clin Immunol. 120 1233-1244.
5. H.Y. Kim, R.H. DeKruyff and D.T. Umetsu (2010) The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat Immunol. 11 577-583.
6. D. Mackay, S. Haw and J.G. Ayres (2010) Smoke-free legislation and hospitalizations for childhood asthma. N Engl J Med. 363 1139-1145.
7. P.M. O'Byrne, S. Pedersen and C.J. Lamm START Investigators Group (2009) Severe exacerbations and decline in lung function in asthma. Am J Respir Crit Care Med 179 19-24.
8. S.E. Wenzel, P.J. Barnes and E.R. Bleecker T03 Asthma Investigators (2009) A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med. 179 549-558.
9. National Institutes of Health (2007) Guidelines for the Diagnosis and Management of Asthma. Bethesda, Md: National Institutes of Health Expert Panel Report 3. Publication no. 08-4051
10. Asthma episodes and current asthma. www.cdc.gov/nchs/data/nhis/earlyrelease/201006_15.pdf Accessed 16.06.10 Available at
11. H.A. Jenkins, C. Cool and S.J. Szefler (2003) Histopathology of severe childhood asthma A case series. Chest 124 32-41.
12. A. Barbato, G. Turato and S. Baraldo (2006) Epithelial damage and angiogenesis in the airways of children with asthma. Am J Respir Crit Care Med. 174 975-981.
13. R.A. Panettieri Jr. (2009) Asthma persistence versus progression: Does airway smooth muscle function predict irreversible airflow obstruction? Allergy Asthma Proc. 30 103-108.
14. M. Contoli, J. Bousquet and L.M. Fabbri (2010) The small airways and distal lung compartment in asthma and COPD: a time for reappraisal. Allergy 65 141-151.
15. M.J. Leckie, A. Brinke and J. Khan (2000) Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyperresponsiveness, and the late asthmatic response. Lancet. 356 2144-2148.
16. B.S. Bochner and G.J. Gleich (2010) What targeting eosinophils has taught us about their role in diseases. Allergy Clin Immunol. 126 16-25.
17. C. Doe, M. Bafadhel and S. Siddiqui (2010) Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD. Chest 138 1140-1147.
18. P.D. Phelan, C.F. Robertson and A. Olinsky (2002) The Melbourne Asthma Study: 1964-1999. J Allergy Clin Immunol. 109 189-194.
19. L.M. Van den Toorn, S.E. Overbeek and J.C. De Jongste (2001) Airway inflammation is present during clinical remission of atopic asthma. Am J Respir Crit Care Med. 164 2107-2113.
20. R.A. Covar, R. Strunk and R.S. Zeiger Childhood Asthma Management Program Research Group (2010) Predictors of remitting, periodic, and persistent childhood asthma. J Allergy Clin Immunol 125 359-366. for the
21. W.R. Henderson Jr., L-Q Tang and S.J. Chu (2002) A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med. 165 108-116.
22. Childhood Asthma Management Program Research Group (2000) Long-term effects of budesonide or nedocromil in children with asthma. N Engl J Med 343 1054-1063.
23. T.W. Guilbert, W.J. Morgan and R.S. Zeiger (2006) Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med. 354 1985-1997.
24. D.M. Murphy and P.M. O'Byrne (2010) Recent advances in the pathophysiology of asthma. Chest 137 1417-1426.
25. S. Jain, V. Bandi and T. Officer (2006) Role of vocal cord function and dysfunction in patients presenting with symptoms of acute asthma exacerbation. J Asthma 43 207-212.
26. R.S. Gruchalla, J. Pongracic and M. Plaut (2005) Inner City Asthma Study: relationships among sensitivity, allergen exposure, and asthma morbidity. J Allergy Clin Immunol. 115 478-485.
27. D.J. Jackson, R.E. Gangnon and M.D. Evans (2008) Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med. 178 667-672.
28. R.F. Lemanske Jr., D.J. Jackson and R.E. Gangnon (2005) Rhinovirus illnesses during infancy predict subsequent childhood wheezing. J Allergy Clin Immunol. 116 571-577.
29. C.E. Loughlin, C.R. Esther Jr. and E.R. Lazarowski (2010) Neutrophilic inflammation is associated with altered airway hydration in stable asthmatics. Respir Med. 104 29-33.
30. R.J. Wright, C.M. Visness and A. Calatroni (2010) Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohort. Am J Respir Crit Care Med. 182 25-33.
31. S.M. Harding, M.R. Guzzo and J.E. Richter (2000) The prevalence of gastroesophageal reflux in asthma patients without reflux symptoms. Am J Respir Crit Care Med. 162 34.
32. K. Thakkar, R.O. Boatright and M.A. Gilger (2010) Gastroesophageal reflux and asthma in children: a systematic review. Pediatrics 125 e925-e930.
33. The American Lung Association Asthma Clinical Research Centers (2009) Efficacy of esomeprazole for treatment of poorly controlled asthma. N Engl J Med 360 1487-1499.
34. C. Jenkins, J. Costello and L. Hodge (2004) Systematic review of prevalence of aspirin induced asthma and its implications for clinical practice. BMJ. 328 434-441.
35. R. Beasley, T. Clayton and J. Crane ISAAC Phase Three Study Group (2008) Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC Programme. Lancet. 372 1039-1048. for the
36. J.M. Brehm, J.C. Celedon and M.E. Soto-Quiros (2009) Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med. 179 765-771.
37. E. Xystrakis, S. Kusumakar and S. Boswell (2006) Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid resistant asthma patients. J Clin Invest. 116 146-155.
38. M.R. Simon, V.M. Chinchilli and B.R. Phillips (2010) Forced expiratory flow between 25% and 75% of vital capacity and FEV1/forced vital capacity ratio in relation to clinical and physiological parameters in asthmatic children with normal FEV1 values. J Allergy Clin Immunol. 126 527-534. www.jacionline.org/article/S0091-6749%2810%2900817-1/fulltext-article-footnote-1 www.jacionline.org/article/S0091-6749%2810%2900817-1/fulltext-article-footnote-2
39. G.R. Vink, H.G. Arets and J. van der Laag (2003) Impulse oscillometry. A measure for airway obstruction. Pediatr Pulmonol. 35 214-219.
40. Guidelines for Methacholine and Exercise Challenge Testing—1999. The American Thoracic Society. Am J Respir Crit Care Med. 161 309-329.
41. A. Sverrild, C. Porsbjerg and S.F. Thomsen (2009) Diagnostic properties of inhaled mannitol in the diagnosis of asthma: a population study. J Allergy Clin Immunol. 124 928-932.
42. R.H. Green, C.E. Brightling and S. McKenna (2002) Asthma exacerbations and sputum eosinophil counts A randomized controlled trial. Lancet. 360 1715-1721.
43. S.A. Kharitonov and P.J. Barnes (2006) Exhaled biomarkers. Chest 130 1541-1546.
44. M.A. Berry, D.E. Shaw and R.H. Green (2005) The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma. Clin Exp Allergy 35 1175-1179.
45. C. Lex, F. Ferreira and A. Zacharasiewiz (2006) Airway eosinophilia in children with severe asthma. Am J Respir Crit Care Med. 174 1286-1291.
46. D.R. Taylor, M.W. Pijnenburg and A.D. Smith (2006) Exhaled nitric oxide measurements: clinical application and interpretation. Thorax 61 817-827.
47. A.M. Fitzpatrick, B.M. Gaston and S.C. Erzurum National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program (2006) Features of severe asthma in school-age children: atopy and increased exhaled nitric oxide. J Allergy Clin Immunol. 118 1218-1825. for the
48. Y. Sivan, T. Gadish and E. Fireman (2009) The use of exhaled nitric oxide in the diagnosis of asthma in school children. J Pediatr. 155 211-216.
49. J. Hunt (2002) Exhaled breath condensate An evolving tool for noninvasive evaluation of lung disease. J Allergy Clin Immunol. 110 28-34.
50. L. Liu, P. Urban and J.F. Hunt (2010) Changes in exhaled nitric oxide and breath pH during fluticasone wean in asthma. Respiration 79 193-199.
51. GINA Report, Global Strategy for Asthma Management and Prevention. www.ginasthma.org/guidelines-gina-report-global-strategy-for-asthma.html Updated December 2009
52. A. Bush and S. Saglani (2010) Management of severe asthma in children. Lancet. 376 814-825.
53. Proceedings of the ATS Workshop on Refractory Asthma (2000) Current understanding, recommendations, and unanswered questions. Am J Respir Crit Care Med. 162 2341-2351.
54. P. Haldar, I.D. Pavord and D.E. Shaw (2008) Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med. 178 218-224.
55. A.T. Hastie, W.C. Moore and D.A. Meyers National Heart, Lung, and Blood Institute Severe Asthma Research Program (2010) Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. J Allergy Clin Immunol. 125 1028-1036. for the
56. J.K. Sont, L.N.A. Willems and E.H. Bel (1999) Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. Am J Respir Crit Care Med. 159 1043-1051.
57. M.V. Pijnenburg, E.M. Bakker and W.C. Hop (2005) Titrating steroids on exhaled nitric oxide in children with asthma. a randomized controlled trial. Am J Respir Crit Care Med. 172 831-836.
58. J.C. de Jongste, S. Carraro and W.C. Hop CHARISM Study Group (2009) Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma. Am J Respir Crit Care Med. 179 93-97. for the
59. S.J. Szefler, H. Mitchell and C.A. Sorkness (2008) Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet. 372 1065-1072.
60. D.K. Agrawal, K. Ariyarathna and P.W. Kelbe (2004) (S)-albuterol activates proconstrictory and pro-inflammatory pathways in human bronchial smooth muscle cells. J Allergy Clin Immunol. 113 503-510.
61. J.C. Carl, T.R. Myers and H.L. Kirchner (2003) Comparison of racemic albuterol and levalbuterol for treatment of acute asthma. J Pediatr. 143 731-736.
62. T. Andrews, E. McGintee and M.K. Mittal (2009) High-dose continuous nebulized levalbuterol for pediatric status asthmaticus: a randomized trial. J Pediatr. 155 205-210.
63. J.M. Drazen, E. Israel and H.A. Boushey (1996) Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. N Engl J Med. 335 841-847.
64. F.D. Martinez, P.E. Graves and M. Baldini (1997) Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest. 100 3184-3188.
65. E. Israel, V.M. Chinchilli and J.G. Ford (2004) Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet. 364 1505-1512.
66. D. Craven, C.M. Kercsmar and T.R. Myers (2001) Ipratropium bromide plus nebulized albuterol for the treatment of hospitalized children with acute asthma. J Pediatr. 138 51-58.
67. S.P. Peters, S.J. Kunselman and N. Icitovic National Heart, Lung, and Blood Institute Asthma Clinical Research Network (2010) Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med. 363 1715-1726. for the
68. N.C. Barnes (2007) The properties of inhaled corticosteroids: similarities and differences. Prim Care Respir J. 16 149-154.
69. T.J. Lasserson, C.J. Cates and A-B Jones (2006) Fluticasone versus HFA-beclomethasone dipropionate for chronic asthma in adults and children. Cochrane Database Syst Rev. (2), CD005309
70. D.P. Skoner, J. Maspero and D. Banerji Ciclesonide Pediatric Growth Study Group (2008) Assessment of the long-term safety of inhaled ciclesonide on growth in children with asthma. Pediatrics 121 e1-e14.
71. D.Y.M. Leung and J.W. Bloom (2003) Update on glucocorticoid action and resistance. J Allergy Clin Immunol. 111 3-22.
72. S.J. Szefler, R.J. Martin and T.S. King (2002) Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol. 109 410-418.
73. L. Agertoft and S. Pedersen (2000) Effect of long-term treatment with inhaled budesonide on adult height in children with asthma. N Engl J Med. 343 1064-1069.
74. M. Johnson (2001) Beta2-adrenoceptors: mechanisms of action of beta2-agonists. Paediatr Respir Rev. 2 57-62.
75. S. Haney and R.J. Hancox (2005) Rapid onset of tolerance to beta-agonist bronchodilation. Respir Med. 99 566-571.
76. R.F. Lemanske Jr., C.A. Sorkness and E.A. Mauger Asthma Clinical Research Network for the National Heart, Lung, and Blood Institute (2001) Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol. A randomized controlled trial. JAMA. 285 2594-2603.
77. H.S. Nelson, S.T. Weiss and E.R. Bleecker (2006) The salmeterol multicenter asthma research trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest 129 15-26.
78. B.A. Chowdhury and P.G. Dal (2010) The FDA and safe use of long-acting beta-agonists in the treatment of asthma. N Engl J Med. 362 1169-1171.
79. M.E. Wechsler, S.J. Kunselman and V.M. Chinchilli National Heart, Lung and Blood Institute's Asthma Clinical Research Network (2009) Effect of β2-adrenergic receptor polymorphism on response to longacting β2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial. Lancet. 374 1754-1764. for the
80. F.M. Ducharme, M. Ni Chroinin and I. Greenstone (2010) Addition of long-acting beta2-agonists to inhaled steroids versus higher dose inhaled steroids in adults and children with persistent asthma. Cochrane Database Syst Rev. (4), CD005533
81. A.A. Verberne, C. Frost and E.J. Duiverman (1998) Addition of salmeterol versus doubling the dose of beclomethasone in children with asthma. The Dutch Asthma Study Group. Am J Respir Crit Care Med. 158 213-219.
82. M. Gappa, W. Zachgo and A. von Berg VIAPAED Study Group (2009) Add-on salmeterol compared to double dose fluticasone in pediatric asthma: a double-blind, randomized trial (VIAPAED). Pediatr Pulmonol. 44 1132-1142.
83. R.F. Lemanske Jr., D.T. Mauger and C.A. Sorkness Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute (2010) Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids. N Engl J Med. 362 975-985. for the
84. P.M. O'Byrne, H. Bisgaard and P.P. Godard Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma (2005) Am J Respir Crit Care Med. 171 129-136.
85. H. Bisgaard, P. Le Roux and D. Bjåmer (2006) Budesonide/formoterol maintenance plus reliever therapy: a new strategy in pediatric asthma. Chest 130 1733-1743.
86. S.R. Salpeter, A.J. Wall and N.S. Buckley (2010) Long-acting beta-agonists with and without inhaled corticosteroids and catastrophic asthma events. Am J Med. 123 322-328.
87. C.A. Sorkness, R.F. Lemanske and D.T. Mauger (2007) Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial. J Allergy Clin Immunol. 119 64-72.
88. S.J. Szefler, B.R. Phillips and F.D. Martinez (2005) Characterization of within-subject responses to fluticasone and montelukast in childhood asthma. J Allergy Clin Immunol. 115 233-242.
89. J.E. Knuffman, C.A. Sorkness and R.F. Lemanske Jr Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute (2009) Phenotypic predictors of long-term response to inhaled corticosteroid and leukotriene modifier therapies in pediatric asthma. J Allergy Clin Immunol. 123 411-416. for the
90. F.E.R. Simons, J.R. Villa and B.W. Lee (2001) Montelukast added to budesonide in children with persistent asthma. A randomized, double-blind, crossover study. J Pediatr. 138 694-698.
91. M. Humbert, R. Beasley and J. Ayres (2005) Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE. Allergy 60 309-316.
92. B. Lanier, T. Bridges and M. Kulus (2009) Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma. J Allergy Clin Immunol. 124 1210-1216.
93. P. Haldar, C.E. Brightling and B. Hargadon (2009) Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med. 360 973-984.
94. D. Price, R.J. Martin and N. Barnes (2010) Prescribing practices and asthma control with hydrofluoroalkane-beclomethasone and fluticasone: a real-world observational study. J Allergy Clin Immunol. 126 511-518.
95. H.A. Boushey, C.A. Sorkness and T.S. King National Heart, Lung, and Blood Institute's Asthma Clinical Research Network (2005) Daily versus as-needed corticosteroids for mild persistent asthma. N Engl J Med. 352 1519-1528. for the
96. M. Turpeinen, K. Nikander and A.S. Pelkonen (2008) Daily versus as-needed inhaled corticosteroid for mild persistent asthma (The Helsinki early intervention childhood asthma study). Arch Dis Child 93 654-659.
97. W.J. Morgan, E.F. Crain and R.S. Gruchalla Inner-City Asthma Study Group (2004) Results of a home-based environmental intervention among urban children with asthma. N Engl J Med. 351 1068-1080. for the
98. C.M. Kercsmar, D.G. Dearborn and M. Schluchter (2006) Reduction in asthma morbidity in children as a result of home remediation aimed at moisture reduction. Environ Health Perspect. 114 1574-1580.
99. J. Oborne, K. Mortimer and R.B. Hubbard (2009) Quadrupling the dose of inhaled corticosteroid to prevent asthma exacerbations: a randomized, double-blind, placebo-controlled, parallel-group clinical trial. Am J Respir Crit Care Med. 180 598-602.
100. C.R. Morris, A.B. Becker and A. Piñieiro (2010) A randomized, placebo-controlled study of intravenous montelukast in children with acute asthma. Ann Allergy Asthma Immunol. 104 161-171.
101. C.M. Kercsmar and T.R. Myers (2002) Clinical pathways in treatment of asthma. Curr Opin Allergy Clin Immunol. 2 183-187.